James G. LinakisProfessor of Emergency Medicine, Professor of Pediatrics
James Linakis is currently Professor of Emergency Medicine and Pediatrics at Brown Medical School and Associate Director of Pediatric Emergency Medicine at Rhode Island Hospital's Hasbro Children's Hospital. He attended University of Oregon Health Sciences Center where he received a PhD in Medical Biopsychology and Yale University School of Medicine where he received his medical degree. Dr. Linakis completed a residency in Pediatrics at Yale-New Haven Hospital and a combined fellowship in Pediatric Emergency Medicine and Toxicology at Children's Hospital in Boston. He has conducted research in the areas of toxicology and injury prevention and in healthcare delivery.
Mahajan P, Kuppermann N, Mejias A, Suarez N, Chaussabel D, Casper TC, Smith B, Alpern ER, Anders J, Atabaki SM, Bennett JE, Blumberg S, Bonsu B, Borgialli D, Brayer A, Browne L, Cohen DM, Crain EF, Cruz AT, Dayan PS, Gattu R, Greenberg R, Hoyle JD Jr, Jaffe DM, Levine DA, Lillis K, Linakis JG, Muenzer J, Nigrovic LE, Powell EC, Rogers AJ, Roosevelt G, Ruddy RM, Saunders M, Tunik MG, Tzimenatos L, Vitale M, Dean JM, Ramilo O, Pediatric Emergency Care Applied Research Network (PECARN).
Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger.
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The long-term goal of the present research program is to enhance the
utilization of evidence-based injury prevention strategies and to
encourage medical practitioners to disseminate focused information
regarding injury prevention in the Pediatric Emergency Department (ED).
The long-term goal of the present research program is to enhance the utilization of evidence-based injury prevention strategies and to encourage medical practitioners to disseminate focused information regarding injury prevention in the Pediatric Emergency Department (ED). The proposed research plan: (1) examines the efficacy of a Brief Motivational Intervention to enhance automobile safety restraint-specific injury prevention behaviors in parents/caregivers of younger children; (2) examines the efficacy of focused, behavior-specific, injury prevention discharge instruction supplements (Enhanced Standard Care) in increasing safety restraint-specific injury prevention behaviors in parents/caregivers of younger children; and (3) examines the impact of assignment to participation in a car-seat distribution and education program on safety restraint practices in parents/caregivers of younger children. We will conduct a randomized, controlled trial of parent/caregivers of children being evaluated in the Children's Hospital Emergency Department. Eligible, consenting participants will be screened with an injury assessment tool for inappropriate use of motor vehicle child safety restraints. High risk participants will be randomized into three intervention groups: Standard Care (SC), Enhanced Standard Care (ESC) and Brief Motivational Intervention (BMI). All participants will then be contacted three months following enrollment and surveyed regarding child safety restraint practices, attitudes, and knowledge. The following main effects will be evaluated with relation to child safety restraint practice and attitude change: (1) Intervention (SC vs. ESC vs. BMI); and (2) Injury status of child (injured vs. non-injured). In addition, we will monitor re-injury rates of the index children of all enrolled parent/caregivers for one year from the time of enrollment and compare on the bases of the above main effects. This study examines the Pediatric Emergency Department as a location for increasing safe car seat practices by parents who are not restraining their children appropriately in motor vehicles. Three different interventions will be tested to determine their effectiveness in increasing safe car seat practices.
American Academy of Toxicology, "Use of Kayexalate to Increase Lithium Clearance: An Animal Model", 1989, $1000, Principal Investigator: James G. Linakis, Ph.D., M.D.
Gustavus and Louise Pfeiffer Research Foundation, "Reduction of Lithium Toxicity by Decreasing its Absorption or Enhancing its Elimination with Sodium Polystyrene Sulfonate", 1991-1992, $27,350, Principal Investigator: James G. Linakis, Ph.D., M.D.
American Heart Association Affiliate Grant-in-Aid, "Ontogeny of Cardiac Reperfusion Injury Following Ischemic Insult: Role of Sarcolemmal Ion Exchangers", 1999-2001, $75,484, Principal Investigator: James G. Linakis, Ph.D., M.D.
Rhode Island Mental Health, State Incentive Grant, "Substance Abuse Prevention", 2004-2006, $160,000, Principal Investigator: Lynne Palmisciano, M.D., Co-Investigator: James G. Linakis, Ph.D., M.D.
"Prospective Epidemiologic Study of the Severity of Bronchiolitis in Infants Treated in Urgent/Emergent and Hospital Settings", contract with Merck, Co., Inc. 2004-2005, $38,000; Site Principal Investigator: Dale W. Steele, M.D., Co-Investigator: James G. Linakis, Ph.D., M.D.
ED Based Prevention Intervention to Delay Alcohol Use by Young Adolescents, 1R21AA018380-01A1, NIAAA, 4/1/2010-3/31/2012 (no cost extension), $ 533,346, Principal Investigators: James G. Linakis, Ph.D., M.D., Anthony Spirito, Ph.D.
Translation of Alcohol Screening and Brief Intervention Guidelines to Pediatric Trauma Centers, R01 CE001586, CDC, 10/1/09-9/30/12 (no cost extension); Mello MJ (PI); Linakis JG (Co-I).
Assessment of AppyScore™ Rapid Test (an MRP 8/14 assay) with a Clinical Pretest Probability (PTP) Assessment Model for Clinical Management of Children and Adolescents with Signs and Symptoms Suspicious for Acute Appendicitis, AspenBio Pharma, 10/1/2011 – 9/30/2012, Site PI: James G. Linakis Ph.D., M.D.
RNA Biosignatures in the Emergency Evaluation of Febrile Infants, 1R01HD062477-01A1, NICHD, 12/01/2011 – 03/31//2013, Mahajan (PI); Linakis (co-I).
Teen Alcohol Screening in the Pediatric Emergency Care Applied Research Network, R01 AA021900, 9/1/12 – 5/31/17; $3,278,096, Principal Investigators: James G. Linakis, Ph.D., M.D., Anthony Spirito, Ph.D.