Jason M. ShapiroAssistant Professor of Pediatrics (Clinical), Assistant Professor of Medicine (Clinical)
Dr. Shapiro grew up in Lincoln, Rhode Island. He attended college and medical school at the University of Vermont before returning home to Rhode Island where he completed his residency in Pediatrics and fellowship in Pediatric Gastroenterology at Hasbro Children's Hospital. Dr. Shapiro is currently a faculty member in the division of Pediatric Gastroenterology, Nutrition and Liver Diseases at Hasbro Children's Hospital and is assistant professor of Pediatrics at the Warren Alpert Medical School of Brown University. His clinical and research interests are focused on pediatric inflammatory bowel disease.
My goal is to determine the factors associated with favorable outcomes of childhood inflammatory bowel disease (IBD). IBD is a chronic, debilitating condition characterized by relapsing and remitting episodes of gastrointestinal inflammation. Pathogenesis has been attributed to a combination of causative factors including genetic predisposition, alterations in the gut microbiome, defects in the innate and adaptive immune system and various putative environmental exposures. The incidence of IBD in children has inexplicably increased over the past few decades and despite new therapies, little is known about how to optimize these treatments to achieve the best long-term outcomes. In 2010 I received an NIH T32 Ruth L. Kirschstein National Research Award to complete my last 2 years of pediatric gastroenterology fellowship here at Rhode Island Hospital/Hasbro Children’s Hospital. Under the mentorship of Dr. Jack Wands, my work focused on the identification and characterization of novel biomarkers of colonic dysplasia, a precursor of colon cancer in patients with long standing IBD. My academic focus remains on clinical and translational aspects of inflammatory bowel disease research. I am currently the co-principal investigator of the Ocean State Crohn’s and Colitis Area Registry (OSCCAR) along with the primary principal investigator, Dr. Bruce E. Sands, the Dr. Burrill B. Crohn Professor of Medicine and Chief of the Henry D. Janowitz Division of Gastroenterology at the Icahn School of Medicine at Mount Sinai. A well defined, inception cohort of patients with newly diagnosed IBD in the state of Rhode Island, OSCCAR represents a unique opportunity to study the natural history of IBD over time. In addition, leveraging the clinical, microbial and genomic data obtained from analysis of the various OSCCAR biospecimens represents an exciting opportunity to further define the immunopathogenesis of inflammatory bowel disease.