Larry K. BrownProfessor of Psychiatry and Human Behavior
Dr. Brown is a board-certified child and adolescent psychiatrist with a particular interest in HIV and risk behaviors among adolescents and young adults. He also conducts clinical treatment trials to reduce substance use and depression for those living with HIV through the Adolescent AIDS Trials Network and is developing and testing an iPhone game to improve medical adherence for adolescents and young adults with HIV. He is Associate Director of the Lifespan / Tufts / Brown Center for AIDS Research and the Program Director of a NIH T32 postdoctoral training program in HIV biobehavioral research.
Brown, L,.Kennard B., G. Emslie, Mayes, T., Whiteley, L.,Behtel, J., Xu, J., Thorton, S., Tanney, M., Hawkins, L., Garvie, P., Subramaniam, G., Worrell, C., Stoff, L., and the Adolescent Trials Network for HIV/AIDS Interventions. Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults living with HIV: A controlled trial, Journal of Acquired Immunodeficiency Syndromes, in press.
Brown, L., Whiteley, L., Harper, G., Nichols, S., Nieves, A. & Adolescent Trials Network for HIV/AIDS Interventions: Psychological symptoms among 2,032 youth living with HIV: A multisite study. AIDS Patient Care and STDs, 29:212-219, 2015. PMID 25585049 PMC Journal - In Process.
Larry Brown's current research interests focus on HIV risk and the efficacy of HIV prevention treatments among subgroups of adolescents and young adults such as those with psychiatric disorders and young MSM. He is the Principal Investigator of several major projects, funded by National Institute of Memtal Health (NIMH), that focus on the relationship between psychopathology and HIV risk behaviors.
Adolescent HIV Prevention Laboratory
Ongoing projects, funded by NIMH and National Institute on Drug Abuse (NIDA), target HIV prevention intervenions for those for at-risk adolescents living with HIV. Studies demonstrate the impact of a family-based intervention to increase adolescent and parent communication and parental monitoring of adolescent activities. This family-based HIV prevention research is one of the first to target adolescents with severe mental illness and their families. Other studies examine interventions for juvenile offenders, media-based interventions for community youth, and interventions for those living with HIV, including the use of mobile gaming. In all studies, HIV-related knowledge, attitudes, and behaviors are targeted through both didactic and skills-based activities. The laboratory provides training in HIV clinical research for clinical psychology interns, post-doctoral fellows, psychiatrists, and other physicians. .
Current Funding (of more than 30 projects total)
"A Pilot Gaming Adherence Program for Youth Living with HIV"
Principal Investigator: Larry K. Brown, M.D. Agency: National Institute of Child Health and Human Development, Type: RO1HD074848 Period: 10/1/2012-6/30/14. This study that utilizes an iPhone app/game to promote healthy decision making and adherence to medication and treatment in youth and young adults living with HIV.
"Drug Use and HIV/STI Risk Trajectories among Court-Involved, Non-Incarcerated Youth" Principal Investigator: Marina Tolou-Shams, Ph.D., Agency: National Institute of Drug Addiction, Type: R01DA034538 Period: 7/1/2013-3/31/2018. The goal of this study is to conduct a longitudinal epidemiological assessment of HIV/STI risk, substance use, psychiatric symptoms and recidivism among 400 court-involved, non-incarcerated juveniles in the Rhode Island Family Court.
"Integrated Mental Health Treatment & HIV Prevention for Court-Involved Youth" Principal Investigator: Larry K. Brown, M.D., Agency: National Institute of Mental Health, Type: R01MH087520 Period: 7/5/2010-4/30/2015. The purpose of this study is to compare the relative efficacy of an integrated mental health treatment and HIV prevention program to standard-of-care mental health treatment for 200 youth receiving mental health evaluations through the RI Family Court, Juvenile Mental Health Clinic.
"Training in Child/Adolescent Biobehavioral HIV Research". Principal Investigator: Larry K. Brown, M.D., Agency: National Institute of Mental Health, Type: T322 MH 07878 Period: 07/01/2013-06/30/2018. This program for postdoctoral psychologists and psychiatrists provides specialized training in Child & Adolescent Biobehavioral HIV research with infected and at-risk populations.
"Digital Star: HIV Prevention for Youth in Mental Health Treatment, Phase 1 and 2" Co-Principal Investigator with D. McDaniels (Virtually Better), Agency: National Institute of Mental Health, Type: R44 MH102140 Period: 08/01/15-07/31/18. This project is adapting into a digital format an evidence-based facilitator-led HIV prevention intervention for adolescents.
"Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center" Principal Investigator: Craig Wilson, M.D., Agency: National Institute of Child Health and Human Development, Type: 2U01 HD040533 Period: 03/01/11-02/28/16. The Adolescent Medicine Leadership group and the Coordinating Center will continue to provide scientific and administrative leadership for the Adolescent Medicine Trials Network for HIV/AIDS Interventions. Dr. Brown is a member of the Behavioral Leadership Group and Chair of Protocols 069 and 080.
"Lifespan/Tufts/Brown Center for AIDS Research" Principal Investigator: Charles Carpenter, M.D., Agency: National Institute of Allergy and Infectious Diseases, Type: P30 AI042853 Period: 07/01/12-6/30/17. This grant supports infrastructure and developmental work related to AIDS at the affiliated institutions. Dr. Brown is the co-Director of the Prevention Core and Associate Director of the CFAR.
“A Multilevel Gaming Intervention for Persons on PrEP” Principal Investigator: Laura Whiteley, MD, Agency: National Institute of Mental Health, Type R34 MH104068 Period: 3/11/2015-1/31/2018. mThis study is developing and testing an iPhone app/game to promote adherence to medication for Pre-exposure prophylaxis (PrEP) among at-risk MSM.
“International Maternal Pediatric Adolescent AIDS Clinical Trials Group: Protocol 2002” Agency: National Institute of Allergy and Infectious Diseases, Type: UM1 AI068632 Period: 4/1/2015-11/30/2016. This study will develop a protocol to test the efficacy of a combined, manualized CBT and medication management algorithm for the treatment of depression in adolescents and young adults who are receiving medical care for HIV/AIDS at IMPAACT sites. Dr. Brown is the Protocol Chair.
Phi Beta Kappa
President International Society for AIDS Education 1994-1995
Faculty Mentor Award, Department of Psychiatry and Human Behavior, Brown University, May 2006
Certificate of Excellence, Department of Psychiatry, Rhode Island Hospital, December, 2007
Psychiatry Research Mentor Award, Department of Psychiatry and Human Behavior, Brown University, May,2008
Norbert and Charlotte Rieger Award for Scientific Achievement from the American Academy of Child and Adolescent Psychiatry for the best scientific paper published in the Journal of the American Academy of Child and Adolescent Psychiatry, 2012
Flanigan, Timothy Professor of Medicine, Professor of Health Services, Policy and Practice
Hadley, Wendy Assistant Professor of Psychiatry and Human Behavior (Research)
Rizzo, Christie Adjunct Associate Professor of Psychiatry and Human Behavior
Whiteley, Laura Assistant Professor of Psychiatry and Human Behavior (Research)
Director of Research, Division of Child and Adolescent Psychiatry, Rhode Island Hospital (2004-present)
co-Director of the Young Adult Behavioral Health Program, Rhode Island Hospital (2013-present)
Lifespan/Brown/Tufts Center for AIDS Research (CFAR)
Director of Behavioral & Social Sciences Program (2006-2011)
Co-Direcctor of the Prevention Core (2011-present)
Associate Director of the CFAR (2015- present)
American Academy of Child and Adolescent Psychiatry.
HIV Issues Committee (1988 - present)
Chair of Committee (10/93 to 10/01)
American Medical Associations Guideline for Adolescent Preventive Services School Health Committee (1994)
American Psychiatric Association's HIV/AIDS Treatment Guidelines Workshop (1998- present)
American Public Health Association
International AIDS Society
International Society for AIDS Education
Rhode Island Medical Society
Rhode Island Psychiatry Society
NIMH Annual International Conference on the Role of Families in Preventing and Adapting to HIV/AIDS, Host Site and Chair Local Planning Committee, 2008
Journal of American Academy of Child and Adolescent Psychiatry (1990 - present).
Member of Editorial Board (2002 present).
Adolescent AIDS Trials Network (NICHD), Member of Behavioral Leadership Group, 2005 - present
Dr. Brown is the Program Director a NIMH-funded T-32 posdoctoral program: "Training in Adolescent / Young Adult Biobehavioral HIV Research." It enrolls five fellow in a two-year postdoctoral training position. Predoctoral trainees also participate in a summer research experience. Dr. Brown has been a primary mentor to 7 academic researchers with NIH clinical research training K awards.