Dr. Carpenter completed her undergraduate degree in honors psychology at the University of Michigan, then worked in the Mood Disorders Research Program at the Western Psychiatric Institute in Pittsburgh, concurrently completing post-baccalaureate premedical coursework at the University of Pittsburgh. She obtained her M.D. from the University of Pennsylvania and went on to complete an internship in internal medicine, a residency program in psychiatry, and a clinical neuroscience research fellowship at Yale University.
She joined the faculty at Brown in 1997 and has continued her path as a physician-scientist investigating the neurobiology of, and new treatments for, major depression and other mood and anxiety disorders. She led a 10-year, federally funded translational research program focusing on the development of laboratory biomarkers signaling risk for mood/anxiety disorders and understanding the impact of early life stress on adult stress biology. She has also conducted a number of randomized clinical trials sponsored by industry and NIH, investigating new drugs and devices for treating depression, including esketamine, Vagus Nerve Stimulation (VNS), Deep Brain Stimulation (DBS), Transcranial Magnetic Stimulation (TMS) and transcranial Direct Current Stimulation (tDCS). Dr. Carpenter’s lab evaluates new neurostimulation treatments and their mechanisms, using both EEG and fMRI. In addition to her role as Deputy Director of the Butler COBRE Center for Neuromodulation, she is Director of the Center’s Neuromodulation and Neuroimaging Core, where she provides training and other resources for neuromodulation researchers in the Rhode Island area.
Carney Institute
| Gonsalves, Meghan A., White, Tara L., Barredo, Jennifer, Fukuda, Andrew M., Joyce, Hannah E., Harris, Ashley D., Carpenter, Linda L. "Repetitive Transcranial Magnetic Stimulation-Associated Changes in Neocortical Metabolites in Major Depression: A Systematic Review." NeuroImage: Clinical, vol. 35, 2022, pp. 103049. |
| Wilson S, Croarkin PE, Aaronson ST, Carpenter LL, Cochran M, Stultz DJ, Kozel FA. "Systematic review of preservation TMS that includes continuation, maintenance, relapse-prevention, and rescue TMS." Journal of affective disorders, vol. 296, 2022, pp. 79-88. |
| Kavanaugh, Brian C., Fryc, Alexa, Temereanca, Simona, Tirrell, Eric, Oberman, Lindsay, Carpenter, Linda L., Spirito, Anthony. "A preliminary investigation of childhood anxiety/depressive symptomatology and working memory across multiple units of analysis." Psychiatry Research, vol. 298, 2021, pp. 113786. |
| Cavallero F, Gold MC, Tirrell E, Kokdere F, Donachie N, Steinfink D, Kriske J, Carpenter LL. "Audio-Guided Mindfulness Meditation During Transcranial Magnetic Stimulation Sessions for the Treatment of Major Depressive Disorder: A Pilot Feasibility Study." Cogn Affect Behav Neurosci, vol. 12, 2021, pp. 678911. |
| Carpenter, LindaL., Aaronson, ScottT., Hutton, Todd M., Mina, Miriam, Pages, Kenneth, Verdoliva, Sarah, West, W. Scott, Sackeim, HaroldA. "Comparison of clinical outcomes with two Transcranial Magnetic Stimulation treatment protocols for major depressive disorder." Brain Stimulation, vol. 14, no. 1, 2021, pp. 173-180. |
| Reiff CM, Richman EE, Nemeroff CB, Carpenter LL, Widge AS, Rodriguez CI, Kalin NH, McDonald WM, Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research. "Psychedelics and Psychedelic-Assisted Psychotherapy." FOC, vol. 19, no. 1, 2021, pp. 95-115. |
| Voigt JD, Leuchter AF, Carpenter LL. "Theta burst stimulation for the acute treatment of major depressive disorder: A systematic review and meta-analysis." Translational psychiatry, vol. 11, no. 1, 2021, pp. 330. |
| Fried PJ, Santarnecchi E, Antal A, Bartres-Faz D, Bestmann S, Carpenter LL, Celnik P, Edwards D, Farzan F, Fecteau S, George MS, He B, Kim YH, Leocani L, Lisanby SH, Loo C, Luber B, Nitsche MA, Paulus W, Rossi S, Rossini PM, Rothwell J, Sack AT, Thut G, Ugawa Y, Ziemann U, Hallett M, Pascual-Leone A. "Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee." Clinical Neurophysiology, vol. 132, no. 3, 2021, pp. 819-837. |
| Beck QM, Tirrell E, Fukuda AM, Kokdere F, Carpenter LL. "Can early treatment response serve as a predictor of antidepressant outcome of repetitive Transcranial Magnetic Stimulation?." Brain Stimulation, vol. 13, no. 2, 2020, pp. 420-421. |
| Sackeim HA, Aaronson ST, Carpenter LL, Hutton TM, Mina M, Pages K, Verdoliva S, West WS. "Clinical outcomes in a large registry of patients with major depressive disorder treated with Transcranial Magnetic Stimulation." Journal of affective disorders, vol. 277, 2020, pp. 65-74. |
| Yuan S, Tirrell E, Gobin AP, Carpenter LL. "Effect of Previous Electroconvulsive Therapy on Subsequent Response to Transcranial Magnetic Stimulation for Major Depressive Disorder." Neuromodulation: Technology at the Neural Interface, vol. 23, no. 3, 2020, pp. 393-398. |
| Dwyer JB, Aftab A, Widge A, Rodriguez CI, Carpenter LL, Nemeroff CB, McDonald WM, Kalin NH, APA Council of Research Task Force on Novel Biomarkers and Treatments. "Hormonal Treatments for Major Depressive Disorder: State of the Art." American Journal of Psychiatry, vol. 177, no. 8, 2020, pp. 686-705. |
| Dichtel LE, Carpenter LL, Nyer M, Mischoulon D, Kimball A, Deckersbach T, Dougherty DD, Schoenfeld DA, Fisher L, Cusin C, Dording C, Trinh NH, Pedrelli P, Yeung A, Farabaugh A, Papakostas GI, Chang T, Shapero BG, Chen J, Cassano P, Hahn EM, Rao EM, Brady RO Jr, Singh RJ, Tyrka AR, Price LH, Fava M, Miller KK. "Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study." American Journal of Psychiatry, vol. 177, no. 10, 2020, pp. 965-973. |
| Zandvakili A, Barredo J, Swearingen HR, Aiken EM, Berlow YA, Greenberg BD, Carpenter LL, Philip NS. "Mapping PTSD symptoms to brain networks: a machine learning study." Translational psychiatry, vol. 10, no. 1, 2020, pp. 195. |
| Kavanaugh BC, Cancilliere MK, Fryc A, Tirrell E, Oliveira J, Oberman LM, Wexler BE, Carpenter LL, Spirito A. "Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence." Child Neuropsychology, vol. 26, no. 6, 2020, pp. 1-16. |
| Brunoni AR, Arns M, Baeken C, Blumberger D, Brunelin J, Carpenter LL, Downar J, Keeser D, Langguth B, Rachid F, Sack AT, Vila-Rodriguez F, Padberg F. "Mixing Apples and Oranges in Assessing Outcomes of Repetitive Transcranial Stimulation Meta-Analyses." Psychotherapy and Psychosomatics, vol. 89, no. 2, 2020, pp. 106-107. |
| Ridout, Kathryn K., Coe, Jesse L., Parade, Stephanie H., Marsit, Carmen J., Kao, Hung-Teh, Porton, Barbara, Carpenter, Linda L., Price, Lawrence H., Tyrka, Audrey R. "Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress." Psychoneuroendocrinology, vol. 116, 2020, pp. 104632. |
| Fukuda AM, Hindley LE, Kang JWD, Tirrell E, Tyrka AR, Ayala A, Carpenter LL. "Peripheral vascular endothelial growth factor changes after transcranial magnetic stimulation in treatment-resistant depression." Neuroreport, vol. 31, no. 16, 2020, pp. 1121-1127. |
| Reiff CM, Richman EE, Nemeroff CB, Carpenter LL, Widge AS, Rodriguez CI, Kalin NH, McDonald WM, the Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research. "Psychedelics and Psychedelic-Assisted Psychotherapy." American Journal of Psychiatry, vol. 177, no. 5, 2020, pp. 391-410. |
| Dhamne SC, Ilmoniemi RJ, Tsuboyama M, Carpenter LL, Pascual-Leone A, Rotenberg A. "Safety of rTMS in patients with intracranial metallic objects." Brain Stimulation, vol. 13, no. 3, 2020, pp. 928-929. |
| Kimball A, Dichtel LE, Nyer MB, Mischoulon D, Fisher LB, Cusin C, Dording CM, Trinh NH, Yeung A, Haines MS, Sung JC, Pinna G, Rasmusson AM, Carpenter LL, Fava M, Klibanski A, Miller KK. "The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause." Psychoneuroendocrinology, vol. 112, 2020, pp. 104512. |
| Carpenter, Linda L., Philip, Noah S. "The Future Is Now? Rapid Advances by Brain Stimulation Innovation." American Journal of Psychiatry, vol. 177, no. 8, 2020, pp. 654-656. |
| Philip NS, McLaughlin NC, Carpenter LL, Phillips ML, Liu H, Haber SN, Greenberg BD. "Transient aphasia induced by intermittent theta burst stimulation." Brain Stimulation, vol. 13, no. 4, 2020, pp. 941-942. |
| Voigt J, Carpenter L, Leuchter A. "A systematic literature review of the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in non-treatment resistant patients with major depressive disorder." BMC Psychiatry, vol. 19, no. 1, 2019, pp. 13. |
| Widge AS, Rodriguez CI, Carpenter LL, Kalin NH, McDonald W, Nemeroff CB. "EEG Biomarkers for Treatment Response Prediction in Major Depressive Illness." American Journal of Psychiatry, vol. 176, no. 1, 2019, pp. 82. |
| Kavanaugh BC, Fryc A, Carpenter LL. "Measurement and Modulation of Working Memory-Related Oscillatory Abnormalities." Journal of the International Neuropsychological Society, vol. 25, no. 10, 2019, pp. 1076-1081. |
| Barredo, Jennifer, Aiken, Emily, van 't Wout-Frank, Mascha, Greenberg, Benjamin D., Carpenter, Linda L., Philip, Noah S. "Neuroimaging Correlates of Suicidality in Decision-Making Circuits in Posttraumatic Stress Disorder." Frontiers in Psychiatry, vol. 10, 2019, pp. 44. |
| Philip NS, Leuchter AF, Cook IA, Massaro J, Goethe JW, Carpenter LL. "Predictors of response to synchronized transcranial magnetic stimulation for major depressive disorder." Depression and Anxiety, vol. 36, no. 3, 2019, pp. 278-285. |
| Fukuda AM, Tirrell E, Gobin AP, Carpenter LL. "Repetitive Transcranial Magnetic Stimulation for depression relapse or recurrence: Naturalistic retreatment series outcomes." Brain Stimulation, vol. 12, no. 5, 2019, pp. 1328-1329. |
| Bushnell DM, McCarrier KP, Bush EN, Abraham L, Jamieson C, McDougall F, Trivedi MH, Thase ME, Carpenter L, Coons SJ, PRO Consortium's Depression Working Group. "Symptoms of Major Depressive Disorder Scale: Performance of a Novel Patient-Reported Symptom Measure." Value in Health, vol. 22, no. 8, 2019, pp. 906-915. |
| Corlier J, Carpenter LL, Wilson AC, Tirrell E, Gobin AP, Kavanaugh B, Leuchter AF. "The relationship between individual alpha peak frequency and clinical outcome with repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)." Brain Stimulation, vol. 12, no. 6, 2019, pp. 1572-1578. |
| Berlow YA, Zandvakili A, Carpenter LL, Philip NS. "Transcranial direct current stimulation for unipolar depression and risk of treatment emergent mania: An updated meta-analysis." Brain Stimulation, vol. 12, no. 4, 2019, pp. 1066-1068. |
| Zandvakili, Amin, Berlow, Yosef Alfred, Carpenter, Linda Leigh, Philip, Noah Stephen. "Transcranial Direct Current Stimulation in Psychiatry: What Psychiatrists Need to Know." FOCUS, vol. 17, no. 1, 2019, pp. 44-49. |
| Zandvakili A, Philip NS, Jones SR, Tyrka AR, Greenberg BD, Carpenter LL. "Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study." Journal of Affective Disorders, vol. 252, 2019, pp. 47-54. |
| Barredo J, Bellone JA, Edwards M, Carpenter LL, Correia S, Philip NS. "White matter integrity and functional predictors of response to repetitive transcranial magnetic stimulation for posttraumatic stress disorder and major depression." Depression and Anxiety, vol. 36, no. 11, 2019, pp. 1047-1057. |
| Carpenter LL, Conelea C, Tyrka AR, Welch ES, Greenberg BD, Price LH, Niedzwiecki M, Yip AG, Barnes J, Philip NS. "5 Hz Repetitive transcranial magnetic stimulation for posttraumatic stress disorder comorbid with major depressive disorder." Journal of affective disorders, vol. 235, 2018, pp. 414-420. |
| Russo GB, Tirrell E, Busch A, Carpenter LL. "Behavioral activation therapy during transcranial magnetic stimulation for major depressive disorder." Journal of affective disorders, vol. 236, 2018, pp. 101-104. |
| Zeier, Zane, Carpenter, Linda L., Kalin, Ned H., Rodriguez, Carolyn I., McDonald, William M., Widge, Alik S., Nemeroff, Charles B. "Clinical Implementation of Pharmacogenetic Decision Support Tools for Antidepressant Drug Prescribing." American Journal of Psychiatry, vol. 175, no. 9, 2018, pp. 873-886. |
| McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH, National Network of Depression Centers rTMS Task Group., American Psychiatric Association Council on Research Task Force on Novel Biomarkers and Treatments. "Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression." J. Clin. Psychiatry, vol. 79, no. 1, 2018. |
| Bennett E, Almeida JRC, Carpenter LL. "Do bipolar disorder soft signs impact outcomes following Transcranial Magnetic Stimulation (TMS) therapy for depression?." Journal of affective disorders, vol. 245, 2018, pp. 237-240. |
| McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH. "Dr McClintock and Colleagues Reply." J. Clin. Psychiatry, vol. 79, no. 1, 2018. |
| McClintock SM, Reti IM, Carpenter LL, Dubin M, Taylor SF, Husain MM, Wall C, Sampson S, George MS, Lisanby SH. "Dr McClintock and Colleagues Reply." J. Clin. Psychiatry, vol. 79, no. 1, 2018. |
| Widge AS, Bilge MT, Montana R, Chang W, Rodriguez CI, Deckersbach T, Carpenter LL, Kalin NH, Nemeroff CB. "Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis." American Journal of Psychiatry, 2018, pp. appiajp201817121358. |
| Welch ES, Weigand A, Hooker JE, Philip NS, Tyrka AR, Press DZ, Carpenter LL. "Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression." Neuromodulation: Technology at the Neural Interface, vol. 22, no. 8, 2018, pp. 898-903. |
| Laferton JAC, Vijapura S, Baer L, Clain AJ, Cooper A, Papakostas G, Price LH, Carpenter LL, Tyrka AR, Fava M, Mischoulon D. "Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression." Frontiers in Psychiatry, vol. 9, 2018, pp. 424. |
| Barredo, Jennifer, Aiken, Emily, van 't Wout-Frank, Mascha, Greenberg, Benjamin D., Carpenter, Linda L., Philip, Noah S. "Network Functional Architecture and Aberrant Functional Connectivity in Post-Traumatic Stress Disorder: A Clinical Application of Network Convergence." Brain Connectivity, vol. 8, no. 9, 2018, pp. 549-557. |
| Kavanaugh BC, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Schneider MB, Carpenter LL. "Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation With a 2-Coil Device in Treatment-Resistant Major Depressive Disorder." The journal of ECT, vol. 34, no. 4, 2018, pp. 258-265. |
| Philip NS, Barredo J, Aiken E, Carpenter LL. "Neuroimaging Mechanisms of Therapeutic Transcranial Magnetic Stimulation for Major Depressive Disorder." Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 3, no. 3, 2018, pp. 211-222. |
| Petrosino, Nicholas J., Zandvakili, Amin, Carpenter, Linda L., Philip, Noah S. "Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation." Frontiers in Psychiatry, vol. 9, 2018, pp. 605. |
| Conelea CA, Philip NS, Yip AG, Barnes JL, Niedzwiecki MJ, Greenberg BD, Tyrka AR, Carpenter LL. "Response to Letter to the Editor regarding "Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic outcomes for younger versus older patients"." Journal of Affective Disorders, vol. 225, 2018, pp. 773-774. |
| Garnaat SL, Yuan S, Wang H, Philip NS, Carpenter LL. "Updates on Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder." Psychiatric Clinics of North America, vol. 41, no. 3, 2018, pp. 419-431. |
| Yip AG, George MS, Tendler A, Roth Y, Zangen A, Carpenter LL. "61% of unmedicated treatment resistant depression patients who did not respond to acute TMS treatment responded after four weeks of twice weekly deep TMS in the Brainsway pivotal trial." Brain Stimulation, vol. 10, no. 4, 2017, pp. 847-849. |
| Kubu CS, Brelje T, Butters MA, Deckersbach T, Malloy P, Moberg P, Tröster AI, Williamson E, Baltuch GH, Bhati MT, Carpenter LL, Dougherty DD, Howland RH, Rezai AR, Malone DA Jr. "Cognitive outcome after ventral capsule/ventral striatum stimulation for treatment-resistant major depression." Journal of Neurology, Neurosurgery & Psychiatry, vol. 88, no. 3, 2017, pp. 262-265. |
| Voigt J, Carpenter L, Leuchter A. "Cost effectiveness analysis comparing repetitive transcranial magnetic stimulation to antidepressant medications after a first treatment failure for major depressive disorder in newly diagnosed patients - A lifetime analysis." PLoS ONE, vol. 12, no. 10, 2017, pp. e0186950. |
| Philip NS, Nelson BG, Frohlich F, Lim KO, Widge AS, Carpenter LL. "Low-Intensity Transcranial Current Stimulation in Psychiatry." American Journal of Psychiatry, vol. 174, no. 7, 2017, pp. appi.ajp.2017.1. |
| Philip, Noah S., Barredo, Jennifer, van ’t Wout-Frank, Mascha, Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder." Biological Psychiatry, vol. 83, no. 3, 2017, pp. 263-272. |
| Carpenter LL, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Stannard EL, Schneider MB. "rTMS with a two-coil array: Safety and efficacy for treatment resistant major depressive disorder." Brain Stimulation, vol. 10, no. 5, 2017, pp. 926-933. |
| Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D, as Work Group of the American Psychiatric Association Council on Research. "S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research." J. Clin. Psychiatry, vol. 78, no. 6, 2017, pp. e656-e667. |
| Conelea CA, Philip NS, Yip AG, Barnes JL, Niedzwiecki MJ, Greenberg BD, Tyrka AR, Carpenter LL. "Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic treatment outcomes for younger versus older patients." Journal of Affective Disorders, vol. 217, 2017, pp. 42-47. |
| Philip NS, Ridout SJ, Albright SE, Sanchez G, Carpenter LL. "5-Hz Transcranial Magnetic Stimulation for Comorbid Posttraumatic Stress Disorder and Major Depression." Journal of Traumatic Stress , vol. 29, no. 1, 2016, pp. 93-6. |
| Philip NS, Dunner DL, Dowd SM, Aaronson ST, Brock DG, Carpenter LL, Demitrack MA, Hovav S, Janicak PG, George MS. "Can Medication Free, Treatment-Resistant, Depressed Patients Who Initially Respond to TMS Be Maintained Off Medications? A Prospective, 12-Month Multisite Randomized Pilot Study." Brain Stimulation, vol. 9, no. 2, 2016, pp. 251-7. |
| Philip NS, Tyrka AR, Albright SE, Sweet LH, Almeida J, Price LH, Carpenter LL. "Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity." Journal of Psychiatric Research, vol. 79, 2016, pp. 93-100. |
| Philip NS, Dunner DL, Dowd SM, Aaronson ST, Brock DG, Carpenter LL, Demitrack MA, Hovav S, Janicak PG, George MS. "Erratum to "Can Medication Free, Treatment-Resistant, Depressed Patients Who Initially Respond to TMS Be Maintained Off Medications? A Prospective, 12-Month Multisite Randomized Pilot Study" [Brain Stimulation 9 (2016) 251-257]." Brain Stimulation, vol. 9, no. 4, 2016, pp. 639. |
| Tyrka AR, Parade SH, Welch ES, Ridout KK, Price LH, Marsit C, Philip NS, Carpenter LL. "Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders." Translational psychiatry, vol. 6, no. 7, 2016, pp. e848. |
| MacDonald K, Thomas ML, Sciolla AF, Schneider B, Pappas K, Bleijenberg G, Bohus M, Bekh B, Carpenter L, Carr A, Dannlowski U, Dorahy M, Fahlke C, Finzi-Dottan R, Karu T, Gerdner A, Glaesmer H, Grabe HJ, Heins M, Kenny DT, Kim D, Knoop H, Lobbestael J, Lochner C, Lauritzen G, Ravndal E, Riggs S, Sar V, Schäfer I, Schlosser N, Schwandt ML, Stein MB, Subic-Wrana C, Vogel M, Wingenfeld K. "Minimization of Childhood Maltreatment Is Common and Consequential: Results from a Large, Multinational Sample Using the Childhood Trauma Questionnaire." PLoS ONE, vol. 11, no. 1, 2016, pp. e0146058. |
| Ridout KK, Carpenter LL, Tyrka AR. "The Cellular Sequelae of Early Stress: Focus on Aging and Mitochondria." Neuropsychopharmacology, vol. 41, no. 1, 2016, pp. 388-9. |
| Philip NS, Ridout SJ, Albright SE, Sanchez G, Carpenter LL. "5 Hz transcranial magnetic stimulation for the treatment of comorbid posttraumatic stress disorder and major depression." Journal of Traumatic Stress , 2015. |
| Philip, Noah S., Carpenter, S. Louisa, Ridout, Samuel J., Sanchez, George, Albright, Sarah E., Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "5Hz Repetitive transcranial magnetic stimulation to left prefrontal cortex for major depression." Journal of affective disorders, vol. 186, 2015, pp. 13-7. |
| Dougherty DD, Rezai AR, Carpenter LL, Howland RH, Bhati MT, O'Reardon JP, Eskandar EN, Baltuch GH, Machado AD, Kondziolka D, Cusin C, Evans KC, Price LH, Jacobs K, Pandya M, Denko T, Tyrka AR, Brelje T, Deckersbach T, Kubu C, Malone DA Jr. "A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression." Biological Psychiatry, vol. 78, no. 4, 2015, pp. 240-8. |
| Tyrka AR, Parade SH, Price LH, Kao HT, Porton B, Philip NS, Welch ES, Carpenter LL. "Alterations of Mitochondrial DNA Copy Number and Telomere Length with Early Adversity and Psychopathology." Biological Psychiatry, 2015. |
| Tyrka, Audrey R., Carpenter, Linda L., Kao, Hung-Teh, Porton, Barbara, Philip, Noah S., Ridout, Samuel J., Ridout, Kathryn K., Price, Lawrence H. "Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults." Experimental Gerontology, vol. 66, 2015, pp. 17-20. |
| Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. "Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression." Brain Stimulation, vol. 8, no. 4, 2015, pp. 787-94. |
| Philip, Noah S., Sweet, Lawrence H., Tyrka, Audrey R., Carpenter, S. Louisa, Albright, Sarah E., Price, Lawrence H., Carpenter, Linda L. "Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task." Brain Imaging and Behavior, vol. 10, no. 1, 2015, pp. 124-35. |
| Sarris J, Price LH, Carpenter LL, Tyrka AR, Ng CH, Papakostas GI, Jaeger A, Fava M, Mischoulon D. "Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial." Pharmacopsychiatry, vol. 48, no. 4-5, 2015, pp. 141-144. |
| Newport DJ, Carpenter LL, McDonald WM, Potash JB, Tohen M, Nemeroff CB, APA Council of Research Task Force on Novel Biomarkers and Treatments. "Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression." American Journal of Psychiatry, vol. 172, no. 10, 2015, pp. 950-66. |
| Leuchter, Andrew F., Phillips, Bill, Jin, Yi, Cook, Ian A., Feifel, David, Goethe, John, Husain, Mustafa, Carpenter, Linda, Thase, Michael, Krystal, Andrew, Burke, William, Howland, Robert, Sheline, Yvette, Jain, Rakesh, Aaronson, Scott, Iosifescu, Dan, O’Reardon, John, Gilmer, William, Burgoyne, Karl, Lisanby, Sarah, George, Mark. "Safety and Efficacy of Synchronized Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder." Brain Stimulation, vol. 8, no. 2, 2015, pp. 404. |
| Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L, Dording CM, Clain AJ, Durham K, Walker R, Ludington E, Fava M. "A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder." J. Clin. Psychiatry, vol. 75, no. 4, 2014, pp. 370-6. |
| Dunner DL, Aaronson ST, Sackeim HA, Janicak PG, Carpenter LL, Boyadjis T, Brock DG, Bonneh-Barkay D, Cook IA, Lanocha K, Solvason HB, Demitrack MA. "A multisite, naturalistic, observational study of transcranial magnetic stimulation for patients with pharmacoresistant major depressive disorder: durability of benefit over a 1-year follow-up period." J. Clin. Psychiatry, vol. 75, no. 12, 2014, pp. 1394-401. |
| Mischoulon, David, Price, Lawrence H., Carpenter, Linda L., Tyrka, Audrey R., Papakostas, George I., Fava, Maurizio. "Dr Mischoulon and Colleagues Reply." J. Clin. Psychiatry, 2014, pp. e1329-e1329. |
| Mischoulon, David, Price, Lawrence H., Carpenter, Linda L., Tyrka, Audrey R., Papakostas, George I., Fava, Maurizio. "Dr Mischoulon and Colleagues Reply." J. Clin. Psychiatry, 2014, pp. e1329-e1329. |
| Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Fava M. "Dr. Mischoulon and colleagues reply." J. Clin. Psychiatry, vol. 75, no. 11, 2014, pp. e1328-9. |
| Philip NS, Valentine TR, Sweet LH, Tyrka AR, Price LH, Carpenter LL. "Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments." Journal of Psychiatric Research, vol. 52, 2014, pp. 63-9. |
| Philip NS, Carpenter SL, Carpenter LL. "Safe use of repetitive transcranial magnetic stimulation in patients with implanted vagus nerve stimulators." Brain Stimulation, vol. 7, no. 4, 2014, pp. 608-12. |
| Janicak, Philip G., Carpenter, Linda. "The Efficacy of Transcranial Magnetic Stimulation for Major Depression: A Review of the Evidence." Psychiatric Annals, vol. 44, no. 6, 2014, pp. 284-292. |
| Philip NS, Sweet LH, Tyrka AR, Price LH, Bloom RF, Carpenter LL. "Decreased default network connectivity is associated with early life stress in medication-free healthy adults." European Neuropsychopharmacology, vol. 23, no. 1, 2013, pp. 24-32. |
| Philip NS, Sweet LH, Tyrka AR, Price LH, Carpenter LL, Kuras YI, Clark US, Niaura RS. "Early life stress is associated with greater default network deactivation during working memory in healthy controls: a preliminary report." Brain Imaging and Behavior, vol. 7, no. 2, 2013, pp. 204-12. |
| McCarrier, K.P., Martin, M.L., Bushnell, D.M., Abraham, L., Bush, E.N., Houle, C.R., Mathews, M., Carpenter, L.L., Blum, S.I. "Qualitative development and cognitive evaluation of the symptoms of major depressive disorder (s-mdd), a consortium-developed patient reported outcome measure." Value in Health, vol. 16, no. 3, 2013, pp. A63. |
| Philip NS, Kuras YI, Valentine TR, Sweet LH, Tyrka AR, Price LH, Carpenter LL. "Regional homogeneity and resting state functional connectivity: associations with exposure to early life stress." Psychiatry Research, vol. 214, no. 3, 2013, pp. 247-53. |
| Price LH, Kao HT, Burgers DE, Carpenter LL, Tyrka AR. "Telomeres and early-life stress: an overview." Biological Psychiatry, vol. 73, no. 1, 2013, pp. 15-23. |
| Tyrka AR, Burgers DE, Philip NS, Price LH, Carpenter LL. "The neurobiological correlates of childhood adversity and implications for treatment." Acta psychiatrica Scandinavica, vol. 128, no. 6, 2013, pp. 434-47. |
| Janicak PG, Dunner DL, Aaronson ST, Carpenter LL, Boyadjis TA, Brock DG, Cook IA, Lanocha K, Solvason HB, Bonneh-Barkay D, Demitrack MA. "Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of quality of life outcome measures in clinical practice." CNS Spectrums, vol. 18, no. 6, 2013, pp. 322-32. |
| Aaronson ST, Carpenter LL, Conway CR, Reimherr FW, Lisanby SH, Schwartz TL, Moreno FA, Dunner DL, Lesem MD, Thompson PM, Husain M, Vine CJ, Banov MD, Bernstein LP, Lehman RB, Brannon GE, Keepers GA, O'Reardon JP, Rudolph RL, Bunker M. "Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects." Brain Stimulation, vol. 6, no. 4, 2013, pp. 631-40. |
| Gawuga, C.E., Tyrka, A.R., Price, L.H., Carpenter, L.L. "145. Temporal associations between IL-6 and cortisol production in response to acute psychosocial stress." Brain, Behavior, and Immunity, vol. 26, 2012, pp. S40. |
| Tyrka AR, Walters OC, Price LH, Anderson GM, Carpenter LL. "Altered response to neuroendocrine challenge linked to indices of the metabolic syndrome in healthy adults." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, vol. 44, no. 7, 2012, pp. 543-9. |
| Carpenter LL, Gawuga CE, Tyrka AR, Price LH. "C-reactive protein, early life stress, and wellbeing in healthy adults." Acta psychiatrica Scandinavica, vol. 126, no. 6, 2012, pp. 402-10. |
| Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. "Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults." PLoS ONE, vol. 7, no. 1, 2012, pp. e30148. |
| Hsieh TH, Dhamne SC, Chen JJ, Carpenter LL, Anastasio EM, Pascual-Leone A, Rotenberg A. "Minimal heating of aneurysm clips during repetitive transcranial magnetic stimulation." Clinical Neurophysiology, vol. 123, no. 7, 2012, pp. 1471-3. |
| McCarrier, K.P., Abraham, L., Carpenter, L.L., Deal, L.S., Thase, M., Trivedi, M., Blum, S.I. "PMH39 Identifying Disease-Defining Concepts Using Spontaneous and Probed Responses From Semi-Structured Qualitative Interviews in Patients With Major Depressive Disorder." Value in Health, vol. 15, no. 7, 2012, pp. A341. |
| Houle, C.R., Blum, S.I., Carpenter, L.L., Dedios, C., Greco, N., Thase, M., Trivedi, M., Martin, M.L., Ramasamy, A. "PMH40 How do Patients Describe Their Depression? - Incorporating the Patient's Voice Into Instrument Development." Value in Health, vol. 15, no. 7, 2012, pp. A341. |
| Andrews S, Handyside R, Carpenter L, Price A, Majewska W, Prime K. "Testing children of mothers with HIV infection: experience in three south-west London HIV clinics." HIV medicine, vol. 13, no. 2, 2012, pp. 138-40. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "The nicotinic acetylcholine receptor as a target for antidepressant drug development." TheScientificWorldJournal, vol. 2012, 2012, pp. 104105. |
| Carpenter LL, Janicak PG, Aaronson ST, Boyadjis T, Brock DG, Cook IA, Dunner DL, Lanocha K, Solvason HB, Demitrack MA. "Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice." Depression and Anxiety, vol. 29, no. 7, 2012, pp. 587-96. |
| Carpenter LL, Tyrka AR, Lee JK, Tracy AP, Wilkinson CW, Price LH. "A placebo-controlled study of sertraline's effect on cortisol response to the dexamethasone/corticotropin-releasing hormone test in healthy adults." Psychopharmacology, vol. 218, no. 2, 2011, pp. 371-9. |
| Carpenter LL, Shattuck TT, Tyrka AR, Geracioti TD, Price LH. "Effect of childhood physical abuse on cortisol stress response." Psychopharmacology, vol. 214, no. 1, 2011, pp. 367-75. |
| Nugent NR, Tyrka AR, Carpenter LL, Price LH. "Gene-environment interactions: early life stress and risk for depressive and anxiety disorders." Psychopharmacology, vol. 214, no. 1, 2011, pp. 175-96. |
| Dhamne, S., Hsieh, T.-H., Carpenter, L., Anastasio, E., Pascual-Leone, A., Rotenberg, A. "P20.10 Minimal heating of aneurysm clips during repetitive transcranial magnetic stimulation." Clinical Neurophysiology, vol. 122, 2011, pp. S148-S149. |
| Cui D, Zhang H, Yang BZ, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. "Variation in NGFB is associated with primary affective disorders in women." Am. J. Med. Genet., vol. 156B, no. 4, 2011, pp. 401-12. |
| Amin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilomäki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landrø NI, Zvartau E, Gelernter J, Epperson CN, Räsänen P, Siironen J, Lappalainen J. "A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls." Am. J. Med. Genet., vol. 153B, no. 1, 2010, pp. 332-5. |
| Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. "Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults." Neuropsychopharmacology, vol. 35, no. 13, 2010, pp. 2617-23. |
| Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL. "Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging." Biological Psychiatry, vol. 67, no. 6, 2010, pp. 531-4. |
| Cusin, Cristina, Evans, Karleyton C., Carpenter, Linda L., Greenberg, Benjamin D., Malone, Donald A., Eskandar, Emad, Dougherty, Darin D. "Deep Brain Stimulation for Treatment Resistant Depression: The Role of the Ventral Capsule/Ventral Striatum." Psychiatric Annals, vol. 40, no. 10, 2010, pp. 477-484. |
| Tyrka AR, Price LH, Carpenter LL, Anderson GM. "In Reply to: Childhood Maltreatment and Hypothalamic-Pituitary-Adrenal Axis Reactivity." Biological Psychiatry, vol. 67, no. 11, 2010, pp. e61-2. |
| Tyrka, Audrey R., Price, Lawrence H., Kao, Hung-Teh, Porton, Barbara, Carpenter, Linda L. "In Response to “No Correlation Between Childhood Maltreatment and Telomere Length”." Biological Psychiatry, vol. 68, no. 6, 2010, pp. e23-e24. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature." Psychopharmacology, vol. 212, no. 1, 2010, pp. 1-12. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era." Expert opinion on pharmacotherapy, vol. 11, no. 5, 2010, pp. 709-22. |
| Schoedl AF, Costa MC, Mari JJ, Mello MF, Tyrka AR, Carpenter LL, Price LH. "The clinical correlates of reported childhood sexual abuse: an association between age at trauma onset and severity of depression and PTSD in adults." Journal of child sexual abuse, vol. 19, no. 2, 2010, pp. 156-70. |
| Yip AG, Carpenter LL. "Transcranial magnetic stimulation for medication-resistant depression." J. Clin. Psychiatry, vol. 71, no. 4, 2010, pp. 502-3. |
| Mello MF, Faria AA, Mello AF, Carpenter LL, Tyrka AR, Price LH. "[Childhood maltreatment and adult psychopathology: pathways to hypothalamic-pituitary-adrenal axis dysfunction]." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 31 Suppl 2, 2009, pp. S41-8. |
| Brown RA, Lejuez CW, Strong DR, Kahler CW, Zvolensky MJ, Carpenter LL, Niaura R, Price LH. "A prospective examination of distress tolerance and early smoking lapse in adult self-quitters." Nicotine & Tobacco Research, vol. 11, no. 5, 2009, pp. 493-502. |
| Tyrka AR, Wyche MC, Kelly MM, Price LH, Carpenter LL. "Childhood maltreatment and adult personality disorder symptoms: influence of maltreatment type." Psychiatry Research, vol. 165, no. 3, 2009, pp. 281-7. |
| Malone, Donald A., Dougherty, Darin D., Rezai, Ali R., Carpenter, Linda L., Friehs, Gerhard M., Eskandar, Emad N., Rauch, Scott L., Rasmussen, Steven A., Machado, Andre G., Kubu, Cynthia S., Tyrka, Audrey R., Price, Lawrence H., Stypulkowski, Paul H., Giftakis, Jonathon E., Rise, Mark T., Malloy, Paul F., Salloway, Stephen P., Greenberg, Benjamin D. "Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression." Biological Psychiatry, vol. 65, no. 4, 2009, pp. 267-275. |
| Carpenter LL, Ross NS, Tyrka AR, Anderson GM, Kelly M, Price LH. "Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls." Psychoneuroendocrinology, vol. 34, no. 8, 2009, pp. 1208-13. |
| Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH. "Effect of childhood emotional abuse and age on cortisol responsivity in adulthood." Biological Psychiatry, vol. 66, no. 1, 2009, pp. 69-75. |
| Tyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL. "Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity." Biological Psychiatry, vol. 66, no. 7, 2009, pp. 681-5. |
| Mello, Marcelo F., Faria, Alvaro A., Mello, Andrea F., Carpenter, Linda L., Tyrka, Audrey R., Price, Lawrence H. "Maus-tratos na infância e psicopatologia no adulto: caminhos para a disfunção do eixo hipotálamo-pituitária-adrenal." Rev. Bras. Psiquiatr., vol. 31, 2009. |
| Philip, Noah S., Carpenter, Linda L., Tyrka, Audrey R., Whiteley, Laura B., Price, Lawrence H. "Varenicline augmentation in depressed smokers: an 8-week, open-label study." J. Clin. Psychiatry, vol. 70, no. 7, 2009, pp. 1026-1031. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Augmentation of antidepressants with atypical antipsychotics: a review of the current literature." Journal of Psychiatric Practice, vol. 14, no. 1, 2008, pp. 34-44. |
| Tyrka AR, Wier L, Price LH, Ross N, Anderson GM, Wilkinson CW, Carpenter LL. "Childhood parental loss and adult hypothalamic-pituitary-adrenal function." Biological Psychiatry, vol. 63, no. 12, 2008, pp. 1147-54. |
| Tyrka AR, Wier L, Price LH, Ross NS, Carpenter LL. "Childhood parental loss and adult psychopathology: effects of loss characteristics and contextual factors." International journal of psychiatry in medicine, vol. 38, no. 3, 2008, pp. 329-344. |
| Tyrka AR, Wier LM, Price LH, Rikhye K, Ross NS, Anderson GM, Wilkinson CW, Carpenter LL. "Cortisol and ACTH responses to the Dex/CRH test: influence of temperament." Hormones and behavior, vol. 53, no. 4, 2008, pp. 518-25. |
| Carpenter LL, Bayat L, Moreno F, Kling MA, Price LH, Tyrka AR, Kinkead B, Owens MJ, Nemeroff CB. "Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy." Psychiatry Research, vol. 157, no. 1-3, 2008, pp. 123-9. |
| Rikhye K, Tyrka AR, Kelly MM, Gagne GG Jr, Mello AF, Mello MF, Price LH, Carpenter LL. "Interplay between childhood maltreatment, parental bonding, and gender effects: impact on quality of life." Child Abuse & Neglect, vol. 32, no. 1, 2008, pp. 19-34. |
| Philip NS, Mello K, Carpenter LL, Tyrka AR, Price LH. "Patterns of quetiapine use in psychiatric inpatients: an examination of off-label use." Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, vol. 20, no. 1, 2008, pp. 15-20. |
| Kelly MM, Tyrka AR, Anderson GM, Price LH, Carpenter LL. "Sex differences in emotional and physiological responses to the Trier Social Stress Test." Journal of Behavior Therapy and Experimental Psychiatry, vol. 39, no. 1, 2008, pp. 87-98. |
| Kelly MM, Tyrka AR, Price LH, Carpenter LL. "Sex differences in the use of coping strategies: predictors of anxiety and depressive symptoms." Depression and Anxiety, vol. 25, no. 10, 2008, pp. 839-46. |
| Greenberg, Benjamin, D. "The evolution of deep brain stimulation for neuropsychiatric disorders." Frontiers in Bioscience, vol. Volume, no. 13, 2008, pp. 4638. |
| Greenberg BD, Askland KD, Carpenter LL. "The evolution of deep brain stimulation for neuropsychiatric disorders." Frontiers in Bioscience, vol. 13, 2008, pp. 4638-48. |
| Abrantes AM, Strong DR, Lejuez CW, Kahler CW, Carpenter LL, Price LH, Niaura R, Brown RA. "The role of negative affect in risk for early lapse among low distress tolerance smokers." Addictive Behaviors, vol. 33, no. 11, 2008, pp. 1394-401. |
| Mello AF, Juruena MF, Pariante CM, Tyrka AR, Price LH, Carpenter LL, Del Porto JA. "[Depression and stress: is there an endophenotype?]." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 29 Suppl 1, 2007, pp. S13-8. |
| Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, Anderson GM, Wilkinson CW, Price LH. "Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment." Biological Psychiatry, vol. 62, no. 10, 2007, pp. 1080-7. |
| Mello, Andrea Feijo, Juruena, Mario Francisco, Pariante, Carmine M, Tyrka, Audrey R, Price, Lawrence H, Carpenter, Linda L, Del Porto, Jose Alberto. "Depressão e estresse: existe um endofenótipo?." Rev. Bras. Psiquiatr., vol. 29, 2007, pp. s13-s18. |
| Tyrka AR, Wier LM, Anderson GM, Wilkinson CW, Price LH, Carpenter LL. "Temperament and response to the Trier Social Stress Test." Acta psychiatrica Scandinavica, vol. 115, no. 5, 2007, pp. 395-402. |
| Grover KE, Carpenter LL, Price LH, Gagne GG, Mello AF, Mello MF, Tyrka AR. "The relationship between childhood abuse and adult personality disorder symptoms." Journal of personality disorders, vol. 21, no. 4, 2007, pp. 442-7. |
| Park MC, Goldman MA, Carpenter LL, Price LH, Friehs GM. "Vagus nerve stimulation for depression: rationale, anatomical and physiological basis of efficacy and future prospects." Acta Neurochirurgica Supplementum, vol. 97, no. Pt 2, 2007, pp. 407-16. |
| Tyrka AR, Carpenter LL, Carvalho JP, Price LH. "Biomarkers in the human stress system: do they signal risk for depression?." Medicine and health, Rhode Island, vol. 89, no. 5, 2006, pp. 180-2. |
| Geracioti, Thomas D., Carpenter, Linda L., Owens, Michael J., Baker, Dewleen G., Ekhator, Nosakhare N., Horn, Paul S., Strawn, Jeffrey R., Sanacora, Gerard, Kinkead, Becky, Price, Lawrence H., Nemeroff, Charles B. "Elevated Cerebrospinal Fluid Substance P Concentrations in Posttraumatic Stress Disorder and Major Depression." American Journal of Psychiatry, vol. 163, no. 4, 2006, pp. 637-643. |
| Wier, Lauren M., Tavares, Sandra B., Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "Levetiracetam-Induced Depression in a Healthy Adult." J. Clin. Psychiatry, vol. 67, no. 07, 2006, pp. 1156. |
| Wier LM, Tavares SB, Tyrka AR, Price LH, Carpenter LL. "Levetiracetam-induced depression in a healthy adult." J. Clin. Psychiatry, vol. 67, no. 7, 2006, pp. 1159-60. |
| DeBattista C, Belanoff J, Glass S, Khan A, Horne RL, Blasey C, Carpenter LL, Alva G. "Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression." Biological Psychiatry, vol. 60, no. 12, 2006, pp. 1343-9. |
| Carpenter LL. "Neurostimulation in resistant depression." Journal of Psychopharmacology, vol. 20, no. 3 Suppl, 2006, pp. 35-40. |
| Garriock HA, Delgado P, Kling MA, Carpenter LL, Burke M, Burke WJ, Schwartz T, Marangell LB, Husain M, Erickson RP, Moreno FA. "Number of risk genotypes is a risk factor for major depressive disorder: a case control study." Behavioral and brain functions : BBF, vol. 2, 2006, pp. 24. |
| Carpenter LL, Schecter JM, Tyrka AR, Mello AF, Mello MF, Haggarty R, Price LH. "Open-Label Tiagabine Monotherapy for Major Depressive Disorder With Anxiety." J. Clin. Psychiatry, vol. 67, no. 01, 2006, pp. 66-71. |
| Tyrka, Audrey R, Price, Lawrence H, Mello, Marcelo F, Mello, Andrea F, Carpenter, Linda L. "Psychotic major depression: a benefit-risk assessment of treatment options." Drug safety : an international journal of medical toxicology and drug experience, vol. 29, no. 6, 2006, pp. 491-508. |
| Friehs GM, Ojakangas C, Carpenter LL, Greenberg B, Chou KL. "Surgical aspects of deep brain stimulation." Medicine and health, Rhode Island, vol. 89, no. 4, 2006, pp. 134-6. |
| Tyrka AR, Mello AF, Mello MF, Gagne GG, Grover KE, Anderson GM, Price LH, Carpenter LL. "Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults." Psychoneuroendocrinology, vol. 31, no. 9, 2006, pp. 1036-45. |
| Carpenter LL, Friehs GM, Tyrka AR, Rasmussen S, Price LH, Greenberg BD. "Vagus nerve stimulation and deep brain stimulation for treatment resistant depression." Medicine and health, Rhode Island, vol. 89, no. 4, 2006, pp. 137, 140-1. |
| George MS, Rush AJ, Marangell LB, Sackeim HA, Brannan SK, Davis SM, Howland R, Kling MA, Moreno F, Rittberg B, Dunner D, Schwartz T, Carpenter L, Burke M, Ninan P, Goodnick P. "A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression." Biological Psychiatry, vol. 58, no. 5, 2005, pp. 364-73. |
| Carpenter LL, Milosavljevic N, Schecter JM, Tyrka AR, Price LH. "Augmentation With Open-Label Atomoxetine for Partial or Nonresponse to Antidepressants." J. Clin. Psychiatry, vol. 66, no. 10, 2005, pp. 1234-1238. |
| Rush AJ, Sackeim HA, Marangell LB, George MS, Brannan SK, Davis SM, Lavori P, Howland R, Kling MA, Rittberg B, Carpenter L, Ninan P, Moreno F, Schwartz T, Conway C, Burke M, Barry JJ. "Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study." Biological Psychiatry, vol. 58, no. 5, 2005, pp. 355-63. |
| Garriock HA, Allen JJ, Delgado P, Nahaz Z, Kling MA, Carpenter L, Burke M, Burke W, Schwartz T, Marangell LB, Husain M, Erickson RP, Moreno FA. "Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance." Molecular Psychiatry, vol. 10, no. 11, 2005, pp. 976-7. |
| Carpenter LL, Schecter JM, Underwood JA, Tyrka AR, Price LH. "Service expectations and clinical characteristics of patients receiving psychiatric emergency services." PS, vol. 56, no. 6, 2005, pp. 743-5. |
| Carpenter LL, Schecter JM, Sinischalchi J, Leon Z, Price LH. "A case series describing orlistat use in patients on psychotropic medications." Medicine and health, Rhode Island, vol. 87, no. 12, 2004, pp. 375-7. |
| Carpenter LL, Tyrka AR, McDougle CJ, Malison RT, Owens MJ, Nemeroff CB, Price LH. "Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects." Neuropsychopharmacology, vol. 29, no. 4, 2004, pp. 777-84. |
| Carpenter LL, Heninger GR, Malison RT, Tyrka AR, Price LH. "Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression." Journal of affective disorders, vol. 79, no. 1-3, 2004, pp. 285-9. |
| Carpenter LL, Moreno FA, Kling MA, Anderson GM, Regenold WT, Labiner DM, Price LH. "Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients." Biological Psychiatry, vol. 56, no. 6, 2004, pp. 418-26. |
| Tyrka AR, Carpenter LL, McDougle CJ, Kirwin PD, Owens MJ, Nemeroff CB, Strong DR, Price LH. "Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults." Biological Psychiatry, vol. 56, no. 7, 2004, pp. 531-4. |
| Carpenter LL, Anderson GM, Siniscalchi JM, Chappell PB, Price LH. "Acute changes in cerebrospinal fluid 5-HIAA following oral paroxetine challenge in healthy humans." Neuropsychopharmacology, vol. 28, no. 2, 2003, pp. 339-47. |
| Carpenter LL, Friehs GM, Price LH. "Cervical vagus nerve stimulation for treatment-resistant depression." Neurosurgery Clinics of North America, vol. 14, no. 2, 2003, pp. 275-82. |
| Greenberg BD, Price LH, Rauch SL, Friehs G, Noren G, Malone D, Carpenter LL, Rezai AR, Rasmussen SA. "Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues." Neurosurgery Clinics of North America, vol. 14, no. 2, 2003, pp. 199-212. |
| Marek GJ, Carpenter LL, McDougle CJ, Price LH. "Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders." Neuropsychopharmacology, vol. 28, no. 2, 2003, pp. 402-12. |
| Mello AF, Mello MF, Carpenter LL, Price LH. "Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 25, no. 4, 2003, pp. 231-8. |
| Carpenter LL, Yasmin S, Price LH. "A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine." Biological Psychiatry, vol. 51, no. 2, 2002, pp. 183-8. |
| Carpenter LL, Heninger GR, McDougle CJ, Tyrka AR, Epperson CN, Price LH. "Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania." Psychiatry Research, vol. 112, no. 3, 2002, pp. 257-62. |
| Carpenter LL, Leon Z, Yasmin S, Price LH. "Do obese depressed patients respond to topiramate? A retrospective chart review." Journal of affective disorders, vol. 69, no. 1-3, 2002, pp. 251-5. |
| Cubells JF, Price LH, Meyers BS, Anderson GM, Zabetian CP, Alexopoulos GS, Nelson JC, Sanacora G, Kirwin P, Carpenter L, Malison RT, Gelernter J. "Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression." Biological Psychiatry, vol. 51, no. 5, 2002, pp. 358-64. |
| Yasmin S, Carpenter LL, Leon Z, Siniscalchi JM, Price LH. "Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review." Journal of affective disorders, vol. 63, no. 1-3, 2001, pp. 243-7. |
| Vythilingam M, Anderson GM, Owens MJ, Halaszynski TM, Bremner JD, Carpenter LL, Heninger GR, Nemeroff CB, Charney DS. "Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone." The Journal of Clinical Endocrinology & Metabolism, vol. 85, no. 11, 2000, pp. 4138-45. |
| Gagné GG Jr, Furman MJ, Carpenter LL, Price LH. "Efficacy of continuation ECT and antidepressant drugs compared to long-term antidepressants alone in depressed patients." American Journal of Psychiatry, vol. 157, no. 12, 2000, pp. 1960-5. |
| Carpenter LL, Price LH. "Psychotic depression: what is it and how should we treat it?." Harvard review of psychiatry, vol. 8, no. 1, 2000, pp. 40-2. |
| Carpenter LL, Leon Z, Yasmin S, Price LH. "Clinical experience with mirtazapine in the treatment of panic disorder." Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, vol. 11, no. 2, 1999, pp. 81-6. |
| Longhurst JG, Carpenter LL, Epperson CN, Price LH, McDougle CJ. "Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder." Biological Psychiatry, vol. 46, no. 4, 1999, pp. 573-6. |
| Malison RT, Anand A, Pelton GH, Kirwin P, Carpenter L, McDougle CJ, Heninger GR, Price LH. "Limited efficacy of ketoconazole in treatment-refractory major depression." Journal of Clinical Psychopharmacology, vol. 19, no. 5, 1999, pp. 466-70. |
| Carpenter LL, Jocic Z, Hall JM, Rasmussen SA, Price LH. "Mirtazapine augmentation in the treatment of refractory depression." J. Clin. Psychiatry, vol. 60, no. 1, 1999, pp. 45-9. |
| Malison RT, McCance E, Carpenter LL, Baldwin RM, Seibyl JP, Price LH, Kosten TR, Innis RB. "[123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts." Psychopharmacology, vol. 137, no. 4, 1998, pp. 321-5. |
| Malison RT, Price LH, Berman R, van Dyck CH, Pelton GH, Carpenter L, Sanacora G, Owens MJ, Nemeroff CB, Rajeevan N, Baldwin RM, Seibyl JP, Innis RB, Charney DS. "Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography." Biological Psychiatry, vol. 44, no. 11, 1998, pp. 1090-8. |
| Carpenter LL, Anderson GM, Pelton GH, Gudin JA, Kirwin PD, Price LH, Heninger GR, McDougle CJ. "Tryptophan depletion during continuous CSF sampling in healthy human subjects." Neuropsychopharmacology, vol. 19, no. 1, 1998, pp. 26-35. |
| Carpenter LL, McDougle CJ, Epperson CN, Price LH. "A risk-benefit assessment of drugs used in the management of obsessive-compulsive disorder." Drug safety : an international journal of medical toxicology and drug experience, vol. 15, no. 2, 1996, pp. 116-34. |
| Geracioti TD Jr, Carpenter LL, Owens MJ, Baker DG, Ekhator NN, Horn PS, Strawn JR, Sanacora G, Kinkead B, Price LH, Nemeroff CB. "Intranasal oxytocin in obsessive-compulsive disorder." American Journal of Psychiatry, vol. 40, no. 4, 1996, pp. 547-9. |
| Platis IE, Carpenter LL, Vojvoda D, Bowers MB Jr, Mazure CM. "Possible acceleration of alcoholic cirrhosis in a patient with bulimia." The International journal of eating disorders, vol. 20, no. 4, 1996, pp. 439-42. |
| Thase ME, Carpenter L, Kupfer DJ, Frank E. "Clinical significance of reversed vegetative subtypes of recurrent major depression." Psychopharmacology bulletin, vol. 27, no. 1, 1991, pp. 17-22. |
| Prien RF, Carpenter LL, Kupfer DJ. "The definition and operational criteria for treatment outcome of major depressive disorder. A review of the current research literature." Archives of General Psychiatry , vol. 48, no. 9, 1991, pp. 796-800. |
| Bulik CM, Carpenter LL, Kupfer DJ, Frank E. "Features associated with suicide attempts in recurrent major depression." Journal of affective disorders, vol. 18, no. 1, 1990, pp. 29-37. |
| Kupfer DJ, Frank E, Carpenter LL, Neiswanger K. "Family history in recurrent depression." Journal of affective disorders, vol. 17, no. 2, 1989, pp. 113-9. |
| Kupfer DJ, Carpenter LL, Frank E. "Is bipolar II a unique disorder?." Comprehensive Psychiatry, vol. 29, no. 3, 1988, pp. 228-36. |
| Kupfer DJ, Carpenter LL, Frank E. "Possible role of antidepressants in precipitating mania and hypomania in recurrent depression." American Journal of Psychiatry, vol. 145, no. 7, 1988, pp. 804-8. |
| Frank E, Carpenter LL, Kupfer DJ. "Sex differences in recurrent depression: are there any that are significant?." American Journal of Psychiatry, vol. 145, no. 1, 1988, pp. 41-5. |
| Jacob M, Frank E, Kupfer DJ, Cornes C, Carpenter LL. "A psychoeducational workshop for depressed patients, family, and friends: description and evaluation." Hospital & community psychiatry, vol. 38, no. 9, 1987, pp. 968-72. |
| Jacob M, Frank E, Kupfer DJ, Carpenter LL. "Recurrent depression: an assessment of family burden and family attitudes." J. Clin. Psychiatry, vol. 48, no. 10, 1987, pp. 395-400. |
| Carpenter LL, Kupfer DJ, Frank E. "Is diurnal variation a meaningful symptom in unipolar depression?." Journal of affective disorders, vol. 11, no. 3, 1986, pp. 255-64. |
| Ridout, Samuel J., Ridout, Kathryn K., Kao, Hung-Teh, Carpenter, Linda L., Philip, Noah S., Tyrka, Audrey R., Price, Lawrence H. "Telomeres, early-life stress and mental illness." Advances in psychosomatic medicine, vol. 34, 1900, pp. 92-108. |
GRANTS
1. NARSAD (Young Investigator Award), “Regulation of Cerebrospinal Fluid Corticotrophin Releasing Factor in Normal Healthy Subjects and Depressed Patients,” Princ. Investig; 7/97 - 6/99, $60,000.
2. Solvay Pharmaceuticals, “A multicenter, double-blind, placebo-controlled, parallel group study of the safety, tolerability and efficacy of three fixed doses of fluvoxamine vs. placebo in outpatients with major depressive disorder,” Co-Investig; 9/97 - 8/98, $240,000.
3. NIAAA, “Motivating Alcoholics to Quit Smoking,” (R01 AA11211-01, Abrams); 9/96 - 9/01, $444,394 (salary support)
4. Pfizer, Inc., "A phase III, randomized, placebo-controlled study evaluating the safety and outcome of treatment with oral ziprasidone in subjects with mania receiving lithium," Co-Investig; 1/98 - 1/99, $169,313.
5. Pfizer, Inc., "An open extension study evaluating the safety and outcome of 40-160 mg daily of oral ziprasidone in the treatment of subjects who have participated in Protocol 602," Co-Investig; 1/98 - 1/00, $36,300.
6. Forest Laboratories, Inc., "An open-label evaluation of the efficacy, safety, and dosing of citalopram in outpatients with depression," Co- Investig; 2/98 - 3/99, $40,040.
7. Forest Laboratories, Inc., "An open-label extension of citalopram treatment in outpatients with depression," Co-Investig; 3/98 - 3/99, $29,912.
8. Eli Lilly and Co., "Comparative efficacy of switching SSRI nonresponders to fluoxetine vs. continued antidepressant treatment with the same SSRI," Co-Investig; 3/98 - 3/00, $74,961.
9. Organon, “Mirtazapine augmentation in the treatment of refractory depression,” Princ. Investig.; Investigator-Initiated Research Grant; 7/98, $95,000.
10. Pfizer, Inc. “Validation of serial CSF collection method for assessment of central serotonergic function,” Co- Investig; 7/98 - 10/98, $47,956.
11. Departmental Research Award, Brown Univ. Dept. of Psychiatry and Human Behavior; “A new method for serial CSF sampling in the study of central serotonergic function and metabolites in depression”; Princ. Investig; 7/97 - 6/99, $58,900.
12. Pfizer, Inc., "A six-week, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of 3 doses of CP-448,187 (0.5, 3, and 10mg) and fluoxetine (Prozac) in subjects with major depressive disorder," Co- Investig; 5/00 - 5/02, $82,797.
13. Merck Research Laboratories, "A double-blind, multicenter study of two doses of L-759274 vs. paroxetine hydrochloride and placebo in the treatment of outpatients with major depressive disorder," Co-Investig; 8/99 - 3/00, $197,520.
14. NCI (1 R21 CA88297-01, Brown), "Biobehavioral Vulnerability to Early Smoking Relapse" Co-Investig; 7/00 - 6/02, $362,500.
15. Cyberonics, Inc. "A multicenter, pivotal, safety and efficacy study of the NeuroCybernetic Prosthesis (NCP) System in Patients with Depression, Study D-02" Princ. Investig; 6/00 - 5/05; $117,145.
16. Cyberonics, Inc. "A long-term, prospective, multicenter study to compare the clinical quality of life, and health care utilization outcomes of the NeuroCybernetic Prosthesis (NCP) System to the standard of care treatment in patients with depression. Princ. Investig; 1/01 - 1/05; $61,680.
17. Cyberonics, Inc. "CSF Neurochemical correlates of vagus nerve stimulation in depressed patients." Princ. Investig; (Investigator-Initiated); 1/01 - 1/03, $157,500.
18. Executive Council On Research (ECOR) Award, Brown University Department of Psychiatry and Human Behavior. "HPA axis function and associated clinical features in adults who were preterm infants," Princ. Investig; 1/01 – 12/01, $10,000.
19. Pfizer, Inc., “A six-week, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of 3 doses of CP-448,187 (0.5, 3, and 10mg) and fluoxetine (Prozac) in subjects with major depressive disorder,” Co- Investig; 5/00- 5/02, $82,797.
20. Merck Research Laboratories, "A worldwide, multicenter, double-blind, parallel, active-controlled, long-term safety study of MK-0869 in outpatients with major depressive disorder (Protocol 066-00)," Co-Investig; 2/01- 2/02, $251,880.
21. Pfizer/Society for Women's Health (SWHR) Research Scholars Grant for Faculty Development in Women's Health 2002. "The relationship between early life stress, HPA axis function, and depression in women" Princ. Investig; 7/02 - 6/05, $195,000.
22. Scirex Corp/Corcept Therapeutics, Inc. "1073-02 A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of C-1073 (Mifepristone) in Patients with Major Depressive Disorder with Psychotic Features" Princ. Investig; 11/01 – 10/03, $14,967.
23. Scirex Corp/Corcept Therapeutics, Inc. "1073-03 A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of C-1073 (Mifepristone) in Patients with Major Depressive Disorder with Psychotic Features Who are not Receiving Antidepressants or Antipsychotics" Princ. Investig; 11/01 – 10/03, $14,967.
24. Cephalon, Inc. “An Open-Label, 8-Week Study with flexible Doses of Gabitril™ (tiagabine hydrochloride) in Patients with Major Depressive Disorder with Anxiety (MDD-A)” Investigator-Initiated; Princ. Investig; 3/02 – 2/04, $127,500.
25. Pfizer, Inc. “Sertraline Treatment and Cortisol Response to the DEX/CRH Test in Healthy Subjects,” Investigator-Initiated; Princ. Investig; 12/04 – 11/06, $300,684.
26. 1 R01 MH0687670-01 “DEX/CRH Response: Mood/Anxiety Disorder Endophenotype,” Princ. Investig; 4/04 – 1/09, $1,227,776.
27. NCCAM/NIMH AT001742-01, "Double-blind, placebo-controlled study of SAMe vs. escitalopram in MDD," Co-Investig; 4/04 - 3/10, $1,002,013.
28. US Department of the Interior, “Perceived Early Life Stress and DEX/CRH Test Response as Predictors of Psychological Sequelae following Exposure of Healthy Adults to War Stress” Princ. Investig; 7/04 – 6/05, $40,000.
29. UCB Pharma, Inc. “Keppra Treatment and Cortisol Response to the DEX/CRH test in Healthy Subjects” Investigator-Initiated; Princ. Investig; 6/04 -3/09, $111,624.
30. Medtronic, Inc. "Electrical Stimulation of the Anterior Limb of the Internal Capsule to Treat Major Depressive Disorder" Co-Investig. 10/02 - 9/04, $315,000
31. NARSAD 2006 Independent Investigator Award. “Do Emotional and Biological Responses to a Laboratory Stress Test Predict Risk for Depression and Anxiety Disorders?” Princ. Investigator; 9/06 – 9/09; $100,000
32. Sepracor, Inc. “ ESRC101: Eszopiclone Treatment and Cortisol Response to HPA Axis Tests;” Princ. Investig; 9/06 – 2/09; $254,318.75
33. NIMH R34 MH073625 (Miller, PI) “Development of an Intervention for Suicide Attempters” 3/1/09-2/28/10; Co-Investigator; $191,848
34. Cyberonics, Inc. “Randomized Comparison of Outcomes in Patients with Treatment-Resistant Depression Who Receive VNS Therapy Administered at Different Amounts of Electrical Charge” Princ. Investig; 11/1/07-9/10; $286,350
35. NIMH R01 MH0687670-01 “DEX/CRH Response: Mood/Anxiety Disorder Endophenotype? PHASE 2,” Princ. Investig; 7/1/2009 – 7/31/2016 (NCE), $3,514,780.
36. Medtronic, Inc. “RECLAIM Deep Brain Stimulation (DBS) Clinical Study for Treatment- Resistant Depression.” Multi-Site; Site Princ. Investigator 4/16/2009 – 7/15/2012.
37. NIH 2R01NR003695-14A1 (Sullivan, PI) “Risk and Protection in Trajectories of Preterm Infants: Birth to Adulthood;” Consultant 4/1/2009 – 4/2013
38. Neuronetics, Inc, “NeuroStar Transcranial Magnetic Stimulation Therapy® System: Data Management, Analysis and Reporting Format for Clinical Treatment Utilization and Outcomes” Princ Investigator 9/2009 – 8/2012.
39. Brown Institute for Brain Sciences “Brain Stimulation Facility Core” (Equipment Grant $400,000) 10/30/2012; Co-Princ Investigator
40. NeoSync, Inc. “Evaluation of Low Emission NeoSync EEG Synchronized TMS Technology for the Treatment of Major Depressive Disorder: A Multicenter Randomized, Double-Blind, Sham-Controlled, Trial” Princ Investigator 4/25/11 – 4/25/14
41. Neuronetics, Inc. “A 12-Month Prospective Randomized Dual-Arm Pilot Study Of Maintenance Neurostar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder“ Co- PI (Butler site); 5/1/12-1/12/14
42. NIMH 1R21MH091508-01A1 (Tyrka, PI) “Childhood Maltreatment: Epigenetic Modulation of the Glucocorticoid Receptor” Co-Investigator 4/21/2011 – 3/31/2013.
43. 3R01MH068767-07S1 “Dex/CRH Response: Mood/Anxiety Disorder Endophenotype?” (Diversity Supplemental Award); Princ. Investig; 6/17/2011 – 2/28/2014 $157,036.
44. 3 R01MH068767 -08W1 07S1 Supplemental Award for Analysis of Telomeres (Carpenter, PI) Princ Investigator 6/17/2012 – 2/28/2014
45. Cervel Neurotech, Inc. “A Prospective, Double-Blind, Randomized, Parallel-Group, Sham-Controlled Feasibility Trial of Multi-Coil rTMS for the Treatment of Major Depressive Disorder” Princ Investigator; 5/31/2013 - 6/1/15.
46. NIMH 1R34MH099310-01A1 “Collaborative Study: Testosterone Augmentation in Women” Princ Investig; 7/1/2013 – 6/30/2016;
47. HHSN2712011000061 (NIMH Contract PI, Fava) “Rapidly-Acting Treatments for Treatment Resistant Depression” Site Princ. Investigator; 2014 – 2016; $242,551 (Total Direct Costs)
48. R01 MHMH101107-1 “Early Life Stress: Epigenetic Regulation of Endocrine and Immune Pathways” (Tyrka, PI) Co-Investigator; 4/17/2014-3/31/2019; $355,494 (Annual Direct Cost)
49. NIMH 1 RO1 MH083704-01A2 (Tyrka, PI) “Childhood Maltreatment: Biomarkers of Risk and Resilience” 12/01/09-11/30/2015 (NCE)
50. Neuronetics, Inc. (Investigator Initiated) “5 Hz Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder comorbid with Major Depressive Disorder” Princ Investigator 9/12/14 – 9/12/16; $29,750 (Direct Costs)
51. The Roddy-Holden Foundation. “Antidepressant efficacy of computerized cognitive-behavioral therapy (CBT) combined with bifrontal transcranial direct current stimulation (tDCS)” Princ Investigator 10/28/2014; $17,600 (Equipment Grant; Direct Cost)
52. Fred M. Roddy Foundation, Inc. “Measuring electroencephalography (EEG) changes during neuromodulation.” Principal Investigator 3/26/2016; $35,000 (Equipment Grant; Direct Cost)
53. 1 P50 MH106435 (Haber, Director; Greenberg, Project PI) “Neurocircuitry of OCD: Effects of Modulation” Role: Core C, Project 4 Co-Investigator (6/1/15 – 5/31/19)
54. R21 MH112055-01 (Liu, PI) “Modulating impulsivity in suicidal adolescents with tDCS: A proof-of-concept study” Role: Co-Investigator (1/1/17 – 12/30/19)
55. 1 R21 DA04298901A1 (Lechner/Philip MPI) “Working Memory Training Combined with Repetitive Magnetic Stimulation in Smokers” Role: Co-Investigator (7/1/17 – 6/30/19)
56. Janssen Research & Development, LLC. “A Randomized, Double-blind, Multicenter, Active-Controlled Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Treatment-resistant Depression” Role: Site PI (6/6/17 – 3/30/2018)
57. Janssen Research & Development, LLC. “An Open-label Long-term Extension Safety Study of Intranasal Esketamine in Treatment-resistant Depression” Role: Site PI (4/7/17 – ongoing).
58. 1 R01 MH113929 (Fox, PI) “Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptoms.” Role Co-Investigator (7/1/2017 – 6/30/2022)
59. NeoSync, Inc. “A Prospective, Multicenter, Double-Blind, Sham-Controlled Adaptive Design Study to Confirm the Safety and Efficacy of NEST sTMS in Subjects with Major Depressive Disorder Who Have Not Responded to at Least One Antidepressant Medication in the Current Episode” Role: Site PI (10/1/17 – 9/20/20)
60. Carney Innovation Award (Brown University) “Luminance-Dependent Brain Activation in Seasonal Affective Disorder and Depression” Role: PI (9/18/18 – 8/18/19)
61. UG3 DA047793-01 (Abrantes & Stein) “tDCS to Decrease Opioid Relapse” Role: Co-Investigator, (09/30/18-08/31/20)
62. P20 GM130452-01 (Greenberg, PI) “COBRE Center for Neuromodulation (CCN)” Roles: Center Deputy Director; CCN Neuromodulation and Neuroimaging Core Director; Project 4 Mentor (2/28/19 – 2/27/24)
63. I01 HX002572 (Primack/Philip, MPI) “Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Suicide Behavior in High-Risk Veterans” (4/1/2019-3/30/2023.)
64. Feelmore Labs, Inc. (Carpenter) “Mechanical Affective Tough Therapy to Improve Symptoms in Anxiety Patients” Role: PI (11/12/18 – 11/11/20)
65. Neuronetics, Inc. (Carpenter) “EMA-Guided Adaptive-Schedule TMS Therapy” Role: PI; 11/6/19 – 11/5/21
66. Janssen Research & Development, LLC. “A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression (54135419TRD4005)” Multisite; Site Princ. Investig; (1/24/21 – ongoing).
67. Neurolief Ltd. “Safety and efficacy of a self-administered treatment for MDD using an external combined occipital and trigeminal nerve stimulator (Relivion®DP).” Multisite Study Lead Investigator, Site Princ. Investig. (7/1/21 – ongoing)
68. DOD W81XWH2110479 (McPartland, PI) “Noninvasive Brain Stimulation to Treat Core Social Deficits in Autism Spectrum Disorder” Consultant (7/1/21 –6/30/24)
| Year | Degree | Institution |
|---|---|---|
| 1993 | MD | University of Pennsylvania |
| 1986 | BA | University of Michigan |
| Research Fellow | Yale School of Medicine | 1995-1997 | New Haven, CT |
| Intern | Yale School of Medicine, Hospital of St. Raphael, internal medicine | 1993-1994 | New Haven, CT |
Member, Scientific Advisory Board, National Depressive & Manic-Depressive Association 1997-2001.
Editorial Advisory Board, The Brown University Psychopharmacology Update, 2002–present.
Editorial Advisory Board, Acta Psychiatrica Scandinavica 2006-2012.
Society of Biological Psychiatry (SOBP): Member (2002- present); Co-Chair, Membership Committee (2007 – 2011); Co-Chair/Chair, Education/Training Task Force (2009 – 2012); Elected Council Member (2011- 2014); Program Committee (2012 –2013); Chair, Travel Award Committee (2014 – 2016); Women’s Leadership Group Committee (2016 – present); SOBP President Elect (2021), SOBP President (2022)
Clinical TMS Society (CTMSS): Member 2016- present; Board of Directors (2016 – 2022); Insurance Advocacy Committee; Education Committee; Annual Meeting Committee (Chair); Fellow (2022); Faculty Presenter, CTMSS National rTMS Training Course (“PULSES”) 2016 - present
American College of Neuropsychopharmacology (ACNP): Associate Member, 2004 -2009; Member 2009 – 2015; Fellow 2016-present; Women’s Task Force (2013); Membership Advisory Task Force (2010- 2015) Education and Training Committee (2015- 2017); Nominating Committee (2021 – 2022); Meeting Mentor
American Psychiatric Association (APA): Member (1989 – present); Component Corresponding Committee on Research on Psychiatric Treatments (2003-2006); Council on Research (2013 – present); Council on Research/Components Member: Diagnostic Markers and Treatments Workgroup (2014- 2016); Task Force on Novel Biomarkers and Treatments (2017- present); Council on Research/Components Member: Committee on Research Training (2016 – present); Chair, Council on Research- Workgroup on Neuromodulation (2022 – present)
Invited Member, National Network of Depression Centers (NNDC) rTMS Task Force, 2009 –2015.
Clinical Expert Panel Member, New England Comparative Effectiveness Public Advisory Council, Non-Pharmacologic Interventions for Treatment-Resistant Depression, 2011
Expert Panel Member, Patient-Reported Outcome (PRO) Consortium Depression Working Group, Critical Path Institute (C-Path) 2011 – 2015
Connecticut Psychiatric Society, 1993-1997.
Society for Neuroscience, 1997-2000.
Rhode Island Psychiatric Society (RIPS), 1997–present.
Depression and Bipolar Support Alliance (DBSA; formerly National Manic and Manic-Depressive Association) 1998-.
NAMI 1998-present.
American Psychopathological Association (APPA), 1999–2002.
Anxiety Disorders Association of America (ADAA), Member 2003, 2014-2017
International Society of Psychoneuroendocrinology, Member 2005-2016
Rhode Island Medical Women’s Association (RIMWA) 2006 –2007
International Society for ECT and Neuromodulation (ISEN), Member 2009 – 2017.
Carney/Brown Institute for Brain Science, Executive Committee, 2017 - present
NIMH Scientific Review Group Member, 2002- present
| Certification | American Board of Psychiatry and Neurology, Psychiatry | 1999- | |
| Medical License | Rhode Island | 1997-Present | |
| Medical License | Connecticut | 1995-1997 |
Brown University
Medical Student Primary Research Mentor/Supervisor 2003-2004 (J. Schecter).
Brown Neuroscience Dept (Bio 195/196) Research Faculty Sponsor 2002-2003 (R. Jaffe).
Brown Brain Science Program Undergraduate Research Fellowship/Thesis Advisor and Neuroscience Research Mentor (R. Jaffe 2001-2002, L. Bayat 2005 – 2006)
Psychiatry Inpatient Supervisor/preceptor, 3rd,4th-year Brown medical students 1997-2010.
Clinical Supervisor, Brown Psychiatry Residents and Neuropsychiatry Fellows (PGY-1 - PGY-4), 1997-present.
Research Mentor, Brown Psychiatry Residents, 2002 – 2014 (Michael Posternak, Audrey Tyrka, David Block, Nada Milosavljevic, Noah Philip, Thaddeus Shattuck)
Doctor-on-call Supervisor, Butler Hosp. Patient Assessment Service, 1997-2007.
BioMed 278-Intro to Clinical Psychiatry, Section Leader (Brown medical students)1998-2005.
Psychopharmacology Course Lecturer, PGY 1-4 Residents, 1998-present.
Psychopathology Course Lecturer and Mood Disorders Module Director, PGY 1-4 Residents 1999 -2015.
Psychiatry Residency “Mock” National Board Examiner - Brown University/Dartmouth Faculty Exchange Program, 2002, 2004, 2007
Faculty Presenter, Brown Medical School Faculty Development Workshop, 2006.
Psychiatry Research Mentor, post-bachelor/post-doctorate trainees (S. Creamer, R. Haggarty, A. Tracy, L. Wier, K. Grover, M. Wyche, J. Lee, S. Wenze, E. Welch)
Mentor, Psychiatry Research Post-Residency Fellowship, Butler Hospital Mood Disorders Research Program (J. Gagne, J. Schecter) 2000- 2005
Mentor, Clinical Neuroscience Research Fellowship on HPA Axis Markers of Early Life Stress (Andrea Feijo de Mello and Marcelo Feijo Feijo de Mello, University of Sao Paulo) 2002 - 2003
Brown Graduate School, Department of Cognitive & Linguistic Sciences Doctoral Thesis Advisor (S. Mather) 2007 -2008
Lecturer, Brown University Neuroscience Department “Bench to Bedside” Lecture Series, 2008 - present
Director/Supervisor, Butler Neuromodulation Clerkship (Brown Psychiatry Residency) 2009 – present.
PhD Student Faculty Trainer/Thesis Adviser, Brown Department of Molecular Pharmacology, Physiology, and Biotechnology (C. Gawuga) 2010 – 2016.
Faculty Mentor (Neuromodulation) Brown University Geriatric Psychiatry Fellowship Training Program 2010 – present
Faculty Mentor or Co-Mentor, K- Awardees/Applicants 2008 – present (N. Philip, G. Epstein-Lubow, U. Clark, S. Wenze, E. Conradt, Agustin Yip, MD PhD, B. Kavanaugh, A. Fukuda)
Faculty Mentor, VA Career Development Award, 2013 – 2017 (N. Philip).
Brown R25 Research Resident Faculty Mentor, (S. Ridout, J. Almeida, A. Zandvakili, B. McCarthy, H. Wang, S. Yuan, A Fukuda) 2015 – present
Brown Department of Neuroscience Undergraduate Research Supervisor/Senior Thesis Advisor (G. Russo 2016-2017; M. Gold, 2019-2020; C. Schremp 2021-2022)
Brown Department of Cognitive, Linguistic and Psychological Science Undergraduate Research Supervisor/Senior Thesis Advisor (F. Kronenberg, 2019-2020; M. Healy 2021-2022)
Faculty Mentor/Thesis Committee Chair, Brown University Neuroscience Department PhD Students (Meghan Gonsalves, 2020-)
Faculty Mentor, Brown International J1 Visiting Research Scholars: Fiamma Cavallero (2019), Fatih Kokdere (2019-2020), Edith Bonnin (2021)
Brown Medical Student Research Supervisor (L. Sullivan)
PhD Thesis Committee Member, Noralie Krepel MsC, Maastriucht University, The Netherlands, Feb 2021
Primary Research Mentor, COBRE Center for Neuromodulation: Project Leader Joshua Brown, MD PhD (2020-present); Pilot Project Awardee (Brian Kavanaugh PsyD 2021- present)
National
Distinguished Lecturer in Psychiatry, ASCP Model Psychopharmacology Curriculum 2006, 2007.
Faculty Mentor, Emory University Sponsored “Future Leaders in Psychiatry” Symposium, 2005
Faculty Mentor, Emory University Sponsored “Psychiatry Residents Symposium” 2007, 2008
Faculty Lecturer, ACNP Junior Investigator Research Colloquium, 2017, 2021
Mentor, Travel Awardee/Junior Investigator Program, ACNP, 2008, 2009, 101, 2011, 2012, 2014, 2015, 2016, 2017
Faculty Mentor, APA Research Colloquium for Junior Investigators, 2007, 2009, 2010, 2012, 2014, 2016, 2017
Faculty Mentor, SOBP Junior Investigator and Travel Award Program, 2010, 2012, 2014, 2015, 2016, 2017
Faculty Mentor for Junior Investigators, Anxiety and Depression Association of America, Career Development Leadership Program, 2015
Faculty Lecturer, “PULSES” Introductory TMS Course (CME) Offered domestically/internationally by the Clinical TMS Society (May 2017 – present)
Faculty Lecturer, Harvard Medical School/Berenson-Allen Center “Intensive Course in Transcranial Magnetic Stimulation (CME) (2013, 2016, 2018, 2019)
Clinical TMS Society Committee Member: Education Committee (2017 – present); Annual Program Committee (2017 – present)
