Robbert J. CretonAssociate Professor of Medical Science (Research)
Robbert Creton received his B.S. in Biology (1990) and Ph.D. in Developmental Biology (1994) from the University of Utrecht in the Netherlands. He completed his post-doctoral training in developmental physiology at the Marine Biological Laboratory in Woods Hole, Massachusetts, and was appointed as an investigator at Women & Infants Hospital of Rhode Island. In 2002, Robbert Creton joined Brown University, where he continued his studies on brain development and behavior using zebrafish as a model system. He is the director of the Leduc Bioimaging Facility and the director of the Molecular Pathology Core.
Research in the Creton laboratory is focused on brain development and behavior, using zebrafish as a model system. The studies aim to provide a better understanding of the basic biological mechanisms that regulate brain development and contribute to the prevention of human developmental brain disorders.
Research in the Creton laboratory is focused on the following projects:
Project 1. Developmental brain defects caused by modulators of calcium signaling
This NIH-funded project (NIH R01 HD060647) is focused on brain defects and behavioral defects caused by embryonic exposures to pharmaceuticals that modulate calcium signaling. The obtained results will provide a better understanding of the basic mechanisms by which modulators of calcium signaling affect brain development. These mechanisms are important, since human embryos may inadvertently be exposed to modulators of calcium signaling by maternal use of medicine during early pregnancy.
Project 2. Effects of organophosphate pesticides on early brain development
The goal of this NIH-funded project (NIH F32 ES021342) is to determine the impact of small doses of chlorpyrifos and malathion on brain development and anxiety-related behavior, using zebrafish as a model system.
Project 3. Automated analyses of behavior in response to visual stimuli
This project is focused on the automated analysis of behavior in response to visual stimuli using zebrafish as a model system. The studies will contribute to a better basic understanding of behaviors that are influenced by visual stimuli and will provide high-throughput tools to evaluate novel treatments of blindness and low vision.
Project 4. Automated analyses of behavior as a tool in developmental neurotoxicology
This project is focused on the development of tools for automated analyses of behavior. The developed tools will be used to examine toxicant-induced developmental brain defects. The studies will provide a better understanding of the basic biological mechanisms that regulate brain development and will contribute to the prevention and treatment of mental illnesses.
NIH R01 HD060647 03/01/2010 - 01/31/2015 (ext. 01/31/16)
Brain defects induced by embryonic exposure to modulators of calcium signaling. The goal of this project is to better understand the basic mechanisms by which modulators of calcium signaling affect brain development. R. Creton is the PI on this project.
NIH F32 ES021342 09/03/2012 - 08/31/2015
The effects of organophosphates on anxiety-related behavior and neurodevelopment. R. Creton serves as a mentor on this project.
NIH P42 ES013660 04/01/09 - 03/31/14 (ext. 03/31/15)
Reuse in RI: A State-based Approach to Complex Exposures. R.Creton is the core leader of the Molecular Pathology Core.
NSF IBN-0421654 08/01/04 - 07/31/07
Calcium signaling in the developing zebrafish brain. The goal of this project is to better understand the mechanisms regulating brain regionalization during early embryonic development, using zebrafish embryos as a model system. R. Creton is the PI on this project.
The Rhode Island Foundation 01/25/05 - 12/31/06
The role of HDACs in zebrafish heart development. The goal of this project is to determine the presence and role of histone deacetylases in cardiac development. R. Creton is the PI on this project.