Silvia Chiang, MD ScM is a physician-researcher who works on childhood and adolescent tuberculosis. She is board cetified in Pediatric Infectious Diseases and General Pediatrics, and attends on the pediatric infectious disease service and the RISE Tuberculosis Clinic.
After graduating from Stanford University, Dr. Chiang worked as a Peace Corps community health volunteer in rural Peru. She then attended medical school at Case Western Reserve University. In 2012, during her last year of pediatrics residency in Boston, she returned to Peru to work with Socios En Salud (Partners In Health-Peru) on tuberculosis research. She continued her collaboration with Socios En Salud throughout her pediatric infectious diseases fellowship, which she completed at Baylor College of Medicine and Texas Children's Hospital.
Dr. Chiang's research focuses on improving outcomes for adolescents with tuberculosis. She conducts most of her work in Peru in collaboration with Socios En Salud and has additional ongoing research projects with Ukranian and South African collaborators. She was awarded a Fulbright U.S. Scholar Award to conduct TB research at the Universidade Federal do Rio de Janeiro (Brazil) during the 2023-24 academic year.
Dr. Chiang collaborated on evidence reviews to inform the 2022 World Health Organization consolidated guidelines and operational handbook on managing tuberculosis in children and adolescents. This work included leading experts from over 18 different countries to produce consensus recommendations on caring for adolescents with tuberculosis. She is the lead author of two international expert consensus documents on the management of children and adolescents with TB.
Dr. Chiang is MPI with Dr. Tim Flanigan for HEIDS, which provides research training and opportunities to medical students and undergraduates planning to pursue medicine. With Dr. Tanya Rogo, Dr. Chiang co-directs the Global Health Scholarly Concentration at Alpert Medical School.
| Chiang SS, Waterous PM, Atieno VF, Bernays S, Bondarenko Y, Cruz AT, de Oliveira MCB, Del Castillo Barrientos H, Enimil A, Ferlazzo G, Ferrand RA, Furin J, Hoddinott G, Isaakidis P, Kranzer K, Maleche-Obimbo E, Mansoor H, Marais BJ, Mohr-Holland E, Morales M, Nguyen AP, Oliyo JO, Sant'Anna CC, Sawyer SM, Schaaf HS, Seddon JA, Sharma S, Skrahina A, Starke JR, Triasih R, Tsogt B, Welch H, Enane LA. "Caring for Adolescents and Young Adults With Tuberculosis or at Risk of Tuberculosis: Consensus Statement From an International Expert Panel." Journal of Adolescent Health, vol. 72, no. 3, 2023, pp. 323-331. |
| Verkuijl S, Sekadde MP, Dodd PJ, Arinaitwe M, Chiang SS, Brands A, Viney K, Sismanidis C, Jenkins HE. "Addressing the Data Gaps on Child and Adolescent Tuberculosis." Pathogens (Basel, Switzerland), vol. 11, no. 3, 2022. |
| Sulis G, Tavaziva G, Gore G, Benedetti A, Solomons R, van Toorn R, Thee S, Day J, Verkuijl S, Brands A, Viney K, Masini T, Ahmad Khan F, Chiang SS. "Comparative Effectiveness of Regimens for Drug-Susceptible Tuberculous Meningitis in Children and Adolescents: A Systematic Review and Aggregate-Level Data Meta-Analysis." Open Forum Infectious Diseases, vol. 9, no. 6, 2022, pp. ofac108. |
| Oliva Rapoport VE, Altamirano E, Senador L, Wong M, Beckhorn CB, Coit J, Roche SD, Lecca L, Galea JT, Chiang SS. "Impact of prolonged isolation on adolescents with drug-susceptible tuberculosis in Lima, Peru: a qualitative study." BMJ Open, vol. 12, no. 9, 2022, pp. e063287. |
| Kuzyk PV, Padilla R, Rybak NR, Hoshovska II, Kitov VO, Savchyna MO, Jenkins HE, Chiang SS, Horsburgh CR, Dolynska M, Petrenko V, Gychka SG. "Missed Tuberculosis Diagnoses: Analysis of Pediatric Autopsy Data From General Hospitals in Lviv, Ukraine." Journal of the Pediatric Infectious Diseases Society, 2022. |
| Goel AR, Chiang SS, Ibrahim O, Yalcindag A. "Multisystem Inflammatory Syndrome in an Adolescent Following SARS-CoV-2 Exposure Despite Three Doses of a COVID-19 Vaccine." Rhode Island medical journal (2013), vol. 105, no. 5, 2022, pp. 41-45. |
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"Mycobacterium tuberculosis." Principles and Practice of Pediatric Infectious Diseases, edited by Sarah S. Long, Charles G. Prober, Marc Fischer, David W. Kimberlin, Philadelphia, Elsevier, 2022, pp. 806-822.
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| Leddy AM, Jaganath D, Triasih R, Wobudeya E, Bellotti de Oliveira MC, Sheremeta Y, Becerra MC, Chiang SS. "Social Determinants of Adherence to Treatment for Tuberculosis Infection and Disease Among Children, Adolescents, and Young Adults: A Narrative Review." Journal of the Pediatric Infectious Diseases Society, vol. 11, no. Supplement_3, 2022, pp. S79-S84. |
| Huang CC, Tan Q, Becerra MC, Calderon R, Chiang SS, Contreras C, Lecca L, Jimenez J, Perez-Velez CM, Roya-Pabon CL, Yataco R, Xu H, Zhang Z, Murray M. "The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis." Am J Respir Crit Care Med, 2022. |
| Weng, Chien-Hsiang, Butt, Wesley Wing Wah, Brooks, Meredith B., Clarke, Claudia, Jenkins, Helen E., Holland, Sabina D., Chiang, Silvia S. "Diagnostic value of symptoms for pediatric SARS-CoV-2 infection in a primary care setting." PLOS ONE, vol. 16, no. 12, 2021, pp. e0249980. |
| Khalife S, Jenkins HE, Dolynska M, Terleieva I, Varchenko I, Liu T, Carter EJ, Horsburgh CR, Rybak NR, Petrenko V, Chiang SS. "Incidence and Mortality of Extrapulmonary Tuberculosis in Ukraine: Analysis of National Surveillance Data." Clinical Infectious Diseases, 2021. |
| Wong M, Coit JM, Mendoza M, Chiang SS, Marin H, Galea JT, Lecca L, Franke MF. "Incident Tuberculosis Diagnoses in Children at High Risk for Disease." Open Forum Infectious Diseases, vol. 8, no. 3, 2021, pp. ofab075. |
| Pandita A, Gillani FS, Shi Y, Hardesty A, McCarthy M, Aridi J, Farmakiotis D, Chiang SS, Beckwith CG. "Predictors of severity and mortality among patients hospitalized with COVID-19 in Rhode Island." PLOS ONE, vol. 16, no. 6, 2021, pp. e0252411. |
| Chiang SS, Jenkins HE. "Shedding Light on Tuberculosis Deaths in Children and Adolescents." Pediatrics, 2021. |
| Moscibrodzki P, Enane LA, Hoddinott G, Brooks MB, Byron V, Furin J, Seddon JA, Meyersohn L, Chiang SS. "The Impact of Tuberculosis on the Well-Being of Adolescents and Young Adults." Pathogens (Basel, Switzerland), vol. 10, no. 12, 2021. |
| Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, Kampmann B, Graham SM, Dodd PJ, Houben RM, Denholm JT, Sawyer SM, Kranzer K. "Adolescent tuberculosis." The Lancet. Child & adolescent health, vol. 4, no. 1, 2020, pp. 68-79. |
| Mbuthia, Grace Wambura, Nyamogoba, Henry D. N., Chiang, Silvia S., McGarvey, Stephen T. "Burden of stigma among tuberculosis patients in a pastoralist community in Kenya: A mixed methods study." PLOS ONE, vol. 15, no. 10, 2020, pp. e0240457. |
| Chiang, Silvia S., Dolynska, Maria, Rybak, Natasha R., Cruz, Andrea T., Aibana, Omowunmi, Sheremeta, Yana, Petrenko, Vasyl, Mamotenko, Andrii, Terleieva, Iana, Horsburgh, C. Robert, Jenkins, Helen E. "Clinical manifestations and epidemiology of adolescent tuberculosis in Ukraine." ERJ Open Research, vol. 6, no. 3, 2020, pp. 00308-2020. |
| Chiang SS, Brooks MB, Jenkins HE, Rubenstein D, Seddon JA, van de Water BJ, Lindeborg MM, Becerra MC, Yuen CM. "Concordance of drug resistance profiles between persons with drug-resistant tuberculosis and their household contacts: a systematic review and meta-analysis." Clinical Infectious Diseases, 2020. |
| Chiang SS, Beckhorn CB, Wong M, Lecca L, Franke MF. "Patterns of suboptimal adherence among adolescents treated for tuberculosis." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 24, no. 7, 2020, pp. 723-725. |
| Gallo Marin B, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, Salazar-Mather TP, Dumenco L, Savaria MC, Aung SN, Flanigan T, Michelow IC. "Predictors of COVID-19 severity: A literature review." Reviews in medical virology, vol. 31, no. 1, 2020, pp. e2146. |
| Chiang SS, Dara M. "TB in children and adolescents." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 24, no. 12, 2020, pp. 1231-1233. |
| Coit J, Wong M, Galea JT, Mendoza M, Marin H, Tovar M, Chiang SS, Lecca L, Franke MF. "Uncovering reasons for treatment initiation delays among children with TB in Lima, Peru." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 24, no. 12, 2020, pp. 1254-1260. |
| Chiang SS, Park S, White EI, Friedman JF, Cruz AT, Del Castillo H, Lecca L, Becerra MC, Seddon JA. "Using Changes in Weight-for-Age z Score to Predict Effectiveness of Childhood Tuberculosis Therapy." Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 2, 2020, pp. 150-158. |
| Chiang SS, Cruz AT. "Minding (and Reducing) the Detection Gap: An Algorithm to Diagnose TB With HIV Infection." Pediatrics, vol. 144, no. 3, 2019. |
| Chiang SS, Sheremeta Y, Padilla RS, Jenkins HE, Horsburgh CR Jr, Petrenko V, Rybak NR. "Pediatric Multidrug-resistant Tuberculosis in Kyiv City, Ukraine." Journal of Epidemiology and Global Health, vol. 9, no. 1, 2019, pp. 56-61. |
| Coit J, Mendoza M, Pinedo C, Marin H, Chiang SS, Lecca L, Franke M. "Performance of a household tuberculosis exposure survey among children in a Latin American setting." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 23, no. 11, 2019, pp. 1223-1227. |
| Szkwarko D, Bouton TC, Rybak NR, Carter EJ, Chiang SS. "Tuberculosis: An Epidemic Perpetuated by Health Inequalities." Rhode Island medical journal (2013), vol. 102, no. 7, 2019, pp. 47-50. |
| Aibana O, Huang CC, Aboud S, Arnedo-Pena A, Becerra MC, Bellido-Blasco JB, Bhosale R, Calderon R, Chiang S, Contreras C, Davaasambuu G, Fawzi WW, Franke MF, Galea JT, Garcia-Ferrer D, Gil-Fortuño M, Gomila-Sard B, Gupta A, Gupte N, Hussain R, Iborra-Millet J, Iqbal NT, Juan-Cerdán JV, Kinikar A, Lecca L, Mave V, Meseguer-Ferrer N, Montepiedra G, Mugusi FM, Owolabi OA, Parsonnet J, Roach-Poblete F, Romeu-García MA, Spector SA, Sudfeld CR, Tenforde MW, Togun TO, Yataco R, Zhang Z, Murray MB. "Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis." PLOS Medicine, vol. 16, no. 9, 2019, pp. e1002907. |
| Tafur KT, Coit J, Leon SR, Pinedo C, Chiang SS, Contreras C, Calderon R, Mendoza MJ, Lecca L, Franke MF. "Feasibility of the string test for tuberculosis diagnosis in children between 4 and 14 years old." BMC infectious diseases, vol. 18, no. 1, 2018, pp. 574. |
| Sieiro TLA, Aurílio RB, Soares ECC, Chiang SS, Sant Anna CC. "The role of the Xpert MTB/RIF assay among adolescents suspected of pulmonary tuberculosis in Rio de Janeiro, Brazil." Revista da Sociedade Brasileira de Medicina Tropical, vol. 51, no. 2, 2018, pp. 234-236. |
| Seddon JA, Chiang SS, Esmail H, Coussens AK. "The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis?." Frontiers in immunology, vol. 9, 2018, pp. 2946. |
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Chiang SS, Furin JJ.
"Treatment of multidrug-resistant tuberculosis in children and adolescents." J Pediatric Infect Dis , vol. 13, 2018, pp. 153-168.
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| Chiang SS, Roche S, Contreras C, Del Castillo H, Canales P, Jimenez J, Tintaya K, Becerra MC, Lecca L. "Barriers to the treatment of childhood tuberculous infection and tuberculosis disease: a qualitative study." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 21, no. 2, 2017, pp. 154-160. |
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Chiang SS, Starke JR.
"Mycobacterium tuberculosis." Principles and Practice of Pediatric Infectious Diseases, edited by Long SS, Prober CG, Fischer M, Elsevier, Inc., 2017.
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| Chiang SS, Starke JR, Miller AC, Cruz AT, Del Castillo H, Valdivia WJ, Tunque G, García F, Contreras C, Lecca L, Alarcón VA, Becerra MC. "Baseline Predictors of Treatment Outcomes in Children With Multidrug-Resistant Tuberculosis: A Retrospective Cohort Study." Clinical Infectious Diseases, vol. 63, no. 8, 2016, pp. 1063-71. |
| Aibana O, Acharya X, Huang CC, Becerra MC, Galea JT, Chiang SS, Contreras C, Calderon R, Yataco R, Velásquez GE, Tintaya K, Jimenez J, Lecca L, Murray MB. "Nutritional Status and Tuberculosis Risk in Adult and Pediatric Household Contacts." PLoS ONE, vol. 11, no. 11, 2016, pp. e0166333. |
| Chiang SS, Roche S, Contreras C, Alarcón V, Del Castillo H, Becerra MC, Lecca L. "Barriers to the diagnosis of childhood tuberculosis: a qualitative study." The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, vol. 19, no. 10, 2015, pp. 1144-52. |
| Chiang SS, Cruz AT, Del Castillo H, Contreras C, Becerra MC, Lecca L. "Evaluation of health-care providers' knowledge of childhood tuberculosis in Lima, Peru." Paediatrics and international child health, vol. 35, no. 1, 2015, pp. 29-35. |
| Chiang SS, Swanson DS, Starke JR. "New Diagnostics for Childhood Tuberculosis." Infectious disease clinics of North America, vol. 29, no. 3, 2015, pp. 477-502. |
| Chiang SS, Paulus JK, Huang CC, Newby PK, Castellón Quiroga D, Boynton-Jarrett R, Antkowiak L. "Tuberculosis screening among Bolivian sex workers and their children." Journal of Epidemiology and Global Health, vol. 5, no. 2, 2015, pp. 205-10. |
| Chiang SS, Khan FA, Milstein MB, Tolman AW, Benedetti A, Starke JR, Becerra MC. "Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis." The Lancet Infectious Diseases, vol. 14, no. 10, 2014, pp. 947-57. |
| Wu X, Gu J, Wu TT, Swisher SG, Liao Z, Correa AM, Liu J, Etzel CJ, Amos CI, Huang M, Chiang SS, Milas L, Hittelman WN, Ajani JA. "Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer." Journal of Clinical Oncology, vol. 24, no. 23, 2006, pp. 3789-98. |
| Wu X, Roth JA, Zhao H, Luo S, Zheng YL, Chiang S, Spitz MR. "Cell cycle checkpoints, DNA damage/repair, and lung cancer risk." Cancer Research, vol. 65, no. 1, 2005, pp. 349-57. |
| Yao JC, Tseng JF, Worah S, Hess KR, Mansfield PF, Crane CH, Schnirer II, Reddy S, Chiang SS, Najam A, Yu C, Giacco GG, Xie K, Wu TT, Feig BW, Pisters PW, Ajani JA. "Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years." Journal of Clinical Oncology, vol. 23, no. 13, 2005, pp. 3094-103. |
| Wu X, Lu C, Chiang SS, Ajani JA. "Pharmacogenetics in esophageal cancer." Seminars in oncology, vol. 32, no. 6 Suppl 9, 2005, pp. S87-9. |
| Yao JC, Schnirer II, Reddy S, Chiang S, Najam A, Yu C, Giacco G, Hess K, Rashid A, Xie K, Lynch P, Ajani JA. "Effects of sex and racial/ethnic group on the pattern of gastric cancer localization." Gastric Cancer, vol. 5, no. 4, 2002, pp. 208-12. |
See CV
| Year | Degree | Institution |
|---|---|---|
| 2022 | ScM | Brown University |
| 2009 | MD | Case Western Reserve University |
| 2002 | BA | Stanford University |
| Clinical Postdoctoral Fellow | Baylor College of Medicine, Texas Children's Hospital, pediatric infectious diseases | - | Houston, TX, USA |
| Resident | Boston Children's Hospital and Boston Medical Center, Pediatrics | - | |
| Research Fellow | Harvard Medical School, Global Health and Social Medicine | - | Boston, MA, USA |
See CV
| Name | Title |
|---|---|
| Flanigan, Timothy | Professor of Health Services, Policy and Practice, Professor of Medicine |
| Friedman, Jennifer | Professor of Pediatrics, Professor of Epidemiology |
| Rogo, Tanya | Associate Professor of Pediatrics, Clinician Educator |
| Rybak, Natasha | Assistant Professor of Medicine, Clinician Educator |
| Attending Physician. Hasbro Children's Hospital, - |
