Dr. Friedman is a pediatrician who conducts international health research out of Lifespan's Center for International Health Research. Her research addresses quantification of and mechanisms of morbidity of parasitic diseases among pregnant women and children.Her recent work addresses treatment strategies to mitigate morbidity among pregnant women and children and how to change and implement policies for more inclusive treatment programs for schistosomiasis.
| Raj, Dipak K., Das Mohapatra, Alok, Jnawali, Anup, Zuromski, Jenna, Jha, Ambrish, Cham-Kpu, Gerald, Sherman, Brett, Rudlaff, Rachel M., Nixon, Christina E., Hilton, Nicholas, Oleinikov, Andrew V., Chesnokov, Olga, Merritt, Jordan, Pond-Tor, Sunthorn, Burns, Lauren, Jolly, Grant, Ben Mamoun, Choukri, Kabyemela, Edward, Muehlenbachs, Atis, Lambert, Lynn, Orr-Gonzalez, Sachy, Gnädig, Nina F., Fidock, David A., Park, Sangshin, Dvorin, Jeffrey D., Pardi, Norbert, Weissman, Drew, Mui, Barbara L., Tam, Ying K., Friedman, Jennifer F., Fried, Michal, Duffy, Patrick E., Kurtis, Jonathan D. "Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria." Nature, vol. 582, no. 7810, 2020, pp. 104-108. |
| Park, Sangshin, Nixon, Christina E, Miller, Olivia, Choi, Nam-Kyong, Kurtis, Jonathan D, Friedman, Jennifer F, Michelow, Ian C. "Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses." The Journal of Infectious Diseases, vol. 222, no. 4, 2020, pp. 538-550. |
| Bustinduy, Amaya L., Kolamunnage-Dona, Ruwanthi, Mirochnick, Mark H., Capparelli, Edmund V., Tallo, Veronica, Acosta, Luz P., Olveda, Remigio M., Friedman, Jennifer F., Hope, William W. "Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women infected with Schistosoma japonicum." Antimicrobial Agents and Chemotherapy, 2020. |
| Chiang SS, Park S, White EI, Friedman JF, Cruz AT, Del Castillo H, Lecca L, Becerra MC, Seddon JA. "Using Changes in Weight-for-Age z Score to Predict Effectiveness of Childhood Tuberculosis Therapy." Journal of the Pediatric Infectious Diseases Society, vol. 9, no. 2, 2020, pp. 150-158. |
| Park S, Nixon CE, Pond-Tor S, Kabyemela ER, Fried M, Duffy PE, Kurtis JD, Friedman JF. "Impact of maternally derived antibodies to Plasmodium falciparum Schizont Egress Antigen-1 on the endogenous production of anti-PfSEA-1 in offspring." Vaccine, vol. 37, no. 35, 2019, pp. 5044-5050. |
| Abioye AI, McDonald EA, Park S, Ripp K, Bennett B, Wu HW, Pond-Tor S, Sagliba MJ, Amoylen AJ, Baltazar PI, Tallo V, Acosta LP, Olveda RM, Kurtis JD, Friedman JF. "Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy." Pediatric Research, vol. 86, no. 3, 2019, pp. 396-402. |
| Abioye AI, McDonald EA, Park S, Joshi A, Kurtis JD, Wu H, Pond-Tor S, Sharma S, Ernerudh J, Baltazar P, Acosta LP, Olveda RM, Tallo V, Friedman JF. "Maternal, placental and cord blood cytokines and the risk of adverse birth outcomes among pregnant women infected with Schistosoma japonicum in the Philippines." PLOS Neglected Tropical Diseases, vol. 13, no. 6, 2019, pp. e0007371. |
| Friedman JF. "Optimizing Delivery of Mass Drug Administration for Schistosomiasis." The American Journal of Tropical Medicine and Hygiene, 2019. |
| Abioye AI, Park S, Ripp K, McDonald EA, Kurtis JD, Wu H, Pond-Tor S, Sharma S, Ernerudh J, Baltazar P, Acosta LP, Olveda RM, Tallo V, Friedman JF. "Anemia of Inflammation during Human Pregnancy Does Not Affect Newborn Iron Endowment." Journal of Nutrition, vol. 148, no. 3, 2018, pp. 427-436. |
| McDonald EA, Stuart R, Joshi A, Wu HW, Olveda RM, Acosta LP, Tallo V, Baltazar PI, Bailey JA, Kurtis JD, Friedman JF. "Endotoxin at the Maternal-Fetal Interface in a Resource-Constrained Setting: Risk Factors and Associated Birth Outcomes." The American Journal of Tropical Medicine and Hygiene, vol. 99, no. 2, 2018, pp. 495-501. |
| Kurtis, Jonathan D, Raj, Dipak K, Michelow, Ian C, Park, Sangshin, Nixon, Christina E, McDonald, Emily A, Nixon, Christian P, Pond-Tor, Sunthorn, Jha, Ambrish, Taliano, Ross J, Kabyemela, Edward R, Friedman, Jennifer F, Duffy, Patrick E, Fried, Michal. "Maternally-derived Antibodies to Schizont Egress Antigen-1 and Protection of Infants From Severe Malaria." Clinical Infectious Diseases, vol. 68, no. 10, 2018, pp. 1718-1724. |
| Friedman JF, Olveda RM, Mirochnick MH, Bustinduy AL, Elliott AM. "Praziquantel for the treatment of schistosomiasis during human pregnancy." Bulletin of the World Health Organization, vol. 96, no. 1, 2018, pp. 59-65. |
| Park S, Srikiatkhachorn A, Kalayanarooj S, Macareo L, Green S, Friedman JF, Rothman AL. "Use of structural equation models to predict dengue illness phenotype." PLOS Neglected Tropical Diseases, vol. 12, no. 10, 2018, pp. e0006799. |
| Nixon CE, Park S, Pond-Tor S, Raj D, Lambert LE, Orr-Gonzales S, Barnafo EK, Friedman JF, Fried M, Duffy PE, Kurtis JD. "Identification of Protective B-Cell Epitopes within the Novel Malaria Vaccine Candidate Plasmodium falciparum Schizont Egress Antigen 1." Clinical and vaccine immunology : CVI, vol. 24, no. 7, 2017. |
| Bustinduy AL, Stothard JR, Friedman JF. "Paediatric and maternal schistosomiasis: shifting the paradigms." British medical bulletin, vol. 123, no. 1, 2017, pp. 115-125. |
| Olveda RM, Acosta LP, Tallo V, Baltazar PI, Lesiguez JL, Estanislao GG, Ayaso EB, Monterde DB, Ida A, Watson N, McDonald EA, Wu HW, Kurtis JD, Friedman JF. "Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial." The Lancet Infectious Diseases, vol. 16, no. 2, 2016, pp. 199-208. |
| Bustinduy, Amaya L., Friedman, Jennifer F., Kjetland, Eyrun Floerecke, Ezeamama, Amara E., Kabatereine, Narcis B., Stothard, J. Russell, King, Charles H. "Expanding Praziquantel (PZQ) Access beyond Mass Drug Administration Programs: Paving a Way Forward for a Pediatric PZQ Formulation for Schistosomiasis." PLOS Neglected Tropical Diseases, vol. 10, no. 9, 2016, pp. e0004946. |
| Blake RA, Park S, Baltazar P, Ayaso EB, Monterde DB, Acosta LP, Olveda RM, Tallo V, Friedman JF. "LBW and SGA Impact Longitudinal Growth and Nutritional Status of Filipino Infants." PLoS ONE, vol. 11, no. 7, 2016, pp. e0159461. |
| Park S, Bellinger DC, Adamo M, Bennett B, Choi NK, Baltazar PI, Ayaso EB, Monterde DB, Tallo V, Olveda RM, Acosta LP, Kurtis JD, Friedman JF. "Mechanistic Pathways From Early Gestation Through Infancy and Neurodevelopment." Pediatrics, vol. 138, no. 6, 2016. |
| Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD. "Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection." Science, vol. 344, no. 6186, 2014, pp. 871-7. |
| Munoz, F. M., Weisman, L. E., Read, J. S., Siberry, G., Kotloff, K., Friedman, J., Higgins, R. D., Hill, H., Seifert, H., Nesin, M. "Assessment of Safety in Newborns of Mothers Participating in Clinical Trials of Vaccines Administered During Pregnancy." Clinical Infectious Diseases, vol. 59, no. suppl 7, 2014, pp. S415-S427. |
| Nixon CP, Nixon CE, Arsyad DS, Chand K, Yudhaputri FA, Sumarto W, Wangsamuda S, Asih PB, Marantina SS, Wahid I, Han G, Friedman JF, Bangs MJ, Syafruddin D, Baird JK. "Distance to Anopheles sundaicus larval habitats dominant among risk factors for parasitemia in meso-endemic Southwest Sumba, Indonesia." Pathogens and global health, vol. 108, no. 8, 2014, pp. 369-80. |
| McDonald EA, Cheng L, Jarilla B, Sagliba MJ, Gonzal A, Amoylen AJ, Olveda R, Acosta L, Baylink D, White ES, Friedman JF, Kurtis JD. "Maternal infection with Schistosoma japonicum induces a profibrotic response in neonates." Infection and Immunity, vol. 82, no. 1, 2014, pp. 350-5. |
| Heney JH, Dimock CC, Friedman JF, Lewis C. "Pediatric refugees in Rhode Island: increases in BMI percentile, overweight, and obesity following resettlement." Rhode Island medical journal (2013), vol. 98, no. 1, 2014, pp. 43-7. |
| McDonald EA, Pond-Tor S, Jarilla B, Sagliba MJ, Gonzal A, Amoylen AJ, Olveda R, Acosta L, Gundogan F, Ganley-Leal LM, Kurtis JD, Friedman JF. "Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments." The Journal of Infectious Diseases, vol. 209, no. 3, 2014, pp. 468-72. |
| McDonald EA, Friedman JF, Sharma S, Acosta L, Pond-Tor S, Cheng L, White ES, Kurtis JD. "Schistosoma japonicum soluble egg antigens attenuate invasion in a first trimester human placental trophoblast model." PLOS Neglected Tropical Diseases, vol. 7, no. 6, 2013, pp. e2253. |
| McDonald EA, Kurtis JD, Acosta L, Gundogan F, Sharma S, Pond-Tor S, Wu HW, Friedman JF. "Schistosome egg antigens elicit a proinflammatory response by trophoblast cells of the human placenta." Infection and Immunity, vol. 81, no. 3, 2013, pp. 704-12. |
| Watts DJ, Friedman JF, Vivier PM, Tompkins CE, Alario AJ. "Health care utilization of refugee children after resettlement." Journal of immigrant and minority health / Center for Minority Public Health, vol. 14, no. 4, 2012, pp. 583-8. |
| Ezeamama AE, McGarvey ST, Hogan J, Lapane KL, Bellinger DC, Acosta LP, Leenstra T, Olveda RM, Kurtis JD, Friedman JF. "Treatment for Schistosoma japonicum, reduction of intestinal parasite load, and cognitive test score improvements in school-aged children." PLOS Neglected Tropical Diseases, vol. 6, no. 5, 2012, pp. e1634. |
| Watts DJ, Friedman JF, Vivier PM, Tompkins CE, Alario AJ. "Immunization status of refugee children after resettlement." Medicine and health, Rhode Island, vol. 94, no. 10, 2011, pp. 290-3. |
| Shaw JG, Friedman JF. "Iron deficiency anemia: focus on infectious diseases in lesser developed countries." Anemia, vol. 2011, 2011, pp. 260380. |
| Kurtis JD, Higashi A, Wu HW, Gundogan F, McDonald EA, Sharma S, PondTor S, Jarilla B, Sagliba MJ, Gonzal A, Olveda R, Acosta L, Friedman JF. "Maternal Schistosomiasis Japonica Is Associated with Maternal, Placental, and Fetal Inflammation." Infection and Immunity, vol. 79, no. 3, 2011, pp. 1254-1261. |
| Fabre V, Wu H, PondTor S, Coutinho H, Acosta L, Jiz M, Olveda R, Cheng L, White ES, Jarilla B, McGarvey ST, Friedman JF, Kurtis JD. "Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection." The Journal of Infectious Diseases, vol. 203, no. 5, 2011, pp. 707-14. |
| Wu HW, Qin YF, Chu K, Meng R, Liu Y, McGarvey ST, Olveda R, Acosta L, Ji MJ, Fernandez T, Friedman JF, Kurtis JD. "High prevalence of Schistosoma japonicum infection in water buffaloes in the Philippines assessed by real-time polymerase chain reaction." The American Journal of Tropical Medicine and Hygiene, vol. 82, no. 4, 2010, pp. 646-52. |
| Leeper SC, Montague BT, Friedman JF, Flanigan TP. "Lessons learned from family-centred models of treatment for children living with HIV: current approaches and future directions." Journal of the International AIDS Society, vol. 13 Suppl 2, 2010, pp. S3. |
| Shaw JG, Aggarwal N, Acosta LP, Jiz MA, Wu HW, Leenstra T, Coutinho HM, Olveda RM, Kurtis JD, McGarvey ST, Friedman JF. "Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the Philippines." The American Journal of Tropical Medicine and Hygiene, vol. 83, no. 2, 2010, pp. 416-21. |
| Xu JM, Acosta LP, Hou M, Manalo DL, Jiz M, Jarilla B, Pablo AO, Ovleda RM, Langdon G, McGarvey ST, Kurtis JD, Friedman JF, Wu HW. "Seroprevalence of cysticercosis in children and young adults living in a helminth endemic community in leyte, the Philippines." Journal of tropical medicine, vol. 2010, 2010, pp. 603174. |
| Olson CL, Acosta LP, Hochberg NS, Olveda RM, Jiz M, McGarvey ST, Kurtis JD, Bellinger DC, Friedman JF. "Anemia of inflammation is related to cognitive impairment among children in Leyte, the Philippines." PLOS Neglected Tropical Diseases, vol. 3, no. 10, 2009, pp. e533. |
| Jiz M, Friedman JF, Leenstra T, Jarilla B, Pablo A, Langdon G, Pond-Tor S, Wu HW, Manalo D, Olveda R, Acosta L, Kurtis JD. "Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4." Infection and Immunity, vol. 77, no. 5, 2009, pp. 2051-8. |
| Friedman JF, Kurtis JD, Kabyemela ER, Fried M, Duffy PE. "The iron trap: iron, malaria and anemia at the mother-child interface." Microbes and infection / Institut Pasteur, vol. 11, no. 4, 2009, pp. 460-6. |
| Jiz M, Wu HW, Meng R, Pond-Tor S, Reynolds M, Friedman JF, Olveda R, Acosta L, Kurtis JD. "Pilot-scale production and characterization of paramyosin, a vaccine candidate for schistosomiasis japonica." Infection and Immunity, vol. 76, no. 7, 2008, pp. 3164-9. |
| Ezeamama AE, McGarvey ST, Acosta LP, Zierler S, Manalo DL, Wu HW, Kurtis JD, Mor V, Olveda RM, Friedman JF. "The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burden." PLOS Neglected Tropical Diseases, vol. 2, no. 6, 2008, pp. e245. |
| Friedman JF, Acosta LP. "Toward comprehensive interventions to improve the health of women of reproductive age." PLOS Neglected Tropical Diseases, vol. 2, no. 9, 2008, pp. e295. |
| Tolentino K, Friedman JF. "An update on anemia in less developed countries." The American Journal of Tropical Medicine and Hygiene, vol. 77, no. 1, 2007, pp. 44-51. |
| Coutinho HM, Leenstra T, Acosta LP, Olveda RM, McGarvey ST, Friedman JF, Kurtis JD. "Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the Philippines." Journal of Nutrition, vol. 137, no. 2, 2007, pp. 433-9. |
| Friedman JF, Mital P, Kanzaria HK, Olds GR, Kurtis JD. "Schistosomiasis and pregnancy." Trends in Parasitology, vol. 23, no. 4, 2007, pp. 159-64. |
| Coutinho HM, Acosta LP, Wu HW, McGarvey ST, Su L, Langdon GC, Jiz MA, Jarilla B, Olveda RM, Friedman JF, Kurtis JD. "Th2 cytokines are associated with persistent hepatic fibrosis in human Schistosoma japonicum infection." The Journal of Infectious Diseases, vol. 195, no. 2, 2007, pp. 288-95. |
| Coutinho HM, Acosta LP, McGarvey ST, Jarilla B, Jiz M, Pablo A, Su L, Manalo DL, Olveda RM, Kurtis JD, Friedman JF. "Nutritional status improves after treatment of schistosoma japonicum-infected children and adolescents." Journal of Nutrition, vol. 136, no. 1, 2006, pp. 183-8. |
| Coutinho HM, Leenstra T, Acosta LP, Su L, Jarilla B, Jiz MA, Langdon GC, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF. "Pro-inflammatory cytokines and C-reactive protein are associated with undernutrition in the context of Schistosoma japonicum infection." The American Journal of Tropical Medicine and Hygiene, vol. 75, no. 4, 2006, pp. 720-6. |
| Kurtis JD, Friedman JF, Leenstra T, Langdon GC, Wu HW, Manalo DL, Su L, Jiz M, Jarilla B, Pablo AO, McGarvey ST, Olveda RM, Acosta LP. "Pubertal development predicts resistance to infection and reinfection with Schistosoma japonicum." Clinical Infectious Diseases, vol. 42, no. 12, 2006, pp. 1692-8. |
| Leenstra T, Coutinho HM, Acosta LP, Langdon GC, Su L, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF. "Schistosoma japonicum reinfection after praziquantel treatment causes anemia associated with inflammation." Infection and Immunity, vol. 74, no. 11, 2006, pp. 6398-407. |
| Leenstra T, Acosta LP, Langdon GC, Manalo DL, Su L, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF. "Schistosomiasis japonica, anemia, and iron status in children, adolescents, and young adults in Leyte, Philippines 1." The American journal of clinical nutrition, vol. 83, no. 2, 2006, pp. 371-9. |
| Leenstra T, Acosta LP, Wu HW, Langdon GC, Solomon JS, Manalo DL, Su L, Jiz M, Jarilla B, Pablo AO, McGarvey ST, Olveda RM, Friedman JF, Kurtis JD. "T-helper-2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicum." Infection and Immunity, vol. 74, no. 1, 2006, pp. 370-81. |
| Ezeamama AE, Friedman JF, Olveda RM, Acosta LP, Kurtis JD, Mor V, McGarvey ST. "Functional significance of low-intensity polyparasite helminth infections in anemia." The Journal of Infectious Diseases, vol. 192, no. 12, 2005, pp. 2160-70. |
| Ezeamama AE, Friedman JF, Acosta LP, Bellinger DC, Langdon GC, Manalo DL, Olveda RM, Kurtis JD, McGarvey ST. "Helminth infection and cognitive impairment among Filipino children." The American Journal of Tropical Medicine and Hygiene, vol. 72, no. 5, 2005, pp. 540-8. |
| Friedman JF, Kanzaria HK, McGarvey ST. "Human schistosomiasis and anemia: the relationship and potential mechanisms." Trends in Parasitology, vol. 21, no. 8, 2005, pp. 386-92. |
| Lee GM, Salomon JA, Friedman JF, Hibberd PL, Ross-Degnan D, Zasloff E, Bediako S, Goldmann DA. "Illness transmission in the home: a possible role for alcohol-based hand gels." Pediatrics, vol. 115, no. 4, 2005, pp. 852-60. |
| Friedman JF, Kwena AM, Mirel LB, Kariuki SK, Terlouw DJ, Phillips-Howard PA, Hawley WA, Nahlen BL, Shi YP, ter Kuile FO. "Malaria and nutritional status among pre-school children: results from cross-sectional surveys in western Kenya." The American Journal of Tropical Medicine and Hygiene, vol. 73, no. 4, 2005, pp. 698-704. |
| Coutinho HM, McGarvey ST, Acosta LP, Manalo DL, Langdon GC, Leenstra T, Kanzaria HK, Solomon J, Wu H, Olveda RM, Kurtis JD, Friedman JF. "Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines." The Journal of Infectious Diseases, vol. 192, no. 3, 2005, pp. 528-36. |
| Friedman JF, Phillips-Howard PA, Mirel LB, Terlouw DJ, Okello N, Vulule JM, Hawley WA, Nahlen BL, ter Kuile F. "Progression of stunting and its predictors among school-aged children in western Kenya." European journal of clinical nutrition, vol. 59, no. 8, 2005, pp. 914-22. |
| Nixon CP, Friedman JF, Knopf PM, Duffy PE, Kurtis JD. "Protective human immunity as a vaccine discovery tool for falciparum malaria." Transfusion, vol. 45, no. 2 Suppl, 2005, pp. 81S-87S. |
| Friedman JF, Kanzaria HK, Acosta LP, Langdon GC, Manalo DL, Wu H, Olveda RM, McGarvey ST, Kurtis JD. "Relationship between Schistosoma japonicum and nutritional status among children and young adults in Leyte, the Philippines." The American Journal of Tropical Medicine and Hygiene, vol. 72, no. 5, 2005, pp. 527-33. |
| Kanzaria HK, Acosta LP, Langdon GC, Manalo DL, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF. "Schistosoma japonicum and occult blood loss in endemic villages in Leyte, the Philippines." The American Journal of Tropical Medicine and Hygiene, vol. 72, no. 2, 2005, pp. 115-8. |
| Friedman JF, Lee GM, Kleinman KP, Finkelstein JA. "Child care center policies and practices for management of ill children." Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association, vol. 4, no. 5, 2004, pp. 455-60. |
| Friedman JF, Lee GM, Kleinman KP, Finkelstein JA. "Acute care and antibiotic seeking for upper respiratory tract infections for children in day care: parental knowledge and day care center policies." Archives of Pediatrics & Adolescent Medicine, vol. 157, no. 4, 2003, pp. 369-74. |
| Friedman JF, Phillips-Howard PA, Hawley WA, Terlouw DJ, Kolczak MS, Barber M, Okello N, Vulule JM, Duggan C, Nahlen BL, ter Kuile FO. "Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western Kenya." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 Suppl, 2003, pp. 78-85. |
| ter Kuile FO, Terlouw DJ, Phillips-Howard PA, Hawley WA, Friedman JF, Kolczak MS, Kariuki SK, Shi YP, Kwena AM, Vulule JM, Nahlen BL. "Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 Suppl, 2003, pp. 100-7. |
| ter Kuile FO, Terlouw DJ, Kariuki SK, Phillips-Howard PA, Mirel LB, Hawley WA, Friedman JF, Shi YP, Kolczak MS, Lal AA, Vulule JM, Nahlen BL. "Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western Kenya." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 Suppl, 2003, pp. 68-77. |
| Friedman JF, Kurtis JD, Mtalib R, Opollo M, Lanar DE, Duffy PE. "Malaria is related to decreased nutritional status among male adolescents and adults in the setting of intense perennial transmission." The Journal of Infectious Diseases, vol. 188, no. 3, 2003, pp. 449-57. |
| Lee GM, Friedman JF, Ross-Degnan D, Hibberd PL, Goldmann DA. "Misconceptions about colds and predictors of health service utilization." Pediatrics, vol. 111, no. 2, 2003, pp. 231-6. |
| Kwena AM, Terlouw DJ, de Vlas SJ, Phillips-Howard PA, Hawley WA, Friedman JF, Vulule JM, Nahlen BL, Sauerwein RW, ter Kuile FO. "Prevalence and severity of malnutrition in pre-school children in a rural area of western Kenya." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 Suppl, 2003, pp. 94-9. |
| ter Kuile FO, Terlouw DJ, Phillips-Howard PA, Hawley WA, Friedman JF, Kariuki SK, Shi YP, Kolczak MS, Lal AA, Vulule JM, Nahlen BL. "Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western Kenya." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 Suppl, 2003, pp. 50-60. |
| Friedman JF, Kurtis JD, McGarvey ST, Fraga AL, Silveira A, Pizziolo V, Gazzinelli G, LoVerde P, Corrêa-Oliveira R. "Comparison of self-reported and observed water contact in an S. mansoni endemic village in Brazil." Acta tropica, vol. 78, no. 3, 2001, pp. 251-9. |
| Pinzon-Ortiz C1, Friedman J, Esko J, Sinnis P. "The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for plasmodium sporozoite attachment to target cells." journal of biologic chem, vol. 276, no. 29, 2001, pp. 26784-91. |
Dr. Friedman's research addresses how parasitic diseases, particularly malaria and schistosomiasis cause morbidity for pregnant women and children. We have focused on how schistosomiasis causes anemia and undernutrition. In particular, we have identified anemia of inflammation as a primary cause of schistosomiasis related anemia. In addition, our studies suggest that pro-inflammatory cytokines may mediate under-nutrition in the context of S. japonicum, due to their cachexia and anorexia inducing effects.
Our current studies seek to quantify the burden of S. japonicum infection during pregnancy and begin to understand the possible mechanisms and best ways to address this. In 2016 we completed a randomized controlled trial in The Philppines to assess the safety and efficacy of praziquantel for the treatment of schistosomiasis during pregnancy. Follow up studies are addressing how schistosomiasis and other helminth infections impact pregnancy and placental health and the longitudinal growth and nutritional stauts of offspring. In addition, we are examining how pre-natal alcohol exposure interacts with other insults in lesser developed countries to impact placental health as well as birth and infant outcomes. These studies are funded by NIH's NIAID and NIAAA.
Finally, a recently funded NIH/NIAID grant will plan a trial investigating the safety and efficacy of praziquantel in children under age four, for whom the drug is not currenlty FDA approved. In this dose finding trial, we will evaluate the PK/PD of different doses and examine factors such as impaired gut absorption of drugs in children living in lesser developed countries.
CURRENT:
Current:
1) NIH/NIAID Tropical Medicine Research Centers Award 6/1/22-3/31/27
U01AI168560
Tropical Medicine Research Centers Award (TMRC)
“Biomarkers to Identify Individuals at Risk for Progression of S. Japonicum Associated Hepatic Fibrosis with Point of Care Test Development”
The overall goal of this study is to build research capacity at the partner site (Research Institute for Topical Medicine in The Philippines) and to identify and validate serum biomarkers that identify individuals at risk for current hepatic fibrosis due to S. Japonicum and risk for fibrosis progression over three years with ultrasound as the gold standard.
Role: MPI (Friedman/Jiz)
2) NIH/NICHD 09/05/18-06/30/23
R01HD095562
$412,397 annual direct costs
“Phase II PK/PD driven dose finding trial of Praziquantel in children under four”
The major goals of this study are to identify the optimal dose and frequency of dosing of praziquantel for the treatment of schistosomiasis among children ages 1-4. Pharmacokinetic and pharmacodynamic (PK/PD) studies will inform optimal dosing based on key outcomes such as cure rate, egg reduction rate, and morbidity measures. We will also examine the effect of environmental enteropathy on both PK/PD and morbidity measures.
Role: MPI (Friedman/Bustinduy)
3) NIH/NIAID 2/15/15-1/31/25 2 K24 AI112964-06 (Midcareer Investigator Award in Patient Oriented Research)
“Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children” (Phase II/Renewal)
$177,303 annual direct costs
$14,184 annual indirect costs
The major goals of this study are to provide protected time for Dr. Friedman to mentor junior clinical faculty members in the conduct of patient oriented research and advance her own career development in areas of assessing gut health and characterizing placental microbiome. These activities will address both longitudinal studies and a randomized controlled trial to optimize interventions to mitigate morbidity among pregnant women their offspring, and young children.
Role: Principal Investigator
4) NIH/NIAID 08/11/17-07/31/22
R01AI127699
“Tfh responses to novel vaccine candidates and protection from pediatric falciparum malaria”
The goal of this R01 application is to evaluate T-follicular helper cellular responses to PfSEA-1 in a cohort of children and to relate these responses to resistance to malaria.
Role: Co-Investigator
5) NIH/GM COBRE 05/01/17-04/30/22
P20GM121298
COBRE “Centers of Biomedical Research Excellence”
“COBRE for Reproductive Health”
The goals of the COBRE award are to advance studies of women’s reproductive health while fostering the career development of promising junior investigators through the support of cores and mentoring by established NIH funded researchers.
Role: Leader of Biostatistics and Data Management Core (Core B)
COMPLETED
1)Albert Einstein Young Scientist Research Fellowship Summer 1991
Laboratory based research investigating B cell somatic hypermutation
$2000 + housing
Role: Principal Investigator
2) N.I.H. Medical Student Summer Research Grant Summer 1993
Laboratory based research investigating malaria parasite invasion of
hepatocytes
$2500
Role: Principal Investigator
3) Brown University Foreign Studies Fellowship to Brazil 1995
Validation of a water contact questionnaire in an S. mansoni endemic village
Travel cost paid
Role: Principal Investigator
4) US Fulbright Fellowship to Kenya with CDC 1996-1997
Impact of insecticide treated bednets (ITBNs) on the growth, nutritional
status, and body composition of primary school children (Principal Investigator)
RCT of impact of ITBNs on under 5 morbidity and mortality (co-investigator)
$22,000 per year
Role: Principal Investigator
5) Children’s Hospital of Philadelphia Resident Research Grant 1999
Travel funds to return to Kenya to oversee completion of ITBN project
Approximately $1500 in travel funds
Role: Principal Investigator
6)National Institutes of Allergy and Infectious Diseases 8/2002-4/2008
K23AI52125-01 Mentored Patient Oriented Research Scientist Development Award
$115, 525 annual direct costs
$9, 242 annual indirect costs
“Mechanisms of S. JaponicumAssociated Anemia and Malnutrition”
Role: Principal Investigator
7) National Institutes of Allergy and Infectious Diseases 09/2005-8/2007
RO3AI64735
Small Grants (RO3)
$50,000 annual direct costs
$23, 591 annual indirect costs
“Inflammation, Iron, and Cognition in S. japonicum”
Role: Principal Investigator
8) NIH/National Institutes of Allergy and Infectious Diseases 10/2003-9/2009
Pediatric Research Loan Repayment Award
Annual Repayment of $13,300-$28,640
Role: Principal Investigator
9) NIH/National Institutes of Allergy and Infectious Diseases 4/2008-3/2012
K02 Independent Scientist Award
K02 4AI077708-01
$96,750 annual direct costs
$7,740 annual indirect costs
“Mechanisms mediating adverse birth outcomes in the context of
S. japonicuminfection”
Role: Principal Investigator
10) NIH/National Institutes of Allergy and Infectious Diseases 9/2009-8/2011
3 K02 AI077708-02S1
K02 Independent Scientist Award, Administrative supplement
$46,030 annual direct costs
$3,122 annual indirect costs
“Mechanisms mediating adverse birth outcomes in the context of
S. japonicuminfection”
Role: Principal Investigator
11) Thrasher Fund 7/2008-3/2012
S. japonicumand infant morbidity: iron and cognition
$57,794 annual direct costs
The goals of this study are to investigate whether treatment for maternal Schistosomiasis japonicum at 12-16 weeks gestation will improve infant iron status, nutritional status, and cognitive development.
Role: Principal Investigator
12) NIH/National Institutes of Allergy and Infectious Diseases 9/1/2012-8/31/2013
R56-AI091753-01A1 (Kurtis)
NIH National Institutes of Allergy and Infectious Diseases
“Vaccines for humanSchistosomiasis japonica”
The major goal of this work was to identify vaccine candidates for using an immuno-epidemiologic approach.
Role: Co-investigator
13) Gates Grand Challenges Explorations Round 8 5/12-10/13
Gates Foundation
$100,000
“Fetal inflammation, cachexia, iron uptake, and LBW”
The major goal of this work was to address the role of fetal inflammation in the pathogenesis of newborn iron insufficiency and low birth weight in the context of S. japonicuminfection
Role: Principal Investigator
14) NIH/National Institutes of Allergy and Infectious Diseases 09/2008-08/2012
1R01AI076353 2008-2012
$378,274 annual direct costs
$166,828 annual indirect costs
Role: Co-investigator
“Targeted Vaccine Development for Pediatric Falciparum Malaria”
The major goal of this work was to identify vaccine candidates for pediatric falciparum malaria using an immuno-epidemiologic approach
Role: Co-investigator
15) NIH/National Institutes of Allergy and Infectious Diseases 04/2006-04/2013
U01 AI066050 (converted from RO-1AI066050)
RO1 Investigator Initiated converted to U01 due to clinical trial status
$454,721 annual direct costs
$165, 647annual indirect costs
“S. Japonicumand pregnancy outcomes: an RCT”
This study examined the effects of praziquantel treatment during pregnancy of women with S. japonicuminfection. It will specifically addressed effects on maternal nutritional status and birth outcomes, with emphasis on both placental and extra-placental mechanisms.
Role: Principal Investigator
16) NIH National Institutes of Allergy and Infectious Diseases 4/1/14-3/31/16
R21 AIAI107520-01 (Friedman)
$150,000 annual direct costs
“S.japonicum, anemia, and iron transport in human pregnancy”
The goals of this study are to 1) assess the role of maternal anemia of inflammation and 2) fetal inflammation, in the pathogenesis of newborn iron insufficiency.
Role: Principal Investigator
17) NIH National Institutes of Allergy and Infectious Diseases 5/10/13-4/30/17 1R01 AI101274-01A1
$348,357 annual direct costs
“Schistosome Vaccines”
The major goal of this project isto identify and evaluate novel candidate antigens for a vaccine against human schistosomiasis japonica using immuno-epidemiologic approaches.
Role: Co-investigator
18)NIH/NIAID 08/01/12-07/31/17
Tropical Medicine Research Center (TMRC) Program Project
TMRC P50AI098481-01
$21,596 annual direct costs to RIH for Dr. Friedman’s project and Core B
“Schistosomiasis vaccine development and morbidity throughout the life course “
The major goals of this program project were to 1) investigate the role of fetal immune priming in the context of maternal schistosomiasis and its relationship to risk of infection and morbidity at age five and 2) investigate the efficacy of a caribou vaccine in early stage development on transmission to humans for this zoonotic infection.
Role: North American PI for one of two projects and one of three cores
19) NIH/GM COBRE 9/1/2013- 5/31/18
1P20GM104317-01
COBRE “Centers of Biomedical Research Excellence”
“Immune Based Interventions Against Infectious Diseases”
$78,712annual direct costs RIH subcontract for Biostatistics Core
ICubed and CIHR researchers will participate in the transformational step of COBRE funding to 1. Establish an integrated research community to provide leadership in translational infectious diseases immunology research to the Rhode Island community, 2. Build infrastructure for immunology research through support for Research Cores in Cellular Analysis and Sorting, Luminex High-Throughput Analysis, and Statistics, 3. Recruit promising junior investigators and provide mentoring by established NIH-funded researchers, and 4. Support a multidisciplinary research program led by junior investigators in translational infectious diseases immunology.
Role: Leader of Biostatistics and Data Management Core (Core B)
20) Brown Brazil Initiative 6/1/15-5/31/18 (NCE)
$140,000 Total costs
“The role of microbial translocation in the pathogenesis of S. mansoni associated morbidity”
Role: Principal Investigator
21) NIH/NIAID P50 Program Project 8/1/13-7/31/18
P01 AI034533
“Flavivirus Infections: Pathogenesis and Prevention”
$19,535 annual direct costs RIH subcontract for Core B ($1,818,530 annual direct costs P01)
The major goals of this program project are to understand immunologic and clinical risk factors for severe dengue infection to ultimately identify vaccine targets and patients at greatest risk for severe disease. The Statistics and Data Management Core will provide key support for individual research projects aiding them in management and analysis of complex data.
Role: Leader of Statistics and Data Management Core
1) Helene Carabin, Maria V. Johansen, Jennifer F Friedman, Stephen T McGarvey, Henry Madsen, Zhou Xiao-Nong, and Steven Riley.(2011) “Zoonotic Schistosomiasis,” Chapter 55, pages 700-9 in Oxford Textbook of Zoonoses: Biology, Clinical Practice, and Public Health Control, Second Edition,S.R. Palmer, Lord Soulsby, Paul Torgerson, and David W. G. Brown Eds.
2) G Richard Olds and Jennifer F Friedman. (2016) “Subtle Morbidity,” Chapter 20 in Schistosoma: Biology, Pathology, Control. EditorBarrie G.M. Jamieson, CRC Press, Taylor and Francis Group.
3) Shaw, JG, Gutierrez, J, Friedman, JF. (2019)“Nutritional Anemia and Its Non-Nutritional Influences
in the Developing World.” Chapter 4 in Nutritional Anemia: Scientific Principles, Clinical Practice, and Public Health. Editor Robert T Means, Cambridge University Press, Cambridge, United Kingdom.
| Year | Degree | Institution |
|---|---|---|
| 2005 | PhD | University of Amsterdam |
| 2002 | MPH | Harvard University |
| 1996 | MD | Brown University |
| 1992 | BA | Brown University |
| Postdoctoral Fellow | Boston Children's Hospital, health services research | 2000-2002 | Boston, MA |
| Resident | Children's Hospital of Philadelphia, Pediatrics | 1998-2000 | Philadelphia, PA |
| Intern | Children's Hospital of Philadelphia, Pediatrics | 1997-1998 | Philadelphia, PA |
| Fellow | Centers for Disease Control, clinical epidemiology | 1996-1997 | Kenya |
Graduate, Magna cum Laude, Brown University, 1992
Received Pediatric Clinical Honors in Pediatric Sub-Internship, 1995-1996
Pediatric Infectious Diseases, Adolescent Medicine, and Pediatric HIV Longitudinal
Fulbright fellowship to Kenya with Centers for Disease Control, 1996-1997
Honor Award for contribution to Insecticide Treated Bednet Trial, 2002
National Center for Infectious Diseases, Atlanta, GA
Partners in Public Health, Group Honor Award to Insecticide Treated Bednet Trial's Kenya Staff, 2002
National Center for Infectious Diseases, Atlanta, GA
Award for excellence in Teaching and Mentoring from Pediatric Residents, 2002
Hasbro Children's Hospital, Providence, RI
Fleet Community Fellow Award for Community Service, 2003
$10,000 Loan Repayment Award
Fleet Bank, Boston, MA
Charles C. Shepard Science Award Nomination, 2004
Presented to Authors of most outstanding peer-reviewed research papers published by
Centers for Disease Control and Agency for Toxic Substances and Disease Registry
Dean's Teaching Excellence Award, 2008
For exemplary teaching of medical students in clinical years
Dean's Teaching Excellence Award,
For exemplary teaching of medical students in pre-clinical years 2004, 2006, 2007, 2008, 2009
Lifespan's Bruce Seyla Award for Research, 2012
American Pediatric Society Member 2015
Elected membership for professionals who have distinguished themselves as
child health leaders, scholars, and/or clinicians and whose important contributions
are recognized nationally or internationally
American Society of Clinical Investigation, Elected Member 2018
Elected membership for physician-scientists who have distinguished themselves
as outstanding scientists
Brown University Presidential Faculty Award 2019
Recognizing members of the Brown faculty who are conducting especially and
important and innovative scholarship (given to two faculty members annually)
| Name | Title |
|---|---|
| De La Monte, Suzanne | Professor of Neurosurgery, Professor of Pathology and Laboratory Medicine |
| Gundogan, Fusun | Professor of Pathology and Laboratory Medicine |
| Kurtis, Jonathan | Stanley M. Aronson Professor of Pathology and Laboratory Medicine, Chair of Pathology and Laboratory Medicine, Executive Director of the MD-PhD Program |
| McDonald, Emily | Assistant Professor of Pathology and Laboratory Medicine (Research), Assistant Professor of Pediatrics (Research) |
| McGarvey, Stephen | Professor of Epidemiology |
| Nixon, Christian | Associate Professor of Pathology and Laboratory Medicine |
| Padbury, James | William and Mary Oh - William and Elsa Zopfi Professor of Pediatrics for Perinatal Research |
| Sharma, Surendra | Professor of Pathology and Laboratory Medicine (Research), Professor of Pediatrics (Research) |
Member, American Academy of Pediatrics, 1997-
Fellow, American Academy of Pediatrics, 2000-
Member, American Society of Tropical Medicine and Hygiene, 2001-
Elected Member, American Pediatric Society 2016
Elected Member, American Society for Clinical Investigation, 2018
| Certification | American Board of Pediatrics, General pediatrics | 2007- | |
| Medical License | Rhode Island | 2002-Present | |
| Medical License | Massachusetts | 2000-2003 | |
| Medical License | Pennsylvania | 1999-2000 |
| Staff Physician. Hasbro Children's Hospital & Brown University, 2002-Present |
| Fellow. Boston Children's Hospital, 2000-2002 |
| Staff Pediatrician. Harvard Vanguard Medical Associates, 2000-2002 |
