Expertise/Certifications: Anatomic Pathology, Neuropathology, Laboratory Medical Director
Office number: 444-5011
(Lab Customer Service: 401-793-4242)
Dr. Anthony is a Professor of Pathology and Laboratory Medicine, and Professor Neurology, at the Warren Alpert School of Medicine at Brown University. He is the Pathologist-in-Chief at Lifespan Academic Medical Center (The Miriam and Rhode Island Hospitals). He received his B.S. in Chemical Engineering from Washington University in St. Louis, and his M.D. and Ph.D. in Experimental Pathology from Duke University. He is board-certified in anatomic pathology and neuropathology, and studies the cellular and molecular basis of disorders that affect the nervous system. His work has been funded by the NIH, NSF, and private foundations, and he has served as a consultant to the National Institutes of Health, Environmental Protection Agency, National Board of Medical Examiners, U.S. Department of Justice, and a number of universities.
Prior academic appointments:
Assistant Professor of Pathology, Duke University
Associate Professor of Pathology, Harvard University
Professor and Chair of Pathology and Anatomy, and Professor of Neurology, University of Missouri
| Chambers KJ, Anthony DC, Randolph GW, Hartnick CJ, Stopa EG, Song PC Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model.. The Laryngoscope. 2016; |
| 97. Lee EJ, Rath P, Liu J, Ryu D, Free A, Pei L, Feng Q, Litofsky NS, Miller DC, Anthony DC, Kirk MD, Laterra JJ, Ryu D, Choi JH, Shi H Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells.. J Genetics Genomics . 2015; 42 : 355-371. |
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Pytel P, Anthony DC
Peripheral nerve and skeletal muscle (In Robbins and Cotran Pathologic Basis of Disease).
2015; : 1227-1250.
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Frosch MP, Anthony DC, DeGirolami UL
The central nervous system (In Robbins and Cotran Pathologic Basis of Disease).
2015; : 1251-1318.
|
| Chen Z, Shin D, Chen S, Mikhail K, Hadass O, Tomlison BN, Korkin D, Shyu CR, Cui J, Anthony DC, Gu Z Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice.. PLoS ONE. 2014; 9 (3) : e92133. |
| Glinskii OV, Sud S, Mossine VV, Mawhinney TP, Anthony DC, Glinsky GV, Pienta KJ, Glinsky VV Inhibition of prostate cancer bone metastasis by synthetic TF antigen mimic/galectin-3 inhibitor lactulose-L-leucine.. Neoplasia (New York, N.Y.). 2012; 14 (1) : 65-73. |
| Li F, Glinskii OV, Zhou J, Wilson LS, Barnes S, Anthony DC, Glinsky VV Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brain.. PLoS ONE. 2011; 6 (7) : e21977. |
| Rath P, Miller DC, Litofsky NS, Anthony DC, Feng Q, Franklin C, Pei L, Free A, Liu J, Ren M, Kirk MD, Shi H Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma.. Experimental and molecular pathology. 2011; 90 (2) : 179-88. |
| Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Pienta KJ, Raz A, Glinsky VV Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia.. Neoplasia (New York, N.Y.). 2007; 9 (8) : 662-70. |
| Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers.. International Journal of Oncology. 2007; 30 (3) : 651-7. |
| Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB Proliferative potential of human astrocytes.. Journal of Neuropathology and Experimental Neurology. 2005; 64 (2) : 163-9. |
| Sudoh Y, Desai SP, Haderer AE, Sudoh S, Gerner P, Anthony DC, De Girolami U, Wang GK Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline.. Regional anesthesia and pain medicine. 2004; 29 (5) : 434-40. |
| Astrakas LG, Zurakowski D, Tzika AA, Zarifi MK, Anthony DC, De Girolami U, Tarbell NJ, Black PM Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors.. Clin Cancer Res . 2004; 10 (24) : 8220-8. |
| Robb RM, Anthony DC Congenital cystic eye: recurrence after initial surgical removal.. Ophthalmic genetics. 2003; 24 (2) : 117-23. |
| Kang PB, Lidov HG, David WS, Torres A, Anthony DC, Jones HR, Darras BT Diagnostic value of electromyography and muscle biopsy in arthrogryposis multiplex congenita.. Annals of neurology. 2003; 54 (6) : 790-5. |
| Tzika AA, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM Multiparametric MR assessment of pediatric brain tumors.. Neuroradiology. 2003; 45 (1) : 1-10. |
| Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy.. Journal of Neurosurgery. 2002; 96 (6) : 1023-31. |
| Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium.. Journal of biomedical materials research. 2002; 59 (3) : 450-9. |
| Gerner P, Mujtaba M, Khan M, Sudoh Y, Vlassakov K, Anthony DC, Wang GK N-phenylethyl amitriptyline in rat sciatic nerve blockade.. Anesthesiology. 2002; 96 (6) : 1435-42. |
| Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging.. AJNR. American journal of neuroradiology. 2002; 23 (2) : 322-33. |
| Feany MB, Anthony DC, Frosch MP, Zane W, De Girolami U August 2000: Two cases with necrosis and hemorrhage in the putamen and white matter.. Brain pathology (Zurich, Switzerland). 2001; 11 (1) : 121-2, 125. |
| Zarifi MK, Tzika AA, Astrakas LG, Poussaint TY, Anthony DC, Darras BT Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease.. Journal of Child Neurology. 2001; 16 (7) : 522-6. |
| Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment.. Neuroradiology. 2001; 43 (2) : 169-77. |
| Bönnemann CG, Cox GF, Shapiro F, Wu JJ, Feener CA, Thompson TG, Anthony DC, Eyre DR, Darras BT, Kunkel LM A mutation in the alpha 3 chain of type IX collagen causes autosomal dominant multiple epiphyseal dysplasia with mild myopathy.. Proceedings of the National Academy of Sciences. 2000; 97 (3) : 1212-7. |
| Cheng LL, Anthony DC, Comite AR, Black PM, Tzika AA, Gonzalez RG Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy.. Neuro-Oncology. 2000; 2 (2) : 87-95. |
| Gerner P, Nakamura T, Quan CF, Anthony DC, Wang GK Spinal tonicaine: potency and differential blockade of sensory and motor functions.. Anesthesiology. 2000; 92 (5) : 1350-60. |
| Young Poussaint T, Yousuf N, Barnes PD, Anthony DC, Zurakowski D, Scott RM, Tarbell NJ Cervicomedullary astrocytomas of childhood: clinical and imaging follow-up.. Pediatr Radiol. 1999; 29 (9) : 662-8. |
| O'Tuama LA, Poussaint TY, Anthony DC, Treves ST Childhood brain tumor: neuroimaging correlated with disease outcome.. Pediatric Neurology. 1998; 19 (4) : 259-62. |
| Madsen JR, Vallat AV, Poussaint TY, Scott RM, De Girolami U, Anthony DC Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases.. Pediatric neurosurgery. 1998; 28 (5) : 261-6. |
| Swoboda KJ, Engle EC, Scheindlin B, Anthony DC, Jones HR Mutilating hand syndrome in an infant with familial carpal tunnel syndrome.. Muscle & nerve. 1998; 21 (1) : 104-11. |
| Feany MB, Anthony DC, Fletcher CD Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge.. Histopathology. 1998; 32 (5) : 405-10. |
| Komori T, Scheithauer BW, Anthony DC, Rosenblum MK, McLendon RE, Scott RM, Okazaki H, Kobayashi M Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm.. The American Journal of Surgical Pathology. 1998; 22 (10) : 1171-83. |
| Wang GK, Vladimirov M, Shi H, Mok WM, Thalhammer JG, Anthony DC Structure-activity relation of N-alkyl tetracaine derivatives as neurolytic agents for sciatic nerve lesions.. Anesthesiology. 1998; 88 (2) : 417-28. |
| Poussaint TY, Kowal JR, Barnes PD, Zurakowski D, Anthony DC, Goumnerova L, Tarbell NJ Tectal tumors of childhood: clinical and imaging follow-up.. AJNR. American journal of neuroradiology. 1998; 19 (5) : 977-83. |
| Le S, Zhu JJ, Anthony DC, Greider CW, Black PM Telomerase activity in human gliomas.. Neurosurgery. 1998; 42 (5) : 1120-4; discussion 1124-5. |
| Poussaint TY, Barnes PD, Nichols K, Anthony DC, Cohen L, Tarbell NJ, Goumnerova L Diencephalic syndrome: clinical features and imaging findings.. AJNR. American journal of neuroradiology. 1997; 18 (8) : 1499-505. |
| Hakim R, Loeffler JS, Anthony DC, Black PM Gangliogliomas in adults.. Cancer. 1997; 79 (1) : 127-31. |
| Young TL, Anthony DC, Pierce E, Foley E, Smith LE Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity.. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1997; 1 (2) : 105-10. |
| Anthony DC Specificity of neurofilament swellings and axonal atrophy: commentary on forum position paper.. Neurotoxicology. 1997; 18 (1) : 23-4; discussion 37-40. |
| Zec N, De Girolami U, Schofield DE, Scott RM, Anthony DC Giant cell ependymoma of the filum terminale. A report of two cases.. The American Journal of Surgical Pathology. 1996; 20 (9) : 1091-101. |
| Poussaint TY, Barnes PD, Anthony DC, Spack N, Scott RM, Tarbell NJ Hemorrhagic pituitary adenomas of adolescence.. AJNR. American journal of neuroradiology. 1996; 17 (10) : 1907-12. |
| Wang GK, Vladimirov M, Quan C, Mok WM, Thalhammer JG, Anthony DC N-butyl tetracaine as a neurolytic agent for ultralong sciatic nerve block.. Anesthesiology. 1996; 85 (6) : 1386-94. |
| Anthony DC, Crain BJ Peripheral nerve biopsies.. Archives of Pathology & Laboratory Medicine. 1996; 120 (1) : 26-34. |
| Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.. Nature Medicine. 1996; 2 (10) : 1146-50. |
| Crofton KM, Padilla S, Tilson HA, Anthony DC, Raymer JH, MacPhail RC The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects.. Toxicology and applied pharmacology. 1996; 139 (1) : 163-76. |
| Laws ER Jr, Stieg PE, Goumnerova L, Schwartz RB, Anthony DC Acute presentation of an intracranial mass.. Neurosurgery. 1995; 37 (1) : 109-13. |
| Schofield D, West DC, Anthony DC, Marshal R, Sklar J Correlation of loss of heterozygosity at chromosome 9q with histological subtype in medulloblastomas.. The American Journal of Pathology. 1995; 146 (2) : 472-80. |
| Poussaint TY, Siffert J, Barnes PD, Pomeroy SL, Goumnerova LC, Anthony DC, Sallan SE, Tarbell NJ Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up.. AJNR. American journal of neuroradiology. 1995; 16 (4) : 693-9. |
| White FV, Anthony DC, Yunis EJ, Tarbell NJ, Scott RM, Schofield DE Nonrandom chromosomal gains in pilocytic astrocytomas of childhood.. Human Pathology. 1995; 26 (9) : 979-86. |
| Graham DG, Amarnath V, Valentine WM, Pyle SJ, Anthony DC Pathogenetic studies of hexane and carbon disulfide neurotoxicity.. Critical reviews in toxicology. 1995; 25 (2) : 91-112. |
| Pyle SJ, Graham DG, Anthony DC Dimethylhexanedione impairs the movement of neurofilament protein subunits, NFM and NFL, in the optic system.. Neurotoxicology. 1994; 15 (2) : 279-86. |
| Rao VV, Anthony DC, Piwnica-Worms D MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase.. Cancer Research. 1994; 54 (6) : 1536-41. |
| Denlinger RH, Anthony DC, Amarnath K, Amarnath V, Graham DG Metabolism of 3,3'-iminodipropionitrile and deuterium-substituted analogs: potential mechanisms of detoxification and activation.. Toxicology and applied pharmacology. 1994; 124 (1) : 59-66. |
| Valentine WM, Graham DG, Anthony DC Covalent cross-linking of erythrocyte spectrin by carbon disulfide in vivo.. Toxicology and applied pharmacology. 1993; 121 (1) : 71-7. |
| Pyle SJ, Amarnath V, Graham DG, Anthony DC Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione exposure.. Cell motility and the cytoskeleton. 1993; 26 (2) : 133-43. |
| Thomas LO, Boyko OB, Anthony DC, Burger PC MR detection of brain iron.. AJNR. American journal of neuroradiology. 1993; 14 (5) : 1043-8. |
| Hulette CM, Earl NL, Anthony DC, Crain BJ Adult onset Niemann-Pick disease type C presenting with dementia and absent organomegaly.. Clinical neuropathology. 1992; 11 (6) : 293-7. |
| Denlinger RH, Anthony DC, Amarnath V, Graham DG Comparison of location, severity, and dose response of proximal axonal lesions induced by 3,3'-iminodipropionitrile and deuterium substituted analogs.. Journal of Neuropathology and Experimental Neurology. 1992; 51 (6) : 569-76. |
| Valentine WM, Amarnath V, Graham DG, Anthony DC Covalent cross-linking of proteins by carbon disulfide.. Chemical research in toxicology. 1992; 5 (2) : 254-62. |
| Vandersteenhoven JJ, Dbaibo G, Boyko OB, Hulette CM, Anthony DC, Kenny JF, Wilfert CM Progressive multifocal leukoencephalopathy in pediatric acquired immunodeficiency syndrome.. The Pediatric Infectious Disease Journal. 1992; 11 (3) : 232-7. |
| Cucchiaro G, Branum GD, Farouk M, Mansour G, Kuhn CM, Anthony DC, Meyers WC The effects of liver denervation on the regulation of hepatic biliary secretion.. Transplantation. 1992; 54 (1) : 129-36. |
| Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GA, Anthony DC, Urbaniak JR The functional recovery of peripheral nerves following defined acute crush injuries.. Journal of Orthopaedic Research. 1992; 10 (5) : 657-64. |
| Pyle SJ, Amarnath V, Graham DG, Anthony DC The role of pyrrole formation in the alteration of neurofilament transport induced during exposure to 2,5-hexanedione.. Journal of Neuropathology and Experimental Neurology. 1992; 51 (4) : 451-8. |
| Dresser LP, Tourian AY, Anthony DC A case of myelinoclastic diffuse sclerosis in an adult.. Neurology. 1991; 41 (2 ( Pt 1)) : 316-8. |
| Graham DG, St Clair MB, Amarnath V, Anthony DC Molecular mechanisms of gamma-diketone neuropathy.. Systems Biology of RNA Binding Proteins. 1991; 283 : 427-31. |
| Amarnath V, Anthony DC, Valentine WM, Graham DG The molecular mechanism of the carbon disulfide mediated cross-linking of proteins.. Chemical research in toxicology. 1991; 4 (2) : 148-50. |
| Wolf HK, Anthony DC, Fuller GN Arterial border zone necrosis of the spinal cord.. Clinical neuropathology. 1990; 9 (2) : 60-5. |
| Cucchiaro G, Yamaguchi Y, Mills E, Kuhn CM, Anthony DC, Branum GD, Epstein R, Meyers WC Evaluation of selective liver denervation methods.. The American journal of physiology. 1990; 259 (5 Pt 1) : G781-5. |
| St Clair MB, Anthony DC, Wikstrand CJ, Graham DG Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum.. Neurotoxicology. 1989; 10 (4) : 743-56. |
| Krendel DA, Parks HP, Anthony DC, St Clair MB, Graham DG Sural nerve biopsy in chronic inflammatory demyelinating polyradiculoneuropathy.. Muscle & nerve. 1989; 12 (4) : 257-64. |
| Boekelheide K, Anthony DC, Giangaspero F, Gottfried MR, Graham DG Aliphatic diketones: influence of dicarbonyl spacing on amine reactivity and toxicity.. Chemical research in toxicology. 1988; 1 (4) : 200-3. |
| Warren LP Jr, Djang WT, Moon RE, Camporesi EM, Sallee DS, Anthony DC, Massey EW, Burger PC, Heinz ER Neuroimaging of scuba diving injuries to the CNS.. American Journal of Roentgenology. 1988; 151 (5) : 1003-8. |
| Genter St Clair MB, Amarnath V, Moody MA, Anthony DC, Anderson CW, Graham DG Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy.. Chemical research in toxicology. 1988; 1 (3) : 179-85. |
| Rosenberg CK, Genter MB, Szakál-Quin G, Anthony DC, Graham DG dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat.. Toxicology and applied pharmacology. 1987; 87 (2) : 363-73. |
| Genter MB, Szakál-Quin G, Anderson CW, Anthony DC, Graham DG Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy.. Toxicology and applied pharmacology. 1987; 87 (2) : 351-62. |
| Rosenberg CK, Anthony DC, Szakál-Quin G, Genter MB, Graham DG Hyperbaric oxygen accelerates the neurotoxicity of 2,5-hexanedione.. Toxicology and applied pharmacology. 1987; 87 (2) : 374-9. |
| Anthony DC, Atwater SK, Rozear MP, Burger PC Occlusion of the basilar artery within a fracture of the clivus. Case report.. Journal of Neurosurgery. 1987; 66 (6) : 929-31. |
| Graham DG, Anthony DC, Szakál-Quin G, Gottfried MR, Boekelheide K Covalent crosslinking of neurofilaments in the pathogenesis of n-hexane neuropathy.. Neurotoxicology. 1985; 6 (4) : 55-63. |
| Griffin JW, Anthony DC, Fahnestock KE, Hoffman PN, Graham DG 3,4-Dimethyl-2,5-hexanedione impairs the axonal transport of neurofilament proteins.. Journal of Neuroscience. 1984; 4 (6) : 1516-26. |
| Graham DG, Szakál-Quin G, Priest JW, Anthony DC In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy.. Proceedings of the National Academy of Sciences. 1984; 81 (15) : 4979-82. |
| Anthony DC, Boekelheide K, Graham DG The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings.. Toxicology and applied pharmacology. 1983; 71 (3) : 362-71. |
| Anthony DC, Boekelheide K, Anderson CW, Graham DG The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.. Toxicology and applied pharmacology. 1983; 71 (3) : 372-82. |
| Anthony DC, Giangaspero F, Graham DG The spatio-temporal pattern of the axonopathy associated with the neurotoxicity of 3,4-dimethyl-2,5-hexanedione in the rat.. Journal of Neuropathology and Experimental Neurology. 1983; 42 (5) : 548-60. |
| Graham DG, Anthony DC, Boekelheide K In vitro and in vivo studies of the molecular pathogenesis of n-Hexane neuropathy.. Neurobehavioral toxicology and teratology. 1982; 4 (6) : 629-34. |
| Graham DG, Anthony DC, Boekelheide K, Maschmann NA, Richards RG, Wolfram JW, Shaw BR Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.. Toxicology and applied pharmacology. 1982; 64 (3) : 415-22. |
Research in our laboratory examines several areas in the cellular and molecular neurosciences with a focus in translational biology and neuropathology. Current projects include the pathobiology of primary brain tumors (those that originate in the brain) and metastatic brain tumors (those that originate elsewhere but travel to the brain). The laboratory also has long-standing interests in neuromuscular pathobiology and the pathobiology of intermediate filaments.
Dr. Anthony's laboratory is conducting research in cellular neurosciences - the study of the brain at a cellular and molecular level. A major focus of the laboratory is the study of cancer involving the brain, both tumors that originate in the brain and those that metastasize to the brain. Dr. Anthony's lab was involved in defining the relationship between the desmoplastic variant of medulloblastoma and the PTCH gene, located on 9q22.3, by recognizing that patients with Gorlin's syndrome (basal cell nevus syndrome) develop this specific variant of medulloblastoma (desmoplastic variant).
Current studies are exploring how the cells of brain tumors propagate and spread. By isolating the progenitor cells of tumors, we have been exploring the biologic behavior of cancer cells and how those behaviors are regulated.
Stem cells in primary brain tumors
Gliomas are a common type of brain tumor, and because the cells of the glioma migrate through the brain, these tumors are difficult to remove surgically. In order to achieve better clinical outcomes in patients with malignant gliomas, a better understanding of the biologic behavior of brain tumors is needed. We are studying the molecular phenotype of malignant glioma cells, with a particular focus on the population of cells within the tumors that are responsible for the growth and aggressive clinical behavior of gliomas. These cells, also known as tumor stem cells, reproduce some of the characteristics of neural stem cells in their growth as neurospheres and in their expression of both neuronal and glial proteins. We have identified these types of tumor-initiating cells from gliomas and other malignant brain tumors. Protein expression and mRNA levels in tumor stem cells are similar in many ways to neural stem cells, but also have distinct features in their expression profiles. The isolation and identification of tumor-initiating cell populations capable of forming tumors creates a powerful model for understanding the development of brain tumors. By studying glioma stem cells, we hope to clarify the pathobiology of these tumors and provide increased understanding of malignant progression. (Additional reading: Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma. Exp Molec Pathol 2011; 90:179-88.)
Breast cancer cells and how they metastasize
Nearly one out of every 10 women will develop breast cancer during her lifetime. Fortunately, with screening methods, such as mammography, most breast cancers are detected early and can be completely removed. However, some breast cancers will not be detected until they have spread through the body in a process known as metastasis. It is this process of metastasis of breast cancer cells that causes death and disability in women with breast cancer, and nearly 20% of patients with metastatic breast cancer will suffer from metastasis to the brain. In order to understand breast cancer metastasis, we are studying breast cancer cells in tissue culture, and identifying markers that are associated with metastasis, especially metastasis to the brain. Our findings suggest that specific signals are involved in the colonization of the brain by metastatic breast cancer cells. (Additional reading: Identification and analysis of signaling networks potentially involved in breast cancer metastasis to the brain. Plos One 2011; 6:e21977; doi:10.1371)
Lee EJ, Rath P, Liu J, Ryu D, Free A, Pei L, Feng Q, Litofsky NS, Miller DC, Anthony DC, Kirk MD, Laterra JJ, Ryu D, Choi JH, Shi H. Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells. J Genetics Genomics 2015;42:355-71. PMID 26233891, PMCID: PMC 4648292
Chambers K, Anthony DC, Randolph G, Hartnick C, Stopa E, Song P. Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model. Laryngoscope 2016; doi: 10.1002/lary.26065. [Epub ahead of print] PubMed PMID: 27271961.
Chen A, Shin D, Chen S, Mikhail K, Hadass O, Tomlison BN, Korkin DN, Shyu CR, Cui J, Anthony DC, Gu Z. Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice. Plos ONE 2014;9(3):e92133. doi:10.1371/journal.pone.0092133
Pytel P, Anthony DC. Peripheral nerve and skeletal muscle. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 9th Edition. Philadelphia: Elsevier Saunders, 2015; 1227-50.
Frosch MP, Anthony DC, DeGirolami UL. The central nervous system. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 9th Edition. Philadelphia: Elsevier Saunders, 2015; 1251-1318.
Glinskii OV, Sud S, Mossine VV, Mawhinney TP, Anthony DC, Glinsky GV, Pienta KJ, Glinsky VV. Inhibition of prostate cancer bone metastasis by synthetic TF-antigen mimic/galectin-3 inhibitor lactulose-L-leucine. Neoplasia 2012;14:65-73.
Li F, Glinskii OV, Zhou J, Wilson LS, Barnes S, Anthony DC, Glinsky VV. Identification and analysis of signaling networks potentially involved in breast cancer metastasis to the brain. Plos One 2011; 6:e21977(1-14) doi:10.1371.
Rath P, Miller DC, Litofsky NS, Anthony DC, Feng Q, Franklin C, Pei L, Free A, Liu J, Ren M, Kirk MD, Shi H. Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma. Exp Molec Pathol 2011; 90:179-88.
Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Peinta KJ, Raz A, Glinskii VV. Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelium. Neoplasia 2007;9:662-70.
Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, DeGirolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Internat J Oncol 2007;30:651-7.
Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB. Proliferative potential of human astrocytes. J Neuropathol Exp Neurol 2005;64:163-9.
Astrakas LG, Zurakowski D, Tzika AA, Zarifi MK, Anthony DC, DeGirolami U, Tarbell NJ, Black PM. Non-invasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. Clin Cancer Res 2004;10:8220-8.
Tzika AA, D, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM. Multiparametric MR assessment of pediatric brain tumors. Neuroradiol 2003;45:1-10.
Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg 2002;96:1023-31.
Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. Am J Neuroradiol (AJNR) 2002;23:322-33.
Zarifi MK, Tzika AA, Astrakas LG, Poussaint TY, Anthony DC, Darras BT. Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease. J Child Neurol 2001;16:522-6.
Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM. Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment. Neuroradiol 2001;43:169-77.
| Year | Degree | Institution |
|---|---|---|
| 1984 | MD | Duke University |
| 1984 | PhD | Duke University |
| 1978 | BSc | Washington University in St. Louis |
| Fellow | Duke University Medical Center, neuropathology | 1985-1986 | Durham, NC |
| Resident | Duke University Medical Center, anatomic pathology | 1984-1987 | Durham, NC |
American Association of Neuropathologists (Chair of Website Committee)
Fellow, College of American Pathologists (CAP)
New England Socieity of Pathologists, President-elect
United States and Canadian Academy of Pathology (USCAP)
Association of Pathology Chairpersons (APC)
Rhode Island Society of Pathology
Society for Neuroscience (SfN)
Society of Toxicology (SOT)
American Society for Neurochemistry (ASN)
American Society for Investigative Pathology (ASIP)
Society for Pediatric Pathology (SPP)
American Medical Association (AMA)
| Controlled Substance License | Rhode Island | 2011-2030 | |
| Medical License | Rhode Island | 2011-2030 | |
| Medical License | Missouri | 2001-2030 | |
| Medical License | Massachusetts | 1992-2002 | |
| Federal DEA License | 1987-2030 | ||
| Certification | American Board of Pathology, anatomic pathology | 1987-2030 | |
| Certification | American Board of Pathology, neuropathology | 1987-2030 | |
| Medical License | North Carolina | 1986-1995 |
| Medical Director. Rhode Island Hospital, Department of Pathology & Laboratory Medicine 2012-Present |
| Medical Director. The Miriam Hospital, Department of Laboratory Medicine 2012-Present |
| Medical Director. University of Missouri Hospital, Pathology Clinical Laboratories 2002-2012 |
