Expertise/Certifications: Anatomic Pathology, Neuropathology, Laboratory Medical Director
Office number: 444-5156
(Lab Customer Service: 401-793-4242)
Dr. Anthony is a Professor of Pathology and Laboratory Medicine, and Professor of Neurology, at the Warren Alpert School of Medicine at Brown University. He received his B.S. in Chemical Engineering from Washington University in St. Louis, and his M.D. and Ph.D. in Experimental Pathology from Duke University. He is board-certified in anatomic pathology and neuropathology, and studies the cellular and molecular basis of disorders that affect the nervous system. His work has been funded by the NIH, NSF, and private foundations, and he has served as a consultant to the National Institutes of Health, Environmental Protection Agency, National Board of Medical Examiners, U.S. Department of Justice, and a number of universities and foundations. He is currently the President of the American Association of Neuropathologists.
Prior academic appointments:
Assistant Professor of Pathology, Duke University
Associate Professor of Pathology, Harvard University
Professor and Chair of Pathology and Anatomy, and Professor of Neurology, University of Missouri
| Lakis NS, Brodsky AS, Karashchuk G, Audesse AJ, Yang D, Sturtevant A, Lombardo K, Wong IY, Webb AE, Anthony DC. "Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation." Acta Neuropathologica Communications, vol. 10, no. 1, 2022, pp. 159. |
| Audesse AJ, Karashchuk G, Gardell ZA, Lakis NS, Maybury-Lewis SY, Brown AK, Leeman DS, Teo YV, Neretti N, Anthony DC, Brodsky AS, Webb AE. "FOXO3 regulates a common genomic program in aging and glioblastoma stem cells." Aging and Cancer, vol. 2, no. 4, 2021, pp. 137-159. |
| He X, Anthony DC, Catoni Z, Cao W. "Pulmonary tumor embolism: A retrospective study over a 30-year period." PLoS ONE, vol. 16, no. 8, 2021, pp. e0255917. |
| Stonebridge R, Taliano RJ, Velilla TD, Anthony DC. "Hypertrophy of the Anterior External Arcuate Fasciculus: A Rare Variant With Implications for the Development of the Arcuate Nucleus." Frontiers in neuroanatomy, vol. 14, 2020, pp. 595500. |
| Cai C, Anthony DC, Pytel P. "A pattern-based approach to the interpretation of skeletal muscle biopsies." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 32, no. 4, 2019, pp. 462-483. |
| Nix JS, Gardner JM, Costa F, Soares AL, Rodriguez FJ, Moore B, Martinez-Lage M, Ahlawat S, Gokden M, Anthony DC. "Neuropathology Education Using Social Media." Journal of Neuropathology and Experimental Neurology, vol. 77, no. 6, 2018, pp. 454-460. |
| Chambers KJ, Anthony DC, Randolph GW, Hartnick CJ, Stopa EG, Song PC. "Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model." The Laryngoscope, vol. 126, no. 12, 2016, pp. 2689-2693. |
| Baumgartner A, Anthony D. "The Decline of the Autopsy in Rhode Island and Nationwide: Past Trends and Future Directions." Rhode Island medical journal (2013), vol. 99, no. 10, 2016, pp. 36-38. |
| Lee EJ, Rath P, Liu J, Ryu D, Free A, Pei L, Feng Q, Litofsky NS, Miller DC, Anthony DC, Kirk MD, Laterra JJ, Ryu D, Choi JH, Shi H. "Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells." J Genetics Genomics , vol. 42, 2015, pp. 355-371. |
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Pytel P, Anthony DC.
"Peripheral nerve and skeletal muscle (In Robbins and Cotran Pathologic Basis of Disease)." Robbins and Cotran Pathologic Basis of Disease, 9th Edition, edited by Kumar V, Abbas AK, Aster JC, Philadelphia, Elsevier, 2015, pp. 1227-1250.
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Frosch MP, Anthony DC, DeGirolami UL.
"The central nervous system (In Robbins and Cotran Pathologic Basis of Disease)." Robbins and Cotran Pathologic Basis of Disease, 9th Edition, edited by Kumar V, Abbas AK, Aster JC, Philadelphia, Oxford: Elsevier, 2015, pp. 1251-1318.
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| Chen Z, Shin D, Chen S, Mikhail K, Hadass O, Tomlison BN, Korkin D, Shyu CR, Cui J, Anthony DC, Gu Z. "Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice." PLoS ONE, vol. 9, no. 3, 2014, pp. e92133. |
| Glinskii OV, Sud S, Mossine VV, Mawhinney TP, Anthony DC, Glinsky GV, Pienta KJ, Glinsky VV. "Inhibition of prostate cancer bone metastasis by synthetic TF antigen mimic/galectin-3 inhibitor lactulose-L-leucine." Neoplasia (New York, N.Y.), vol. 14, no. 1, 2012, pp. 65-73. |
| Li F, Glinskii OV, Zhou J, Wilson LS, Barnes S, Anthony DC, Glinsky VV. "Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brain." PLoS ONE, vol. 6, no. 7, 2011, pp. e21977. |
| Rath P, Miller DC, Litofsky NS, Anthony DC, Feng Q, Franklin C, Pei L, Free A, Liu J, Ren M, Kirk MD, Shi H. "Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma." Experimental and molecular pathology, vol. 90, no. 2, 2011, pp. 179-88. |
| Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Pienta KJ, Raz A, Glinsky VV. "Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia." Neoplasia (New York, N.Y.), vol. 9, no. 8, 2007, pp. 662-70. |
| Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. "Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers." International Journal of Oncology, vol. 30, no. 3, 2007, pp. 651-7. |
| Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB. "Proliferative potential of human astrocytes." Journal of Neuropathology and Experimental Neurology, vol. 64, no. 2, 2005, pp. 163-9. |
| Sudoh Y, Desai SP, Haderer AE, Sudoh S, Gerner P, Anthony DC, De Girolami U, Wang GK. "Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline." Regional anesthesia and pain medicine, vol. 29, no. 5, 2004, pp. 434-40. |
| Astrakas LG, Zurakowski D, Tzika AA, Zarifi MK, Anthony DC, De Girolami U, Tarbell NJ, Black PM. "Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors." Clin Cancer Res , vol. 10, no. 24, 2004, pp. 8220-8. |
| Robb RM, Anthony DC. "Congenital cystic eye: recurrence after initial surgical removal." Ophthalmic genetics, vol. 24, no. 2, 2003, pp. 117-23. |
| Kang PB, Lidov HG, David WS, Torres A, Anthony DC, Jones HR, Darras BT. "Diagnostic value of electromyography and muscle biopsy in arthrogryposis multiplex congenita." Annals of neurology, vol. 54, no. 6, 2003, pp. 790-5. |
| Tzika AA, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM. "Multiparametric MR assessment of pediatric brain tumors." Neuroradiology, vol. 45, no. 1, 2003, pp. 1-10. |
| Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. "Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy." Journal of Neurosurgery, vol. 96, no. 6, 2002, pp. 1023-31. |
| Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. "Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium." Journal of biomedical materials research, vol. 59, no. 3, 2002, pp. 450-9. |
| Gerner P, Mujtaba M, Khan M, Sudoh Y, Vlassakov K, Anthony DC, Wang GK. "N-phenylethyl amitriptyline in rat sciatic nerve blockade." Anesthesiology, vol. 96, no. 6, 2002, pp. 1435-42. |
| Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. "Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging." AJNR. American journal of neuroradiology, vol. 23, no. 2, 2002, pp. 322-33. |
| Feany MB, Anthony DC, Frosch MP, Zane W, De Girolami U. "August 2000: Two cases with necrosis and hemorrhage in the putamen and white matter." Brain pathology (Zurich, Switzerland), vol. 11, no. 1, 2001, pp. 121-2, 125. |
| Zarifi MK, Tzika AA, Astrakas LG, Poussaint TY, Anthony DC, Darras BT. "Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease." Journal of Child Neurology, vol. 16, no. 7, 2001, pp. 522-6. |
| Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM. "Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment." Neuroradiology, vol. 43, no. 2, 2001, pp. 169-77. |
| Bönnemann CG, Cox GF, Shapiro F, Wu JJ, Feener CA, Thompson TG, Anthony DC, Eyre DR, Darras BT, Kunkel LM. "A mutation in the alpha 3 chain of type IX collagen causes autosomal dominant multiple epiphyseal dysplasia with mild myopathy." Proceedings of the National Academy of Sciences, vol. 97, no. 3, 2000, pp. 1212-7. |
| Cheng LL, Anthony DC, Comite AR, Black PM, Tzika AA, Gonzalez RG. "Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy." Neuro-Oncology, vol. 2, no. 2, 2000, pp. 87-95. |
| Gerner P, Nakamura T, Quan CF, Anthony DC, Wang GK. "Spinal tonicaine: potency and differential blockade of sensory and motor functions." Anesthesiology, vol. 92, no. 5, 2000, pp. 1350-60. |
| Young Poussaint T, Yousuf N, Barnes PD, Anthony DC, Zurakowski D, Scott RM, Tarbell NJ. "Cervicomedullary astrocytomas of childhood: clinical and imaging follow-up." Pediatr Radiol, vol. 29, no. 9, 1999, pp. 662-8. |
| O'Tuama LA, Poussaint TY, Anthony DC, Treves ST. "Childhood brain tumor: neuroimaging correlated with disease outcome." Pediatric Neurology, vol. 19, no. 4, 1998, pp. 259-62. |
| Madsen JR, Vallat AV, Poussaint TY, Scott RM, De Girolami U, Anthony DC. "Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases." Pediatric neurosurgery, vol. 28, no. 5, 1998, pp. 261-6. |
| Swoboda KJ, Engle EC, Scheindlin B, Anthony DC, Jones HR. "Mutilating hand syndrome in an infant with familial carpal tunnel syndrome." Muscle & nerve, vol. 21, no. 1, 1998, pp. 104-11. |
| Feany MB, Anthony DC, Fletcher CD. "Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge." Histopathology, vol. 32, no. 5, 1998, pp. 405-10. |
| Komori T, Scheithauer BW, Anthony DC, Rosenblum MK, McLendon RE, Scott RM, Okazaki H, Kobayashi M. "Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm." The American Journal of Surgical Pathology, vol. 22, no. 10, 1998, pp. 1171-83. |
| Wang GK, Vladimirov M, Shi H, Mok WM, Thalhammer JG, Anthony DC. "Structure-activity relation of N-alkyl tetracaine derivatives as neurolytic agents for sciatic nerve lesions." Anesthesiology, vol. 88, no. 2, 1998, pp. 417-28. |
| Poussaint TY, Kowal JR, Barnes PD, Zurakowski D, Anthony DC, Goumnerova L, Tarbell NJ. "Tectal tumors of childhood: clinical and imaging follow-up." AJNR. American journal of neuroradiology, vol. 19, no. 5, 1998, pp. 977-83. |
| Le S, Zhu JJ, Anthony DC, Greider CW, Black PM. "Telomerase activity in human gliomas." Neurosurgery, vol. 42, no. 5, 1998, pp. 1120-4; discussion 1124-5. |
| Poussaint TY, Barnes PD, Nichols K, Anthony DC, Cohen L, Tarbell NJ, Goumnerova L. "Diencephalic syndrome: clinical features and imaging findings." AJNR. American journal of neuroradiology, vol. 18, no. 8, 1997, pp. 1499-505. |
| Hakim R, Loeffler JS, Anthony DC, Black PM. "Gangliogliomas in adults." Cancer, vol. 79, no. 1, 1997, pp. 127-31. |
| Young TL, Anthony DC, Pierce E, Foley E, Smith LE. "Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity." Journal of American Association for Pediatric Ophthalmology and Strabismus, vol. 1, no. 2, 1997, pp. 105-10. |
| Anthony DC. "Specificity of neurofilament swellings and axonal atrophy: commentary on forum position paper." Neurotoxicology, vol. 18, no. 1, 1997, pp. 23-4; discussion 37-40. |
| Zec N, De Girolami U, Schofield DE, Scott RM, Anthony DC. "Giant cell ependymoma of the filum terminale. A report of two cases." The American Journal of Surgical Pathology, vol. 20, no. 9, 1996, pp. 1091-101. |
| Poussaint TY, Barnes PD, Anthony DC, Spack N, Scott RM, Tarbell NJ. "Hemorrhagic pituitary adenomas of adolescence." AJNR. American journal of neuroradiology, vol. 17, no. 10, 1996, pp. 1907-12. |
| Wang GK, Vladimirov M, Quan C, Mok WM, Thalhammer JG, Anthony DC. "N-butyl tetracaine as a neurolytic agent for ultralong sciatic nerve block." Anesthesiology, vol. 85, no. 6, 1996, pp. 1386-94. |
| Anthony DC, Crain BJ. "Peripheral nerve biopsies." Archives of Pathology & Laboratory Medicine, vol. 120, no. 1, 1996, pp. 26-34. |
| Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC. "The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology." Nature Medicine, vol. 2, no. 10, 1996, pp. 1146-50. |
| Crofton KM, Padilla S, Tilson HA, Anthony DC, Raymer JH, MacPhail RC. "The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects." Toxicology and Applied Pharmacology, vol. 139, no. 1, 1996, pp. 163-76. |
| Laws ER Jr, Stieg PE, Goumnerova L, Schwartz RB, Anthony DC. "Acute presentation of an intracranial mass." Neurosurgery, vol. 37, no. 1, 1995, pp. 109-13. |
| Schofield D, West DC, Anthony DC, Marshal R, Sklar J. "Correlation of loss of heterozygosity at chromosome 9q with histological subtype in medulloblastomas." The American Journal of Pathology, vol. 146, no. 2, 1995, pp. 472-80. |
| Poussaint TY, Siffert J, Barnes PD, Pomeroy SL, Goumnerova LC, Anthony DC, Sallan SE, Tarbell NJ. "Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up." AJNR. American journal of neuroradiology, vol. 16, no. 4, 1995, pp. 693-9. |
| White FV, Anthony DC, Yunis EJ, Tarbell NJ, Scott RM, Schofield DE. "Nonrandom chromosomal gains in pilocytic astrocytomas of childhood." Human Pathology, vol. 26, no. 9, 1995, pp. 979-86. |
| Graham DG, Amarnath V, Valentine WM, Pyle SJ, Anthony DC. "Pathogenetic studies of hexane and carbon disulfide neurotoxicity." Critical reviews in toxicology, vol. 25, no. 2, 1995, pp. 91-112. |
| Pyle SJ, Graham DG, Anthony DC. "Dimethylhexanedione impairs the movement of neurofilament protein subunits, NFM and NFL, in the optic system." Neurotoxicology, vol. 15, no. 2, 1994, pp. 279-86. |
| Rao VV, Anthony DC, Piwnica-Worms D. "MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase." Cancer Research, vol. 54, no. 6, 1994, pp. 1536-41. |
| Denlinger RH, Anthony DC, Amarnath K, Amarnath V, Graham DG. "Metabolism of 3,3'-iminodipropionitrile and deuterium-substituted analogs: potential mechanisms of detoxification and activation." Toxicology and Applied Pharmacology, vol. 124, no. 1, 1994, pp. 59-66. |
| Valentine WM, Graham DG, Anthony DC. "Covalent cross-linking of erythrocyte spectrin by carbon disulfide in vivo." Toxicology and Applied Pharmacology, vol. 121, no. 1, 1993, pp. 71-7. |
| Pyle SJ, Amarnath V, Graham DG, Anthony DC. "Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione exposure." Cell motility and the cytoskeleton, vol. 26, no. 2, 1993, pp. 133-43. |
| Thomas LO, Boyko OB, Anthony DC, Burger PC. "MR detection of brain iron." AJNR. American journal of neuroradiology, vol. 14, no. 5, 1993, pp. 1043-8. |
| Hulette CM, Earl NL, Anthony DC, Crain BJ. "Adult onset Niemann-Pick disease type C presenting with dementia and absent organomegaly." Clinical neuropathology, vol. 11, no. 6, 1992, pp. 293-7. |
| Denlinger RH, Anthony DC, Amarnath V, Graham DG. "Comparison of location, severity, and dose response of proximal axonal lesions induced by 3,3'-iminodipropionitrile and deuterium substituted analogs." Journal of Neuropathology and Experimental Neurology, vol. 51, no. 6, 1992, pp. 569-76. |
| Valentine WM, Amarnath V, Graham DG, Anthony DC. "Covalent cross-linking of proteins by carbon disulfide." Chemical Research in Toxicology, vol. 5, no. 2, 1992, pp. 254-62. |
| Vandersteenhoven JJ, Dbaibo G, Boyko OB, Hulette CM, Anthony DC, Kenny JF, Wilfert CM. "Progressive multifocal leukoencephalopathy in pediatric acquired immunodeficiency syndrome." The Pediatric Infectious Disease Journal, vol. 11, no. 3, 1992, pp. 232-7. |
| Cucchiaro G, Branum GD, Farouk M, Mansour G, Kuhn CM, Anthony DC, Meyers WC. "The effects of liver denervation on the regulation of hepatic biliary secretion." Transplantation, vol. 54, no. 1, 1992, pp. 129-36. |
| Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GA, Anthony DC, Urbaniak JR. "The functional recovery of peripheral nerves following defined acute crush injuries." Journal of Orthopaedic Research, vol. 10, no. 5, 1992, pp. 657-64. |
| Pyle SJ, Amarnath V, Graham DG, Anthony DC. "The role of pyrrole formation in the alteration of neurofilament transport induced during exposure to 2,5-hexanedione." Journal of Neuropathology and Experimental Neurology, vol. 51, no. 4, 1992, pp. 451-8. |
| Dresser LP, Tourian AY, Anthony DC. "A case of myelinoclastic diffuse sclerosis in an adult." Neurology, vol. 41, no. 2 ( Pt 1), 1991, pp. 316-8. |
| Graham DG, St Clair MB, Amarnath V, Anthony DC. "Molecular mechanisms of gamma-diketone neuropathy." Systems Biology of RNA Binding Proteins, vol. 283, 1991, pp. 427-31. |
| Amarnath V, Anthony DC, Valentine WM, Graham DG. "The molecular mechanism of the carbon disulfide mediated cross-linking of proteins." Chemical Research in Toxicology, vol. 4, no. 2, 1991, pp. 148-50. |
| Wolf HK, Anthony DC, Fuller GN. "Arterial border zone necrosis of the spinal cord." Clinical neuropathology, vol. 9, no. 2, 1990, pp. 60-5. |
| Cucchiaro G, Yamaguchi Y, Mills E, Kuhn CM, Anthony DC, Branum GD, Epstein R, Meyers WC. "Evaluation of selective liver denervation methods." The American journal of physiology, vol. 259, no. 5 Pt 1, 1990, pp. G781-5. |
| St Clair MB, Anthony DC, Wikstrand CJ, Graham DG. "Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum." Neurotoxicology, vol. 10, no. 4, 1989, pp. 743-56. |
| Krendel DA, Parks HP, Anthony DC, St Clair MB, Graham DG. "Sural nerve biopsy in chronic inflammatory demyelinating polyradiculoneuropathy." Muscle & nerve, vol. 12, no. 4, 1989, pp. 257-64. |
| Boekelheide K, Anthony DC, Giangaspero F, Gottfried MR, Graham DG. "Aliphatic diketones: influence of dicarbonyl spacing on amine reactivity and toxicity." Chemical Research in Toxicology, vol. 1, no. 4, 1988, pp. 200-3. |
| Warren LP Jr, Djang WT, Moon RE, Camporesi EM, Sallee DS, Anthony DC, Massey EW, Burger PC, Heinz ER. "Neuroimaging of scuba diving injuries to the CNS." American Journal of Roentgenology, vol. 151, no. 5, 1988, pp. 1003-8. |
| Genter St Clair MB, Amarnath V, Moody MA, Anthony DC, Anderson CW, Graham DG. "Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy." Chemical Research in Toxicology, vol. 1, no. 3, 1988, pp. 179-85. |
| Rosenberg CK, Genter MB, Szakál-Quin G, Anthony DC, Graham DG. "dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat." Toxicology and Applied Pharmacology, vol. 87, no. 2, 1987, pp. 363-73. |
| Genter MB, Szakál-Quin G, Anderson CW, Anthony DC, Graham DG. "Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy." Toxicology and Applied Pharmacology, vol. 87, no. 2, 1987, pp. 351-62. |
| Rosenberg CK, Anthony DC, Szakál-Quin G, Genter MB, Graham DG. "Hyperbaric oxygen accelerates the neurotoxicity of 2,5-hexanedione." Toxicology and Applied Pharmacology, vol. 87, no. 2, 1987, pp. 374-9. |
| Anthony DC, Atwater SK, Rozear MP, Burger PC. "Occlusion of the basilar artery within a fracture of the clivus. Case report." Journal of Neurosurgery, vol. 66, no. 6, 1987, pp. 929-31. |
| Graham DG, Anthony DC, Szakál-Quin G, Gottfried MR, Boekelheide K. "Covalent crosslinking of neurofilaments in the pathogenesis of n-hexane neuropathy." Neurotoxicology, vol. 6, no. 4, 1985, pp. 55-63. |
| Griffin JW, Anthony DC, Fahnestock KE, Hoffman PN, Graham DG. "3,4-Dimethyl-2,5-hexanedione impairs the axonal transport of neurofilament proteins." Journal of Neuroscience, vol. 4, no. 6, 1984, pp. 1516-26. |
| Graham DG, Szakál-Quin G, Priest JW, Anthony DC. "In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy." Proceedings of the National Academy of Sciences, vol. 81, no. 15, 1984, pp. 4979-82. |
| Anthony DC, Boekelheide K, Graham DG. "The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings." Toxicology and Applied Pharmacology, vol. 71, no. 3, 1983, pp. 362-71. |
| Anthony DC, Boekelheide K, Anderson CW, Graham DG. "The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking." Toxicology and Applied Pharmacology, vol. 71, no. 3, 1983, pp. 372-82. |
| Anthony DC, Giangaspero F, Graham DG. "The spatio-temporal pattern of the axonopathy associated with the neurotoxicity of 3,4-dimethyl-2,5-hexanedione in the rat." Journal of Neuropathology and Experimental Neurology, vol. 42, no. 5, 1983, pp. 548-60. |
| Graham DG, Anthony DC, Boekelheide K. "In vitro and in vivo studies of the molecular pathogenesis of n-Hexane neuropathy." Neurobehavioral toxicology and teratology, vol. 4, no. 6, 1982, pp. 629-34. |
| Graham DG, Anthony DC, Boekelheide K, Maschmann NA, Richards RG, Wolfram JW, Shaw BR. "Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking." Toxicology and Applied Pharmacology, vol. 64, no. 3, 1982, pp. 415-22. |
Research in our laboratory examines several areas in the cellular and molecular neurosciences and cancer with a focus in translational biology and neuropathology. Current projects include the pathobiology of primary brain tumors (those that originate in the brain) and metastatic brain tumors (those that originate elsewhere but travel to the brain). The laboratory also has long-standing interests in neuromuscular pathobiology and the pathobiology of intermediate filaments.
Dr. Anthony's laboratory is conducting research in cellular neurosciences - the study of the brain at a cellular and molecular level. A major focus of the laboratory is the study of cancer involving the brain, both tumors that originate in the brain and those that metastasize to the brain. Dr. Anthony's lab was involved in defining the relationship between the desmoplastic/nodular variant of medulloblastoma and the PTCH gene, located on 9q22.3 by recognizing that patients with Gorlin's syndrome (basal cell nevus syndrome) develop this specific variant of medulloblastoma (desmoplastic variant), later recognized as the sonic hedgehog altered medulloblastoma.
Current studies are exploring how the cells of brain tumors propagate and spread. By isolating the progenitor cells of tumors, we have been exploring the biologic behavior of cancer cells and how those behaviors are regulated.
Stem cells in primary brain tumors
Gliomas are a common type of brain tumor, and because the cells of the glioma migrate through the brain, these tumors are difficult to remove surgically. In order to achieve better outcomes in patients with malignant gliomas, a better understanding of the biologic behavior of brain tumors is needed. We are studying the molecular phenotype of malignant glioma cells, with a particular focus on the population of cells within the tumors that are responsible for the growth and aggressive clinical behavior. These tumorigenic cells, sometimes called "tumor stem cells", share some characteristics of neural stem cells of the brain in their ability to grow as neurospheres and in their expression of broad phenotypic markers, including neuronal and glial proteins. We have identified these types of tumor-initiating cells from gliomas, and have been able to isolate them. The proteome and transcriptome of tumor stem cells are similar in many ways to neural stem cells, but also have distinct biomarkers and metabolic pathways. The isolation and identification of thes "stem cell" populations creates a powerful model for understanding the development of brain tumors, and their resistance to therapy. By studying these cells from glioblastomas, we hope to provide increased understanding of the progression of malignancy, resistance to therapy, and late recurrences. (Additional reading: Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma. Exp Molec Pathol 2011; 90:179-88; FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging and Cancer, 2021; DOI: 10.1002/aac2.12043. Acta Neuropathol Commun 2022, Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation. Online@ https://rdcu.be/cY0e3)
Grants since 2005:
3D Capture Technology for Isolation and Analysis of Live Circulating Tumor Cells
SBIR - US Small Business Administration, 2019-2022
Site Principal Investigator (H.T. Kao, Overall PI)
Goal: To develop and validate the use of specific cell-signaling pathways to characterize cancer cells and isolate cancer cells from complex mixtures.
Allele – Enabling Cutting-Edge Genomic Analysis to Guide Patient Care
Accelerating Brain Cancer Cure (ABC2), 2019-2023
Site Principal Investigator (Keith Ligon, Overall PI)
Goal: To bring robust genomic profiling to brain cancer patients and accelerate the discovery of genomic markers that predict positive outcomes in individually-targeted therapies.
Role of Epigenetic Regulation in Human Glioma: Non-coding RNA and RNA Methylation
Warren Alpert Foundation Research Grant, 2019-2023
PI for Biorepository Core (Steven Toms, Overall PI)
Goal – To identify how epigenetic modification of messenger RNA and non-coding RNA occurs in malignant gliomas, and the impact of these epigenetic pathways on the biologic behavior of malignant glioma cells.
Trans-nasal Delivery of Chemotherapy to Glioblastoma using Magnetic Nanoparticles and Magnetic Focusing.
STTR R41 CA213540, 2017-2019
Co-Investigator (Irving Weinberg, PI)
Goal: To use magnetic nanoparticles to focus drug delivery directly to glioblastoma tumor beds at higher therapeutic levels than could otherwise be achieved using systemic delivery.
CTSA Planning Grant: MU Institute for Clinical & Translational Sciences (ICTS)
National Institutes of Health/CTSA, 1P20-RR023527-01
Director of Translational Educational Programs ICTS, and Co-Investigator
Goal: To create a transdisciplinary institute at the University of Missouri that supports the rapid translation of basic research findings to clinical utility.
Building Networks for the Center for Translational Neuroscience
Missouri Advantage Innovation Program Grant
Principal Investigator
Goal: To develop and integrate comprehensive neurosciences across a university setting.
Profiling heterogeneous invasion and resistance using 3D tumor organoids
P30GM 110759-01, COBRE Project (NIGMS), 2015 – 2018
Co-Investigator
Goal: To measure the epithelial-mesenchymal transitions in 2D and 3D cultures after stimulation of specific pathways, and determine how the transition is affected by specific therapeutic regimens.
Targeting tumor invasion and drug resistance using 3D human organoids
Dean’s Award, Brown University, 2015-2017
Co-Investigator
Goal: To measure the emergence of drug resistance and invasiveness in biomimetic 3D organoids of breast cancer and glioblastoma.
Medley Genomics Feasibility of Cell Lineage Determination in Human Cancer
Rhode Island Innovation Voucher, 2017 – 2019
Co-Investigator
Goal - To compare molecular signatures in primary tumors and metastases using Genomic HeterogeneityTM Software to identify and characterize tumor cell subpopulations.
Continuum of Guidance With a Network of Mentors
NSF Presidential Recognition Award/ HRD-0328407
Principal Investigator
Goal: To establish a network of mentoring for underrepresented groups and facilitate their inclusion in scientific and medical professions.
Ovarian Cancer Cell Invasion and Metastasis
National Institutes of Health, NCI 3R01-CA086984-12S, Subcontract
Principal Investigator
Goal: To support a collaborative program to identify the mechanisms involved in ovarian cancer invasion and metastasis.
Application of 454 Sequencing to Cancer Epigenetics
National Institutes of Health/1R33-CA134304-01A1
Co-investigator
Goal: To develop a sequencing-based approach to provide efficient methods for deeply exploring the cancer epigenome in brain tumors.
Beta-galectin mediated pathways as therapeutic targets in prostate cancer
VA Merit Award
Co-investigator
Goal: To define the mechanisms of galectin-3 mediated prostate cancer homing to the microvasculature of distant organs and its role in site-specific metastasis.
Therapeutic Na+ Channel Blockers: Receptor and Drug Design
National Institutes of Health/2RO1- GM48090
Co-investigator
Goal: To gain a better understanding of the mechanism of action of long-acting pain blockers and their potential toxicity.
Lakis NS, Brodsky AS, Karashchuk G, Audesse A, Yang D, Sturtevant A, Lombardo K, Wong IY, Webb A, Anthony DC. Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation. 2022, Acta Neuropathol Commun. (Online@ https://rdcu.be/cY0e3)
Audasse A, Karashchuk G, Gardell Z, Lakis N, Maybury-Lewis S, Brown A, Leeman D, Teo YV, Neretti N, Anthony DC, Brodsky A, Webb A. FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging and Cancer, 2021; DOI: 10.1002/aac2.12043.
Lee EJ, Rath P, Liu J, Ryu D, Free A, Pei L, Feng Q, Litofsky NS, Miller DC, Anthony DC, Kirk MD, Laterra JJ, Ryu D, Choi JH, Shi H. Identification of global DNA methylation signatures in glioblastoma-derived cancer stem cells. J Genetics Genomics 2015;42:355-71. PMID 26233891, PMCID: PMC 4648292
Pytel P, Anthony DC. Peripheral nerve and skeletal muscle. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 9th Edition. Philadelphia: Elsevier Saunders, 2020; 1217-1240.
Stonebridge R, Taliano R, Velilla T, Anthony DC. Hypertrophy of the anterior external arcuate fasciculus: a rare variant with implications for the development of the arcuate nucleus. Front Neuroanat 14:595500 (doi:10.3389/fnana.2020.595500); PMID: 33328906; PMCID: PMC7729007
Anthony DC, DeGirolami U, Vallat JM. Peripheral nerve. In Gray F, De Girolami U, Duyckaerts C, eds. Escourolle and Poirier Manual of Basic Neuropathology, 6th Edition. Oxford, UK: Oxford University Press, 2019;341-372.
Cai C, Anthony DC, Pytel P. A pattern-based approach to the interpretation of skeletal muscle biopsies. Mod Pathol 2018; doi.org/10.1038/s41379-018-0164-x, [Epub ahead of print], PMID: 30401945.
Nix JS, Gardner JM, Costa F, Soares AL, Rodriguez FJ, Moore B, Martinez-Lage M, Ahlawat S, Gokden M, Anthony DC. Neuropathology education using social media. J Neuropathol Exp Neurol 2018;77:454-60. PMID 29788115.
Chambers K, Anthony DC, Randolph G, Hartnick C, Stopa E, Song P. Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model. Laryngoscope 2016; doi: 10.1002/lary.26065. [Epub ahead of print] PubMed PMID: 27271961.
Chen A, Shin D, Chen S, Mikhail K, Hadass O, Tomlison BN, Korkin DN, Shyu CR, Cui J, Anthony DC, Gu Z. Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice. Plos ONE 2014;9(3):e92133. doi:10.1371/journal.pone.0092133
Frosch MP, Anthony DC, DeGirolami UL. The central nervous system. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease, 9th Edition. Philadelphia: Elsevier Saunders, 2015; 1251-1318.
Glinskii OV, Sud S, Mossine VV, Mawhinney TP, Anthony DC, Glinsky GV, Pienta KJ, Glinsky VV. Inhibition of prostate cancer bone metastasis by synthetic TF-antigen mimic/galectin-3 inhibitor lactulose-L-leucine. Neoplasia 2012;14:65-73.
Li F, Glinskii OV, Zhou J, Wilson LS, Barnes S, Anthony DC, Glinsky VV. Identification and analysis of signaling networks potentially involved in breast cancer metastasis to the brain. Plos One 2011; 6:e21977(1-14) doi:10.1371.
Rath P, Miller DC, Litofsky NS, Anthony DC, Feng Q, Franklin C, Pei L, Free A, Liu J, Ren M, Kirk MD, Shi H. Isolation and characterization of a population of stem-like progenitor cells from an atypical meningioma. Exp Molec Pathol 2011; 90:179-88.
Johnson KD, Glinskii OV, Mossine VV, Turk JR, Mawhinney TP, Anthony DC, Henry CJ, Huxley VH, Glinsky GV, Peinta KJ, Raz A, Glinskii VV. Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelium. Neoplasia 2007;9:662-70.
Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, DeGirolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Internat J Oncol 2007;30:651-7.
Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB. Proliferative potential of human astrocytes. J Neuropathol Exp Neurol 2005;64:163-9.
Astrakas LG, Zurakowski D, Tzika AA, Zarifi MK, Anthony DC, DeGirolami U, Tarbell NJ, Black PM. Non-invasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. Clin Cancer Res 2004;10:8220-8.
Tzika AA, D, Astrakas LG, Zarifi MK, Petridou N, Young-Poussaint T, Goumnerova L, Zurakowski D, Anthony DC, Black PM. Multiparametric MR assessment of pediatric brain tumors. Neuroradiol 2003;45:1-10.
Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg 2002;96:1023-31.
Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. Am J Neuroradiol (AJNR) 2002;23:322-33.
Zarifi MK, Tzika AA, Astrakas LG, Poussaint TY, Anthony DC, Darras BT. Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease. J Child Neurol 2001;16:522-6.
Tzika AA, Zurakowski D, Poussaint TY, Goumnerova L, Astrakas LG, Barnes PD, Anthony DC, Billett AL, Tarbell NJ, Scott RM, Black PM. Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment. Neuroradiol 2001;43:169-77.
| Year | Degree | Institution |
|---|---|---|
| 1984 | MD | Duke University |
| 1984 | PhD | Duke University |
| 1978 | BSc | Washington University in St. Louis |
| Fellow | Duke University Medical Center, neuropathology | 1985-1986 | Durham, NC |
| Resident | Duke University Medical Center, anatomic pathology | 1984-1987 | Durham, NC |
Tau Beta Pi
Omicron Delta Kappa
Phi Beta Kappa
Sigma Xi
Honorable Mention for Weil Award in Experimental Neuropathology
Clinical Investigator Development Award, NINDS
International Society of Toxicology, Neurotoxicology Subsection Award
Society of Toxicology, Mechanism Subsection Award
Feodor Lynen Research Award, Alexander von Humboldt Foundation
Miyawaki Neuroscience Teaching Award, Harvard Medical School
Recognition Award for Faculty, US and Canadian Academy of Pathology
Excellence in Teaching Award, University of Missouri
Excellence in Education Award, MSAC, University of Missouri
Order of Socrates, University of Missouri
Dean's Award for Teaching, Brown University
| Name | Title |
|---|---|
| Brodsky, Alexander | Associate Professor of Pathology and Laboratory Medicine (Research) |
| Elco, Christopher | Assistant Professor of Dermatology, Assistant Professor of Pathology and Laboratory Medicine |
American Association of Neuropathologists (President; Executive Council)
International Society of Neuropathologists (past Vice President)
New England Socieity of Pathologists (Past President)
College of American Pathologists, CAP (Fellow)
United States and Canadian Academy of Pathology (USCAP)
Rhode Island Medical Society (Council Member)
Association of Pathology Chairpersons (APC)
Rhode Island Society of Pathology
Society for Neuroscience (SfN)
Society of Toxicology (SOT)
American Society for Neurochemistry (ASN)
American Society for Investigative Pathology (ASIP)
Society for Pediatric Pathology (SPP)
American Medical Association (AMA)
| Certificate of Recognition in Laboratory Leadership | CAP | 2014-Present | |
| Medical License | Rhode Island | 2011-Present | |
| Medical License | Missouri | 2001-Present | |
| Certification | American Board of Pathology, Anatomic pathology | 1987-Present | |
| Certification | American Board of Pathology, Neuropathology | 1987-Present |
| Medical Director. Rhode Island Hospital, 2012-2022 |
| Medical Director. The Miriam Hospital, 2012-2022 |
| Pathologist-in-Chief. Lifespan, 2012-Present |
| Director of Neuropathology. Boston Children's Hospital, 1992-2001 |
