My research area aims to decipher the descending motor neural circuit in neurodegenerative diseases utilising electrophysiology, optogenetics, neurocomputation, AI and machine learning.
In my recent research, i discovered real-time field-programmable gate array-based closed-loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia (CNS Neuroscience & Therapeutics 2024), developed artificial intelligence-assisted graphical user interface for early detection of depression using EEG and facial expression recognition (Neural Computing Applications 2024), computation model of Cerebellar ataxia (Neural Networks 2023), artificial intelligence and machine learning model to predict the finger kinematics (Neurocomputing, 2023), deep brain stimulation to ameliorate the ataxia (Molecular Neurobiology, 2022), elucidate the target-specific neural activity and visual function recovery after optic nerve injury (npj Regenerative Medicine, 2022; PNAS, 2022), dissect the mechanism of glutamatergic system impacts on spontaneous motor recovery (npj Regenerative Medicine, 2022).
Kaur, Amandeep, Kahlon, Karanjeet Singh, Gajendra, Kumar, Singh, Kuldeep. "A Fuzzy Logic Based Novel Tool to Assess the Impact of Online Learning on Mental Health of Students During Covid-19 Pandemic." Wireless Personal Communications, vol. 139, no. 2, 2024, pp. 1119-1147. |
Gajendra Kumar, Tanaya Das, Kuldeep Singh. "Early detection of depression through facial expression recognition and electroencephalogram-based artificial intelligence-assisted graphical user interface." Neural Computing and Applications, 2024, pp. 1-18. |
Yan Y, Gao Y, Kumar G, Fang Q, Yan H, Zhang N, Zhang Y, Song L, Li J, Zheng Y, Zhang N, Zhang P, Ma C. "Exosomal MicroRNAs modulate the cognitive function in fasudil treated APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease." Metabolic brain disease, 2024. |
Choudhury, Hirakjyoti, Goswami, Rupam, Kumar, Gajendra, Kakoty, Nayan M. "Memristors as Prospective Devices for Silicon and Post-Silicon Eras: Theory, Applications and Perspectives." Nanoelectronic Devices and Applications, 2024, pp. 297-334. |
Kumar G, Zhou Z, Wang Z, Kwan KM, Tin C, Ma CHE. "Real-time field-programmable gate array-based closed-loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia." CNS Neuroscience & Therapeutics, vol. 30, no. 3, 2024, pp. e14638. |
Kaur, Amandeep, Singh, Kuldeep, Kaur, Prabhpreet, Priya, Bhanu, Kumar, Gajendra, Sharma, Abhishek. "Smart Health Monitoring Approach to Diagnose Attention-Deficit Hyperactivity Disorderbased on Real-Time Activity and Heart Rate Variability using Boosting Models." Recent Advances in Computer Science and Communications, vol. 18, 2024. |
Das, Tanaya, Gohain, Lakhyajit, Kakoty, Nayan M, Malarvili, MB, Widiyanti, Prihartini, Kumar, Gajendra. "Hierarchical approach for fusion of electroencephalography and electromyography for predicting finger movements and kinematics using deep learning." Neurocomputing, vol. 527, 2023, pp. 184-195. |
Au, Ngan Pan Bennett, Wu, Tan, Kumar, Gajendra, Jin, Yuting, Li, Yolanda Yuen Tung, Chan, Shun Lam, Lai, Joseph Ho Chi, Chan, Kannie Wai Yan, Yu, Kwan Ngok, Wang, Xin, Ma, Chi Him Eddie. "Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke." Brain, Behavior, and Immunity, vol. 115, 2023, pp. 43-63. |
Kumar, Gajendra, Ma, Chi Him Eddie. "Toward a cerebello-thalamo-cortical computational model of spinocerebellar ataxia." Neural Networks, 2023. |
Au NPB, Chand R, Kumar G, Asthana P, Tam WY, Tang KM, Ko CC, Ma CHE. "A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function." Proceedings of the National Academy of Sciences, vol. 119, no. 44, 2022, pp. e2121273119. |
Asthana P, Kumar G, Milanowski LM, Au NPB, Chan SC, Huang J, Feng H, Kwan KM, He J, Chan KWY, Wszolek ZK, Ma CHE. "Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression." NPJ Regenerative medicine, vol. 7, no. 1, 2022, pp. 45. |
Au NPB, Kumar G, Asthana P, Gao F, Kawaguchi R, Chang RCC, So KF, Hu Y, Geschwind DH, Coppola G, Ma CHE. "Clinically relevant small-molecule promotes nerve repair and visual function recovery." NPJ Regenerative medicine, vol. 7, no. 1, 2022, pp. 50. |
Kumar G, Asthana P, Yung WH, Kwan KM, Tin C, Ma CHE. "Deep Brain Stimulation of the Interposed Nucleus Reverses Motor Deficits and Stimulates Production of Anti-inflammatory Cytokines in Ataxia Mice." Molecular neurobiology, vol. 59, no. 7, 2022, pp. 4578-4592. |
Yan H, Yan Y, Gao Y, Zhang N, Kumar G, Fang Q, Li Z, Li J, Zhang Y, Song L, Wang J, Sun J, Zhang HT, Ma CG. "Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease." Scientific reports, vol. 12, no. 1, 2022, pp. 6625. |
Chine VB, Au NPB, Kumar G, Ma CHE. "Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy." Molecular neurobiology, vol. 56, no. 5, 2019, pp. 3244-3259. |
Yan Y, Yu J, Gao Y, Kumar G, Guo M, Zhao Y, Fang Q, Zhang H, Yu J, Jiang Y, Zhang HT, Ma CG. "Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms." Metabolic brain disease, vol. 34, no. 2, 2019, pp. 377-384. |
Asthana P, Zhang N, Kumar G, Chine VB, Singh KK, Mak YL, Chan LL, Lam PKS, Ma CHE. "Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit." Molecular neurobiology, vol. 55, no. 8, 2018, pp. 6769-6787. |
Kumar G, Au NPB, Lei ENY, Mak YL, Chan LLH, Lam MHW, Chan LL, Lam PKS, Ma CHE. "Acute Exposure to Pacific Ciguatoxin Reduces Electroencephalogram Activity and Disrupts Neurotransmitter Metabolic Pathways in Motor Cortex." Molecular neurobiology, vol. 54, no. 7, 2017, pp. 5590-5603. |
Au NP, Kumar G, Asthana P, Tin C, Mak YL, Chan LL, Lam PK, Ma CH. "Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury." Scientific reports, vol. 6, 2016, pp. 26809. |
Asthana P, Vong JS, Kumar G, Chang RC, Zhang G, Sheikh KA, Ma CH. "Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach." Molecular neurobiology, vol. 53, no. 7, 2016, pp. 4981-91. |
Year | Degree | Institution |
---|---|---|
2013 | PhD | All India Institute of Medical Sciences |
2007 | MSc | All India Institute of Medical Sciences |
2005 | BSc | All India Institute of Medical Sciences |
“Gold Medal” Invention Geneva Evaluation Days (IGED 2022). AI-based Pharmaco- electroencephalography (EEG) Platform for Drug Screening (Dr Gajendra KUMAR & Dr MA Chi-Him Eddie).
Hong Kong SciTech Pioneers Award, AniTech Limited, 2022 (Gajendra KUMAR & Dr MA Chi-Him Eddie).
IPHatch Hong Kong 2022, IP portfolio Sapphire; Neural Network Circuit, Panasonic (Gajendra KUMAR & Dr MA Chi-Him Eddie).
“Silver Medal” Invention Geneva Evaluation Days (IGED 2021). Neural Motor prosthesis Prototype for the Restoration of Motor Function in Spinocerebellar Ataxia (Dr MA Chi-Him Eddie, Dr Gajendra KUMAR, Dr. TIN Chung).
Seed fund for strat-up (2021), HK Tech 300, City University of Hong Kong, “AniTech Limited” as pre-clinical CRO for “Artificial intelligence-based EEG platform for drug screening.
Postdoc top-up funding award (2014): Education Development and Gateway Education (EDGE), City University of Hong Kong, Hong Kong.
Graduate Teaching Assistant (GTA) fellowship (2013): City University of Hong Kong, Hong Kong.
Name | Title |
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Liu, Judy | Sidney A. Fox and Dorothea Doctors Fox Professor of Ophthalmology and Visual Science, Associate Professor of Neurology |
Morrow, Eric | Mencoff Family Professor of Biology, Professor of Brain Science, Professor of Neuroscience, Professor of Psychiatry and Human Behavior |