|Palomaki, Glenn E., Eklund, Elizabeth E., Neveux, Louis M., Lambert Messerlian, Geralyn M. Evaluating first trimester maternal serum screening combinations for Down syndrome suitable for use with reflexive secondary screening via sequencing of cell free DNA: high detection with low rates of invasive procedures.. Prenat Diagn. 2015; 35 (8) : 789-796.|
|Scherzer, Rebecca, Bacchetti, Peter, Messerlian, Geralyn, Goderre, Johanna, Maki, Pauline M., Seifer, David B., Anastos, Kathryn, Karim, Roksana, Greenblatt, Ruth M. Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women. American Journal of Reproductive Immunology. 2014; 73 (3) : 273-284.|
Inhibin was a reproductive hormone about which very little was known in 1990. I was involved in the development of the first specific immunoassays for inhibin and performed studies that helped to define its normal physiology in men and women. This work subsequently led to the study inhibin and related proteins, such as activin, in infertility, cancer and pregnancy. In that regard, I had an instrumental role in the development of two clinical applications of the inhibin immunoassay; prenatal screening for Down syndrome and assessment of ovarian reserve. These tests are now widely used throughout the world.
I have ongoing research projects on serum markers in the areas of preeclampsia, ovarian cancer, prenatal screening and other aspects of women's health, in collaboration with investigators in the Departments of Obstetrics and Gynecology and Pathology at Women & Infants Hospital and elsewhere.
In addition to my basic research interests, I have served as the manager for the laboratory portion of largest multicenter NIH obstetrical grant. The objective of the FASTER trial was to compare first and second trimester prenatal screening in 38,000 women across the country with all serum measurements performed in our laboratory. We extended this work to find normative data for thyroid hormones in pregnancy. Most recently our group has conducted funded research to implement cell free DNA in maternal plasma as a marker for fetal aneuploidy during pregnancy.
Please see CV for publications list
|Bourjeily, Ghada||Associate Professor of Medicine|
|Haddow, James||Professor Emeritus of Pathology and Laboratory Medicine|
|Lechner, Beatrice||Associate Professor of Pediatrics|
|McGarvey, Stephen||Professor of Epidemiology, Director of International Health Institute|
|Palomaki, Glenn||Professor of Pathology and Laboratory Medicine (Research)|
|Sung, Vivian||Professor of Obstetrics and Gynecology|
|Director. Women and Infants Hospital of Rhode Island, 1995-Present|
|BIOL 0300 - Endocrinology|