| Hernandez AM, Mossman JA, Toapanta FR, Previte DM, Ross TM, Nau GJ. "Altered transcriptional responses in the lungs of aged mice after influenza infection." Immunity & ageing : I & A, vol. 19, no. 1, 2022, pp. 27. |
| Fredericks AM, Jentzsch MS, Cioffi WG, Cohen M, Fairbrother WG, Gandhi SJ, Harrington EO, Nau GJ, Reichner JS, Ventetuolo CE, Levy MM, Ayala A, Monaghan SF. "Deep RNA sequencing of intensive care unit patients with COVID-19." Scientific reports, vol. 12, no. 1, 2022, pp. 15755. |
| Fredericks AM, East KW, Shi Y, Liu J, Maschietto F, Ayala A, Cioffi WG, Cohen M, Fairbrother WG, Lefort CT, Nau GJ, Levy MM, Wang J, Batista VS, Lisi GP, Monaghan SF. "Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations." Frontiers in molecular biosciences, vol. 9, 2022, pp. 1080964. |
| Wambier CG, Nau GJ. "Re: Karin Welén, Ebba Rosendal, Magnus Gisslén, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. 2022;81:285-93: Positive Effects of Enzalutamide for Hospitalized COVID-19 Patients." European Urology, vol. 81, no. 6, 2022, pp. e141-e142. |
| Wambier CG, Goren A, Vaño-Galván S, Ramos PM, Ossimetha A, Nau G, Herrera S, McCoy J. "Androgen sensitivity gateway to COVID-19 disease severity." Drug development research, 2020. |
| Nau GJ, Horzempa J, O'Dee D, Brown MJ, Russo BC, Hernandez A, Dillon ST, Cheng J, Kane LP, Sanker S, Hukriede NA. "A predicted Francisella tularensis DXD-motif glycosyltransferase blocks immune activation." Virulence, vol. 10, no. 1, 2019, pp. 643-656. |
| Talbot GH, Jezek A, Murray BE, Jones RN, Ebright RH, Nau GJ, Rodvold KA, Newland JG, Boucher HW, Infectious Diseases Society of America. "The Infectious Diseases Society of America's 10 × '20 Initiative (10 New Systemic Antibacterial Agents US Food and Drug Administration Approved by 2020): Is 20 × '20 a Possibility?." Clinical Infectious Diseases, vol. 69, no. 1, 2019, pp. 1-11. |
| Talbot GH, Jezek A, Murray BE, Jones RN, Ebright RH, Nau GJ, Rodvold KA, Newland JG, Boucher HW. "The Infectious Diseases Society of America's 10 × '20 Initiative (Ten New Systemic Antibacterial Agents FDA-approved by 2020): Is 20 × '20 a Possibility?." Clinical Infectious Diseases, 2019. |
| Patel KM, Johnson JE, Boxerman JL, Nau GJ. "Group A streptococcus acute otitis media progressing to neuroinvasive disease in adults." IDCases, vol. 12, 2018, pp. 161-164. |
| Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ, Ausubel FM, Mylonakis E. "Characterization of a Francisella tularensis-Caenorhabditis elegans pathosystem for the evaluation of therapeutic compounds." Antimicrobial Agents and Chemotherapy, 2017. |
| Li, M, Lee, K, Hsu, M, Nau, G, Mylonakis, E, Ramratnam, B. "Lactobacillus-derived extracellular vesicles enhance host immune responses against vancomycin-resistant enterococci." BMC Microbiology, vol. 17, no. 1, 2017, pp. 66. |
| Uyeki TM, Erickson BR, Brown S, McElroy AK, Cannon D, Gibbons A, Sealy T, Kainulainen MH, Schuh AJ, Kraft CS, Mehta AK, Lyon GM 3rd, Varkey JB, Ribner BS, Ellison RT 3rd, Carmody E, Nau GJ, Spiropoulou C, Nichol ST, Ströher U. "Ebola Virus Persistence in Semen of Male Survivors." Clinical Infectious Diseases, vol. 62, no. 12, 2016, pp. 1552-1555. |
| Zinman GE, Naiman S, O'Dee DM, Kumar N, Nau GJ, Cohen HY, Bar-Joseph Z. "ModuleBlast: identifying activated sub-networks within and across species." Nucleic acids research, vol. 43, no. 3, 2015, pp. e20. |
| Kling HM, Nau GJ, Ross TM, Evans TG, Chakraborty K, Empey KM, Flynn JL. "Challenges and future in vaccines, drug development, and immunomodulatory therapy." Annals of the American Thoracic Society, vol. 11 Suppl 4, 2014, pp. S201-10. |
| Khan S, Sallum UW, Zheng X, Nau GJ, Hasan T. "Rapid optical determination of β-lactamase and antibiotic activity." BMC microbiology, vol. 14, 2014, pp. 84. |
| Brown MJ, Russo BC, O'Dee DM, Schmitt DM, Nau GJ. "The contribution of the glycine cleavage system to the pathogenesis of Francisella tularensis." Microbes and infection / Institut Pasteur, vol. 16, no. 4, 2014, pp. 300-9. |
| Russo BC, Brown MJ, Nau GJ. "MyD88-dependent signaling prolongs survival and reduces bacterial burden during pulmonary infection with virulent Francisella tularensis." The American Journal of Pathology, vol. 183, no. 4, 2013, pp. 1223-32. |
| Schmitt DM, O'Dee DM, Brown MJ, Horzempa J, Russo BC, Morel PA, Nau GJ. "Role of NK cells in host defense against pulmonary type A Francisella tularensis infection." Microbes and infection / Institut Pasteur, vol. 15, no. 3, 2013, pp. 201-11. |
| Schmitt DM, O'Dee DM, Cowan BN, Birch JW, Mazzella LK, Nau GJ, Horzempa J. "The use of resazurin as a novel antimicrobial agent against Francisella tularensis." Frontiers in cellular and infection microbiology, vol. 3, 2013, pp. 93. |
| Schmitt DM, O'Dee DM, Horzempa J, Carlson PE Jr, Russo BC, Bales JM, Brown MJ, Nau GJ. "A Francisella tularensis live vaccine strain that improves stimulation of antigen-presenting cells does not enhance vaccine efficacy." PLoS ONE, vol. 7, no. 2, 2012, pp. e31172. |
| Robinson CM, Jung JY, Nau GJ. "Interferon-γ, tumor necrosis factor, and interleukin-18 cooperate to control growth of Mycobacterium tuberculosis in human macrophages." Cytokine, vol. 60, no. 1, 2012, pp. 233-41. |
| Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE Jr, Xavier RJ, Nau GJ. "A Francisella tularensis locus required for spermine responsiveness is necessary for virulence." Infection and Immunity, vol. 79, no. 9, 2011, pp. 3665-76. |
| Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ. "Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity." Proceedings of the National Academy of Sciences, vol. 108 Suppl 1, 2011, pp. 4631-8. |
| Horzempa J, O'Dee DM, Stolz DB, Franks JM, Clay D, Nau GJ. "Invasion of erythrocytes by Francisella tularensis." The Journal of Infectious Diseases, vol. 204, no. 1, 2011, pp. 51-9. |
| Zinman G, Brower-Sinning R, Emeche CH, Ernst J, Huang GT, Mahony S, Myers AJ, O'Dee DM, Flynn JL, Nau GJ, Ross TM, Salter RD, Benos PV, Bar Joseph Z, Morel PA. "Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque." PLoS ONE, vol. 6, no. 7, 2011, pp. e22401. |
| Kalivoda EJ, Horzempa J, Stella NA, Sadaf A, Kowalski RP, Nau GJ, Shanks RM. "New vector tools with a hygromycin resistance marker for use with opportunistic pathogens." Molecular biotechnology, vol. 48, no. 1, 2011, pp. 7-14. |
| Lu Y, Rosenfeld R, Nau GJ, Bar-Joseph Z. "Cross species expression analysis of innate immune response." Journal of Computational Biology, vol. 17, no. 3, 2010, pp. 253-68. |
| Robinson CM, O'Dee D, Hamilton T, Nau GJ. "Cytokines involved in interferon-gamma production by human macrophages." Journal of innate immunity, vol. 2, no. 1, 2010, pp. 56-65. |
| Horzempa J, O'Dee DM, Shanks RM, Nau GJ. "Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo." Infection and Immunity, vol. 78, no. 6, 2010, pp. 2607-19. |
| Sheridan KR, Potoski BA, Shields RK, Nau GJ. "Presence of adequate intravitreal concentrations of daptomycin after systemic intravenous administration in a patient with endogenous endophthalmitis." Pharmacotherapy, vol. 30, no. 12, 2010, pp. 1247-51. |
| Horzempa J, Shanks RM, Brown MJ, Russo BC, O'Dee DM, Nau GJ. "Utilization of an unstable plasmid and the I-SceI endonuclease to generate routine markerless deletion mutants in Francisella tularensis." Journal of microbiological methods, vol. 80, no. 1, 2010, pp. 106-8. |
| Carlson PE Jr, Horzempa J, O'Dee DM, Robinson CM, Neophytou P, Labrinidis A, Nau GJ. "Global transcriptional response to spermine, a component of the intramacrophage environment, reveals regulation of Francisella gene expression through insertion sequence elements." Journal of bacteriology, vol. 191, no. 22, 2009, pp. 6855-64. |
| Lu Y, Rosenfeld R, Simon I, Nau GJ, Bar-Joseph Z. "A probabilistic generative model for GO enrichment analysis." Nucleic acids research, vol. 36, no. 17, 2008, pp. e109. |
| Stella NA, Kalivoda EJ, O'Dee DM, Nau GJ, Shanks RM. "Catabolite repression control of flagellum production by Serratia marcescens." Research in microbiology, vol. 159, no. 7-8, 2008, pp. 562-8. |
| Horzempa J, Tarwacki DM, Carlson PE Jr, Robinson CM, Nau GJ. "Characterization and application of a glucose-repressible promoter in Francisella tularensis." Applied and Environmental Microbiology, vol. 74, no. 7, 2008, pp. 2161-70. |
| Horzempa J, Carlson PE Jr, O'Dee DM, Shanks RM, Nau GJ. "Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis." BMC microbiology, vol. 8, 2008, pp. 172. |
| Turnquist HR, Sumpter TL, Tsung A, Zahorchak AF, Nakao A, Nau GJ, Liew FY, Geller DA, Thomson AW. "IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells." The Journal of Immunology, vol. 181, no. 1, 2008, pp. 62-72. |
| Robinson CM, Nau GJ. "Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis." The Journal of Infectious Diseases, vol. 198, no. 3, 2008, pp. 359-66. |
| Kalivoda EJ, Stella NA, O'Dee DM, Nau GJ, Shanks RM. "The cyclic AMP-dependent catabolite repression system of Serratia marcescens mediates biofilm formation through regulation of type 1 fimbriae." Applied and Environmental Microbiology, vol. 74, no. 11, 2008, pp. 3461-70. |
| Shanks RM, Stella NA, Kalivoda EJ, Doe MR, O'Dee DM, Lathrop KL, Guo FL, Nau GJ. "A Serratia marcescens OxyR homolog mediates surface attachment and biofilm formation." Journal of bacteriology, vol. 189, no. 20, 2007, pp. 7262-72. |
| Anderson BL, Nau GJ, Simhan HN. "Idiopathic vertebral abscess in pregnancy: case report and literature review." American journal of perinatology, vol. 24, no. 6, 2007, pp. 377-9. |
| Carlson PE Jr, Carroll JA, O'Dee DM, Nau GJ. "Modulation of virulence factors in Francisella tularensis determines human macrophage responses." Microbial pathogenesis, vol. 42, no. 5-6, 2007, pp. 204-14. |
| O'Riordan K, Sharlin DS, Gross J, Chang S, Errabelli D, Akilov OE, Kosaka S, Nau GJ, Hasan T. "Photoinactivation of Mycobacteria in vitro and in a new murine model of localized Mycobacterium bovis BCG-induced granulomatous infection." Antimicrobial Agents and Chemotherapy, vol. 50, no. 5, 2006, pp. 1828-34. |
| Ernst J, Nau GJ, Bar-Joseph Z. "Clustering short time series gene expression data." Bioinformatics, vol. 21 Suppl 1, 2005, pp. i159-68. |
| Meyn MA 3rd, Schreiner SJ, Dumitrescu TP, Nau GJ, Smithgall TE. "SRC family kinase activity is required for murine embryonic stem cell growth and differentiation." Molecular pharmacology, vol. 68, no. 5, 2005, pp. 1320-30. |
| Nau GJ, Schlesinger A, Richmond JF, Young RA. "Cumulative Toll-like receptor activation in human macrophages treated with whole bacteria." The Journal of Immunology, vol. 170, no. 10, 2003, pp. 5203-9. |
| Nau GJ, Richmond JF, Schlesinger A, Jennings EG, Lander ES, Young RA. "Human macrophage activation programs induced by bacterial pathogens." Proceedings of the National Academy of Sciences, vol. 99, no. 3, 2002, pp. 1503-8. |
| O'Regan AW, Nau GJ, Chupp GL, Berman JS. "Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks." Immunology today, vol. 21, no. 10, 2000, pp. 475-8. |
| Nau GJ, Chupp GL, Emile JF, Jouanguy E, Berman JS, Casanova JL, Young RA. "Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection." The American Journal of Pathology, vol. 157, no. 1, 2000, pp. 37-42. |
| Nau GJ, Liaw L, Chupp GL, Berman JS, Hogan BL, Young RA. "Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin." Infection and Immunity, vol. 67, no. 8, 1999, pp. 4223-30. |
| Nau GJ, Guilfoile P, Chupp GL, Berman JS, Kim SJ, Kornfeld H, Young RA. "A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis." Proceedings of the National Academy of Sciences, vol. 94, no. 12, 1997, pp. 6414-9. |
| Nau GJ, Kim DK, Fitch FW. "Agents that mimic antigen receptor signaling inhibit proliferation of cloned murine T lymphocytes induced by IL-2." The Journal of Immunology, vol. 141, no. 10, 1988, pp. 3557-63. |
| Kim DK, Nau GJ, Lancki DW, Dawson G, Fitch FW. "Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP." The Journal of Immunology, vol. 141, no. 10, 1988, pp. 3429-37. |
| Moldwin RL, Nau GJ, Havran WL, Lancki DW, Fitch FW. "Anti-L3T4 monoclonal antibody inhibits T-cell activation by anti-T-cell receptor antibody through a pathway not involving "associative recognition"." Annales de l'Institut Pasteur. Immunology, vol. 138, no. 1, 1987, pp. 131-4. |
| Moldwin RL, Havran WL, Nau GJ, Lancki DW, Kim DK, Fitch FW. "Antibodies to the L3T4 and Lyt-2 molecules interfere with antigen receptor-driven activation of cloned murine T cells." The Journal of Immunology, vol. 139, no. 3, 1987, pp. 657-64. |
| Nau GJ, Moldwin RL, Lancki DW, Kim DK, Fitch FW. "Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody." The Journal of Immunology, vol. 139, no. 1, 1987, pp. 114-22. |
| Kim DK, Otten G, Moldwin RL, Dunn DE, Nau GJ, Fitch FW. "PMA alone induces proliferation of some murine T cell clones but not others." The Journal of Immunology, vol. 137, no. 9, 1986, pp. 2755-60. |
5P20GM121344 Animal Models Core - COBRE Center for Antimicrobial Resistance and Therapeutic Discovery
| Year | Degree | Institution |
|---|---|---|
| 1990 | PhD | University of Chicago |
| 1990 | MD | University of Chicago |
| 1983 | BS | University of Notre Dame |
| Visiting Scientist | Whitehead Institute for Biomedical Research, Molecular biology | 1994-2003 | Cambridge, MA |
Fellow, Infectious Diseases Society of America, 2014
Attending Teaching Award, Consultant of the Year, 2016
Dean's Excellence in Teaching Award, 2023
| Name | Title |
|---|---|
| Fredericks, Alger | Assistant Professor of Surgery (Research) |
| Gravenstein, Stefan | David S. Greer Professor of Geriatric Medicine, Director, Division of Geriatrics and Palliative Care, Professor of Health Services, Policy and Practice |
| Monaghan, Sean | Associate Professor of Surgery |
| Rogers, Ralph | Assistant Professor of Medicine, Clinician Educator |
| Wambier, Carlos | Associate Professor of Dermatology, Clinician Educator |
Department of Medicine, Division of Infectious Diseases
Brown Medicine
Infectious Diseases Society of America
American Society for Microbiology
| Physician | State of Rhode Island | - |
