Joseph Bliss is a neonatologist with a special interest in fungal infections in premature infants. He obtained his BA in Biology from Ithaca College in 1990, and his MD and PhD degrees from the University of Rochester in 1998. After completing his residency and fellowship training, he joined the Brown faculty in 2003. In addition to his clinical work, he studies host-defense mechanisms against infection with the fungus, Candida with special emphasis on the premature infant.
| McKinley LT, Przystac L, Tucker R, Trail-Burns E, Vohr BR, Laptook AR, Bliss JM. "Implementation of a Nutrition Care Bundle and Improved Weight Gain of Extremely Preterm Infants to 36 Weeks Postmenstrual Age." The Journal of Pediatrics, vol. 241, 2022, pp. 42-47.e2. |
| Romo JA, Arsenault AB, Laforce-Nesbitt SS, Bliss JM, Kumamoto CA. "Minimal Effects of Medium-Chain Triglyceride Supplementation on the Intestinal Microbiome Composition of Premature Infants: A Single-Center Pilot Study." Nutrients, vol. 14, no. 10, 2022. |
| Shaw, Sunil K., Longley, Sarah J., Laforce-Nesbitt, Sonia S., Bliss, Joseph M. "Adhesion of Candida parapsilosis to Bovine Serum Albumin under Fluid Shear." Journal of Visualized Experiments, no. 171, 2021. |
| Smith MJ, Boutzoukas A, Autmizguine J, Hudak ML, Zinkhan E, Bloom BT, Heresi G, Lavery AP, Courtney SE, Sokol GM, Cotten CM, Bliss JM, Mendley S, Bendel C, Dammann CEL, Weitkamp JH, Saxonhouse MA, Mundakel GT, Debski J, Sharma G, Erinjeri J, Gao J, Benjamin DK Jr, Hornik CP, Smith PB, Cohen-Wolkowiez M, Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee. "Antibiotic Safety and Effectiveness in Premature Infants With Complicated Intraabdominal Infections." The Pediatric Infectious Disease Journal, vol. 40, no. 6, 2021, pp. 550-555. |
| Mao Q, Chu S, Shapiro S, Bliss JM, De Paepe ME. "Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS)." Placenta, vol. 105, 2021, pp. 7-13. |
| Bliss, Joseph M. "Special Issue: Host Defense against Fungi." Journal of Fungi, vol. 7, no. 12, 2021, pp. 1054. |
| Bliss JM, Tollefson GA, Cuevas A, Longley SJ, Neale MN, Uzun A, Shaw SK. "Transcription Profiles Associated with Inducible Adhesion in Candida parapsilosis." mSphere, vol. 6, no. 1, 2021. |
| McGovern M, Giannoni E, Kuester H, Turner MA, van den Hoogen A, Bliss JM, Koenig JM, Keij FM, Mazela J, Finnegan R, Degtyareva M, Simons SHP, de Boode WP, Strunk T, Reiss IKM, Wynn JL, Molloy EJ, Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR. "Challenges in developing a consensus definition of neonatal sepsis." Pediatric Research, vol. 88, no. 1, 2020, pp. 14-26. |
| Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, Kuester H, Turner MA, Giannoni E, Mazela J, Degtyareva M, Strunk T, Simons SHP, Janota J, Plotz FB, van den Hoogen A, de Boode W, Schlapbach LJ, Reiss IKM, Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR. "Correction: Neonatal sepsis: need for consensus definition, collaboration and core outcomes." Pediatric Research, 2020. |
| Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, Kuester H, Turner MA, Giannoni E, Mazela J, Degtyaeva M, Strunk T, Simons SHP, Janota J, Plotz FB, van den Hoogen A, de Boode W, Schlapbach LJ, Reiss IKM, Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR. "Neonatal sepsis: need for consensus definition, collaboration and core outcomes." Pediatric Research, vol. 88, no. 1, 2020, pp. 2-4. |
| Tóth R, Nosek J, Mora-Montes HM, Gabaldon T, Bliss JM, Nosanchuk JD, Turner SA, Butler G, Vágvölgyi C, Gácser A. "Candida parapsilosis: from Genes to the Bedside." Clinical microbiology reviews, vol. 32, no. 2, 2019. |
| Verma P, Laforce-Nesbitt SS, Tucker R, Mao Q, De Paepe ME, Bliss JM. "Galectin-3 expression and effect of supplementation in neonatal mice with disseminated Candida albicans infection." Pediatric Research, vol. 85, no. 4, 2019, pp. 527-532. |
| Natarajan G, Shankaran S, Nolen TL, Sridhar A, Kennedy KA, Hintz SR, Phelps DL, DeMauro SB, Carlo WA, Gantz MG, Das A, Greenberg RG, Younge NE, Bliss JM, Seabrook R, Sánchez PJ, Wyckoff MH, Bell EF, Vohr BR, Higgins RD. "Neurodevelopmental Outcomes of Preterm Infants With Retinopathy of Prematurity by Treatment." Pediatrics, vol. 144, no. 2, 2019. |
| Hemedez C, Trail-Burns E, Mao Q, Chu S, Shaw SK, Bliss JM, De Paepe ME. "Pathology of Neonatal Non- albicans Candidiasis: Autopsy Study and Literature Review." Pediatric and Developmental Pathology, vol. 22, no. 2, 2019, pp. 98-105. |
| Bearer C, Agostoni C, Anand KJS, Ambalavanan N, Bhandari V, Bliss JM, Bloomfield F, Bonifacio SL, Buhimschi I, Cilio MR, Coppes M, Czinn SJ, El-Khuffash A, Embleton N, Felderhoff-Müser U, Ferriero DM, Florin T, Fuentes-Afflick E, Gardner W, Gospe SM Jr, Gunn A, Gressens P, Guissani D, Haiden N, Hauptman M, Kim KS, Klebanoff M, Lachman P, Lanphear B, Ozen S, Roehr C, Roland D, Rosenblum N, Schwarz M, Staiano A, Stroustrup A, Valente EM, Wilson-Costello D, Wynn J, Molloy E. "Toward the elimination of bias in Pediatric Research." Pediatric Research, vol. 86, no. 6, 2019, pp. 680-681. |
| Arsenault AB, Gunsalus KTW, Laforce-Nesbitt SS, Przystac L, DeAngelis EJ, Hurley ME, Vorel ES, Tucker R, Matthan NR, Lichtenstein AH, Kumamoto CA, Bliss JM. "Dietary Supplementation with Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants." The Pediatric Infectious Disease Journal, 2018. |
| Balakrishnan M, Jennings A, Przystac L, Phornphutkul C, Tucker R, Vohr B, Stephens BE, Bliss JM. "Growth and Neurodevelopmental Outcomes of Early, High-Dose Parenteral Amino Acid Intake in Very Low Birth Weight Infants." Journal of Parenteral and Enteral Nutrition, vol. 42, no. 3, 2018, pp. 014860711769633. |
| Neale MN, Glass KA, Longley SJ, Kim DJ, Laforce-Nesbitt SS, Wortzel JD, Shaw SK, Bliss JM. "Role of the inducible adhesin, CpAls7, in binding of <i>Candida parapsilosis</i> to extracellular matrix under fluid shear." Infection and Immunity, 2018. |
| Gonia S, Archambault L, Shevik M, Altendahl M, Fellows E, Bliss JM, Wheeler RT, Gale CA. "<i>Candida parapsilosis</i> Protects Premature Intestinal Epithelial Cells from Invasion and Damage by <i>Candida albicans</i>." Frontiers in pediatrics, vol. 5, 2017, pp. 54. |
| Bliss JM, Wynn JL. "Editorial: The Neonatal Immune System: A Unique Host-Microbial Interface." Frontiers in Pediatrics, vol. 5, 2017, pp. 274. |
| Smith AM, Papaleo C, Reid CW, Bliss JM. "RNA-Seq reveals a central role for lectin, C1q and von Willebrand factor A domains in the defensive glue of a terrestrial slug." Biofouling, 2017, pp. 1-14. |
| Chow BD, Reardon JL, Perry EO, Laforce-Nesbitt SS, Tucker R, Bliss JM. "Host Defense Proteins in Breast Milk and Neonatal Yeast Colonization." Journal of human lactation : official journal of International Lactation Consultant Association, vol. 32, no. 1, 2016, pp. 168-73. |
| Bliss, Joseph M. "Candida parapsilosis : An emerging pathogen developing its own identity." Virulence, vol. 6, no. 2, 2015, pp. 109-111. |
| Arsenault AB, Bliss JM. "Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface." Current fungal infection reports, vol. 9, no. 4, 2015, pp. 246-252. |
| Byrd AS, O'Brien XM, Laforce-Nesbitt SS, Parisi VE, Hirakawa MP, Bliss JM, Reichner JS. "NETosis in Neonates: Evidence of a Reactive Oxygen Species-Independent Pathway in Response to Fungal Challenge." The Journal of Infectious Diseases, vol. 213, no. 4, 2015, pp. 634-9. |
| Glass, Kyle A, Longley, Sarah J, Bliss, Joseph M, Shaw, Sunil K. "Protection of Candida parapsilosis from neutrophil killing through internalization by human endothelial cells." Virulence, vol. 6, no. 5, 2015, pp. 504-14. |
| Chow, B. D. W., Reardon, J. R., Perry, E. O., Laforce-Nesbitt, S. S., Tucker, R., Bliss, J. M. "Expressed Breast Milk as a Predictor of Neonatal Yeast Colonization in an Intensive Care Setting." Journal of the Pediatric Infectious Diseases Society, vol. 3, no. 3, 2014, pp. 213-220. |
| Gabriel I, Kur K, Laforce-Nesbitt SS, Pulickal AS, Bliss JM, Milewski S. "Phenotypic consequences of LYS4 gene disruption in Candida albicans." Yeast (Chichester, England), vol. 31, no. 8, 2014, pp. 299-308. |
| Ronchi A, Michelow IC, Chapin KC, Bliss JM, Pugni L, Mosca F, Sánchez PJ. "Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I study." The Journal of Pediatrics, vol. 165, no. 4, 2014, pp. 690-6. |
| Pammi M, Holland L, Butler G, Gacser A, Bliss JM. "Candida parapsilosis is a significant neonatal pathogen: a systematic review and meta-analysis." The Pediatric Infectious Disease Journal, vol. 32, no. 5, 2013, pp. e206-16. |
| Linden JR, De Paepe ME, Laforce-Nesbitt SS, Bliss JM. "Galectin-3 plays an important role in protection against disseminated candidiasis." Med Mycol, vol. 51, no. 6, 2013, pp. 641-51. |
| Shintaku T, Glass KA, Hirakawa MP, Longley SJ, Bennett RJ, Bliss JM, Shaw SK. "Human endothelial cells internalize Candida parapsilosis via N-WASP-mediated endocytosis." Infection and Immunity, vol. 81, no. 8, 2013, pp. 2777-87. |
| Bliss, Joseph M., Reid, Christopher W. "Medical Mycology and the Chemistry Classroom: Germinating Student Interest in Organic Chemistry." J. Chem. Educ., vol. 90, no. 10, 2013, pp. 1320-1324. |
| Linden JR, Kunkel D, Laforce-Nesbitt SS, Bliss JM. "The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils." Cellular microbiology, vol. 15, no. 7, 2013, pp. 1127-42. |
| Chow BD, Linden JR, Bliss JM. "Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting." Expert review of anti-infective therapy, vol. 10, no. 8, 2012, pp. 935-46. |
| Bliss JM, Wong AY, Bhak G, Laforce-Nesbitt SS, Taylor S, Tan S, Stoll BJ, Higgins RD, Shankaran S, Benjamin DK Jr, Candida Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. "Candida virulence properties and adverse clinical outcomes in neonatal candidiasis." The Journal of Pediatrics, vol. 161, no. 3, 2012, pp. 441-447.e2. |
| Tsai NY, Laforce-Nesbitt SS, Tucker R, Bliss JM. "A murine model for disseminated candidiasis in neonates." Pediatric Research, vol. 69, no. 3, 2011, pp. 189-93. |
| Balakrishnan M, Tucker R, Stephens BE, Bliss JM. "Blood urea nitrogen and serum bicarbonate in extremely low birth weight infants receiving higher protein intake in the first week after birth." Journal of perinatology : official journal of the California Perinatal Association, vol. 31, no. 8, 2011, pp. 535-9. |
| Al-Rawi N, Laforce-Nesbitt SS, Bliss JM. "Deletion of Candida albicans SPT6 is not lethal but results in defective hyphal growth." Fungal genetics and biology : FG & B, vol. 47, no. 4, 2010, pp. 288-96. |
| Linden, Jennifer R., Maccani, Matthew A., Laforce-Nesbitt, Sonia S., Bliss, Joseph M. "High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils." Med Mycol, vol. 48, no. 2, 2010, pp. 355-364. |
| Linden JR, Maccani MA, Laforce-Nesbitt SS, Bliss JM. "High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils." Med Mycol, vol. 48, no. 2, 2010, pp. 355-64. |
| Destin KG, Linden JR, Laforce-Nesbitt SS, Bliss JM. "Oxidative burst and phagocytosis of neonatal neutrophils confronting Candida albicans and Candida parapsilosis." Early human development, vol. 85, no. 8, 2009, pp. 531-5. |
| Kochilas L, Gundogan F, Atalay M, Bliss JM, Vatta M, Pena LS, Abuelo D. "A novel mutation of the fibrillin-1 gene in a newborn with severe Marfan syndrome." Journal of perinatology : official journal of the California Perinatal Association, vol. 28, no. 4, 2008, pp. 303-5. |
| Laforce-Nesbitt SS, Sullivan MA, Hoyer LL, Bliss JM. "Inhibition of Candida albicans adhesion by recombinant human antibody single-chain variable fragment specific for Als3p." FEMS immunology and medical microbiology, vol. 54, no. 2, 2008, pp. 195-202. |
| Bliss JM, Basavegowda KP, Watson WJ, Sheikh AU, Ryan RM. "Vertical and horizontal transmission of Candida albicans in very low birth weight infants using DNA fingerprinting techniques." The Pediatric Infectious Disease Journal, vol. 27, no. 3, 2008, pp. 231-5. |
| Bliss JM, Laforce-Nesbitt SS. "Toxicity to Candida albicans mediated by human serum and peripheral blood mononuclear cells." FEMS immunology and medical microbiology, vol. 46, no. 3, 2006, pp. 452-60. |
| Bliss JM, Bigelow CE, Foster TH, Haidaris CG. "Susceptibility of Candida species to photodynamic effects of photofrin." Antimicrobial Agents and Chemotherapy, vol. 48, no. 6, 2004, pp. 2000-6. |
| Bliss JM, Wellington M, Gigliotti F. "Antifungal pharmacotherapy for neonatal candidiasis." Seminars in Perinatology, vol. 27, no. 5, 2003, pp. 365-74. |
| Bliss JM, Sullivan MA, Malone J, Haidaris CG. "Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae." Journal of clinical microbiology, vol. 41, no. 3, 2003, pp. 1152-60. |
| Wellington M, Bliss JM, Haidaris CG. "Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment." Infection and Immunity, vol. 71, no. 12, 2003, pp. 7228-31. |
| Haidaris CG, Malone J, Sherrill LA, Bliss JM, Gaspari AA, Insel RA, Sullivan MA. "Recombinant human antibody single chain variable fragments reactive with Candida albicans surface antigens." Journal of immunological methods, vol. 257, no. 1-2, 2001, pp. 185-202. |
| Bliss JM, Silver RP. "Evidence that KpsT, the ATP-binding component of an ATP-binding cassette transporter, is exposed to the periplasm and associates with polymer during translocation of the polysialic acid capsule of Escherichia coli K1." Journal of bacteriology, vol. 179, no. 4, 1997, pp. 1400-3. |
| Bliss JM, Silver RP. "Coating the surface: a model for expression of capsular polysialic acid in Escherichia coli K1." Molecular Microbiology, vol. 21, no. 2, 1996, pp. 221-31. |
| Bliss JM, Garon CF, Silver RP. "Polysialic acid export in Escherichia coli K1: the role of KpsT, the ATP-binding component of an ABC transporter, in chain translocation." Glycobiology, vol. 6, no. 4, 1996, pp. 445-52. |
| Wunder DE, Aaronson W, Hayes SF, Bliss JM, Silver RP. "Nucleotide sequence and mutational analysis of the gene encoding KpsD, a periplasmic protein involved in transport of polysialic acid in Escherichia coli K1." Journal of bacteriology, vol. 176, no. 13, 1994, pp. 4025-33. |
NICHD/NIH “Salivary Diagnostics for Sepsis Screening in the Neonate”, 8/9/19-4/30/24
NICHD/NIH “Dietary Supplementation of Medium Chain Triglyceride (MCT) Oil to Reduce Candida Colonization in Preterm Infants”, 8/15/17-7/31/20
NIGMS/NIH “COBRE for Perinatal Biology”, Principal Investigator for Pilot Project: “Contribution of Galectin-3 to Host Defense against Disseminated Candidiasis”, 10/1/17-9/30/20
Rhode Island Research Alliance Collaborative Grant Award, "Antigenic Targets of Candida albicans Specific Antibody Fragments", 2011-2012.
NCRR/NIH "COBRE for Perinatal Biology", Principal Investigator for Project 1: "Neonatal Candidiasis and Immune Compromise during Development", 2008-2013.
March of Dimes Basil O'Connor Starter Scholar Research Award, "The Role of Specific Antibody in Host-Defense Against Neonatal Candidiasis", 2006-2008.
NIAID/NIH, "Antibody in Defense Against Neonatal Candida Infections". 2005-2009.
| Year | Degree | Institution |
|---|---|---|
| 1998 | PhD | University of Rochester |
| 1998 | MD | University of Rochester |
| 1994 | MS | University of Rochester |
| 1990 | BA | Ithaca University |
| Fellow | University of Rochester, Children's Hospital at Strong, neonatal-perinatal medicine | 2000-2003 | Rochester, NY |
| Resident | University of Rochester, Children's Hospital at Strong, Pediatrics | 1998-2000 | Rochester, NY |
| Name | Title |
|---|---|
| Bennett, Richard | Charles A. and Helen B. Stuart Professor of Molecular Microbiology and Immunology, Chair of Molecular Microbiology and Immunology |
| Reichner, Jonathan | Professor of Surgery (Research) |
| Shaw, Sunil | Associate Professor of Pediatrics (Research) |
| Uzun, Alper | Associate Professor of Pediatrics (Research), Associate Professor of Pathology and Laboratory Medicine (Research) |
American Academy of Pediatrics
American Society for Microbiology
Eastern Society for Pediatric Research
Society for Pediatric Research
American Pediatric Society
| Certification | American Board of Pediatrics, Neonatal-perinatal medicine | 2005- | |
| Certification | American Board of Pediatrics, General pediatrics | 2003- | |
| Medical License | Massachusetts | - | |
| Medical License | Rhode Island | - | #MD11123 |
| Drug Enforcement Agency | - | #BB8211358 |
| Pediatrics/Neonatology. Sturdy Memorial Hospital, 2006-Present |
| Staff Neonatologist. Women & Infants Hospital of Rhode Island, 2003-Present |
