Throughout Dr. Jill Kreiling’s scientific career she has actively pursued a research program focused on fundamental aspects of human health. She originally trained in the fields of microbiology and molecular biology in Dr. Nyles Charon’s laboratory at West Virginia University. She performed postdoctoral research in the field of developmental neurotoxicology in affiliation with Dr. Carol Reinisch at the Marine Biological Laboratory. In 2006 she was appointed to the rank of Assistant Professor (Research) at Brown University. She is currently a Professor (Research) and the Associate Director for Program Development of the Center on the Biology of Aging. Her research focuses on identifying biomarkers of Alzheimer’s Disease and Parkinson’s Disease, the roles of miRNA regulation of neurodegeneration, and repurposing of FDA approved drugs to treat Alzheimer’s disease.
| Wen S, Yu C, Kelsey MMG, Pereira M, Alaimo H, Teixeira E, Pracht J, Daiello LA, Drake J, Sedivy JM, Wu Z, Quesenberry P, Kreiling JA. "RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations." Frontiers in aging, vol. 6, 2026, pp. 1707720. |
| Dou Z, Kreiling JA, Heynen-Genel S, Jurk D, Neretti N, Adams PD, Sedivy JM, Passos JF. "Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?." EMBO J, vol. 44, no. 19, 2025, pp. 5239-5243. |
| Del Rosario Hernandez, T.S., Joshi, N.R., Gore, S.V., Kreiling, J.A., Creton, R. "Combining supervised and unsupervised analyses to quantify behavioral phenotypes and validate therapeutic efficacy in a triple transgenic mouse model of Alzheimer's disease." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 181, 2024, pp. 117718. |
| Del Rosario Hernández T, Gore SV, Kreiling JA, Creton R. "Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 171, 2024, pp. 116096. |
| Kreiling JA. "Dysregulation of endogenous retroviruses triggers aging and senescence." Nature aging, vol. 4, no. 12, 2024, pp. 1670-1672. |
| Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. "Loss of epigenetic information as a cause of mammalian aging." Cell, vol. 187, no. 5, 2024, pp. 1312-1313. |
| Petrashen AP, Lin Y, Kun B, Kreiling JA. "A cluster of X-linked miRNAs are de-repressed with age in mouse liver and target growth hormone signaling." Frontiers in aging, vol. 4, 2023, pp. 1261121. |
| Del Rosario Hernández T, Joshi NR, Gore SV, Kreiling JA, Creton R. "An 8-cage imaging system for automated analyses of mouse behavior." Scientific reports, vol. 13, no. 1, 2023, pp. 8113. |
| Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. "Loss of epigenetic information as a cause of mammalian aging." Cell, vol. 186, no. 2, 2023, pp. 305-326.e27. |
| Elias AE, Nuñez TA, Kun B, Kreiling JA. "primiReference: a reference for analysis of primary-microRNA expression in single-nucleus sequencing data." Journal of genetics and genomics = Yi chuan xue bao, vol. 50, no. 2, 2023, pp. 108-121. |
| Petrashen AP, Verdesca AD, Kreiling JA, Sedivy JM. "Regulation of the somatotropic axis by MYC-mediated miRNA repression." Frontiers in Cell and Developmental Biology, vol. 11, 2023, pp. 1269860. |
| Yao, Hongwei, Wallace, Joselynn, Peterson, Abigail L., Scaffa, Alejandro, Rizal, Salu, Hegarty, Katy, Maeda, Hajime, Chang, Jason L., Oulhen, Nathalie, Kreiling, Jill A., Huntington, Kelsey E., De Paepe, Monique E., Barbosa, Guilherme, Dennery, Phyllis A. "Timing and cell specificity of senescence drives postnatal lung development and injury." Nature Communications, vol. 14, no. 1, 2023, pp. 273. |
| Zhang, Shengliang, Huntington, Kelsey E., Zhou, Lanlan, Seyhan, Attila A., Kun, Bianca, Carneiro, Benedito A., Kreiling, Jill, Sedivy, John M., El-Deiry, Wafik S. "TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment." biorxiv, 2023. |
| Tucker Edmister S, Ibrahim R, Kakodkar R, Kreiling JA, Creton R. "A zebrafish model for calcineurin-dependent brain function." Behavioural Brain Research, vol. 416, 2022, pp. 113544. |
| Tucker Edmister S, Del Rosario Hernández T, Ibrahim R, Brown CA, Gore SV, Kakodkar R, Kreiling JA, Creton R. "Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles." Scientific reports, vol. 12, no. 1, 2022, pp. 6120. |
| Bronikowski, Anne M., Meisel, Richard P., Biga, Peggy R., Walters, James R., Mank, Judith E., Larschan, Erica, Wilkinson, Gerald S., Valenzuela, Nicole, Conard, Ashley Mae, de Magalhães, João Pedro, Duan, Jingyue (Ellie), Elias, Amy E., Gamble, Tony, Graze, Rita M., Gribble, Kristin E., Kreiling, Jill A., Riddle, Nicole C. "Sex‐specific aging in animals: Perspective and future directions." Aging Cell, vol. 21, no. 2, 2022. |
| Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM. "The role of retrotransposable elements in ageing and age-associated diseases." Nature, vol. 596, no. 7870, 2021, pp. 43-53. |
| Elias, Amy E., Kreiling, Jill A. "MicroRNA dysregulation influences growth hormone signaling." Aging, 2019. |
| Elias AE, Kun B, Sabula IMC, Golomb-Mello G, Cespedes Zablah A, Kreiling JA. "The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver." Aging Cell, vol. 18, no. 2, 2019, pp. e12892. |
| Ciocanel MV, Kreiling JA, Gagnon JA, Mowry KL, Sandstede B. "Analysis of Active Transport by Fluorescence Recovery after Photobleaching." Biophysical Journal, vol. 112, no. 8, 2017, pp. 1714-1725. |
| Criscione SW, De Cecco M, Siranosian B, Zhang Y, Kreiling JA, Sedivy JM, Neretti N. "Reorganization of chromosome architecture in replicative cellular senescence." Science Advances, vol. 2, no. 2, 2016, pp. e1500882. |
| Powrie EA, Ciocanel V, Kreiling JA, Gagnon JA, Sandstede B, Mowry KL. "Using in vivo imaging to measure RNA mobility in Xenopus laevis oocytes." Methods, vol. 98, 2015, pp. 60-65. |
| Sedivy JM, Kreiling JA, Neretti N, De Cecco M, Criscione SW, Hofmann JW, Zhao X, Ito T, Peterson AL. "Death by transposition - the enemy within?." BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 35, no. 12, 2013, pp. 1035-43. |
| Gagnon JA, Kreiling JA, Powrie EA, Wood TR, Mowry KL. "Directional transport is mediated by a Dynein-dependent step in an RNA localization pathway." PLoS biology, vol. 11, no. 4, 2013, pp. e1001551. |
| De Cecco M, Criscione SW, Peckham EJ, Hillenmeyer S, Hamm EA, Manivannan J, Peterson AL, Kreiling JA, Neretti N, Sedivy JM. "Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements." Aging Cell, vol. 12, no. 2, 2013, pp. 247-56. |
| De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM, Kreiling JA. "Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues." Aging, vol. 5, no. 12, 2013, pp. 867-83. |
| Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM. "Age-associated increase in heterochromatic marks in murine and primate tissues." Aging Cell, vol. 10, no. 2, 2011, pp. 292-304. |
| Lopes SS, Lourenço R, Pacheco L, Moreno N, Kreiling J, Saúde L. "Notch signalling regulates left-right asymmetry through ciliary length control." Development, vol. 137, no. 21, 2010, pp. 3625-32. |
| Kreiling JA, Reinisch C. "The developing brain on PCBs." Mol. Reprod. Dev., vol. 76, no. 4, 2009, pp. 319. |
| Messitt TJ, Gagnon JA, Kreiling JA, Pratt CA, Yoon YJ, Mowry KL. "Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes." Developmental Cell, vol. 15, no. 3, 2008, pp. 426-36. |
| Kreiling JA, Balantac ZL, Crawford AR, Ren Y, Toure J, Zchut S, Kochilas L, Creton R. "Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain." Mechanisms of development, vol. 125, no. 5-6, 2008, pp. 396-410. |
| Kreiling JA, Prabhat, Williams G, Creton R. "Analysis of Kupffer's vesicle in zebrafish embryos using a cave automated virtual environment." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 236, no. 7, 2007, pp. 1963-9. |
| Kreiling JA, Creton R, Reinisch C. "Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish." Journal of toxicology and environmental health. Part A, vol. 70, no. 12, 2007, pp. 1005-1013. |
| Dewilde S, Ebner B, Vinck E, Gilany K, Hankeln T, Burmester T, Kreiling J, Reinisch C, Vanfleteren JR, Kiger L, Marden MC, Hundahl C, Fago A, Van Doorslaer S, Moens L. "The nerve hemoglobin of the bivalve mollusc Spisula solidissima: molecular cloning, ligand binding studies, and phylogenetic analysis." Journal of Biological Chemistry, vol. 281, no. 9, 2006, pp. 5364-72. |
| Kreiling JA, Stephens RE, Reinisch CL. "A mixture of environmental contaminants increases cAMP-dependent protein kinase in Spisula embryos." Environmental Toxicology and Pharmacology, vol. 19, no. 1, 2005, pp. 9-18. |
| Jessen-Eller K, Kreiling JA, Begley GS, Steele ME, Walker CW, Stephens RE, Reinisch CL. "A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls." Environ Health Perspect, vol. 110, no. 4, 2002, pp. 377-85. |
| Kreiling JA, Jessen-Eller K, Miller J, Seegal RF, Reinisch CL. "Early development of the serotonergic and dopaminergic nervous system in Spisula solidissima (surf clam) larvae." Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol. 130, no. 2, 2001, pp. 341-51. |
| Kreiling JA, Stephens RE, Kuzirian AM, Jessen-Eller K, Reinisch CL. "Polychlorinated biphenyls are selectively neurotoxic in the developing Spisula solidissima embryo." Journal of toxicology and environmental health. Part A, vol. 61, no. 8, 2000, pp. 657-75. |
| Créton R, Kreiling JA, Jaffe LF. "Presence and roles of calcium gradients along the dorsal-ventral axis in Drosophila embryos." Developmental Biology, vol. 217, no. 2, 2000, pp. 375-85. |
| Créton R, Kreiling JA, Jaffe LF. "Calcium imaging with chemiluminescence." Microscopy research and technique, vol. 46, no. 6, 1999, pp. 390-7. |
| Kreiling JA, Duncan R, Faggart MA, Cornell NW. "Comparison of the beluga whale (Delphinapterus leucas) expressed genes for 5-aminolevulinate synthase with those in other vertebrates." Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, vol. 123, no. 2, 1999, pp. 163-74. |
| Goldstein SF, Charon NW, Kreiling JA. "Borrelia burgdorferi swims with a planar waveform similar to that of eukaryotic flagella." Proceedings of the National Academy of Sciences, vol. 91, no. 8, 1994, pp. 3433-7. |
| Charon NW, Goldstein SF, Block SM, Curci K, Ruby JD, Kreiling JA, Limberger RJ. "Morphology and dynamics of protruding spirochete periplasmic flagella." Journal of bacteriology, vol. 174, no. 3, 1992, pp. 832-40. |
| Stevenson JR, Kreiling JA, Taylor R. "Effects of corticosterone on responses of murine splenic B and T cells to phytohemagglutinin, concanavalin A, and lipopolysaccharide." Immunological investigations, vol. 18, no. 8, 1989, pp. 951-60. |
Zimmerman Award, Kreiling (MPI) 4/1/24 – 3/31/26 $100,000
Brown University
Drug discovery for the Prevention and Treatment of Alzheimer's Disease.
The goals of this project are to identify FDA-approved drugs with potential to treat Alzheimer’s disease
Role: Principal Investigator
R01AG074284, Kreiling, J.A. and Lori Daiello (MPI) 6/1/22 – 3/31/27 $499,999/yr
NIH/NIA
Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease and Related Disorders.
The goals of this project are to identify biomarkers in salivary vesicles for screening for preclinical Alzheimer’s disease and related disorders.
Role: Principal Investigator, contact PI
3P20GM119943-03S1, Quesenberry, P.J. (PI) 7/1/19 – 6/30/23 $250,000
NIH/NIGMS
COBRE Stem Cells and Aging Administrative Supplement
Retrotransposable Element Expression in Neural Stem Cell Senescence and Aging.
The goals of this project are to identify biomarkers in salivary vesicles for screening for preclinical Alzheimer’s disease. This award is currently in a no-cost extension.
Role: Project Leader
P20GM119943, Quesenberry, P.J. (PI) 7/1/17 – 6/30/22 $142,800/yr
NIH/NIGMS
COBRE Stem Cells and Aging
Retrotransposable Element Expression in Neural Stem Cell Senescence and Aging.
The goals of this project are to determine the molecular mechanisms behind neural stem cell decline with age.
This award is currently in a no-cost extension.
Role: Project Leader
1K01AG039410, Kreiling, J.A. (PI) 9/11-5/16
NIH/NIA
Regulation of Age-Associated Heterochromatin Formation
Role: Principal Investigator
P30GM103410, Atwood, W.A. (PI) 6/13-3/14
NIH/NIGMS
COBRE Center for Cancer Signaling Networks
Chromatin Structure and Repetitive Element Expression in Aging
Role: Lead Investigator of a Seed Funds Project
5P30-4G038072, Barzilai, N. (PI) 1/13-12/13
NIH/NIA
Nathan Shock Center of Excellence
Repetitive Element Expression in Normal Aging
Role: Lead Investigator of a Pilot and Feasibility Project
ARRA Administrative Supplement 8/09-8/11
P20 RR015578-10S1, Atwood, W. (PI)
NIH/NCRR
Senescence-associated Heterochromatin Formation in Mitotic and Post-mitotic Tissues
Role: Lead investigator
R01 AG035328-01, Sedivy, J.M. (PI) 10/09-09/12
NIH/NIA
The Wnt-chromatin axis in aging
Role: Co-investigator
Pilot Project, Kreiling (PI) 1/08 - 4/08
RI-INBRE P20RR016457 to URI (NCRR)
The effects of early embryonic exposure to PCB on the developing nervous system.
Role: Principal Investigator
Wen, S., Yu, C., Pereira, M. Alaimo, H., Teixeira, E., Pracht, J., Denby, C., Daiello, L., Drake, J., Wu, Z., Quesenberry, P., Kreiling J.A. 2025. Characterization of Neurodegeneration-Related Transcripts in Salivary Extracellular Vesicle RNA Cargo in Aged Populations. Front. Aging. 2025;6:1707720. PubMed Central PMCID: PMC12832735.
Dou, Z., Kreiling, J.A., Heynen-Genel, S., Jurk, D., Neretti, N., Adams, P.D., Sedivy, J.M., Passos, J.F. 2025. Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling? EMBO J. doi: 10.1038/s44318-025-00531-z.
Kreiling, J.A. 2024. Dysregulation of endogenous retroviruses triggers aging and senescence. Nature Aging. Nat Aging, 4(12):1670-1672. PMID: 39567758.
Del Rosario Hernandez, T.S., Joshi, N.R., Gore, S.V., Kreiling, J.A., Creton, R. 2024. Combining supervised and unsupervised analyses to quantify behavioral phenotypes and validate therapeutic efficacy in a triple transgenic mouse model of Alzheimer's disease. Biomed. Pharmacother. 181:117718. PMID: 39637754.
Del Rosario Hernandez, T.S., Gore, S.V., Kreiling, J.A., and Creton, R. 2024. Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles. Biomed. Pharmacother. 171:116096. PMID: 38185043.
Zhang, S., Huntington, K.E., Zhou, L., Seyhan, A.A., Kun, B., Carneiro, B.A., Kreiling, J.A., Sedivy, J.M., El-Deiry, W.S. 2023. TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironment. bioRxiv. 2023.11.30.569479; doi: https://doi.org/10.1101/2023.11.30.569479.
Petrashen, A., Lin, Y., Kun, B., Kreiling, J.A. (2023). A Cluster of X-linked miRNAs are De-repressed with Age in Mouse Liver and Target Growth Hormone Signaling. In preparation.
Del Rosario Hernandez, T.S., Joshi, N., Gore, S.V., Kreiling, J.A., and Creton, R. (2023). An 8-cage imaging system for automated analyses of mouse behavior. Submitted to Nat. Commun.
Elias, E.A.; Nunez, T.A.; Kun, B.; Kreiling, J.A. (2023). primiReference: A Reference for Analysis of Primary-microRNA Expression in Single-Nucleus Sequencing Data. J. Genet. Genomics. Journal of Genetics and Genomics 50:112-125. PMID: 36371075.
Yao, H., Peterson, A.L., Rizal, S., Scaffa, A., Wallace, J., Kreiling, J.A., Chang, J., De Paepe, M.E., Dennery, P.A. (2023). Timing and cell specificity of senescence drives postnatal lung development and injury. Nat Commun. 2023:273. PMID: 36650158.
Yang, J. ; Hayano, M.; Griffin, P.T.; Amorim, J.A.; Bonkowski, M.S.; Apostolides, J.K.; Blanchette, M.; Munding, E.M.; Bhakta, M.; Salfati, E.; Lu, Y.; Vera, D.L.; Ross, J.M.; Coppotelli, G.; Ching Chew, Y.; Guo, W.; Yang, X.; Meer, M.; Tian, X.; Dou, Z.; Xu, C.; Pippin, J.W.; Creswell, M.; Mitchell, S.J.; Das, A.; O'Connell, B.; Thakur, S.; Kane, A.E.; Su, Q.; Mohri, Y.; Nishimura, E.K.; Schaevitz, L.; Garg, N.; Balta, A.; Rego, M.A.; Gregory-Ksander, M.; Jakobs, T.C.; Zhong, L.; Wakimoto, H.; Mostoslavsky, R.; Wagers, A.J.; Tsubota, K.; Bonasera, S.J.; Palmeira, C.M.; Seidman, J.G.; Seidman, C.E.; Wolf, N.S.; Kreiling, J.A.; Sedivy, J.M.; Murphy, G.F.; Green, R.E.; Garcia, B.A.; Berger, S.L.; Oberdoerffer, P.; Shankland, S.J.; Gladyshev, V.N.; Ksander, B.R.; Pfenning, A.R.; Rajman, L.A.; Sinclair, D.A. (2023). Loss of epigenetic information as a cause of mammalian aging. Cell. 186:305-326. PMID: 36638792.
Tucker Edmister, Del Rosario Hernandez, T. S., Ibrahim, R., Brown, C., Gore, S., Kakodkar, R., Kreiling, J.A., Creton R. (2022). Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles. Science Advances. 12(1): 6120. PMID: 35449173.
Tucker Edmister, S., Ibrahim, R., Kakodkar, R., Kreiling, J.A., Creton R. (2022). A zebrafish model for calcineurin-dependent brain function. Behav Brain Res. 416:113544. PMID: 34425181.
Bronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J. R., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., de Magalhães, J. P., Duan, J, Elias, A. E., Gamble, T., Graze, R. M., Gribble, K. E., Kreiling, J. A., & Riddle, N. C. (2022). Sex-specific aging in animals: Perspective and future directions. Aging Cell, 21(2):e13542. doi: 10.1111/acel.13542.
Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyo, D., Boeke, J.D., Linker, S.B., Gage, F.H., Kreiling, J.A., Petrashen, A.P., Woodham, T.A., Taylor, J.R., Helfand, S.L., Sedivy, J.M. (2021). The role of retrotransposable elements in aging and age-associated diseases. Nature. 596(7870):43-53. PMID: 34349292.
Elias, A.E., and Kreiling, J.A. 2019. MicroRNA Dysregulation Influences Growth Hormone Signaling. Aging (Albany NY) 11(15): 5294-5295.
Elias, A.E., Kun, B., Sabula, I.M., Golomb-Mello, G., Cespedes Zablah, A., Kreiling, J.A. 2019. The mir‐465 family is upregulated with age and attenuates growth hormone signaling in mouse liver. Aging Cell. 18(2):e12892. PMID:30637918.
Ciocanel, M.V, Kreiling, J.A., Gagnon, J.A., Mowry, K.L., Sandstede,B. 2017. Analysis of active transport by fluorescence recovery after photobleaching. Biophys J. 112(8):1714-1725.
Prowrie, E.A., Ciocanel, V., Kreiling, J.A., Gagnon, J.A., Sandstede, B., Mowry, K.L. 2016. Using in vivo imaging to measure RNA mobility in Xenopus laevis oocytes. Methods. S1046-2023(15):30141-9.
Criscione, S.W., De Cecco, M., Siranosian, B., Zhang, Y., Kreiling, J.A., Sedivy, J.M., Neretti, N. 2015. Reorganization of chromosome architecture in replicative cellular senescence. Science Advances 2: e1500882.
Sedivy, J.M., Kreiling, J.A., Neretti, N., De Cecco, M., Criscione, S.W., Hofmann, J.W, Zhao, X., Ito, T., Peterson, A.L. 2013. Death by transposition – the enemy within? BioEssays. Dec;35(12):1035-43.
De Cecco, M., Criscione, S.W., Peterson, A.L., Neretti, N., Sedivy, J.M., Kreiling, J.A. 2013. Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) 5(12):867-83.
De Cecco, M., Criscione, S.W., Peckham, E.J., Hillenmeyer, S., Hamm, E.A., Manivannan, J., Peterson, A.L., Kreiling, J.A., Neretti, N. and Sedivy, J.M. 2013. Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell 12: 247-256.
Gagnon J.A., Kreiling J.A., Powrie E.A., Wood T.R., Mowry K.L. 2013. Directional transport Is mediated by a dynein-dependent step in an RNA localization pathway. PLoS Biol 11(4): e1001551.
Kreiling J.A., Tamamori-Adachi M., Sexton A.N., Jeyapalan J.C., Munoz-Najar U., Peterson A.L., Manivannan J., Rogers E.S., Pchelintsev N.A., Adams P.D., Sedivy J.M. 2011. Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell. Apr;10(2):292-304.
Lopes S.S., Lourenço R., Pacheco L., Moreno N., Kreiling J.A. and Saúde L. 2010. Notch signalling regulates left-right asymmetry through ciliary length control. Development. 137(21):3625-32.
Messitt T.J., Gagnon J.A., Kreiling J.A., Pratt C.A., Yoon Y.J., Mowry K.L. 2008. Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes. Dev Cell. 15(3):426-36.
Kreiling J.A., Balantac Z.L, Toure J,., Zchut S., Kochilas L., and Creton R. 2008. Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain. Mech Dev. 125(5-6):396-410. Epub 2008 Feb 20.
Kreiling J.A., Creton R.J., Reinisch C.L. 2007. Early Embryonic Exposure to PCBs Disrupts Heat Shock Protein 70 Cognate Expression in Zebrafish Embryos. J Tox Envir Health, part A. 70(12):1005-13.
Kreiling J.A., Prabhat, Williams G., and Creton R. 2007. Analysis of Kupffer's Vesicle in Zebrafish Embryos using a Cave Automated Virtual Environment. Dev Dyn. 236(7):1963-9. May 14; (Epub ahead of print).
Dewilde, S, B. Ebner, E. Vinck, K. Gilany, T. Hankeln, T. Burmester, J. Kreiling, C. Reinisch, J. Vanfleteren, L. Kiger, M.C. Marden, C. Hundahl, A. Fago, S. Van Doorslaer, L. Moens. 2006. The nerve hemoglobin of the bivalve mollusc Spisula solidissima: Molecular cloning, ligand binding studies and phylogenetic analysis. J Biol Chem. Mar 3;281(9):5364-5372. Epub 2005 Dec 13.
Kreiling, J.A., R.E. Stephens, C.L. Reinisch. 2005. A Mixture of Environmental Contaminants Increases PKA-RII expression in Spisula embryo. Environ Tox Pharm 19: 9-18.
Jessen-Eller, K., J. Kreiling, G.S. Begley, M.E. Steele, C.W. Walker, R.E. Stephens, C.L. Reinisch. 2002. A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls. Environ Health Perspect 110:377-85.
Kreiling J.A., K. Jessen-Eller, J. Miller, R.F. Seegal, C.L. Reinisch. 2001. Early Development of the Serotonergic and Dopaminergic Nervous System in Spisula solidissima (surf clam) Larvae. Comp Biochem Physiol A Mol Integr Physiol 130:341-51.
Creton, R., J. Kreiling, L. Jaffe. 2000. Presence and Roles of Calcium Gradients along the Dorsal-Ventral Axis in Drosophila Embryos. Developmental Biology. 217: 375-385.
Kreiling, J.A., R. Stephens, A.M. Kuzirian, K. Jessen-Eller, C.L.Reinisch. 2000. Polychlorinated Biphenyls are Selectively Neurotoxic to the Developing Spisula Solidissima Embryo. . Tox Envir Health, part A 61: 101-119.
Kreiling, J., R. Duncan, M., Faggart, N. Cornell.1999. Comparison of the Beluga Whale (Delphinapterus leucas) Expressed Genes for 5-aminolevulinate Synthase with Those in Other Vertebrates. Comp Biochem Physio, part B 123:163-174.
Creton, R., J. Kreiling, L. Jaffe. 1999. Calcium Imaging with Luminescent Indicators. Microscopy Research and Technique 46:390-397.
Srimal, S., J. Kreiling, J. Quigley, P. Armstrong, N. Wainwright. 1996. Antimicrobial Activity of Limulus Blood: Role of C-Reactive Protein (CRP) and Limulus Anti-Lipopolysaccharide Factor (LALF). Biol Bull 191: 300-301.
Goldstein,S., N. Charon, J. Kreiling. 1994. Borrelia burgdorferi Swims with a Planar Waveform Similar to those of Eukaryotic Flagella. Proc Nat Acad Sci 91: 3433-37.
Charon, N., S. Goldstein, S. Block, K. Curci, J. Ruby, J. Kreiling, R. Limberger. 1992. Morphology and Dynamics of Protruding Spirochete Periplasmic Flagella. J Bacteriol 174: 832-840.
Stevenson, J., J. Kreiling, R. Taylor. 1989. Effects of Corticosterone on Responses of Murine Splenic B and T Cells to Phytohemagglutinin, Concanavalin A, and Lipopolysaccharide. Immun Invest 18: 951-960.
| Year | Degree | Institution |
|---|---|---|
| 1994 | PhD | West Virginia University |
| 1988 | BS | Kent State University |
Mentored Research Scientist Development Award (K01), NIA, 2011-2017.
NIA Summer Training Course in Experimental Aging Research, Buck Institute for Aging Research,
Keck Fellowship. Albert Einstein College of Medicine, Bronx, NY, 1995.
Zeiss Summer Fellowship. Marine Biological Laboratory. Woods Hole, MA, 1993.
Scholarship Microbial Diversity Course, Marine Biological Laboratory, Woods Hole, 1993.
Invited participant at the NIH Conference on Lyme Disease, Cold Spring Harbor, NY. 1993.
American Society for Microbiology Allegheny Branch, 2nd place in research competition, 1992.
Graduated Summa Cum Laude with Departmental Honors, Kent State University, 1988.
Phi Beta Kapp, Kent State University. Awarded in junior year. 1987.
| Name | Title |
|---|---|
| Creton, Robbert | Professor of Medical Science (Research), Professor of Pathology and Laboratory Medicine (Research) |
| Neretti, Nicola | Associate Professor of Molecular Biology, Cell Biology, and Biochemistry, Associate Director for the Center on the Biology of Aging |
| Sedivy, John | Hermon C. Bumpus Professor of Biology, Associate Dean and Director, Center for the Biology of Aging |
