Dr. Simeral is a Assistant Professor of Engineering (Research) at Brown University, a Research Biomedical Engineer with the Department of Veterans Affairs Rehabilitation R&D Service, and leader of the focus area Restoring Communication and Mobility in the VA Center for Neurorestoration and Neurotechnology. His research is dedicated to integrating neuroscience and engineering disciplines to create unprecedented neural prosthetic technologies to enable communication and control of assistive devices by individuals with paralysis or locked-in syndrome resulting from spinal cord injury, ALS (Lou Gehrig's disease), stoke and other neurological disorders. He directs development of the system architecture, hardware and software for the BrainGate Neural Interface System (in clinical trial, IDE) that decodes intracortical brain signals into commands to control computer cursors, dexterous prosthetic robotic arms and hands, and other assistive technologies. In addition to research expertise in the neurophysiological basis of movement, Dr. Simeral has a decade of industry engineering experience including the design of massively parallel computer systems and high performance microelectronic VLSI microprocessors.
|Masse, Nicolas Y., Jarosiewicz, Beata, Simeral, John D., Bacher, Daniel, Stavisky, Sergey D., Cash, Sydney S., Oakley, Erin M., Berhanu, Etsub, Eskandar, Emad, Friehs, Gerhard, Hochberg, Leigh R., Donoghue, John P. Reprint of “Non-causal spike filtering improves decoding of movement intention for intracortical BCIs”. Journal of Neuroscience Methods. 2015; 244 : 94-103.|
|Vogel, Joern, Haddadin, Sami, Simeral, John D., Stavisky, Sergey D., Bacher, Daniel, Hochberg, Leigh R., Donoghue, John P., van der Smagt, Patrick Continuous Control of the DLR Light-Weight Robot III by a Human with Tetraplegia Using the BrainGate2 Neural Interface System. Experimental Robotics. 2014; : 125-136.|
|Bacher, D., Jarosiewicz, B., Masse, N. Y., Stavisky, S. D., Simeral, J. D., Newell, K., Oakley, E. M., Cash, S. S., Friehs, G., Hochberg, L. R. Neural Point-and-Click Communication by a Person With Incomplete Locked-In Syndrome. Neurorehabilitation and Neural Repair. 2014; 29 (5) : 462-471.|
|Masse, Nicolas Y., Jarosiewicz, Beata, Simeral, John D., Bacher, Daniel, Stavisky, Sergey D., Cash, Sydney S., Oakley, Erin M., Berhanu, Etsub, Eskandar, Emad, Friehs, Gerhard, Hochberg, Leigh R., Donoghue, John P. Non-causal spike filtering improves decoding of movement intention for intracortical BCIs. Journal of Neuroscience Methods. 2014; 236 : 58-67.|
|Thompson, David E, Quitadamo, Lucia R, Mainardi, Luca, Laghari, Khalil ur Rehman, Gao, Shangkai, Kindermans, Pieter-Jan, Simeral, John D, Fazel-Rezai, Reza, Matteucci, Matteo, Falk, Tiago H, Bianchi, Luigi, Chestek, Cynthia A, Huggins, Jane E Performance measurement for brain–computer or brain–machine interfaces: a tutorial. J. Neural Eng.. 2014; 11 (3) : 035001.|
|Ajiboye, A. B., Simeral, J. D., Donoghue, J. P., Hochberg, L. R., Kirsch, R. F. Prediction of Imagined Single-Joint Movements in a Person With High-Level Tetraplegia. IEEE Transactions on Biomedical Engineering. 2012; 59 (10) : 2755-2765.|
|Hochberg LR, Bacher D, Jarosiewicz B, Masse NY, Simeral JD, Vogel J, Haddadin S, Liu J, Cash SS, van der Smagt P, Donoghue JP Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. J. Geophys. Res.. 2012; 485 (7398) : 372-5.|
|Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia.. J. Neural Eng.. 2011; 8 (3) : 034003.|
|Simeral JD, Kim SP, Black MJ, Donoghue JP, Hochberg LR Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array.. J. Neural Eng.. 2011; 8 (2) : 025027.|
|Sung-Phil Kim, None, Simeral, John D, Hochberg, Leigh R, Donoghue, J P, Friehs, G M, Black, Michael J Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.. IEEE Trans. Neural Syst. Rehabil. Eng.. 2011; 19 (2) : 193-203.|
|Song, Y.-K., Borton, D.A., Park, S., Patterson, W.R., Bull, C.W., Laiwalla, F., Mislow, J., Simeral, J.D., Donoghue, J.P., Nurmikko, A.V. Active Microelectronic Neurosensor Arrays for Implantable Brain Communication Interfaces. IEEE Trans. Neural Syst. Rehabil. Eng.. 2009; 17 (4) : 339-345.|
|Yoon-Kyu Song, None, Patterson, William R., Bull, Christopher W., Borton, David A., Nurmikko, Arto V., Simeral, John D., Donoghue, John P. A neural interface microsystem with all optical telemetry for brain implantable neuroengineering application. 2008 Conference on Lasers and Electro-Optics. 2008;|
|Song, Y.-K., Borton, D. A., Park, S., Patterson, W. R., Bull, C. W., Mislow, J., Simeral, J., Donoghue, J. P., Nurmikko, A. V. Microelectronic neurosensor arrays: Towards implantable brain communication interfaces. 2008 IEEE International Electron Devices Meeting. 2008;|
|Kim, Sung-Phil, Simeral, John D, Hochberg, Leigh R, Donoghue, John P, Black, Michael J Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.. J. Neural Eng.. 2008; 5 (4) : 455-476.|
|Song, Yoon-Kyu, Patterson, William R., Bull, Christopher W., Borton, David A., Li, Yanqiu, Nurmikko, Arto V., Simeral, John D., Donoghue, John P. A Brain Implantable Microsystem with Hybrid RF/IR Telemetry for Advanced Neuroengineering Applications. 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2007;|
|Kim, Sung-Phil, Simeral, John D., Hochberg, Leigh R., Donoghue, John P., Friehs, Gerhard M., Black, Michael J. Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia. 2007 3rd International IEEE/EMBS Conference on Neural Engineering. 2007;|
|Song YK, Patterson WR, Bull CW, Beals J, Hwang N, Deangelis AP, Lay C, McKay JL, Nurmikko AV, Fellows MR, Simeral JD, Donoghue JP, Connors BW Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications.. IEEE Trans. Neural Syst. Rehabil. Eng.. 2005; 13 (2) : 220-226.|
Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue, JP, Hochberg LR, Kirsch RF. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. The Lancet, 2017.
Heelan C, Komar J, Vargas-Irwin CE, Simeral JD, Nurmikko AV. A mobile embedded platform for high performance neural signal computation and communication. IEEE Biomedical Circuits and Systems Conference (BioCAS) 2015. Atlanta, GA. 2015
Jarosiewicz B, Bacher D, Sarma AA, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Cash SS, Eskandar E, Friehs G, Shenoy KV, Henderson JM, Donoghue JP, Hochberg LR. Virtual typing by people with tetraplegia using a stabilized, self-calibrating intracortical brain-computer interface. Science Translational Medicine, 7(313):313ra179, 2015.
Gilja V*, Pandarinath C*, Blabe CH, Nuyujukian P, Simeral JD, Sarma AA, Sorice BL, Perge JA, Jarosiewicz B, Eskandar EN, Hochberg LR, Shenoy KV**, Henderson JM**. Clinical translation of a high performance neural prosthesis. Nature Medicine 21:1142-1145, 2015.
Vogel J, Haddadin S, Simeral JD, Bacher D, Jarosiewicz B, Hochberg LR, Donoghue JP, van der Smagt P. An assistive decision and control architecture for force-sensitive hand-arm systems driven via human-machine interfaces. Intl. J. of Robotics Research, 34(6): 763-780, 2015.
Hochberg LR, *Bacher D., *Jarosiewicz B, *Masse NY, *Simeral JD, Vogel J, Haddadin S, Liu J, Cash SS, van der Smagt P and Donoghue JP.. Reach and grasp by people with tetraplegia using a neurally-controlled robotic arm. Nature, 485(7398):372-375, 2012.
Simeral JD, Kim S-P, Black MJ, Donoghue JP and Hochberg LR. Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array. J Neural Eng, 8(2):025027, 2011.
Kim S-P, Simeral JD, Hochberg LR, Donoghue, JP, Friehs GM and Black MJ. Point-and-click cursor control with an intracortical neural interface system in humans with tetraplegia. IEEE Trans Neural Syst Rehabil Eng, 19(2):193-203, 2011.
Song YK, Borton DA, Park S, Patterson WR, Bull CW, Laiwalla F, Mislow J, Simeral JD, Donoghue JP and Nurmikko AV. Active microelectronic neurosensor arrays for implantable brain communications interfaces. IEEE Trans Neural Systems and Rehabil Eng, 17(4):339-45, 2009.
Kim S-P, Simeral JD, Hochberg LR, Donoghue JP and Black MJ. Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia. J Neural Eng 5(4):455-76, 2008.
Song YK, Patterson WR, Bull CW, Borton DA, Li Y, Nurmikko AV, Simeral JD and Donoghue JP. A brain implantable microsystem with hybrid RF/IR telemetry for advanced neuroengineering applications. Conf Proc IEEE Eng med Biol Soc, 2007, 445-8, 2007.
Simeral JD, Hampson RE, Deadwyler SA. Behaviorally relevant neural codes in hippocampal ensembles: Detection on single trials Synaptic Plasticity: From Basic Mechanisms to Clinical Applications. ed Baudry M and Schreiber S (Cambridge: MIT Press) pp 459-476. 2005.
Hampson RE, Simeral JD and Deadwyler SA. Distribution of spatial and nonspatial information in dorsal hippocampus. Nature, 402:610-614, 1999.
|2003||PhD||Wake Forest University|
|1989||MS||University of Texas|
System and Method for Mobile Medical Monitoring, US2015/025595, pending 
ECL-to-CMOS Converter, Canadian # 1,304,459 [June 30, 1992]
ECL-to-CMOS Converter, United States # 4,888,501 [June 18, 1990]
Israel Brain Technologies B.R.A.I.N. prize international competition, 2013. Co-awardee with D. Rosler, A. Nurmikko, J. Donoghue and L. Hochberg.
Martin Research Prize for Excellence in Basic Research, 2012, by Massachusetts General Hospital for “Reach and grasp by people with tetraplegia using a neurally-controlled robotic arm,” Nature, 2012.
Journal of Neural Engineering "Most cited publication for 2010-2011" for Simeral et al. (2011) "Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array".
"Highlights of 2011" award by Journal of Neural Engineering for Simeral et al. (2011) publication "Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array", based on 'the highest praise from our international referees and the highest number of downloads.
|Borton, David||Assistant Professor of Engineering|
|Donoghue, John||Henry Merritt Wriston Professor of Neuroscience|
|Hochberg, Leigh||Professor of Engineering|
|Nurmikko, Arto||L. Herbert Ballou University Professor of Engineering, Professor of Physics|
|Rosler, David||Senior Research Associate in Engineering|
2006 Consultant, Biomedical Engineering
Cyberkinetics Neurotechnology Systems, Inc
1993-1995 Senior Principal Engineer, Project Leader
Global Information Solutions Development
Rancho Bernardo, CA
1990-1993 Principal Engineer, Memory subsystem and ASIC VLSI design
Joint Development Organization of Teradata and NCR
Torrey Pines, CA
1987-1990 Engineer, Custom VLSI CPU design
Rancho Bernardo, CA
1986-1987 Research Assistant, VLSI multichip module development
Microelectronics and Computer Technology Corporation (MCC)
1988-present Senior Member, IEEE
1996-present Society for Neuroscience, member (SFN)
1996-present Engineering in Medicine and Biology Society, member (IEEE EMBS)
1999-2010 American Association for the Advancement of Science, member (AAAS)
2006 Founding member, IEEE EMBS, Providence Chapter
2007-present Biomedical Engineering Society, member (BMES)
2015-present Founding member, BCI Society
Transforming Society - Technology and Choices for the Future [2014-present]
School of Engineering
Deptartment of Biology
Deptartment of Neuroscience
Cognitive Neuroscience [2006-2007]
Deptartment of Neuroscience
Neuroanatomy with gross neuroanatomy lab [2005-2007]
(Introductory series for first-year medical students)
Brown University School of Medicine
Microelectronics Systems 
Electrical & Computer Engineering Dept.
University of California San Diego
Electronics Design Laboratory 1985-1986 (Teaching Assistant)
(Required core course for for Juniors in ECE)
Department of Electrical and Computer Engineering
University of Texas at Austin