Sharon Rounds MD is Professor of Medicine and of Pathology and Laboratory Medicine at Brown Medical School and staff pulmonary/critical care physician at the Providence VA Medical Center. A native of Maine, Dr. Rounds is a graduate of Wellesley College and of Tufts University School of Medicine. She trained in internal medicine at the University of California-San Francisco where she was a Chief Medical Resident at San Francisco General Hospital. Dr. Rounds did a Pulmonary/Critical Care fellowship at the University of Colorado where she was a research fellow in the Cardiovascular-Pulmonary Research Laboratory. She subsequently returned to New England where she was an Assistant, then Associate, Professor of Medicine in the Pulmonary Section at Boston University School of Medicine. Dr. Rounds was appointed Associate Professor of Medicine at Brown Medical School in 1987 and Professor of Medicine in 1994. She was Associate Dean of Medicine (Faculty Affairs) at Brown Medical School from 2001-2006. She was Chief of the Medical Service at the Providence VA Medical Center from 2006-2015. She is now Associate Dean for Clinical Affairs at the Warren Alpert Medical School of Brown University.
Dr. Rounds has combined careers in clinical pulmonary/critical care medicine, teaching, and research on the pulmonary circulation. Basic science research interests include mechanisms of endothelial cell injury and effects of post-translational processing on small GTPase function. Her clinical research interests are pulmonary hypertension and factors impairing compliance with therapy of lung diseases. An author of over 100 publications, she has been continuously supported by research grants from the NIH and/or VA since 1981.
Dr. Rounds was Principal Investigator for the Short-Term Training Program to Increase Diversity in Health-Related Research Training Grant awarded to Brown by the National Heart Lung Blood Institute from 1999-2012. This grant funds summer research experiences for under-represented undergraduate students in research laboratories at Brown Medical School. Dr. Rounds was co-Director of the Brown CardioPulmonary Research Training Program, a $2.5 million program that trained young investigators in Cardiovascular and Pulmonary Molecular Pathobiology or Health Services/Outcomes research. She is currently multi-PI on the Brown Reapiratory Research Training Program, funded by a T32 from the NHLBI. Dr. Rounds is a member of the Executive Committee for the T35 grant to fund summer research experiences for Brown medical students.
Dr. Rounds is PI of the CardioPulmonary Vascular Biology Center for Biomedical Research Excellence (CPVB COBRE). This multi-investigator grant builds vascular biology expertise in Rhode Island and involves cores and investigators from the Providence VAMC, Rhode Island Hospital, and Brown University.
Dr. Rounds has served as a regular member of NIH study sections--Respiratory and Applied Physiology, Lung Biology and Pathology, and Respiratory Integrative Biology and Translational --as well as on numerous panels and advisory groups. She has served as a member of the VA Career Development Review Committee and the VA Cardiopulmonary Medical Research Advisory Group. Long interested in career development, she has served on study sections for career development grants for the American Lung Association, the VA, the American Heart Association, the NHLBI, the Francis Family Foundation, the American Thoracic Society, and as a member of the NHLBI Institutional Training Grant Review Committee. Dr. Rounds currently chairs the Observational Study Board for PVDOMICS study for the NHLBI, and she is currently a regular member of the Respiratory Integrative Biology Translational (RIBT) study section.
Dr. Rounds has been an active volunteer for the American Thoracic Society and was President in 2004-05. In her work for the ATS, she has been a leader in the Women's Mentoring Program and founded a program for Minority Trainee Travel Awards. She led planning for the ATS centennial celebration in 2004-05. Dr. Rounds chaired the ATS Scientific Advisory Committee, and as such she was responsible for raising funds, administering, and reviewing applications for a research program totaling $4 Million in 2008-09. She currently serves on the Board of Trustees of the ATS Foundation. She is series editor for the Springer/ATS Respiration book series and an Associate Editor for Phsysiological Reports, an open access journal sponsored by the American Physiological Society and The Physiological Society.
I recognition of liflong achievements in clinical care, research, and education in the area of pulmonary/critical care medicine, Dr. Rounds was named Edward Livingston Trudeau Medalist by the American Thoracic Society in May, 2017.
|Sakhatskyy P, Wang Z, Borgas D, Lomas-Neira J, Chen Y, Ayala A, Rounds S, Lu Q Double-hit mouse model of cigarette smoke priming for acute lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology/AJP: Lung Cellular and Molecular Physiology. 2017; 312 (1) : ajplung.00436.2016.|
|Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.. AJP: Lung Cellular and Molecular Physiology. 2017; 312 (5) : ajplung.00393.2016.|
|Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L Enhancing Insights into Pulmonary Vascular Disease (PVD) Through a Precision Medicine Approach. A Joint NHLBI-CMREF Workshop Report.. Am J Respir Crit Care Med. 2017;|
|Borgas, Diana, Chambers, Eboni, Newton, Julie, Ko, Junsuk, Rivera, Stephanie, Rounds, Sharon, Lu, Qing Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. American Journal of Respiratory Cell and Molecular Biology/American Journal of Respiratory Cell and Molecular Biology. 2016; 54 (5) : 683-96.|
|Okereke, Ikenna C., Bates, Maria F., Jankowich, Matthew D., Rounds, Sharon I., Kimble, Brian A., Baptiste, Janelle V., Ng, Thomas T., Nici, Linda L. Effects of Implementation of Lung Cancer Screening at One Veterans Affairs Medical Center.. Chest/CHEST Journal. 2016; 150 (5) : 1023-1029.|
|Dweik RA, Rounds S, Erzurum SC, Archer S, Fagan K, Hassoun PM, Hill NS, Humbert M, Kawut SM, Krowka M, Michelakis E, Morrell NW, Stenmark K, Tuder RM, Newman J, ATS Committee on Pulmonary Hypertension Phenotypes An official American Thoracic Society Statement: pulmonary hypertension phenotypes.. Am J Respir Crit Care Med. 2014; 189 (3) : 345-55.|
|Sakhatskyy P, Gabino Miranda GA, Newton J, Lee CG, Choudhary G, Vang A, Rounds S, Lu Q Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α.. Microvascular Research. 2014; 94 : 80-9.|
|Schraufnagel, Dean E., Rounds, Sharon Gordon l. Snider, M.D., 1922–2013. Annals of the American Thoracic Society. 2013; 10 (5) : 557-557.|
|Aliotta JM, Pereira M, Amaral A, Sorokina A, Igbinoba Z, Hasslinger A, El-Bizri R, Rounds SI, Quesenberry PJ, Klinger JR Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.. Cardiovascular research. 2013; 100 (3) : 354-62.|
|Maron BA, Goldstein RH, Rounds SI, Shapiro S, Jankowich M, Garshick E, Moy ML, Gagnon D, Choudhary G Study design and rational for investigating phosphodiesterase type 5 inhibition for the treatment of pulmonary hypertension due to chronic obstructive lung disease: the TADA-PHiLD (TADAlafil for Pulmonary Hypertension associated with chronic obstructive Lung Disease) trial. 2013. 2013; 3 (4) : 889-897.|
|Lu Q, Sakhatskyy P, Newton J, Shamirian P, Hsiao V, Curren S, Gabino Miranda GA, Pedroza M, Blackburn MR, Rounds S Sustained adenosine exposure causes lung endothelial apoptosis: a possible contributor to cigarette smoke-induced endothelial apoptosis and lung injury.. AJP: Lung Cellular and Molecular Physiology. 2013; 304 (5) : L361-70.|
|Sakhatskyy, Pavlo, Newton, Julie, Vang, Alexander, Choudhary, Gaurav, Rounds, Sharon I.S., Lu, Qing Apoptosis Potential Is Associated With Susceptibility To Cigarette Smoke-Induced Emphysema. C64. PULMONARY VASCULAR STRUCTURE, FUNCTION, AND SIGNALING. 2012;|
|Sakhatskyy, Pavlo, El-Bizri, Rabih, Aliota, Jason, Rounds, Sharon I.S., Lu, Qing Circulating Microparticles As An Early Marker Of Cigarette Smoke Injury In A Mouse Model. D60. HEALTH EFFECTS OF SMOKING. 2012;|
|Jankowich MD, Rounds SI Combined pulmonary fibrosis and emphysema syndrome: a review.. CHEST Journal. 2012; 141 (1) : 222-31.|
|Lu Q, Rounds S Focal adhesion kinase and endothelial cell apoptosis.. Microvascular Research. 2012; 83 (1) : 56-63.|
|Chichger H, Grinnell KL, Casserly B, Chung CS, Braza J, Lomas-Neira J, Ayala A, Rounds S, Klinger JR, Harrington EO Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury.. AJP: Lung Cellular and Molecular Physiology. 2012; 303 (10) : L880-8.|
|Grinnell K, Duong H, Newton J, Rounds S, Choudhary G, Harrington EO Heterogeneity in apoptotic responses of microvascular endothelial cells to oxidative stress.. Journal of cellular physiology. 2012; 227 (5) : 1899-910.|
|Grinnell, Katie L., Duong, Huetran, Rudlaff, Rachel, Rounds, Sharon I.S., Harrington, Elizabeth O. Oxidative Stress In The Endothelium: To Live Or To Die?. C64. PULMONARY VASCULAR STRUCTURE, FUNCTION, AND SIGNALING. 2012;|
|Chichger, Havovi, Grinnell, Katie L., Casserly, Brian, Duong, Huetran, Braza, Julie, Chung, Chun-Shiang, Lomas, Joanne, Ayala, Alfred, Rounds, Sharon I.S., Klinger, James R., Harrington, Elizabeth O. The Protective Role Of Protein Kinase Cd (PKCd) In LPS-Induced Pulmonary Edema. D27. SIGNALING MOLECULES INVOLVED IN PULMONARY ENDOTHELIAL INJURY AND REPAIR. 2012;|
|Lu, Qing, Newton, Julie, Harrington, Elizabeth O., Rounds, Sharon Adenosine Enhances Endothelial Barrier Function Via Alteration Of Small Gtpases. A61. LUNG ENDOTHELIUM FUNCTIONS: THE BARRIER AND BEYOND. 2011;|
|Yoder M, Rounds S Bad blood, bad endothelium: ill fate?. Blood. 2011; 117 (13) : 3479-80.|
|Casserly B, Mazer JM, Vang A, Harrington EO, Klinger JR, Rounds S, Choudhary G C-type natriuretic peptide does not attenuate the development of pulmonary hypertension caused by hypoxia and VEGF receptor blockade.. Life sciences. 2011; 89 (13-14) : 460-6.|
|Lu, Qing, Newton, Julie, Sakhatskyy, Pavlo, Al-Qadi, Mazen O., Grinnell, Katie L., Ortiz, Melanie, Harrington, Elizabeth O., Rounds, Sharon Cigarette Smoke Causes Lung Endothelial Barrier Dysfunction And Apoptosis Through Oxidative Stress-Mediated Loss Of FAK And RhoA Activities. A61. LUNG ENDOTHELIUM FUNCTIONS: THE BARRIER AND BEYOND. 2011;|
|Lu Q, Sakhatskyy P, Grinnell K, Newton J, Ortiz M, Wang Y, Sanchez-Esteban J, Harrington EO, Rounds S Cigarette smoke causes lung vascular barrier dysfunction via oxidative stress-mediated inhibition of RhoA and focal adhesion kinase.. AJP: Lung Cellular and Molecular Physiology. 2011; 301 (6) : L847-57.|
|Grinnell, Katie L., Duong, Huetran, Newton, Julie, Rounds, Sharon, Choudhary, Gaurav, Harrington, Elizabeth O. Differences In PKCd Expression Cause Heterogeneic Responses Of Lung And Heart Microvascular Endothelial Cells To Oxidant-Induced Apoptosis. A61. LUNG ENDOTHELIUM FUNCTIONS: THE BARRIER AND BEYOND. 2011;|
|Lu, Qing, Newton, Julie, Blackburn, Michael, Rounds, Sharon Prolonged Adenosine Exposure Increases Lung Endothelial Permeability Via RAC1-Mediated Oxidative Stress. A61. LUNG ENDOTHELIUM FUNCTIONS: THE BARRIER AND BEYOND. 2011;|
|Lu Q, Harrington EO, Newton J, Casserly B, Radin G, Warburton R, Zhou Y, Blackburn MR, Rounds S Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement.. AJP: Lung Cellular and Molecular Physiology/AJP: Lung Cellular and Molecular Physiology. 2010; 298 (6) : L755-L767.|
|Lu Q, Jankowich M, Newton J, Harrington EO, Rounds S Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis.. AJP: Lung Cellular and Molecular Physiology. 2010; 298 (4) : L501-8.|
|Lu, Qing, Newton, Julie, Ortiz, Melanie, Kang, Min-Jong, Lee, Chun Geun, Elias, Jack A., Harrington, Elizabeth O., Rounds, Sharon I.S. Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Activation Of Unfolded Protein Response And Autophagy. B60. REGULATION OF THE ENDOTHELIUM: BARRIER FUNCTION AND ENDOTHELIAL CELL INTEGRITY. 2010;|
|Lu, Qing, Newton, Julie, Kang, Min-Jong, Lee, Chun Geun, Elias, Jack A., Harrington, Elizabeth O., Rounds, Sharon I.S. Cigarette Smoke Causes Lung Vascular Endothelial Cell Apoptosis And Alterations Of TGF-²1 Signaling. B60. REGULATION OF THE ENDOTHELIUM: BARRIER FUNCTION AND ENDOTHELIAL CELL INTEGRITY. 2010;|
|Lu, Qing, Newton, Julie, Gabino-Miranda, Gustavo, Ortiz, Melanie, Harrington, Elizabeth O., Rounds, Sharon I.S. Cigarette Smoke Extract Increases Lung Endothelial Permeability Through Oxidative Stress-mediated Alterations Of Small GTPases. B60. REGULATION OF THE ENDOTHELIUM: BARRIER FUNCTION AND ENDOTHELIAL CELL INTEGRITY. 2010;|
|Jankowich MD, Rounds S Combined pulmonary fibrosis and emphysema alters physiology but has similar mortality to pulmonary fibrosis without emphysema.. Lung. 2010; 188 (5) : 365-73.|
|Rounds S Innovative approaches to healthcare delivery at the Providence VA Medical Center.. Medicine and health, Rhode Island. 2010; 93 (1) : 6-7.|
|Rounds S Overview of the Providence VA Medical Center.. Medicine and health, Rhode Island. 2010; 93 (1) : 4-5.|
|Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW 2nd, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.. Am J Respir Crit Care Med. 2010; 182 (12) : 1554-62.|
|Jankowich, MD, Rounds, SI Combined Pulmonary Fibrosis and Emphysema (CPFE) Is Common in Hospitalized Veterans with Pulmonary Fibrosis (PF) and Results in a Unique Clinical Phenotype.. B38. CLINICAL ASPECTS OF ILD. 2009;|
|Lu, Q, Mazer, J, Choudhary, G, Harrington, EO, Rounds, S Imbalance of TGF-β1 Signaling Promotes Pulmonary Microvascular Endothelial Cell Proliferation: Implications for Formation of Plexiform Lesions in PAH.. A51. EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION. 2009;|
|Harrington, EO, Duong, H, Newton, J, Choudhary, G, Rounds, S Lung Microvascular Endothelial Cells Are More Susceptible to Reactive Oxygen Species-Induced Apoptosis Via p38.. D96. BUILDING A FIREWALL: ENDOTHELIAL BARRIER DYSFUNCTION. 2009;|
|Lu, Q, Radin, G, Newton, J, Rounds, S Pentostatin Enhances Endothelial Baseline Barrier Function through Rac-1 Activation.. D96. BUILDING A FIREWALL: ENDOTHELIAL BARRIER DYSFUNCTION. 2009;|
|Lu Q, Patel B, Harrington EO, Rounds S Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.. AJP: Lung Cellular and Molecular Physiology. 2009; 296 (5) : L825-38.|
|Martin K, Stanchina M, Kouttab N, Harrington EO, Rounds S Circulating endothelial cells and endothelial progenitor cells in obstructive sleep apnea.. Lung. 2008; 186 (3) : 145-50.|
|Jankowich MD, Polsky M, Klein M, Rounds S Heterogeneity in combined pulmonary fibrosis and emphysema.. Respiration; international review of thoracic diseases. 2008; 75 (4) : 411-7.|
|Rounds S, Lu Q, Harrington EO, Newton J, Casserly B Pulmonary endothelial cell signaling and function.. Transactions of the American Clinical and Climatological Association. 2008; 119 : 155-67; discussion 167-9.|
|Lu Q, Harrington EO, Newton J, Jankowich M, Rounds S Inhibition of ICMT induces endothelial cell apoptosis through GRP94.. American Journal of Respiratory Cell and Molecular Biology. 2007; 37 (1) : 20-30.|
|Almenoff P, Sales A, Rounds S, Miller M, Schroeder K, Lentz K, Perlin J Intensive care services in the Veterans Health Administration.. CHEST Journal. 2007; 132 (5) : 1455-62.|
|Martin KB, Klinger JR, Rounds SI Pulmonary arterial hypertension: new insights and new hope.. Respirology (Carlton, Vic.). 2006; 11 (1) : 6-17.|
|Harrington EO, Stefanec T, Newton J, Rounds S Release of soluble E-selectin from activated endothelial cells upon apoptosis.. Lung. 2006; 184 (5) : 259-66.|
|Lu Q, Harrington EO, Jackson H, Morin N, Shannon C, Rounds S Transforming growth factor-beta1-induced endothelial barrier dysfunction involves Smad2-dependent p38 activation and subsequent RhoA activation.. Journal of Applied Physiology. 2006; 101 (2) : 375-84.|
|Lu Q, Harrington EO, Rounds S Apoptosis and lung injury.. The Keio journal of medicine. 2005; 54 (4) : 184-9.|
|Rounds, Sharon I.S. Evidence for Expanding Physician Supply. Annals of Internal Medicine. 2005; 142 (6) : 473.|
|Rounds SI, Angus DC Evidence for expanding physician supply.. Annals of Internal Medicine. 2005; 142 (6) : 473-4; author reply 474.|
|Harrington EO, Newton J, Morin N, Rounds S Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium.. AJP: Lung Cellular and Molecular Physiology. 2004; 287 (6) : L1091-7.|
|Lu Q, Harrington EO, Hai CM, Newton J, Garber M, Hirase T, Rounds S Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation.. Circulation research. 2004; 94 (3) : 306-15.|
|Kramer K, Harrington EO, Lu Q, Bellas R, Newton J, Sheahan KL, Rounds S Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.. Molecular biology of the cell. 2003; 14 (3) : 848-57.|
|Harrington EO, Brunelle JL, Shannon CJ, Kim ES, Mennella K, Rounds S Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function.. American Journal of Respiratory Cell and Molecular Biology. 2003; 28 (5) : 626-36.|
|Poppas A, Rounds S Congestive heart failure.. Am J Respir Crit Care Med. 2002; 165 (1) : 4-8.|
|Bellas RE, Harrington EO, Sheahan KL, Newton J, Marcus C, Rounds S FAK blunts adenosine-homocysteine-induced endothelial cell apoptosis: requirement for PI 3-kinase.. AJP: Lung Cellular and Molecular Physiology. 2002; 282 (5) : L1135-42.|
|Russo-Magno P, O'Brien A, Panciera T, Rounds S Compliance with CPAP therapy in older men with obstructive sleep apnea.. Journal of the American Geriatrics Society. 2001; 49 (9) : 1205-11.|
|Koutkia P, Mylonakis E, Rounds S, Erickson A Cutaneous leucocytoclastic vasculitis associated with oxacillin.. Diagnostic microbiology and infectious disease. 2001; 39 (3) : 191-4.|
|O'Brien A, Russo-Magno P, Karki A, Hiranniramol S, Hardin M, Kaszuba M, Sherman C, Rounds S Effects of withdrawal of inhaled steroids in men with severe irreversible airflow obstruction.. Am J Respir Crit Care Med. 2001; 164 (3) : 365-71.|
|Koutkia P, Mylonakis E, Rounds S, Erickson A Leucocytoclastic vasculitis: an update for the clinician.. Scandinavian journal of rheumatology. 2001; 30 (6) : 315-22.|
|Harrington EO, Smeglin A, Newton J, Ballard G, Rounds S Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis.. AJP: Lung Cellular and Molecular Physiology. 2001; 280 (2) : L342-53.|
|Harrington EO, Smeglin A, Parks N, Newton J, Rounds S Adenosine induces endothelial apoptosis by activating protein tyrosine phosphatase: a possible role of p38alpha.. AJP: Lung Cellular and Molecular Physiology. 2000; 279 (4) : L733-42.|
|O'Brien A, Rounds S Pulmonary hypertension update.. Comprehensive therapy. 2000; 26 (3) : 190-6.|
|Cutaia M, Tollefson K, Kroczynski J, Parks N, Rounds S Role of the Na/H antiport in pH-dependent cell death in pulmonary artery endothelial cells.. AJP: Lung Cellular and Molecular Physiology. 2000; 278 (3) : L536-44.|
|Mylonakis E, Vittorio CC, Hollik DA, Rounds S Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome.. Annals of Pharmacotherapy. 1999; 33 (5) : 557-9.|
|Rounds S, Likar LL, Harrington EO, Kim KC, Smeglin A, Heins K, Parks N Nucleotide-induced PMN adhesion to cultured epithelial cells: possible role of MUC1 mucin.. The American journal of physiology. 1999; 277 (5 Pt 1) : L874-80.|
|Muster AR, Rounds S, Cutaia M Autobullectomy: spontaneous improvements in pulmonary function and symptoms in a patient with bullous emphysema.. Medicine and health, Rhode Island. 1998; 81 (9) : 297-9.|
|Cutaia MV, Parks N, Centracchio J, Rounds S, Yip KP, Sun AM Effect of hypoxic exposure on Na+/H+ antiport activity, isoform expression, and localization in endothelial cells.. The American journal of physiology. 1998; 275 (3 Pt 1) : L442-51.|
|Rounds S, Yee WL, Dawicki DD, Harrington E, Parks N, Cutaia MV Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells.. The American journal of physiology. 1998; 275 (2 Pt 1) : L379-88.|
|Rounds S, Cutaia M, Charles A, Meharg J, Dawicki D, Oldmixon E, Kuhn C Oxidant stress stimulates Na/K pump activity in bovine pulmonary arterial endothelial cells.. CHEST Journal. 1998; 114 (1 Suppl) : 22S-24S.|
|Cutaia M, Parks N, Rounds SI, Yip KP Remodeling of the Na/H antiport and the cytoskeleton of human pulmonary artery endothelial cells: response to an oxygen deficit.. CHEST Journal. 1998; 114 (1 Suppl) : 35S.|
|Cutaia M, Dawicki DD, Papazian LM, Parks N, Clarke E, Rounds S Differences in nucleotide effects on intracellular pH, Na+/H+ antiport activity, and ATP-binding proteins in endothelial cells.. In vitro cellular & developmental biology. Animal. 1997; 33 (8) : 608-14.|
|Rounds S, Piggott D, Dawicki DD, Farber HW Effect of hypercarbia on surface proteins of cultured bovine endothelial cells.. The American journal of physiology. 1997; 273 (6 Pt 1) : L1141-6.|
|Dawicki DD, Chatterjee D, Wyche J, Rounds S Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells.. The American journal of physiology. 1997; 273 (2 Pt 1) : L485-94.|
|Likar LL, Panciera TM, Erickson AD, Rounds S Group education sessions and compliance with nasal CPAP therapy.. CHEST Journal. 1997; 111 (5) : 1273-7.|
|Charles A, Dawicki DD, Oldmixon E, Kuhn C, Cutaia M, Rounds S Studies on the mechanism of short-term regulation of pulmonary artery endothelial cell Na/K pump activity.. The Journal of laboratory and clinical medicine. 1997; 130 (2) : 157-68.|
|Cutaia M, Davis R, Parks N, Rounds S Effect of ATP-induced permeabilization on loading of the Na+ probe SBFI into endothelial cells.. Journal of Applied Physiology. 1996; 81 (1) : 509-15.|
|Parker AL, Clarke EM, Rounds S Hemoptysis in sarcoidosis: a case report.. Medicine and health, Rhode Island. 1996; 79 (9) : 328-30.|
|Parker AL, Likar LL, Dawicki DD, Rounds S Mechanism of ATP-induced leukocyte adherence to cultured pulmonary artery endothelial cells.. The American journal of physiology. 1996; 270 (5 Pt 1) : L695-703.|
|Dawicki DD, McGowan-Jordan J, Bullard S, Pond S, Rounds S Extracellular nucleotides stimulate leukocyte adherence to cultured pulmonary artery endothelial cells.. The American journal of physiology. 1995; 268 (4 Pt 1) : L666-73.|
|Rounds S, Hsieh L, Agarwal KC Effects of endotoxin injury on endothelial cell adenosine metabolism.. The Journal of laboratory and clinical medicine. 1994; 123 (2) : 309-17.|
|Agarwal KC, Clarke E, Rounds S, Parks RE Jr, Huzoor-Akbar Platelet-activating factor (PAF)-induced platelet aggregation. Modulation by plasma adenosine and methylxanthines.. Biochemical pharmacology. 1994; 48 (10) : 1909-16.|
|Bonitati AE, Agarwal KC, Rounds S A simple assay for ecto-5'-nucleotidase using intact pulmonary artery endothelial cells. Effect of endotoxin-induced cell injury.. Biochemical pharmacology. 1993; 46 (8) : 1467-73.|
|Cutaia M, Bullard SR, Rudio K, Rounds S Characteristics of amphotericin B-induced endothelial cell injury.. The Journal of laboratory and clinical medicine. 1993; 121 (2) : 244-56.|
|Meharg JV, McGowan-Jordan J, Charles A, Parmelee JT, Cutaia MV, Rounds S Hydrogen peroxide stimulates sodium-potassium pump activity in cultured pulmonary arterial endothelial cells.. The American journal of physiology. 1993; 265 (6 Pt 1) : L613-21.|
|Karlinsky JB, Rounds S, Farber HW Effects of hypoxia on heparan sulfate in bovine aortic and pulmonary artery endothelial cells.. Circulation research. 1992; 71 (4) : 782-9.|
|Charles A, Rounds S, Farber HW Neutrophil chemoattractant production by cultured serotonin-stimulated bovine and human endothelial cells.. The American journal of physiology. 1991; 261 (2 Pt 1) : L133-9.|
|Braman SS, Eby E, Kuhn C, Rounds S Primary pulmonary hypertension in the elderly.. Arch Intern Med. 1991; 151 (12) : 2433-8.|
|Villanueva AG, Farber HW, Rounds S, Goldstein RH Stimulation of fibroblast collagen and total protein formation by an endothelial cell-derived factor.. Circulation research. 1991; 69 (1) : 134-41.|
|Farber HW, Center DM, Rounds S, Danilov SM Components of the angiotensin system cause release of a neutrophil chemoattractant from cultured bovine and human endothelial cells.. European heart journal. 1990; 11 Suppl B : 100-7.|
|Farber HW, Rounds S Effect of long-term hypoxia on cultured aortic and pulmonary arterial endothelial cells.. Experimental Cell Research. 1990; 191 (1) : 27-36.|
|Cutaia M, Rounds S Hypoxic pulmonary vasoconstriction. Physiologic significance, mechanism, and clinical relevance.. CHEST Journal. 1990; 97 (3) : 706-18.|
|Farber HW, Fairman RP, Rounds S, Millan JE, Glauser FL Pulmonary hypertensive response to foreign body microemboli.. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 1990; 39 (2) : 151-7.|
|Eveloff SE, Rounds S, Braman SS Unilateral lung hyperinflation and herniation as a manifestation of intrinsic PEEP.. CHEST Journal. 1990; 98 (1) : 228-9.|
|Farber HW, Fairman RP, Millan JE, Rounds S, Glauser FL Pulmonary response to foreign body microemboli in dogs: release of neutrophil chemoattractant activity by vascular endothelial cells.. American Journal of Respiratory Cell and Molecular Biology. 1989; 1 (1) : 27-35.|
|Rounds S, Farber HW, Render ML, Barnard FA Effects of hypoxia and hypercarbia on cultured endothelial cells.. CHEST Journal. 1988; 93 (3 Suppl) : 156S-157S.|
|Render ML, Rounds S Studies on the mechanism of decreased neutrophil adherence to postconfluent cultured endothelial cells.. The American review of respiratory disease. 1988; 138 (5) : 1115-23.|
|Corral R, Hinshaw JE, Clark SB, Rounds S Chylomicron metabolism by normal and injured isolated rat lungs.. Experimental lung research. 1987; 13 (1) : 45-58.|
|Farber HW, Center DM, Rounds S Effect of ambient oxygen on cultured endothelial cells from different vascular beds.. The American journal of physiology. 1987; 253 (4 Pt 2) : H878-83.|
|Rounds S, Vaccaro CA The binding of cationic probes to apical and basal surfaces of rat lung capillary endothelium and of endothelial cells in tissue culture.. The American review of respiratory disease. 1987; 135 (3) : 725-30.|
|Farber HW, Weller PF, Rounds S, Beer DJ, Center DM Generation of, lipid neutrophil chemoattractant activity by histamine-stimulated cultured endothelial cells.. The Journal of Immunology. 1986; 137 (9) : 2918-24.|
|Farber HW, Center DM, Rounds S Bovine and human endothelial cell production of neutrophil chemoattractant activity in response to components of the angiotensin system.. Circulation research. 1985; 57 (6) : 898-902.|
|Rounds S, Farber HW, Hill NS, O'Brien RF Effects of endothelial cell injury on pulmonary vascular reactivity.. CHEST Journal. 1985; 88 (4 Suppl) : 213S-216S.|
|O'Brien RF, Makarski JS, Rounds S Studies on the mechanism of decreased angiotensin I conversion in rat lungs injured with alpha-naphthylthiourea.. Experimental lung research. 1985; 8 (4) : 243-59.|
|Brody JS, Vaccaro CA, Hill NS, Rounds S Binding of charged ferritin to alveolar wall components and charge selectivity of macromolecular transport in permeability pulmonary edema in rats.. Circulation research. 1984; 55 (2) : 155-67.|
|Rounds S, Hill NS Pulmonary hypertensive diseases.. CHEST Journal. 1984; 85 (3) : 397-405.|
|Rounds S, Brody JS Putting PEEP in perspective.. New England Journal of Medicine. 1984; 311 (5) : 323-5.|
|Hill NS, O'Brien RF, Rounds S Repeated lung injury due to alpha-naphthylthiourea causes right ventricular hypertrophy in rats.. Journal of applied physiology: respiratory, environmental and exercise physiology. 1984; 56 (2) : 388-96.|
|O'Brien RF, Seton MP, Makarski JS, Center DM, Rounds S Thiourea causes endothelial cells in tissue culture to produce neutrophil chemoattractant activity.. The American review of respiratory disease. 1984; 130 (1) : 103-9.|
|Hill NS, Rounds S Amrinone dilates pulmonary vessels and blunts hypoxic vasoconstriction in isolated rat lungs.. Proceedings of the Society for Experimental Biology and Medicine. 1983; 173 (2) : 205-12.|
|Rounds S, Hill NS, O'Brien RF Pulmonary vascular reactivity after acute lung injury.. Progress in clinical and biological research. 1983; 136 : 133-40.|
|Hill NS, Rounds S Vascular reactivity is increased in rat lungs injured with alpha-naphthylthiourea.. Journal of applied physiology: respiratory, environmental and exercise physiology. 1983; 54 (6) : 1693-701.|
|Fuchs KI, Moore LG, Rounds S Pulmonary vascular reactivity is blunted in pregnant rats.. Journal of applied physiology: respiratory, environmental and exercise physiology. 1982; 53 (3) : 703-7.|
|McMurtry IF, Rounds S, Stanbrook HS Studies of the mechanism of hypoxic pulmonary vasoconstriction.. Advances in shock research. 1982; 8 : 21-33.|
|Rounds SS, McMurtry IF, Reeves JT Glucose metabolism accelerates the decline of hypoxic vasoconstriction in rat lungs.. Respiration physiology. 1981; 44 (2) : 239-49.|
|Rounds S, McMurtry IF Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs.. Circulation research. 1981; 48 (3) : 393-400.|
|Rounds SI, Moore LG, Voelkel NF, McMurtry IF, Reeves JT Cardiac output is decreased and hypoxic vasoconstriction is intact in chronically hypoxic sheep.. Proceedings of the Society for Experimental Biology and Medicine. 1980; 165 (1) : 1-5.|
Sharon Rounds is interested in mechanisms of lung vascular injury in conditions causing pulmonary hypertension and acute lung injury. Her work focuses on the way in which endothelial cells of the lung circulation are injured. Current research focuses on the role of small GTPase post-translational processing in modulation of lung vascular permeability and apoptosis; the effects of tobacco smoke exposure on lung vascular permeability and lung endothelial cell apoptosis; and the effects of adenosine on lung vascular permeability.
She is also interested in chronic obstructive pulmonary disease and factors that impair compliance with therapy. Other clinical research interests are pulmonary hypertension and combined pulmonary fibrosis and emphysema.
VA Merit Review
“Lung Endothelial Cell Apoptosis and Emphysema”
PI: Sharon Rounds, MD
Effort: 20% VA Effort
Agency: VA BLR&D
Annual Direct Costs: $150,000
The goal of this project is to ascertain the role and mechanisms of endothelial apoptosis in cigarette smoke-induced emphysema.
VA Merit Review
“Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease”
PI: Ronald Goldstein (Sharon Rounds, co-PI)
Agency: VA Clinical Sciences R&D
Effort: 10% VA effort/1.5 cal months
Annual Direct Costs: $150,000 per year
Period of Support: 4/1/13-3/31/18
The goal of this multicenter clinical trial is to determine the effect of tadalafil on pulmonary hypertension associated with COPD.
“Endothelial Injury and Repair: CardioPulmonary Vascular Biology COBRE”
PI: Sharon Rounds
Effort: 25%/4 months
The goal of this Center grant is to improve understanding of the pathogenesis and treatment of pulmonary and cardiovascular diseases.
Annual Direct Costs: $1,987,405
Deans Emerging Areas of New Science (DEANS).
“Cigarette Smoke Effects on Mitochondria—From Flies to Lungs”
PI: David Rand (Co-PI: Sharon Rounds)
Agency: Alpert Medical School of Brown University
Annual Direct Costs: $80,000
The goal of this grant is to determine the effects of cigarette smoke on mitochondrial and nuclear gene expression changes and effects on endothelial cell and lung mitochondrial function and mitophagy.
Lu, Q*, Jankowich, MD*, Newton, J, Harrington, EO, and S. Rounds. Alterations in molecular chaperones and eIF2a during lung endothelial cell apoptosis. Am J Physiol:Lung Cell Molec Physiol. 298:501-508, 2010. *shared first authorship
Lu, Q, Harrington, EO, Newton, J, Casserly, B, Radin, G, Warburton,R, Zhou, Y, Blackburn MR, and Rounds, S. Adenosine protected against pulmonary edema through transporter- and receptor2-mediated endothelial barrier enhancement. Am J Physiol:Lung Cell Molec Physiol, 298:L755-767, 2010.
Lu, Q, Patel, B, Harrington, EO, and Rounds, S. Transforming Growth Factor-β1 Causes Pulmonary Microvascular Endothelial Cell Apoptosis via ALK5. Am J Physiol:Lung Cell Molec Physiol. 296:L825-L838, 2009.
Lu, Q, Harrington, EO, Newton, J, Jankowich, M, and S. Rounds. Inhibition of ICMT induces endothelial cell apoptosis through GRP94. Am J Resp Cell Mol Biol. 37:20-30, 2007. An illustration from this paper was Cover Image for the journal.
Lu, Q, Harrington, EO, Jackson, H, Morin, N, Shannon, C, and Rounds. S. Transforming Growth Factor-β1 -induced barrier dysfunction involves Smad-dependent p38 activation and subsequent RhoA activation. Journal of Applied Physiology. 101:375-384, 2006.
Harrington, EO, Newton, J, Morin, N, and Rounds, S. Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium. Am J Physiol:Lung Molecular Cellular Physiology. 287:L1091-L1097, 2004.
Lu Q, Harrington EO, Hai C-M, Newton J, Garber M, Rounds S. Isoprenylcysteine carboxyl methyltransferase (ICMT) modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation. Circulation Research.94:306-315, 2004.
Kramer K, Harrington EO, Bellas R, Newton J, Sheahan KL, and S. Rounds. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. Molecular Biology of the Cell, 14:848-857, 2003.
Bellas, R, Harrington, EO, Sheahan, KL, Newton, J, and S Rounds. Over-expression of focal adhesion kinase protects against adenosine/homocysteine-induced apoptosis. Am J Physiol. Lung Cell Molec Physiol. 282:L1135-L1142, 2002.
Russo-Magno, P, Karki, A, O'Brien, A, Hiranniramol, S, Hardin, M, Kaszuba, M, and S. Rounds. Effects of withdrawal of inhaled corticosteroids in patients with irreversible airflow obstruction. American J Respiratory and Critical Care Medicine, 164:365-71, 2001.
Harrington, EO, Smeglin, A, Newton, J, Ballard, G, and S Rounds. Adenosine/homocysteine-induced disruption of endothelial cell focal adhesion contacts requires protein tyrosine phosphatase and caspase activity. Am J Physiol. Lung Cell and Molec Physiol. 280:L342-L353, 2001.
Harrington, EO, Smeglin, A, Parks, N, and S. Rounds. Adenosine induces endothelial cell apoptosis by activating protein tyrosine phosphatase: a possible role of p38α. Am J Physiol. Lung Cell and Molec Physiol. 279:L733-L742, 2000.
Rounds, S, Yee WL, Dawicki, D, Parks, N, and M Cutaia. Mechanism of extracellular ATP and adenosine-induced apoptosis of cultured endothelial cells. Am J Physiol.275 (Lung Cell. Mol., Physiol. 19):L379-L388, 1998.
Likar, L., Panciera, T., Erickson, A., and S. Rounds. Group education sessions and compliance with nasal CPAP therapy. Chest.111:1273-1277, 1997.
Dawicki, D.D., Chatterjee, D., Wyche, J., and S. Rounds. ATP and adenosine cause apoptosis of pulmonary artery endothelial cells. Am J Physiol.Lung Cell. Mol. Physiol. 273:L485-L494, 1997.
•American Lung Association Training Fellowship, 1976-78
•E.L. Trudeau Fellow, American Lung Association, 1981-84
•NIH Clinical Investigator Award, 1981-1986
•Listed in "Best Doctors in America", Woodward/White, 1994, 1998, 2002, 2003, 2004. 2005, 2006, 2008, 2009, 2010, 2013
•Listed in "Best Doctors in America: Northeast Region, Woodward/White.
•Fellow, American College of Chest Physicians
•Fellow, American Heart Association
•Visiting Professor, Pulmonary Medicine, Chiba University, Chiba, Japan, May, 2004
•13th Kass Lecturer, University of Nebraska Medical Center, May, 2004
•Dr. David Cugell Lecturer, Department of Medicine, Feinberg School of Medicine, Northwestern University, February 8, 2005
*Visiting Professor, Keio University, Tokyo, Japan, March, 2005
•Visiting Professor, University of Hawaii, March, 2007
•Dr. Thomas A. Neff Lecturer, University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine, April, 2007
•Visiting Professor, University of South Alabama, Lung Biology Center, March, 2008
•Inkley Lecturer and Visiting Professor, Case Western Reserve University, March, 2009
•Scientific Achievement Award, American Thoracic Society, May, 2009
•Frumkin Lecturer, Norwalk Hospital, Norwalk CT, March, 2010
•Visiting Professor, Pulmonary/Critical Care and Department of Physiology, University of Illinois-Chicago, September, 2010
•Roland Ingram, Jr, MD, Memorial Lecturer, Pulmonary/Allergy/Critical Care Division, Emory University, October, 2010
•Visiting Professor, Department of Medicine Grand Rounds, Pulmonary/Critical Care Grand Rounds, University of Alabama-Birmingham, March, 2011
• Tisdale Visiting Professor, University of Vermont School of Medicine, Medical Grand Rounds, September, 2011
•Elected to Colorado Pulmonary Hall of Fame, 2014
*Visiting Professor, University of Chicago, December, 2014
*Visiting Professor, Department of Physiology, University of Tennessee, April, 2015
*Visiting Professor, Department of Internal Medicine, Univesity of South Florida, Tampa, FLA, December 5, 2015.
*Invited speaker, Pulmonary Center, Boston University School of Medicine, January 31, 2016.
•Visting Distinguished Scientist, Department of Cell and Molecular Physiology, Albany Medical College, October, 2016.
•Edward Livingston Trudeau Medal, American Thoracic Society, May, 2017.
•Robert M. Rogers Lectureship, University of Pittsburgh Pulmonary Allergy Critical Came Medicine, June 9, 2017.
Dean’s Teaching Excellence Award, 2001-02
Dean’s Teaching Excellence Award, 2002-03
Dean’s Teaching Excellence Award, 2003-04
Dean’s Teaching Excellence Award, 2005-06
Dean’s Teaching Excellence Award, 2006-07
Certificate of Recognition for Exemplary Teaching, Alpert Medical School, 2009, 2010, 2011, 2012
Beckwith Teaching Award, Department of Medicine, Warren Alpert Medical School, 2011
•Outstanding Mentor Award. Brown University/Women and Infants Hospital, Center of Excellence in Women’s Health, February, 2006
•Elizabeth A. Rich, MD, Award, American Thoracic Society, May, 2010 “for outstanding mentoring and service to the ATS”
•Dean’s Award for the Advancement of Women Faculty, November, 2011
•Federal Employee of the Year, Professional Category, RI, 1999
•Federal Employee of the Year, Bud Gifford Leadership Award, awarded by the Federal Executive Council of RI, May, 2004
•Rhode Island Woman Physician of the Year, RI Medical Women’s Association, May, 2010
•Leadership Award, Pulmonary Circulation Assembly, American Thoracic Society, May, 2011
•EL Trudeau Medal from the American Thoracic Society for lifelong contributions to clinical care, resaerch and education in Pulmonary/Critical Care/Sleep Medicine
|Aliotta, Jason||Assistant Professor of Medicine, Clinician Educator|
|Choudhary, Gaurav||Associate Professor of Medicine|
|Harrington, Elizabeth||Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology and Medicine, Professor of Medicine (Research)|
|Klinger, James||Professor of Medicine|
|Lu, Qing||Associate Professor of Medicine (Research)|
|Rand, David||Stephen T. Olney Professor of Natural History, Professor of Biology, Chair of Ecology and Evolutionary Biology|
|Research Fellow||University of Colorado Medical Center, cardiovascular pulmonary research||1977-1979|
|Fellow||University of Colorado Medical Center, pulmonary/critical care||1976-1979|
|Chief Resident||San Francisco General Hospital, medicine||1975-1976||San Francisco, CA|
|Resident||University of California, medicine||1973-1975||San Francisco, CA|
|Intern||San Francisco General Hospital, medicine||1972-1973||San Francisco, CA|
|Medical License||Rhode Island||1988-|
|Certification||American Board of Internal Medicine, critical care medicine||1988-2008|
|Certification||American Board of Internal Medicine, pulmonary disease||1978-|
|Certification||American Board of Internal Medicine, internal medicine||1975-|
|Chief. Providence VA Medical Center, Medical Service 2006-2015|
|Staff Physician. Boston City Hospital, Tuberculosis Clinic 1983-1987|
|Staff Physician. Boston City Hospital, Pulmonary Section, Department of Medicine 1982-1987|
|Medical Director. University Hospital, Medical Intensive Care Unit 1979-1981|
|Medical Director. University Hospital, Respiratory Therapy 1979-1987|
|Staff Physician. University Hospital, Pulmonary Section, Evans Memorial Department of Medicine and Clinical Research 1979-1987|