Dr. Zhang had trainings in both medicine and biology before obtaining her Ph.D degree in biostatistics from University of Washington, Seattle. Since graduation, she had worked both in the academia and the pharmaceutical industry. She is the leading statistician for multiple large multicenter cancer imaging trials, the results of which were published in prominent peer-reviewed journals. Her statistical methodological work covers ROC curve analysis, agreement method and decision making.
| Gerstner ER, Zhang Z, Fink JR, Muzi M, Hanna L, Greco E, Prah M, Schmainda KM, Mintz A, Kostakoglu L, Eikman EA, Ellingson BM, Ratai EM, Sorensen AG, Barboriak DP, Mankoff DA, ACRIN 6684 Trial Group. "ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI." Clin Cancer Res , vol. 22, no. 20, 2016, pp. 5079-5086. |
| Tromberg BJ, Zhang Z, Leproux A, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue BW, Jiang S, Kaufman PA, Yodh AG, Chung SH, Schnall M, Snyder BS, Hylton N, Boas DA, Carp SA, Isakoff SJ, Mankoff D, ACRIN 6691 investigators. "Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging." Cancer Research, vol. 76, no. 20, 2016, pp. 5933-5944. |
| Atri M, Zhang Z, Dehdashti F, Lee SI, Ali S, Marques H, Koh WJ, Moore K, Landrum L, Kim JW, DiSilvestro P, Eisenhauer E, Schnell F, Gold M. "Utility of PET-CT to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: Results of ACRIN6671/GOG0233 trial." Gynecologic Oncology, vol. 142, no. 3, 2016, pp. 413-9. |
| Mountz, James M., Laymon, Charles M., Cohen, Ann D., Zhang, Zheng, Price, Julie C., Boudhar, Sanaa, McDade, Eric, Aizenstein, Howard J., Klunk, William E., Mathis, Chester A. "Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects." NeuroImage: Clinical, vol. 9, 2015, pp. 592-598. |
| Schmainda, Kathleen M., Zhang, Zheng, Prah, Melissa, Snyder, Bradley S., Gilbert, Mark R., Sorensen, A. Gregory, Barboriak, Daniel P., Boxerman, Jerrold L. "Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial." Neuro-Oncology, vol. 17, no. 8, 2015, pp. 1148-1156. |
| Barr RG, Zhang Z. "Shear-wave elastography of the breast: value of a quality measure and comparison with strain elastography." Radiology, vol. 275, no. 1, 2015, pp. 45-53. |
| Atri, Mostafa, Zhang, Zheng, Marques, Helga, Gorelick, Jeremy, Harisinghani, Mukesh, Sohaib, Aslam, Koh, Dow-Mu, Raman, Steven, Gee, Michael, Choi, Haesun, Landrum, Lisa, Mannel, Robert, Chuang, Linus, Yu, Jian Qin (Michael), McCourt, Carolyn Kay, Gold, Michael. "Utility of preoperative ferumoxtran-10 MRI to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: Results of ACRIN 6671/GOG 0233." European Journal of Radiology Open, vol. 2, 2015, pp. 11-18. |
| Zhang Z, Wang Y, Duan F. "An AUC-like index for agreement assessment." Journal of biopharmaceutical statistics, vol. 24, no. 4, 2014, pp. 893-907. |
| Fidler, Jeff L., Zhang, Zheng, Herman, Benjamin A., Limburg, Paul J., Fletcher, J. G., Dachman, Abraham, Heiken, Jay P., Kuo, Mark D., Menias, Christine O., Siewert, Bettina, Cheema, Jugesh I., Obregon, Richard G., Zimmerman, Peter, Horton, Karen M., Coakley, Kevin, Iyer, Revathy B., Hara, Amy, Halvorsen, Robert A., Casola, Giovanna, Yee, Judy, Burgart, Lawrence J., Johnson, C. Daniel. "CT Colonography for the Detection of Nonpolypoid Adenomas: Sensitivity Assessed With Restricted National CT Colonography Trial Criteria." American Journal of Roentgenology, vol. 203, no. 6, 2014, pp. W614-W622. |
| Cole, Elodia B., Zhang, Zheng, Marques, Helga S., Edward Hendrick, R., Yaffe, Martin J., Pisano, Etta D. "Impact of Computer-Aided Detection Systems on Radiologist Accuracy With Digital Mammography." American Journal of Roentgenology, vol. 203, no. 4, 2014, pp. 909-916. |
| Zhang Z, Duckart J, Slatore CG, Fu Y, Petrik AF, Thorp ML, Cohen DM. "Individuality of the plasma sodium concentration." American journal of physiology. Renal physiology, vol. 306, no. 12, 2014, pp. F1534-43. |
| Kim, Eunhee, Zhang, Zheng, Wang, Youdan, Zeng, Donglin. "Power calculation for comparing diagnostic accuracies in a multi-reader, multi-test design." Biometrics, vol. 70, no. 4, 2014, pp. 1033-1041. |
| Kessler, L. G., Barnhart, H. X., Buckler, A. J., Choudhury, K. R., Kondratovich, M. V., Toledano, A., Guimaraes, A. R., Filice, R., Zhang, Z., Sullivan, D. C. "The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions." Statistical methods in medical research, vol. 24, no. 1, 2014, pp. 9-26. |
| Boxerman JL, Zhang Z, Safriel Y, Larvie M, Snyder BS, Jain R, Chi TL, Sorensen AG, Gilbert MR, Barboriak DP. "Early post-bevacizumab progression on contrast-enhanced MRI as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 Central Reader Study." Neuro-Oncology, vol. 15, no. 7, 2013, pp. 945-54. |
| Ratai EM, Zhang Z, Snyder BS, Boxerman JL, Safriel Y, McKinstry RC, Bokstein F, Gilbert MR, Sorensen AG, Barboriak DP. "Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677." Neuro-Oncology, vol. 15, no. 7, 2013, pp. 936-44. |
| Berg WA, Zhang Z, Cormack JB, Mendelson EB. "Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up." Radiology, vol. 268, no. 3, 2013, pp. 673-83. |
| Barr, Richard G., Zhang, Zheng, Cormack, Jean B., Mendelson, Ellen B., Berg, Wendie A. "Probably Benign Lesions at Screening Breast US in a Population with Elevated Risk: Prevalence and Rate of Malignancy in the ACRIN 6666 Trial." Radiology, vol. 269, no. 3, 2013, pp. 701-712. |
| Zhang, Zheng, Huang, Ying. "A Linear Regression Framework for the Receiver Operating Characteristic(ROC) Curve Analysis." J Biomet Biostat, vol. 03, no. 02, 2012. |
| Wolk DA, Zhang Z, Boudhar S, Clark CM, Pontecorvo MJ, Arnold SE. "Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography." Journal of Neurology, Neurosurgery & Psychiatry, vol. 83, no. 9, 2012, pp. 923-6. |
| Cole EB, Zhang Z, Marques HS, Nishikawa RM, Hendrick RE, Yaffe MJ, Padungchaichote W, Kuzmiak C, Chayakulkheeree J, Conant EF, Fajardo LL, Baum J, Gatsonis C, Pisano E. "Assessing the stand-alone sensitivity of computer-aided detection with cancer cases from the Digital Mammographic Imaging Screening Trial." American Journal of Roentgenology, vol. 199, no. 3, 2012, pp. W392-401. |
| Berg WA, Zhang Z, Lehrer D, Jong RA, Pisano ED, Barr RG, Böhm-Vélez M, Mahoney MC, Evans WP 3rd, Larsen LH, Morton MJ, Mendelson EB, Farria DM, Cormack JB, Marques HS, Adams A, Yeh NM, Gabrielli G, ACRIN 6666 Investigators. "Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk." JAMA, vol. 307, no. 13, 2012, pp. 1394-404. |
| Barr RG, Zhang Z. "Effects of precompression on elasticity imaging of the breast: development of a clinically useful semiquantitative method of precompression assessment." Journal of Ultrasound in Medicine, vol. 31, no. 6, 2012, pp. 895-902. |
| Berg, Wendie A., Barr, Richard G., Zhang, Zheng. "Supplementary Imaging for Breast Cancer Screening in High-Risk Women—Reply." JAMA, vol. 308, no. 3, 2012, pp. 236. |
| Mosher TJ, Zhang Z, Reddy R, Boudhar S, Milestone BN, Morrison WB, Kwoh CK, Eckstein F, Witschey WR, Borthakur A. "Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial." Radiology, vol. 258, no. 3, 2011, pp. 832-42. |
| Berg WA, Sechtin AG, Marques H, Zhang Z. "Cystic breast masses and the ACRIN 6666 experience." Radiologic Clinics of North America, vol. 48, no. 5, 2010, pp. 931-87. |
| Yang XY, Zhao H, Zhang Z, Rodland KD, Roullet JB, Cohen DM. "Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry." American journal of physiology. Renal physiology, vol. 280, no. 1, 2001, pp. F162-71. |
| Tian W, Zhang Z, Cohen DM. "MAPK signaling and the kidney." American journal of physiology. Renal physiology, vol. 279, no. 4, 2000, pp. F593-604. |
| Zhang Z, Yang XY, Soltoff SP, Cohen DM. "PI3K signaling in the murine kidney inner medullary cell response to urea." American journal of physiology. Renal physiology, vol. 278, no. 1, 2000, pp. F155-64. |
| Zhang Z, Tian W, Cohen DM. "Urea protects from the proapoptotic effect of NaCl in renal medullary cells." American journal of physiology. Renal physiology, vol. 279, no. 2, 2000, pp. F345-52. |
| Yang XY, Zhang Z, Cohen DM. "ERK activation by urea in the renal inner medullary mIMCD3 cell line." The American journal of physiology, vol. 277, no. 2 Pt 2, 1999, pp. F176-85. |
| Zhang Z, Yang XY, Cohen DM. "Urea-associated oxidative stress and Gadd153/CHOP induction." The American journal of physiology, vol. 276, no. 5 Pt 2, 1999, pp. F786-93. |
| Zhang Z, Yang XY, Cohen DM. "Hypotonicity activates transcription through ERK-dependent and -independent pathways in renal cells." American Journal of Physiology, vol. 275, pp. C1104-12. |
U10 CA180794 (PI Gray and Gatsonis) 04/29/14-02/28/19
Dana Farber/NCI
ECOG-ACRIN Network Group Statistics and Data Management Center
This subcontract covers support for the operations of Brown office of the Statistics and Data Management Center (SDMC) of ECOG-ACRIN Cancer Research Group. The SDMC is organized and operated jointly by the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute (DFCI), the Department of Biostatistics at Brown University, the Frontier Science and Technology Research Foundation (FSTRF) and the American College of Radiology (ACR), under the direction of the Group Statisticians.
Role: Faculty Statistician
U01 CA190254(PI Schnall CSS PI Gatsonis) 03/20/15-02/29/20
American College of Radiology/NCI
ECOG-ACRIN-Based QIN Resource for Advancing Quantitative Cancer imaging in Clinical Trials
This subcontract will provide support for CSS participation in the ECOG-ACRIN Quantitative Imaging Network (QIN) resource for advancing quantitative cancer imaging in clinical trials. CSS faculty and staff will provide methodologic expertise, leadership and support for the design of studies by QIN investigators using ECOG-ACRIN quantitative imaging and clinical data, the incorporation of QIN developed advanced image analysis methods and metrics into new ECOG-ACRIN trials, and the development and implementation of evaluations of image metrics.
Role: Faculty Statistician
WORK IN PROGRESS
Zhang Z. Estimating optimal threshold of biomarkers with binary or time-dependent gold standard by ROC curve analysis.
Zhang Z. Estimating optimal threshold of predictors for survival outcome.
Lee T, Ng C, Zhang Z, etc. CT perfusion as an early biomarker of treatment efficacy in advanced ovarian cancer: Results from ACRIN 6695/GOG 0262 study. Submitted to Clinical Cancer Research.
Boxerman, J, Zhang Z, etc. Prognostic Value of Contrast Enhancement and FLAIR for Overall Survival in Newly Diagnosed Glioblastoma Treated With and Without Bevacizumab: Results from the ACRIN 6686/RTOG 0825 Central Reader Study.
Boxerman, J, Zhang Z, etc. Early Post-Bevacizumab Change in rCBV from DSC-MRI Predicts Overall Survival in Recurrent Glioblastoma Whereas 2D-T1 Response Status Does Not: Results from the ACRIN 6677/RTOG 0625 Multi-Center Study.
Zhang Z. The Summary Predictive Curve for predictive marker assessment.
Zhang Z. Semiparametric Estimation of the Receiver Operating Characteristic (ROC) Surface: Theory and Application.
| Name | Title |
|---|---|
| Boxerman, Jerrold | Professor of Diagnostic Imaging |
| Duan, Fenghai | Professor of Biostatistics |
| Gatsonis, Constantine | Henry Ledyard Goddard University Professor of Statistical Sciences, Director of the Center for Biostatistics and Health Data Science |
