As a trauma/surgical critical care surgeon, I focus on the immune and inflammatory dysfunction of sepsis and the long term effects of critical illness. My work also involves translating bench findings into bedside observations in ICU patients. Specifically, I foucs on the role of invariant Natural Killer T-cells (iNKT-cells) in modulating the immune dysfunction of critical illness. We have shown in both murine models as well as across a spectrum of ages that iNKT-cells control and modulate a variety of inflammatory and immune responses that are key to the short and long term response to critical illness.
Both the immune and clinical responses are unique among geriatic critically ill surgical patients. A clinical arm of the research component focuses on the unique aspects of geriatric surgical patients with critical illness.