Dr. Ayala is Professor of Surgery (Research) and the Director of the Division of Surgical Research at Lifespan-Rhode Island Hospital/the Alpert School of Medicine at Brown University. He has been recognized by his peers through election as a “Fellow”-American Association for the Advancement of Science (AAAS) (22’) and was selected as the 2024 "Legacy Awardee" of the Society of Leukocyte Biology (SLB). He was a NIH-NIGMS-Consultant/Panel member for ‘National Advisory General Medical Sciences (NAGMS) Working Group on Sepsis’ (18'-19'). He served as a standing member of the National Institutes of Health (NIH)-Lung Cellular Molecular & Immunology (LCMI)-Study Section as well as previously on the NIH-Surgery Anesthesia Trauma (SAT)-Study Section, and has served as an ad hoc on various NIH site visit teams/SEPs/ad hoc review pannels, the Veteran's Administration (VA)-Department of Defense (DoD) Merit Review Board, Wellcome Trust as well as Shriners Research Hospitals (over 12 years). He has been recognized by his peers through election to President (04'-05'), Treasurer (02'-04'), and Scientific Program Chairman (01) of the Shock Society; as selection as Recorder/Executive Council (05'-07') of the Surgical Infection Society, and by appointment to the Society of Leukocyte Biology council (11'-13'). Dr. Ayala was also the recipient of a "Maximizing Investigators' Research Award (MIRA)" for Established Investigators (R35) from the NIH-NIGMS (16'); the Shock Society's 10th annual 'Scientific Achievement Award' (07'); and the 15th annual 'Distinquished Service Award' (09'). He has over 300 manuscripts/review articles to his credit and has been continuously funded by the NIH since 1991. He is also a member of the training faculty of the Brown University Graduate Pathobiology Program; the Therapuatic Sciences Graduate Program, the Department of Cell Biology, Molecular Biology & Biochemistry Graduate Program; and is an adjunct Professor/mentor in the Univ. R.I. graduate program in the Department of Cellular & Molecular Biology. During his tenure at Brown University and previously at Michigan State University he has had the privilege of mentoring students ranging from undergraduates and medical students to surgical residents, post-doctoral fellows and Junior Faculty. Research interests include projects looking at: the differential effects of sepsis on immune cell function; the role of programmed cell death/ apoptosis in immune dysfunction observed following hemorrhage and/or sepsis; as well as, the contribution of 'checkpoint' protein/ accessory molecule expression to the pathological process mediating acute lung injury resultant from shock and/or septic insults.
Division of Surgical Research
'Ayala Lab' Site-Staff list/Bios.
'Ayala Lab' Site-Alumni
Molecular Biology, Cell Biology, & Biochemistry Graduate Program
Graduate Pathobiology Program
Therapeutic Sciences Graduate Program
IMSD-Brown University
Division of Biology & Medicine
Undergraduate Res. Offerings
| Wakeley ME, Denning NL, Jiang J, De Paepe ME, Chung CS, Wang P, Ayala A. "Herpes virus entry mediator signaling blockade produces mortality in neonatal sepsis through induced cardiac dysfunction." Frontiers in immunology, vol. 15, 2024, pp. 1365174. |
| Heffernan DS, Chun TT, Monaghan SF, Chung CS, Ayala A. "invariant Natural Killer T Cells Modulate the Peritoneal Macrophage Response to Polymicrobial Sepsis." Journal of Surgical Research, vol. 300, 2024, pp. 211-220. |
| Gray CC, Armstead BE, Chung CS, Chen Y, Ayala A. "VISTA Non-redundantly Regulates Proliferation and CD69low γδ T cell Accumulation in the Intestine in Murine Sepsis." Journal of Leukocyte Biology, vol. 115, no. 6, 2024, pp. 1005-1019. |
| Armstead, Brandon E., Lee, Chung Sunny, Chen, Yaping, Zhao, Runping, Chung, Chun-Shiang, Fredericks, Alger M., Monaghan, Sean F., Ayala, Alfred. "Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung." Frontiers in Medicine, vol. 10, 2023, pp. 1003121. |
| Wakeley, Michelle E., Armstead, Brandon E., Gray, Chyna C., Tindal, Elizabeth W., Heffernan, Daithi S., Chung, Chun-Shiang, Ayala, Alfred. "Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression." Frontiers in Medicine, vol. 10, 2023. |
| Heffernan DS, Chung CS, Ayala A. "Severity of critical illness correlates with CD3-low expression on iNKT-cells among septic surgical patients." Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. |
| Heffernan DS, Chung CS, Ayala A. "SPLENIC INVARIANT NATURAL KILLER T CELLS PLAY A SIGNIFICANT ROLE IN THE RESPONSE TO POLYMICROBIAL SEPSIS." Shock, vol. 60, no. 3, 2023, pp. 443-449. |
| Fredericks AM, Jentzsch MS, Cioffi WG, Cohen M, Fairbrother WG, Gandhi SJ, Harrington EO, Nau GJ, Reichner JS, Ventetuolo CE, Levy MM, Ayala A, Monaghan SF. "Deep RNA sequencing of intensive care unit patients with COVID-19." Scientific reports, vol. 12, no. 1, 2022, pp. 15755. |
| Fredericks AM, East KW, Shi Y, Liu J, Maschietto F, Ayala A, Cioffi WG, Cohen M, Fairbrother WG, Lefort CT, Nau GJ, Levy MM, Wang J, Batista VS, Lisi GP, Monaghan SF. "Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations." Frontiers in molecular biosciences, vol. 9, 2022, pp. 1080964. |
| Gray, Chyna C., Biron-Girard, Bethany, Wakeley, Michelle E., Chung, Chun-Shiang, Chen, Yaping, Quiles-Ramirez, Yael, Tolbert, Jessica D., Ayala, Alfred. "Negative Immune Checkpoint Protein, VISTA, Regulates the CD4+ Treg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival." Frontiers in Immunology, vol. 13, 2022, pp. 861670. |
| White A, Wang Z, Wang X, King M, Guo C, Mantsounga C, Ayala A, Morrison AR, Choudhary G, Sellke F, Chambers E, Ware LB, Rounds S, Lu Q. "NLRP3 inflammasome activation in cigarette smoke priming for Pseudomonas aeruginosa-induced acute lung injury." Redox biology, vol. 57, 2022, pp. 102467. |
| Zhu J, Li J, Chung CS, Lomas-Neira JL, Ayala A. "Patho-Mechanisms For Hemorrhage/Sepsis-Induced Indirect Acute Respiratory Distress Syndrome (iARDS): A Role For Lung Tie1 and Its Regulation By Neutrophils." Shock, vol. 57, no. 4, 2022, pp. 608-615. |
| Hensler, Emily, Petros, Habesha, Gray, Chyna C., Chung, Chun-Shiang, Ayala, Alfred, Fallon, Eleanor A. "The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers." Frontiers in Immunology, vol. 13, 2022, pp. 940930. |
| Tindal, Elizabeth W., Armstead, Brandon E., Monaghan, Sean F., Heffernan, Daithi S., Ayala, Alfred. "Emerging therapeutic targets for sepsis." Expert Opinion on Therapeutic Targets, vol. 25, no. 3, 2021, pp. 175-189. |
| Fallon, Eleanor A., Chung, Chun-Shiang, Heffernan, Daithi S., Chen, Yaping, De Paepe, Monique E., Ayala, Alfred. "Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology." Frontiers in Immunology, vol. 12, 2021, pp. 634529. |
| Phares TW, Kotraiah V, Chung CS, Unsinger J, Mazer M, Remy KE, Browne CD, Buontempo P, Mansour M, Pannucci J, Ayala A, Hotchkiss RS, Gutierrez GM. "A Peptide-Based Checkpoint Immunomodulator Alleviates Immune Dysfunction in Murine Polymicrobial Sepsis." Shock, 2020. |
| Fredericks AM, Wang LJ, Fairbrother WG, Ayala A, Monaghan SF. "Alternative RNA splicing and alternative transcription start/end in acute respiratory distress syndrome." Intensive care medicine, 2020. |
| Xu S, Yang Q, Bai J, Tao T, Tang L, Chen Y, Chung CS, Fallon EA, Ayala A. "BLOCKADE OF ENDOTHELIAL, BUT NOT EPITHELIAL, CELL EXPRESSION OF PD-L1 FOLLOWING SEVERE SHOCK ATTENUATES THE DEVELOPMENT OF INDIRECT ACUTE LUNG INJURY IN MICE." American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020. |
| Chambers, Eboni D., White, Alexis, Vang, Alexander, Wang, Zhengke, Ayala, Alfred, Weng, Tingting, Blackburn, Michael, Choudhary, Gaurav, Rounds, Sharon, Lu, Qing. "Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation." The FASEB Journal, vol. 34, no. 1, 2020, pp. 1516-1531. |
| Wakeley, Michelle E., Gray, Chyna C., Monaghan, Sean F., Heffernan, Daithi S., Ayala, Alfred. "Check Point Inhibitors and Their Role in Immunosuppression in Sepsis." Critical Care Clinics, vol. 36, no. 1, 2020, pp. 69-88. |
| Wakeley ME, Shubin NJ, Monaghan SF, Gray CC, Ayala A, Heffernan DS. "Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression." Journal of Surgical Research, vol. 245, 2020, pp. 610-618. |
| Kotraiah V, Phares TW, Browne CD, Pannucci J, Mansour M, Noe AR, Tucker KD, Christen JM, Reed C, MacKay A, Weir GM, Rajagopalan R, Stanford MM, Chung CS, Ayala A, Huang J, Tsuji M, Gutierrez GM. "Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics." Frontiers in immunology, vol. 11, 2020, pp. 264. |
| Fukuda AM, Hindley LE, Kang JWD, Tirrell E, Tyrka AR, Ayala A, Carpenter LL. "Peripheral vascular endothelial growth factor changes after transcranial magnetic stimulation in treatment-resistant depression." Neuroreport, vol. 31, no. 16, 2020, pp. 1121-1127. |
| Jiang J, Hu B, Chung CS, Chen Y, Zhang Y, Tindal EW, Li J, Ayala A. "SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model." Molecular Medicine, vol. 26, no. 1, 2020, pp. 89. |
| Heffernan IM, McGeary JE, Chung CS, Ayala A, Heffernan DS. "Unmasking Unique Immune Altering Aspects of the Microbiome as a Tool to Correct Sepsis-Induced Immune Dysfunction." Surgical Infections, vol. 22, no. 4, 2020, pp. 400-408. |
| Rossi AL, Le M, Chung CS, Chen Y, Fallon EA, Matoso A, Xu S, Chun TT, Erickson C, Ayala A. "A Novel Role for Programmed Cell Death Receptor Ligand 2 (PD-L2) in Sepsis-Induced Hepatic Dysfunction." American journal of physiology. Gastrointestinal and liver physiology, vol. 316, 2019, pp. G106-G114. |
| Lee K, Cohen JT, Wilson ZS, Zhao R, Lomas-Neira J, Chung CS, Chen Y, Jamieson AM, Ayala A, Lefort CT. "Hemorrhage Attenuates Neutrophil Recruitment in Response to Secondary Respiratory Infection by Pseudomonas Aeruginosa." SHOCK, vol. 52, no. 5, 2019, pp. 506-512. |
| Cheng T, Bai J, Chung CS, Chen Y, Fallon EA, Ayala A. "Herpes Virus Entry Mediator (HVEM) Expression Promotes Inflammation/ Organ Injury in Response to Experimental Indirect-Acute Lung Injury." Shock, vol. 51, 2019, pp. 487–494. |
| Libert C, Ayala A, Bauer M, Cavaillon JM, Deutschman C, Frostell C, Knapp S, Kozlov AV, Wang P, Osuchowski MF, Remick DG. "Part II: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints." Shock, vol. 51, 2019, pp. 23–32. |
| Remick DG, Ayala A, Chaudry I, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski M. "Premise for Standardized Sepsis Models." Shock, vol. 51, 2019, pp. 4-9. |
| Fallon, Eleanor A., Biron-Girard, Bethany M., Chung, Chun-Shiang, Lomas-Neira, Joanne, Heffernan, Daithi S., Monaghan, Sean F., Ayala, Alfred. "A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis." Journal of Leukocyte Biology, 2018. |
| Monaghan, Sean F., Banerjee, Debasree, Chung, Chun-Shiang, Lomas-Neira, Joanne, Cygan, Kamil J., Rhine, Christy L., Fairbrother, William G., Heffernan, Daithi S., Levy, Mitchell M., Cioffi, William G., Ayala, Alfred. "Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness." Molecular Medicine, vol. 24, no. 1, 2018, pp. 32. |
| Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. "Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis." Infection, vol. 46, no. 5, 2018, pp. 745-747. |
| Chun TT, Chung CS, Fallon EA, Hutchins NA, Clarke E, Rossi AL, Cioffi WG, Heffernan DS, Ayala A. "Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis." The American Journal of Pathology, vol. 188, no. 9, 2018, pp. 2097-2108. |
| Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. "Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis." Infection, vol. 46, no. 5, 2018, pp. 687-691. |
| Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. "Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis." Shock, vol. 50, no. 4, 2018, pp. 377-380. |
| Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. "Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis." Intensive Care Medicine Experimental, vol. 6, no. 1, 2018, pp. 26. |
| Lomas-Neira J, Monaghan SF, Huang X, Fallon EA, Chung CS, Ayala A. "Novel Role for PD-1:PD-L1 as Mediator of Pulmonary Vascular Endothelial Cell Functions in Pathogenesis of Indirect ARDS in Mice." Frontiers in Immunology, vol. 9, 2018, pp. 3030. |
| Biron, Bethany M., Chung, Chun-Shiang, Chen, Yaping, Wilson, Zachary, Fallon, Eleanor A., Reichner, Jonathan S., Ayala, Alfred. "PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis." The Journal of Immunology, vol. 200, no. 5, 2018, pp. ji1700639. |
| Biron BM, Chung CS, O'Brien XM, Chen Y, Reichner JS, Ayala A. "Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model." Journal of innate immunity, vol. 9, no. 1, 2017, pp. 22-32. |
| Bruns B, Hönle T, Kellermann P, Ayala A, Perl M. "Divergent Effects of Neutrophils on Fas-Induced Pulmonary Inflammation, Apoptosis, and Lung Damage." SHOCK, vol. 47, no. 2, 2017, pp. 225-235. |
| Sakhatskyy P, Wang Z, Borgas D, Lomas-Neira J, Chen Y, Ayala A, Rounds S, Lu Q. "Double-hit mouse model of cigarette smoke priming for acute lung injury." American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 312, no. 1, 2017, pp. ajplung.00436.2016. |
| Fallon, Eleanor A., Chun, Tristen T., Young, Whitney A., Gray, Chyna, Ayala, Alfred, Heffernan, Daithi S. "Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis." Frontiers in Immunology, vol. 8, 2017. |
| Wu, Youping, Chung, Chun-Shiang. "A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction." Molecular Medicine, vol. 22, no. 1, 2016, pp. 1. |
| Lomas-Neira JL, Heffernan DS, Ayala A, Monaghan SF. "BLOCKADE OF ENDOTHELIAL GROWTH FACTOR, ANGIOPOIETIN-2, REDUCES INDICES OF ARDS AND MORTALITY IN MICE RESULTING FROM THE DUAL-INSULTS OF HEMORRHAGIC SHOCK AND SEPSIS." Shock, vol. 45, no. 2, 2016, pp. 157-165. |
| Wang F, Huang X, Chung CS, Chen Y, Hutchins NA, Ayala A. "Contribution of Programmed Cell Death Receptor (PD)-1 to Kupffer Cell Dysfunction in Murine Polymicrobial Sepsis." American journal of physiology. Gastrointestinal and liver physiology, 2016, pp. ajpgi.00371.2015. |
| Cheng T, Bai J, Chung CS, Chen Y, Biron BM, Ayala A. "Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis." Shock, vol. 45, no. 1, 2016, pp. 40-9. |
| Young, Whitney A., Fallon, Eleanor A., Heffernan, Daithi S., Efron, Philip A., Cioffi, William G., Ayala, Alfred. "Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates." Surgery, vol. 161, no. 5, 2016, pp. 1387-1393. |
| Heffernan DS, Monaghan SF, Ayala A. "Lymphocyte integrin expression differences between SIRS and sepsis patients." Irish Journal of Medical Science (1971 -), vol. 186, no. 4, 2016, pp. 981-987. |
| Monaghan SF, Chung CS, Chen Y, Lomas-Neira J, Fairbrother WG, Heffernan DS, Cioffi WG, Ayala A. "Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)." Journal of Translational Medicine, vol. 14, no. 1, 2016, pp. 312. |
| Biron BM, Ayala A, Lomas-Neira JL. "Biomarkers for Sepsis: What Is and What Might Be?." Biomarker Insights, vol. 10, no. Suppl 4, 2015, pp. 7-17. |
| Young JS, Monaghan SF, Chung CS, Cioffi WG, Ayala A, Heffernan DS. "Divergent Invariant Natural Killer T-Cell Response to Sepsis of Abdominal vs. Non-Abdominal Origin in Human Beings." Surgical infections, vol. 16, no. 1, 2015, pp. 29-35. |
| Young, John S., Heffernan, Daithi S., Chung, Chun-Shiang, Kettenmann, Maude L., Young, Whitney A., Guillen, Valeria Sanabria, Cioffi, William G., Ayala, Alfred. "Effect of PD-1: PD-L1 in Invariant Natural Killer T Cell Emigration and Chemotaxis Following Sepsis." SHOCK, vol. 45, no. 5, 2015, pp. 534-9. |
| Burga RA, Thorn M, Point GR, Guha P, Nguyen CT, Licata LA, DeMatteo RP, Ayala A, Joseph Espat N, Junghans RP, Katz SC. "Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T." Cancer immunology, immunotherapy : CII, 2015. |
| Tang L, Bai J, Chung CS, Lomas-Neira J, Chen Y, Huang X, Ayala A. "PD-L1 Regulates the Tregs' Capacity to Repress Shock/Sepsis Induced Indirect Lung Injury (iALI) by Recruiting Phosphatase SHP-1." Shock, vol. 43, no. 1, 2015, pp. 47-54. |
| Ottinger ME, Monaghan SF, Gravenstein S, Cioffi WG, Ayala A, Heffernan DS. "The geriatric cytokine response to trauma: time to consider a new threshold." Surgical Infections, vol. 15, no. 6, 2015, pp. 800-805. |
| Heffernan DS, Monaghan SF, Chung CS, Cioffi WG, Gravenstein S, Ayala A. "A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved." Human immunology, vol. 75, no. 3, 2014, pp. 277-82. |
| Tang, L., Bai, J., Chung, C.-S., Lomas-Neira, J., Chen, Y., Huang, X., Ayala, A. "Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1." Journal of Leukocyte Biology, vol. 96, 2014, pp. 809-920. |
| Ramachandran G, Kaempfer R, Chung CS, Shirvan A, Chahin AB, Palardy JE, Parejo NA, Chen Y, Whitford M, Arad G, Hillman D, Shemesh R, Blackwelder W, Ayala A, Cross AS, Opal SM. "CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and Gram-negative bacterial peritonitis." The Journal of Infectious Diseases, vol. 211, no. 6, 2014, pp. 809-20. |
| Huang X, Chen Y, Chung CS, Yuan Z, Monaghan SF, Wang F, Ayala A. "Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis." The Journal of Immunology, vol. 192, no. 3, 2014, pp. 1091-9. |
| Young, J.S., Heffernan, D.S., Chung, C., Cioffi, W.G., Ayala, A. "Migrating Invariant Natural Killer T-Cells Modulate Chemokine Receptor Expression in Response to Polymicrobial Sepsis." Journal of Surgical Research, vol. 186, no. 2, 2014, pp. 510. |
| Lomas-Neira J, Venet F, Chung CS, Thakkar R, Heffernan D, Ayala A. "Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice." American Journal of Respiratory Cell and Molecular Biology, vol. 50, no. 1, 2014, pp. 193-200. |
| Young, John S., Chung, Chun-Shiang, Young, Whitney A., Cioffi, William G., Ayala, Alfred, Heffernan, Daithi S. "Peritoneal Macrophage Activation and Phenotype Changes After Polymicrobial Sepsis Is Dependent upon Invariant Natural Killer T (iNKT) Cells." Journal of the American College of Surgeons, vol. 219, no. 3, 2014, pp. S38. |
| Ayala A, Elphick GF, Kim YS, Huang X, Carreira-Rosario A, Santos SC, Shubin NJ, Chen Y, Reichner J, Chung CS. "Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency." Journal of innate immunity, vol. 6, no. 3, 2014, pp. 325-38. |
| Young, W.A., Young, J.S., Monaghan, S.F., Chung, C.S., Cioffi, W.G., Ayala, A., Heffernan, D.S. "SIRS Following Trauma Induces Loss Of Both CD3+ And γδ-T-Lymphocytes, But Clinical Resolution Is Associated With Differential Recovery Of Lymphocyte Populations." Journal of Surgical Research, vol. 186, no. 2, 2014, pp. 582. |
| Bai, J., Tang, L., Loma-Neira, J., Chen, Y., McLeish, K. R., Uriarte, S. M., Chung, C.-S., Ayala, A. "TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury." Innate Immunity, vol. 21, no. 1, 2014, pp. 42-54. |
| Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A. "The new normal: immunomodulatory agents against sepsis immune suppression." Trends in molecular medicine, vol. 20, no. 4, 2014, pp. 224-33. |
| Shubin NJ, Monaghan SF, Heffernan DS, Chung CS, Ayala A. "B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients." Critical Care, vol. 17, no. 6, 2013, pp. R276. |
| Licata LA, Nguyen CT, Burga RA, Falanga V, Espat NJ, Ayala A, Thorn M, Junghans RP, Katz SC. "Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils." Journal of Leukocyte Biology, vol. 94, no. 4, 2013, pp. 813-23. |
| Kettenmann, Maude L., Heffernan, Daithi S., Monaghan, Sean F., Shubin, Nicholas J., Ayala, Alfred A., Cioffi, William G., Irwin, Lydea R. "Herpes virus entry mediator expression in critically ill trauma patients." Journal of the American College of Surgeons, vol. 217, no. 3, 2013, pp. S52. |
| Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A. "Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function." Shock, vol. 40, no. 2, 2013, pp. 122-8. |
| Hutchins NA, Wang F, Wang Y, Chung CS, Ayala A. "Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1." Journal of Leukocyte Biology, vol. 94, no. 5, 2013, pp. 963-70. |
| Hutchins NA, Chung CS, Borgerding JN, Ayala CA, Ayala A. "Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130." The American Journal of Pathology, vol. 182, no. 3, 2013, pp. 742-54. |
| Shubin NJ, Chung CS, Heffernan DS, Irwin LR, Monaghan SF, Ayala A. "BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction." Journal of Leukocyte Biology, vol. 92, no. 3, 2012, pp. 593-603. |
| Perl M, Kieninger M, Huber-Lang MS, Gross HJ, Bachem MG, Braumüller S, Gebhard F, Ayala A, Knöferl MW. "Divergent effects of activated neutrophils on inflammation, Kupffer cell/splenocyte activation, and lung injury following blunt chest trauma." Shock, vol. 37, no. 2, 2012, pp. 210-8. |
| Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A. "Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern." Critical Care, vol. 16, no. 1, 2012, pp. R12. |
| Chichger H, Grinnell KL, Casserly B, Chung CS, Braza J, Lomas-Neira J, Ayala A, Rounds S, Klinger JR, Harrington EO. "Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 303, no. 10, 2012, pp. L880-8. |
| Monaghan SF, Thakkar RK, Heffernan DS, Huang X, Chung CS, Lomas-Neira J, Cioffi WG, Ayala A. "Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1." Annals of Surgery, vol. 255, no. 1, 2012, pp. 158-64. |
| Monaghan SF, Thakkar RK, Tran ML, Huang X, Cioffi WG, Ayala A, Heffernan DS. "Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient." Shock, vol. 38, no. 2, 2012, pp. 117-22. |
| Perl M, Hohmann C, Denk S, Kellermann P, Lu D, Braumüller S, Bachem MG, Thomas J, Knöferl MW, Ayala A, Gebhard F, Huber-Lang MS. "Role of activated neutrophils in chest trauma-induced septic acute lung injury." Shock, vol. 38, no. 1, 2012, pp. 98-106. |
| Nacionales DC, Cuenca AG, Ungaro R, Gentile LF, Joiner D, Satoh M, Lomas-Neira J, Ayala A, Bihorac A, Delano MJ, Ang DN, Efron PA. "The acute immunological response to blood transfusion is influenced by polymicrobial sepsis." Shock, vol. 38, no. 6, 2012, pp. 598-606. |
| Lomas-Neira J, Perl M, Venet F, Chung CS, Ayala A. "The role and source of tumor necrosis factor-α in hemorrhage-induced priming for septic lung injury." Shock, vol. 37, no. 6, 2012, pp. 611-20. |
| Lomas-Neira JL, Ayala A. "What's new in Shock, March 2012?." Shock, vol. 37, no. 3, 2012, pp. 239-41. |
| Shubin NJ, Monaghan SF, Ayala A. "Anti-inflammatory mechanisms of sepsis." Contributions to microbiology, vol. 17, 2011, pp. 108-24. |
| Newsome CT, Flores E, Ayala A, Gregory S, Reichner JS. "Improved antimicrobial host defense in mice following poly-(1,6)-β-D-glucopyranosyl-(1,3)-β-D-glucopyranose glucan treatment by a gender-dependent immune mechanism." Clinical and vaccine immunology : CVI, vol. 18, no. 12, 2011, pp. 2043-9. |
| Thakkar RK, Chung CS, Chen Y, Monaghan SF, Lomas-Neira J, Heffernan DS, Cioffi WG, Ayala A. "Local tissue expression of the cell death ligand, fas ligand, plays a central role in the development of extrapulmonary acute lung injury." Shock, vol. 36, no. 2, 2011, pp. 138-43. |
| Perl M, Lomas-Neira J, Venet F, Chung CS, Ayala A. "Pathogenesis of indirect (secondary) acute lung injury." Expert review of respiratory medicine, vol. 5, no. 1, 2011, pp. 115-26. |
| Guan YJ, Zhang Z, Yu C, Ma L, Hu W, Xu L, Gao JS, Chung CS, Wang L, Yang ZF, Fast LD, Chung AS, Kim M, Ayala A, Zhuang S, Zheng S, Chin YE. "Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration." The Journal of Immunology, vol. 187, no. 3, 2011, pp. 1289-97. |
| Guignant C, Lepape A, Huang X, Kherouf H, Denis L, Poitevin F, Malcus C, Chéron A, Allaouchiche B, Gueyffier F, Ayala A, Monneret G, Venet F. "Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients." Critical Care, vol. 15, no. 2, 2011, pp. R99. |
| McNeal SI, LeGolvan MP, Chung CS, Ayala A. "The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis." Shock, vol. 35, no. 5, 2011, pp. 499-505. |
| Chung CS, Venet F, Chen Y, Jones LN, Wilson DC, Ayala CA, Ayala A. "Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival." Shock, vol. 34, no. 2, 2010, pp. 150-61. |
| Wang P, Varghese AJ, Ayala A, Wang D, Quinn MA. "Editorial board 2010." International journal of clinical and experimental medicine, vol. 3, no. 4, 2010, pp. 347-9. |
| Venet F, Huang X, Chung CS, Chen Y, Ayala A. "Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice." The American Journal of Pathology, vol. 176, no. 2, 2010, pp. 764-73. |
| Perl M, Chung CS, Perl U, Thakkar R, Lomas-Neira J, Ayala A. "Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury." Critical care medicine, vol. 38, no. 4, 2010, pp. 1179-86. |
| Stromberg PE, Woolsey CA, Clark AT, Clark JA, Turnbull IR, McConnell KW, Chang KC, Chung CS, Ayala A, Buchman TG, Hotchkiss RS, Coopersmith CM. "CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis." The FASEB Journal, vol. 23, no. 6, 2009, pp. 1817-25. |
| Fritzell JA Jr, Mao Q, Gundavarapu S, Pasquariello T, Aliotta JM, Ayala A, Padbury JF, De Paepe ME. "Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice." American Journal of Respiratory Cell and Molecular Biology, vol. 40, no. 5, 2009, pp. 575-87. |
| Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohé J, Lepape A, Ayala A, Monneret G. "Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients." Intensive care medicine, vol. 35, no. 4, 2009, pp. 678-86. |
| Venet F, Chung CS, Huang X, Lomas-Neira J, Chen Y, Ayala A. "Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury." The Journal of Immunology, vol. 183, no. 5, 2009, pp. 3472-80. |
| Huang X, Venet F, Wang YL, Lepape A, Yuan Z, Chen Y, Swan R, Kherouf H, Monneret G, Chung CS, Ayala A. "PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis." Proceedings of the National Academy of Sciences, vol. 106, no. 15, 2009, pp. 6303-8. |
| Elphick GF, Sarangi PP, Hyun YM, Hollenbaugh JA, Ayala A, Biffl WL, Chung HL, Rezaie AR, McGrath JL, Topham DJ, Reichner JS, Kim M. "Recombinant human activated protein C inhibits integrin-mediated neutrophil migration." Blood, vol. 113, no. 17, 2009, pp. 4078-85. |
| Hu CK, Venet F, Heffernan DS, Wang YL, Horner B, Huang X, Chung CS, Gregory SH, Ayala A. "The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock." The Journal of Immunology, vol. 182, no. 4, 2009, pp. 2467-75. |
| Ayala A, Perl M, Venet F, Lomas-Neira J, Swan R, Chung CS. "Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets." Current pharmaceutical design, vol. 14, no. 19, 2008, pp. 1853-9. |
| Perl M, Lomas-Neira J, Chung CS, Ayala A. "Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs." Molecular Medicine, vol. 14, no. 7-8, 2008, pp. 465-75. |
| Wesche-Soldato DE, Lomas-Neira J, Perl M, Chung CS, Ayala A. "Hydrodynamic delivery of siRNA in a mouse model of sepsis." Methods in Molecular Biology, vol. 442, 2008, pp. 67-73. |
| Venet F, Chung CS, Monneret G, Huang X, Horner B, Garber M, Ayala A. "Regulatory T cell populations in sepsis and trauma." Journal of Leukocyte Biology, vol. 83, no. 3, 2008, pp. 523-35. |
| Lomas-Neira J, Chung CS, Ayala A. "RNA interference as a potential therapeutic treatment for inflammation associated lung injury." International journal of clinical and experimental medicine, vol. 1, no. 2, 2008, pp. 154-60. |
| Ward NS, Casserly B, Ayala A. "The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients." Clinics in Chest Medicine, vol. 29, no. 4, 2008, pp. 617-25, viii. |
| Wang P, Ayala A, Wang D. "The launch of the international journal of clinical and experimental medicine." International journal of clinical and experimental medicine, vol. 1, no. 1, 2008, pp. 1. |
| Perl M, Chung CS, Perl U, Biffl WL, Cioffi WG, Ayala A. "Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult." Journal of the American College of Surgeons, vol. 204, no. 5, 2007, pp. 840-52; discussion 852-3. |
| Ayala A, Wesche-Soldato DE, Perl M, Lomas-Neira JL, Swan R, Chung CS. "Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis." Novartis Foundation symposium, vol. 280, 2007, pp. 37-49; discussion 49-52, 160-4. |
| Wesche-Soldato DE, Chung CS, Gregory SH, Salazar-Mather TP, Ayala CA, Ayala A. "CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL." The American Journal of Pathology, vol. 171, no. 1, 2007, pp. 87-96. |
| Huang X, Venet F, Chung CS, Lomas-Neira J, Ayala A. "Changes in dendritic cell function in the immune response to sepsis. Cell- & tissue-based therapy." Expert opinion on biological therapy, vol. 7, no. 7, 2007, pp. 929-38. |
| Lomas-Neira JL, Ayala A. "CXCL2 polymorphism in sepsis and acute respiratory distress syndrome: pathological significance lost in translation." Critical care medicine, vol. 35, no. 10, 2007, pp. 2439-40. |
| Venet F, Tissot S, Debard AL, Faudot C, Crampé C, Pachot A, Ayala A, Monneret G. "Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock." Critical care medicine, vol. 35, no. 8, 2007, pp. 1910-7. |
| Perl M, Chung CS, Perl U, Lomas-Neira J, de Paepe M, Cioffi WG, Ayala A. "Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury." Am J Respir Crit Care Med, vol. 176, no. 6, 2007, pp. 591-601. |
| Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. "MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis." Journal of Experimental Medicine, vol. 204, no. 6, 2007, pp. 1463-74. |
| Swan R, Chung CS, Albina J, Cioffi W, Perl M, Ayala A. "Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages." Surgery, vol. 142, no. 2, 2007, pp. 253-61. |
| Perl, Mario, Chung, Chun-Shiang, Swan, Ryan, Ayala, Alfred. "Role of programmed cell death in the immunopathogenesis of sepsis." Drug Discovery Today: Disease Mechanisms, vol. 4, no. 4, 2007, pp. 223-230. |
| Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A. "SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis." Apoptosis : an international journal on programmed cell death, vol. 12, no. 7, 2007, pp. 1143-53. |
| Wesche-Soldato DE, Swan RZ, Chung CS, Ayala A. "The apoptotic pathway as a therapeutic target in sepsis." Current drug targets, vol. 8, no. 4, 2007, pp. 493-500. |
| Wisnoski N, Chung CS, Chen Y, Huang X, Ayala A. "The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis." Shock, vol. 27, no. 3, 2007, pp. 251-7. |
| Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. "Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis." Blood, vol. 110, no. 10, 2007, pp. 3673-81. |
| Doughty LA, Carlton S, Galen B, Cooma-Ramberan I, Chung CS, Ayala A. "Activation of common antiviral pathways can potentiate inflammatory responses to septic shock." Shock, vol. 26, no. 2, 2006, pp. 187-94. |
| Perl M, Chung CS, Garber M, Huang X, Ayala A. "Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis." Frontiers in Bioscience, vol. 11, 2006, pp. 272-99. |
| Chung CS, Watkins L, Funches A, Lomas-Neira J, Cioffi WG, Ayala A. "Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 291, no. 5, 2006, pp. R1338-43. |
| Ayala A, Wesche-Soldato DE, Garber M, Swan R, Perl M. "No good deed goes unpunished!." Intensive care medicine, vol. 32, no. 5, 2006, pp. 637-8. |
| Lomas-Neira J, Chung CS, Perl M, Gregory S, Biffl W, Ayala A. "Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge." American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 290, no. 1, 2006, pp. L51-8. |
| Ayala, Alfred, Chaudry, Irshad. "A MEMORIAL TO MOHAMMED M. SAYEED." Shock, vol. 24, no. 1, 2005, pp. 1-2. |
| Perl M, Chung CS, Ayala A. "Apoptosis." Critical care medicine, vol. 33, no. 12 Suppl, 2005, pp. S526-9. |
| Lomas-Neira J, Chung CS, Grutkoski PS, Dunican A, Simms HH, Cioffi WG, Ayala A. "Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury." Cytokine, vol. 31, no. 3, 2005, pp. 169-79. |
| Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. "In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice." Blood, vol. 106, no. 7, 2005, pp. 2295-301. |
| Lomas-Neira JL, Chung CS, Wesche DE, Perl M, Ayala A. "In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury." Journal of Leukocyte Biology, vol. 77, no. 6, 2005, pp. 846-53. |
| Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. "Leukocyte apoptosis and its significance in sepsis and shock." Journal of Leukocyte Biology, vol. 78, no. 2, 2005, pp. 325-37. |
| Song GY, Chung CS, Rhee RJ, Cioffi WG, Ayala A. "Loss of signal transducer and activator of transduction 4 or 6 signaling contributes to immune cell morbidity and mortality in sepsis." Intensive care medicine, vol. 31, no. 11, 2005, pp. 1564-9. |
| Lomas-Neira J, Ayala A. "Pepducins: an effective means to inhibit GPCR signaling by neutrophils." Trends in Immunology, vol. 26, no. 12, 2005, pp. 619-21. |
| Perl M, Gebhard F, Brückner UB, Ayala A, Braumüller S, Büttner C, Kinzl L, Knöferl MW. "Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge." Critical care medicine, vol. 33, no. 6, 2005, pp. 1351-8. |
| Lomas-Niera, J L, Perl, Mario, Chung, Chun-Shiang, Ayala, Alfred. "SHOCK AND HEMORRHAGE: AN OVERVIEW OF ANIMAL MODELS." Shock, vol. 24, no. Supplement 1, 2005, pp. 33-39. |
| Lomas-Niera JL, Perl M, Chung CS, Ayala A. "Shock and hemorrhage: an overview of animal models." Shock, vol. 24 Suppl 1, 2005, pp. 33-9. |
| Perl M, Chung CS, Lomas-Neira J, Rachel TM, Biffl WL, Cioffi WG, Ayala A. "Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis." The American Journal of Pathology, vol. 167, no. 6, 2005, pp. 1545-59. |
| Wesche-Soldato, D. E., Lomas-Neira, J. L., Perl, M., Jones, L., Chung, C.-S., Ayala, A. "The role and regulation of apoptosis in sepsis." Journal of Endotoxin Research, vol. 11, no. 6, 2005, pp. 375-382. |
| Wesche-Soldato DE, Lomas-Neira JL, Perl M, Jones L, Chung CS, Ayala A. "The role and regulation of apoptosis in sepsis." Journal of Endotoxin Research, vol. 11, no. 6, 2005, pp. 375-82. |
| Lomas-Neira JL, Chung CS, Grutkoski PS, Miller EJ, Ayala A. "CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice." Journal of Leukocyte Biology, vol. 76, no. 1, 2004, pp. 58-64. |
| Ding Y, Chung CS, Newton S, Chen Y, Carlton S, Albina JE, Ayala A. "Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice." Shock, vol. 22, no. 2, 2004, pp. 137-44. |
| Grutkoski, Patricia S., Chen, Yaping, Chung, Chun-Shiang, Cioffi, William G., Ayala, Alfred. "Putative Mechanism of Hemorrhage-Induced Leukocyte Hyporesponsiveness: Induction of Suppressor of Cytokine Signaling-3." The Journal of trauma, vol. 56, no. 4, 2004, pp. 742-748. |
| Grutkoski PS, Chen Y, Chung CS, Cioffi WG, Ayala A. "Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3." The Journal of trauma, vol. 56, no. 4, 2004, pp. 742-7; discussion 747-8. |
| Newton S, Ding Y, Chung CS, Chen Y, Lomas-Neira JL, Ayala A. "Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response." Surgical infections, vol. 5, no. 4, 2004, pp. 375-83. |
| Lomas JL, Chung CS, Grutkoski PS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A. "Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice." Shock, vol. 19, no. 4, 2003, pp. 358-65. |
| Ayala A, Lomas JL, Grutkoski PS, Chung S. "Fas-ligand mediated apoptosis in severe sepsis and shock." Scandinavian journal of infectious diseases, vol. 35, no. 9, 2003, pp. 593-600. |
| Rhee RJ, Carlton S, Lomas JL, Lane C, Brossay L, Cioffi WG, Ayala A. "Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction." Journal of Surgical Research, vol. 115, no. 1, 2003, pp. 74-81. |
| Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A. "Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity." Journal of Leukocyte Biology, vol. 74, no. 3, 2003, pp. 344-51. |
| Ayala A, Chung CS, Grutkoski PS, Song GY. "Mechanisms of immune resolution." Critical care medicine, vol. 31, no. 8 Suppl, 2003, pp. S558-71. |
| Meldrum DR, Partrick DA, Cleveland JC Jr, Shenkar R, Meldrum KK, Raiesdana A, Ayala A, Brown JW, Harken AH. "On-pump coronary artery bypass surgery activates human myocardial NF-kappaB and increases TNF-alpha in the heart." Journal of Surgical Research, vol. 112, no. 2, 2003, pp. 175-9. |
| Ayala A, Lomas JL, Grutkoski PS, Chung CS. "Pathological aspects of apoptosis in severe sepsis and shock?." The International Journal of Biochemistry & Cell Biology, vol. 35, no. 1, 2003, pp. 7-15. |
| Ayala A, Ding Y, Rhee RJ, Doughty LA, Grutkoski PS, Chung CS. "PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK." Recent research developments in immunology, vol. 5, 2003, pp. 13-35. |
| Grutkoski PS, Chen Y, Chung CS, Ayala A. "Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes." Journal of Leukocyte Biology, vol. 74, no. 5, 2003, pp. 916-22. |
| Angele MK, Nitsch S, Knoferl MW, Ayala A, Angele P, Schildberg FW, Jauch KW, Chaudry IH. "Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol." AJP: Endocrinology and Metabolism, vol. 285, no. 1, 2003, pp. E189-96. |
| Ayala A. "An immune perspective on selective decontamination of the digestive tract." Critical care medicine, vol. 30, no. 6, 2002, pp. 1397-8. |
| Schwacha MG, Chung CS, Ayala A, Bland KI, Chaudry IH. "Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury." AJP: Cell Physiology, vol. 282, no. 2, 2002, pp. C263-70. |
| Yang S, Chung CS, Ayala A, Chaudry IH, Wang P. "Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse." Shock, vol. 17, no. 1, 2002, pp. 55-60. |
| Knöferl MW, Angele MK, Diodato MD, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis." Annals of Surgery, vol. 235, no. 1, 2002, pp. 105-12. |
| Song GY, Chung CS, Jarrar D, Cioffi WG, Ayala A. "Mechanism of immune dysfunction in sepsis: inducible nitric oxide-meditated alterations in p38 MAPK activation." The Journal of trauma, vol. 53, no. 2, 2002, pp. 276-82; discussion 282-3. |
| Joshi AR, Chung CS, Song GY, Lomas J, Priester RA, Ayala A. "NF-kappaB activation has tissue-specific effects on immune cell apoptosis during polymicrobial sepsis." Shock, vol. 18, no. 4, 2002, pp. 380-6. |
| Grutkoski PS, Graeber CT, Ayala A, Simms HH. "Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak." Shock, vol. 17, no. 1, 2002, pp. 47-54. |
| Ayala A, Chung CS, Lomas JL, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski PS. "Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency." The American Journal of Pathology, vol. 161, no. 6, 2002, pp. 2283-94. |
| Grutkoski PS, D'Amico R, Ayala A, Simms HH. "Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner." Critical care medicine, vol. 30, no. 3, 2002, pp. 591-7. |
| Knöferl MW, Jarrar D, Angele MK, Ayala A, Schwacha MG, Bland KI, Chaudry IH. "17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage." AJP: Cell Physiology, vol. 281, no. 4, 2001, pp. C1131-8. |
| Song GY, Chung CS, Jarrar D, Chaudry IH, Ayala A. "Evolution of an immune suppressive macrophage phenotype as a product of P38 MAPK activation in polymicrobial sepsis." Shock, vol. 15, no. 1, 2001, pp. 42-8. |
| Ayala A, Chung CS, Song GY, Chaudry IH. "IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis." Cytokine, vol. 14, no. 1, 2001, pp. 37-48. |
| Chung CS, Wang W, Chaudry IH, Ayala A. "Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated." American journal of physiology. Gastrointestinal and liver physiology, vol. 280, no. 5, 2001, pp. G812-8. |
| Chung CS, Yang S, Song GY, Lomas J, Wang P, Simms HH, Chaudry IH, Ayala A. "Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis." Surgery, vol. 130, no. 2, 2001, pp. 339-45. |
| Song GY, Chung CS, Chaudry IH, Ayala A. "MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis." AJP: Cell Physiology, vol. 281, no. 2, 2001, pp. C662-9. |
| Dunican AL, Leuenroth SJ, Ayala A, Simms HH. "CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent." Shock, vol. 13, no. 3, 2000, pp. 244-50. |
| Knöferl MW, Diodato MD, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage?." Archives of surgery (Chicago, Ill. : 1960), vol. 135, no. 4, 2000, pp. 425-33. |
| Angele MK, Schwacha MG, Ayala A, Chaudry IH. "Effect of gender and sex hormones on immune responses following shock." Shock, vol. 14, no. 2, 2000, pp. 81-90. |
| Wichmann MW, Zellweger R, Ayala A, Chaudry IH. "Effect of naloxone on immune responses after hemorrhagic shock." Critical care medicine, vol. 28, no. 1, 2000, pp. 184-9. |
| Song GY, Chung CS, Chaudry IH, Ayala A. "IL-4-induced activation of the Stat6 pathway contributes to the suppression of cell-mediated immunity and death in sepsis." Surgery, vol. 128, no. 2, 2000, pp. 133-8. |
| Ayala A, Song GY, Chung CS, Redmond KM, Chaudry IH. "Immune depression in polymicrobial sepsis: the role of necrotic (injured) tissue and endotoxin." Critical care medicine, vol. 28, no. 8, 2000, pp. 2949-55. |
| Kahlke V, Angele MK, Ayala A, Schwacha MG, Cioffi WG, Bland KI, Chaudry IH. "Immune dysfunction following trauma-haemorrhage: influence of gender and age." Cytokine, vol. 12, no. 1, 2000, pp. 69-77. |
| Song GY, Chung CS, Chaudry IH, Ayala A. "Immune suppression in polymicrobial sepsis: differential regulation of Th1 and Th2 responses by p38 MAPK." Journal of Surgical Research, vol. 91, no. 2, 2000, pp. 141-6. |
| Knöferl MW, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhage." AJP: Cell Physiology, vol. 279, no. 1, 2000, pp. C72-80. |
| Schwacha MG, Ayala A, Chaudry IH. "Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injury." Journal of Leukocyte Biology, vol. 67, no. 5, 2000, pp. 644-50. |
| Angele MK, Fitzal F, Smail N, Knöferl MW, Schwacha MG, Ayala A, Wang P, Chaudry IH. "L-arginine attenuates trauma-hemorrhage-induced liver injury." Critical care medicine, vol. 28, no. 9, 2000, pp. 3242-8. |
| Chung CS, Song GY, Moldawer LL, Chaudry IH, Ayala A. "Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis/peritonitis." Journal of Surgical Research, vol. 91, no. 2, 2000, pp. 147-53. |
| Dunican A, Grutkoski P, Leuenroth S, Ayala A, Simms HH. "Neutrophils regulate their own apoptosis via preservation of CXC receptors." Journal of Surgical Research, vol. 90, no. 1, 2000, pp. 32-8. |
| Kahlke V, Angele MK, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Reversal of sexual dimorphism in splenic T lymphocyte responses after trauma-hemorrhage with aging." AJP: Cell Physiology, vol. 278, no. 3, 2000, pp. C509-16. |
| Chung CS, Song GY, Wang W, Chaudry IH, Ayala A. "Septic mucosal intraepithelial lymphoid immune suppression: role for nitric oxide not interleukin-10 or transforming growth factor-beta." The Journal of trauma, vol. 48, no. 5, 2000, pp. 807-12; discussion 812-3. |
| Leuenroth SJ, Grutkoski PS, Ayala A, Simms HH. "Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity." Surgery, vol. 128, no. 2, 2000, pp. 171-7. |
| Leuenroth SJ, Grutkoski PS, Ayala A, Simms HH. "The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis." Journal of Leukocyte Biology, vol. 68, no. 1, 2000, pp. 158-66. |
| Catania RA, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes." Cytokine, vol. 11, no. 6, 1999, pp. 443-50. |
| Knöferl MW, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Do different rates of fluid resuscitation adversely or beneficially influence immune responses after trauma-hemorrhage?." The Journal of trauma, vol. 46, no. 1, 1999, pp. 23-33. |
| Ayala A, Xu YX, Chung CS, Chaudry IH. "Does Fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis?." Shock, vol. 11, no. 3, 1999, pp. 211-7. |
| Angele MK, Xu YX, Ayala A, Schwacha MG, Catania RK, Cioffi WG, Bland KI, Chaudry IH. "Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis." Shock, vol. 12, no. 4, 1999, pp. 316-22. |
| Angele MK, Knöferl MW, Schwacha MG, Ayala A, Bland KI, Cioffi WG, Josephson SL, Chaudry IH. "Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection." Annals of Surgery, vol. 229, no. 5, 1999, pp. 651-60; discussion 660-1. |
| Angele MK, Schwacha MG, Smail N, Catania RA, Ayala A, Cioffi WG, Chaudry IH. "Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages." The American journal of physiology, vol. 276, no. 2 Pt 1, 1999, pp. C285-90. |
| Ayala A, Chung CS, Xu YX, Evans TA, Redmond KM, Chaudry IH. "Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin." Immunology, vol. 97, no. 1, 1999, pp. 45-55. |
| Angele MK, Smail N, Knöferl MW, Ayala A, Cioffi WG, Chaudry IH. "L-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow." The American journal of physiology, vol. 276, no. 1 Pt 1, 1999, pp. C145-51. |
| Angele MK, Smail N, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage." The Journal of trauma, vol. 46, no. 1, 1999, pp. 34-41. |
| Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury." Biochimica et biophysica acta, vol. 1455, no. 1, 1999, pp. 45-53. |
| Angele MK, Knöferl MW, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage." The American journal of physiology, vol. 277, no. 1 Pt 1, 1999, pp. C35-42. |
| Song GY, Chung CS, Schwacha MG, Jarrar D, Chaudry IH, Ayala A. "Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling." Journal of Surgical Research, vol. 83, no. 1, 1999, pp. 36-43. |
| Angele MK, Knöferl MW, Ayala A, Albina JE, Cioffi WG, Bland KI, Chaudry IH. "Trauma-hemorrhage delays wound healing potentially by increasing pro-inflammatory cytokines at the wound site." Surgery, vol. 126, no. 2, 1999, pp. 279-85. |
| Song GY, Chung CS, Chaudry IH, Ayala A. "What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?." Surgery, vol. 126, no. 2, 1999, pp. 378-83. |
| Wichmann MW, Remmers D, Ayala A, Chaudry IH. "[Contribution of soft tissue trauma and/or bone fracture to immune suppression after hemorrhagic shock in the animal experiment]." Der Unfallchirurg, vol. 101, no. 1, 1998, pp. 37-41. |
| Angele MK, Catania RA, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage." Archives of surgery (Chicago, Ill. : 1960), vol. 133, no. 12, 1998, pp. 1281-8. |
| Ayala A, Evans TA, Chaudry IH. "Does hepatocellular injury in sepsis involve apoptosis?." Journal of Surgical Research, vol. 76, no. 2, 1998, pp. 165-73. |
| Ayala A, Xin Xu Y, Ayala CA, Sonefeld DE, Karr SM, Evans TA, Chaudry IH. "Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process." Blood, vol. 91, no. 4, 1998, pp. 1362-72. |
| Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A. "Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?." Archives of surgery (Chicago, Ill. : 1960), vol. 133, no. 11, 1998, pp. 1213-20. |
| Zellweger R, Wichmann MW, Ayala A, Chaudry IH. "Metoclopramide: a novel and safe immunomodulating agent for restoring the depressed macrophage immune function after hemorrhage." The Journal of trauma, vol. 44, no. 1, 1998, pp. 70-7. |
| Xu YX, Ayala A, Chaudry IH. "Prolonged immunodepression after trauma and hemorrhagic shock." The Journal of trauma, vol. 44, no. 2, 1998, pp. 335-41. |
| Chung CS, Xu YX, Chaudry IH, Ayala A. "Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression." Journal of Surgical Research, vol. 77, no. 1, 1998, pp. 63-70. |
| Wichmann MW, Ayala A, Chaudry IH. "Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock." Critical care medicine, vol. 26, no. 8, 1998, pp. 1372-8. |
| Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH. "Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage." The Journal of trauma, vol. 44, no. 1, 1998, pp. 78-85. |
| Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. "Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage." AJP: Cell Physiology, vol. 274, no. 6, 1998, pp. C1530-C1536. |
| Samy TS, Ayala A, Catania RA, Chaudry IH. "Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cells." Shock, vol. 9, no. 6, 1998, pp. 443-50. |
| Meldrum DR, Cain BS, Cleveland JC Jr, Meng X, Ayala A, Banerjee A, Harken AH. "Adenosine decreases post-ischaemic cardiac TNF-alpha production: anti-inflammatory implications for preconditioning and transplantation." Immunology, vol. 92, no. 4, 1997, pp. 472-7. |
| Zhu XH, Zellweger R, Wichmann MW, Ayala A, Chaudry IH. "Effects of prolactin and metoclopramide on macrophage cytokine gene expression in late sepsis." Cytokine, vol. 9, no. 6, 1997, pp. 437-46. |
| Ayala A, Karr SM, Evans TA, Chaudry IH. "Factors responsible for peritoneal granulocyte apoptosis during sepsis." Journal of Surgical Research, vol. 69, no. 1, 1997, pp. 67-75. |
| Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH. "Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males." Critical care medicine, vol. 25, no. 1, 1997, pp. 106-10. |
| Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry IH. "Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock." Shock, vol. 8, no. 4, 1997, pp. 242-8. |
| Wichmann MW, Ayala A, Chaudry IH. "Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage." The American journal of physiology, vol. 273, no. 4 Pt 1, 1997, pp. C1335-40. |
| Xu YX, Ayala A, Monfils B, Cioffi WG, Chaudry IH. "Mechanism of intestinal mucosal immune dysfunction following trauma-hemorrhage: increased apoptosis associated with elevated Fas expression in Peyer's patches." Journal of Surgical Research, vol. 70, no. 1, 1997, pp. 55-60. |
| Ayala A, O'Neill PJ, Uebele SA, Herdon CD, Chaudry IH. "Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators." The Journal of trauma, vol. 42, no. 5, 1997, pp. 882-8. |
| Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH. "Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis." Archives of surgery (Chicago, Ill. : 1960), vol. 132, no. 11, 1997, pp. 1207-14. |
| Xu YX, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH. "Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF." Journal of Surgical Research, vol. 68, no. 1, 1997, pp. 24-30. |
| Ayala A, Tu Y, Flye MW, Chaudry IH. "Depressed splenic function after hemorrhage results from gastrointestinal tract stimulation of hepatic-mediator release. Correction with portacaval shunt." Archives of surgery (Chicago, Ill. : 1960), vol. 131, no. 11, 1996, pp. 1209-14; discussion 1215. |
| Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. "Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation." Cytokine, vol. 8, no. 11, 1996, pp. 853-63. |
| Ayala A, Chaudry IH. "Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis." Shock, vol. 6 Suppl 1, 1996, pp. S27-38. |
| Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Williams C, Chaudry IH. "Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone." Archives of surgery (Chicago, Ill. : 1960), vol. 131, no. 9, 1996, pp. 995-1000. |
| Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. "Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone." Archives of surgery (Chicago, Ill. : 1960), vol. 131, no. 11, 1996, pp. 1186-91; discussion 1191-2. |
| Wichmann MW, Zellweger R, DeMaso, Ayala A, Chaudry IH. "Melatonin administration attenuates depressed immune functions trauma-hemorrhage." Journal of Surgical Research, vol. 63, no. 1, 1996, pp. 256-62. |
| Zellweger R, Zhu XH, Wichmann MW, Ayala A, DeMaso CM, Chaudry IH. "Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis." The Journal of Immunology, vol. 157, no. 12, 1996, pp. 5748-54. |
| Zellweger R, Wichmann MW, Ayala A, DeMaso CM, Chaudry IH. "Prolactin: a novel and safe immunomodulating hormone for the treatment of immunodepression following severe hemorrhage." Journal of Surgical Research, vol. 63, no. 1, 1996, pp. 53-8. |
| Ayala A, Ertel W, Chaudry IH. "Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes." Shock, vol. 5, no. 2, 1996, pp. 79-90. |
| Zellweger R, Ayala A, Zhu XL, Holme KR, DeMaso CM, Chaudry IH. "A novel nonanticoagulant heparin improves splenocyte and peritoneal macrophage immune function after trauma-hemorrhage and resuscitation." Journal of Surgical Research, vol. 59, no. 1, 1995, pp. 211-8. |
| Ayala A, Chaudry IH. "Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before or after trauma." Nutrition (Burbank, Los Angeles County, Calif.), vol. 11, no. 1, 1995, pp. 1-11. |
| Ayala A, Deol ZK, Lehman DL, Herdon CD, Chaudry IH. "Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?." Archives of surgery (Chicago, Ill. : 1960), vol. 130, no. 11, 1995, pp. 1178-84; discussion 1184-5. |
| Zellweger R, Ayala A, Zhu XL, Morrison MH, Chaudry IH. "Effect of surgical trauma on splenocyte and peritoneal macrophage immune function." The Journal of trauma, vol. 39, no. 4, 1995, pp. 645-50. |
| Schmand JF, Ayala A, Morrison MH, Chaudry IH. "Effects of hydroxyethyl starch after trauma-hemorrhagic shock: restoration of macrophage integrity and prevention of increased circulating interleukin-6 levels." Critical care medicine, vol. 23, no. 5, 1995, pp. 806-14. |
| Zellweger R, Ayala A, Schmand JF, Morrison MH, Chaudry IH. "PAF-antagonist administration after hemorrhage-resuscitation prevents splenocyte immunodepression." Journal of Surgical Research, vol. 59, no. 3, 1995, pp. 366-70. |
| Chaudry IH, Zellweger R, Ayala A. "The role of bacterial translocation on Kupffer cell immune function following hemorrhage." Progress in clinical and biological research, vol. 392, 1995, pp. 209-18. |
| Zellweger R, Ayala A, DeMaso CM, Chaudry IH. "Trauma-hemorrhage causes prolonged depression in cellular immunity." Shock, vol. 4, no. 2, 1995, pp. 149-53. |
| Ertel W, Morrison MH, Ayala A, Chaudry IH. "Biological significance of elevated TNF levels: in vivo administration of monoclonal antibody against tnf following haemorrhage shock increases the capacity of macrophages to release TNF while restoring immunoresponsiveness." Cytokine, vol. 6, no. 6, 1994, pp. 624-32. |
| Schmand JF, Ayala A, Morrison MH, Chaudry IH. "Dextran 70 administration after trauma-hemorrhagic shock does not impair cellular immune functions." Journal of Critical Care, vol. 9, no. 4, 1994, pp. 244-54. |
| Schmand JF, Ayala A, Chaudry IH. "Effects of trauma, duration of hypotension, and resuscitation regimen on cellular immunity after hemorrhagic shock." Critical care medicine, vol. 22, no. 7, 1994, pp. 1076-83. |
| Ayala A, Chaudry IH. "Hemorrhage induces a reduction in the capacity of macrophages to mobilize intracellular calcium secondary to formyl-methionyl-leucyl-phenylalanine stimulation: association with alterations in cells surface Fc receptor expression and increased prostaglandin release." Shock, vol. 1, no. 3, 1994, pp. 228-35. |
| Ayala A, Lehman DL, Herdon CD, Chaudry IH. "Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release." Archives of surgery (Chicago, Ill. : 1960), vol. 129, no. 11, 1994, pp. 1172-8. |
| Zhu XL, Ayala A, Zellweger R, Morrison MH, Chaudry IH. "Peritoneal macrophages show increased cytokine gene expression following haemorrhagic shock." Immunology, vol. 83, no. 3, 1994, pp. 378-83. |
| Ertel W, Singh G, Morrison MH, Ayala A, Chaudry IH. "Chemically induced hypotension increases PGE2 release and depresses macrophage antigen presentation." The American journal of physiology, vol. 264, no. 4 Pt 2, 1993, pp. R655-60. |
| Zhu X, Ertel W, Ayala A, Morrison MH, Perrin MM, Chaudry IH. "Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription." Immunology, vol. 80, no. 1, 1993, pp. 122-6. |
| Meldrum DR, Ayala A, Chaudry IH. "Mechanism of diltiazem's immunomodulatory effects after hemorrhage and resuscitation." The American journal of physiology, vol. 265, no. 2 Pt 1, 1993, pp. C412-21. |
| Chaudry IH, Ayala A. "Mechanism of increased susceptibility to infection following hemorrhage." The American Journal of Surgery, vol. 165, no. 2A Suppl, 1993, pp. 59S-67S. |
| Ertel W, Morrison MH, Ayala A, Chaudry IH. "Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock." Archives of surgery (Chicago, Ill. : 1960), vol. 128, no. 1, 1993, pp. 15-20; discussion 20-1. |
| Ayala A, Knotts JB, Ertèl W, Perrin MM, Morrison MH, Chaudry IH. "Role of interleukin 6 and transforming growth factor-beta in the induction of depressed splenocyte responses following sepsis." Archives of surgery (Chicago, Ill. : 1960), vol. 128, no. 1, 1993, pp. 89-94; discussion 94-5. |
| Ayala A, Meldrum DR, Perrin MM, Chaudry IH. "The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression." Immunology, vol. 79, no. 3, 1993, pp. 479-84. |
| Ertel W, Morrison MH, Ayala A, Chaudry IH. "Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis." Archives of surgery (Chicago, Ill. : 1960), vol. 127, no. 1, 1992, pp. 70-5; discussion 75-6. |
| Ayala A, Perrin MM, Ertel W, Chaudry IH. "Differential effects of hemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release." Cytokine, vol. 4, no. 1, 1992, pp. 66-75. |
| Ayala A, Kisala JM, Felt JA, Perrin MM, Chaudry IH. "Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?." Archives of surgery (Chicago, Ill. : 1960), vol. 127, no. 2, 1992, pp. 191-6; discussion 196-7. |
| Meldrum DR, Ayala A, Chaudry IH. "Energetics of defective macrophage antigen presentation after hemorrhage as determined by ultraresolution 31P nuclear magnetic resonance spectrometry: restoration with adenosine triphosphate-MgCl2." Surgery, vol. 112, no. 2, 1992, pp. 150-6; discussion 156-8. |
| Ertel W, Morrison MH, Meldrum DR, Ayala A, Chaudry IH. "Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage." Journal of Surgical Research, vol. 53, no. 1, 1992, pp. 55-61. |
| Ertel W, Morrison MH, Ayala A, Dean RE, Chaudry IH. "Interferon-gamma attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis." Surgery, vol. 111, no. 2, 1992, pp. 177-87. |
| Ayala A, Perrin MM, Kisala JM, Ertel W, Chaudry IH. "Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor)." Circulatory shock, vol. 36, no. 3, 1992, pp. 191-9. |
| Ertel W, Morrison MH, Ayala A, Perrin MM, Chaudry IH. "Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression." Immunology, vol. 74, no. 2, 1991, pp. 290-7. |
| Ertel W, Morrison MH, Ayala A, Perrin MM, Chaudry IH. "Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock." Annals of Surgery, vol. 213, no. 3, 1991, pp. 265-71. |
| Ertel W, Morrison MH, Ayala A, Chaudry IH. "Chloroquine attenuates hemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release." Blood, vol. 78, no. 7, 1991, pp. 1781-8. |
| Meldrum DR, Ayala A, Perrin MM, Ertel W, Chaudry IH. "Diltiazem restores IL-2, IL-3, IL-6, and IFN-gamma synthesis and decreases host susceptibility to sepsis following hemorrhage." Journal of Surgical Research, vol. 51, no. 2, 1991, pp. 158-64. |
| Ayala A, Perrin MM, Wang P, Ertel W, Chaudry IH. "Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen." The Journal of Immunology, vol. 147, no. 12, 1991, pp. 4147-54. |
| Ertel W, Morrison MH, Ayala A, Chaudry IH. "Insights into the mechanisms of defective antigen presentation after hemorrhage." Surgery, vol. 110, no. 2, 1991, pp. 440-5; discussion 445-7. |
| Rana MW, Ayala A, Dean RE, Chaudry IH. "Decreased Fc receptor expression on macrophages following simple hemorrhage as observed by scanning immunoelectron microscopy." Journal of Leukocyte Biology, vol. 48, no. 6, 1990, pp. 512-8. |
| Ayala A, Perrin MM, Chaudry IH. "Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens." Immunology, vol. 70, no. 1, 1990, pp. 33-9. |
| Ayala A, Perrin MM, Wagner MA, Chaudry IH. "Enhanced susceptibility to sepsis after simple hemorrhage. Depression of Fc and C3b receptor-mediated phagocytosis." Archives of surgery (Chicago, Ill. : 1960), vol. 125, no. 1, 1990, pp. 70-4; discussion 74-5. |
| Ayala A, Perrin MM, Meldrum DR, Ertel W, Chaudry IH. "Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin." Cytokine, vol. 2, no. 3, 1990, pp. 170-4. |
| Ertel W, Meldrum DR, Morrison MH, Ayala A, Chaudry IH. "Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatability class II antigen expression, and interleukin-1 synthesis after hemorrhage." Surgery, vol. 108, no. 2, 1990, pp. 154-9; discussion 159-60. |
| Stephan RN, Ayala A, Harkema JM, Dean RE, Border JR, Chaudry IH. "Mechanism of immunosuppression following hemorrhage: defective antigen presentation by macrophages." Journal of Surgical Research, vol. 46, no. 6, 1989, pp. 553-6. |
Research interests include projects looking at: 1) determing how select expression of cell surface co-inhibitory proteins (checkpoint proteins) and their ligands, on innate immune cells as well as non-immune cells; alter the morbid events associated with adult sepsis. 2) Utilizing a novel model of indirect-acute lung (iALI) to ask how checkpoint protein expression affects the patho-mechanisms driving iALI. Finally, 3) since the neonate possesses a unique/ naive immune system and is more susceptible to morbid response in the face of infectious challenge, we are examining if the expression of checkpoint protein family members have a comparative impact on the neonate's response to septic insult.
The work in our laboratory has centered on understanding the patho-physiological effects of shock/ tissue injury/ sepsis that lead to immune dysfunction and subsequent multiple organ failure in the critically ill trauma patient (through animal modeling and collaborative clinical studies). We have described, over the years, numerous deficits in both components of cell-mediated (T-cell, NKT-cell, gd T-cell, Treg-cell, ILC2, etc) and innate (macrophage, neutrophil, dendritic cells) immune responsiveness induced by shock or sepsis, which are underpinned by alterations in cell signaling, protein translation and transcription patterns. Particular emphasis has been directed at defining the role of soluble mediators (e.g., IL-4, IL-10, IL-16, IL-33, MCP-1, MIP-2/KC/IL-8, TGF-b, PGE2, NO, steroids, etc.), inhibitory receptors/checkpoint proteins (e.g., PD-1:PD-L1/L2, BTLA:HVEM, VISTA, FasL:Fas, etc.) and/or cellular pathways (e.g., p38 MAPKs, STATs, SOCS 1/3, Shp1/2, Rip1/3, NFkB, etc.) involved in orchestrating these changes in mouse models and critically ill patient. We have also found evidence of alterations of the immune cell's apoptotic process, present in these animals and are actively examining the contribution of this pathway. It is our hope that, by understanding the cellular/molecular mechanisms which control these alterations in the traumatized or septic animal/patient, we will improve our ability to treat them.
Major Theme of Research: injury, shock, organ dysfunction, immunology and infection
Laboratory Staff-Contact List (Rev: 12/11/2024):
Fellows:
Brandon Armstead, Ph.D., M.S.
T32-Nat. Res. Serv. Award/
Post-Doctoral Fellow
Aldrich 226
401-444-6482
Brandon_Armstead@brown.edu
Graduate Students:
Fernando Gutierrez-Garcia, B.S., M.S.
Grad. Pathol. prog.-Grad. Student
Aldrich 242
401-444-6706
Fernando_Gutierrez_Garcia@brown.edu
Sr. Research Assistant:
Yaping Chen, B.S.
Sr. Res. Assist.
Aldrich 230
401-444-6728
YChen2@lifespan.org
Administrative:
Nicole Desmarais
Div. Surg. Res. – Admin. Assistant
Nursing Arts Bldg. 217
401-444-4296
nicole.desmarais@lifespan.org
Undergraduate/Medical Students:
Joanna Renedo
Jai Singh
*For more information/news on people/lab alumni go to: "Ayala Lab" website
Collaborators at Other Institutions:
Jianwen (Jen) Bai, M.D., Ph.D.
Fabienne Venet, Pharm.D., Ph.D.
Samithamby Jeyaseelan (Jey), D.V.M., Ph.D.
Laboratory Alumni (back to: 2000):
*For more information/news on people/lab alumni go to: "Ayala Lab" website
Chun-Shiang Chung, PhD, MS (emeritus/retired)
Elizabeth Tindal, M.D., M.P.H.
Valeria Sanabria Guillen, B.S.
*For more information/news on people/lab alumni go to: "Ayala Lab" website
Active Grant Support:
2016-2026
NIH-NIGMS Research Grant: "Mechanism of Immune Dysfunction and Morbid Outcome in Response to Shock/Sepsis."
Grant No.: R35 GM118097
Principal Investigator: Alfred Ayala
Total Support = $2,812,574 in direct & indirect cost (for 2021-2026).
NIH-NIGMS Administrative Supplement to Promote Diversity in Health-Related Research: "Mechanism of Immune Dysfunction and Morbid Outcome in Response to Shock/Sepsis."
Grant No.: R35 GM118097-07S1
Principal Investigator: Alfred Ayala
Total Support = $144,655 in direct & indirect cost (for 2022-2025).
2004-2025
NIH-NIGMS Post-Doctoral Training Grant: "Trauma-inflammation Research Training."
Grant No.: T32-GM08768
Program Director: Alfred Ayala
Executive Committee/Training Faculty: Alfred Ayala
Total Support Requested = $1,309,020 in direct and indirect cost (for 2020-2025).
Grants/Funding on which 'role' is other than Principle Investigator:
2018-2023
NCRR COBRE Grant: "CardioPulmonary Vascular Biology-COBRE:Endothelial
Cell Injury & Repair."
Grant No. P20-RR032693
Program Director: Sharon Rounds
Executive Committee/Mentor (for Sean Monahghan): Alfred Ayala
Total Support = $7,410,000 in direct and indirect cost (for 2018-2023).
2007-2022
NIH-NIHLBI Undergraduate Student Training Grant: "Short-term Training Program to Increase Diversity in Health-Related Research."
Grant No.: R25-HL088992
Principal Investigator: Elizabeth Harrington
Faculty Trainer/Exec. Comm.: Alfred Ayala
Total Support = $101,258 in direct and indirect cost annually.
2021-2026
NIH-NIGMS Research Grant: "Improving Sepsis Care with Deep RNA Sequencing Data.”
Grant No.: R35-GM142638
Principle Investigator: Sean F. Monaghan
Collaborator: Alfred Ayala
Total Support Requested = $1,978,996 in direct and indirect cost (for 2021-2026).
BOOK CHAPTERS:
Chun, T.T., Potz, B.A., Young, W.A., Ayala, A. 2017. Chapter 4: Overview of the Molecular Pathways and Mediators of Sepsis. In: “Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management”; Edited by: Ward, N.S. & Levy, M.M.; Springer, Heidelberg, Germany, pg 47-69.
Monaghan, S.F., Ayala, A. 2016. Part 14.3: Inflammationand the Host Response; Section 311: Adaptive Immunity in Critical Illness. In the “Oxford Textbook of Critical Care, 2nd Edition. Editors: Webb, A., Angus, D., Finfer, S., Gattinoni, L., Singer, M. Oxford University Press, Oxford, UK.
Thakkar, R.K., Huang, X., Lomas-Neira, J., Heffernan, D., Ayala, A. 2011. Chapter 5: Sepsis and the immune response, in: Essential Immunology for Surgeons, Edited by Eremin, O. & Sewell, H., Oxford University Press, Oxford, U.K. pg 303-342.
Chung, C.S., Swan, R., Wesche-Soldato, D.E., Perl, M., Ayala, A. 2009. Apoptosis: in Sepsis and non-infectious SIRS. In: Sepsis and Non-Infectious Systemic Inflammation. Editors: J-M. Cavaillon & C. Adrie. Wiley-VCH, WeinHeim, Germany, pg 205-229.
Wesche-Soldato, D.E., Lomas-Neira, J., Perl, M., Chung, C.S., Ayala, A. 2008. Hydrodynamic Delivery of siRNA in a Mouse Model of Sepsis. Chapter 5 in: Methods in Molecular Biology, volume 442: RNAi: Design and Application. Editors: S. Barik. Human Press Inc., Totowa, NJ, pg 67-73.
Ayala, A., Wesche-Soldato, D.E., Perl, M., Lomas-Neira, J.L., Swan, R., Chung, C.S. 2007. Novartis Foundation Symposium No. 280 on Sepsis-New Insights, New Therapies. Chapter: Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis. Wiley Press, Chichester, U.K., pg. 37-52.
Grutkoski, P.S., Chung, C.S., Albina, J.E., Biffl, W.L., Ayala, A. 2004. Chapter: 38. Apoptosis in the Critically Ill. In: Textbook of Critical Care, 5th Edition. Editors: Abraham, E. W.B. Saunders Publishers, Philadelphia, PA, pg. 195-202.
Ayala, A., Chung, C.S., Song, G.Y., Grutkoski, P.S., Simms, H.H. 2002. Chapter 3. Down-Regulation of the Immune Response. In: Molecular & Cellular Biology of Critical Care Medicine. Editors: Linden, P. and Doughty L.A. Kluwer Academic Publishers, Norwell, MA, pg 41-78.
Angele, M.K., Schwacha, M.G., Ayala, A., Chaudry, I.H. 2001. The role of macrophages following hemorrhagic shock. In: Shock, Editors: Z-Y Luo, C-S. Tang, H-M Gin. TianGin Science and Technology Press. TianGin, China. 699-721.
Ayala, A., Wang, P., Chaudry, I.H. 2001. Chapter 27: Shock Models: Hemorrhage. In: Surgical Research. Editors: Souba, W., Wilmore, D. Academic Press, San Diego, CA, pg 317-330.
Chung, C.S., Chaudry, I.H., Ayala, A. 2000. The apoptotic response of the lymphoid immune system to trauma, shock and sepsis. In: Yearbook of Intensive Care and Emergency Medicine-2000. Editors: Vincent, J.L. Springer-Verlag, Heidelberg, Germany pg 27-40.
Ayala, A., Chung, C.S., Song, G.Y. 1999. Lymphocyte anergy, apoptosis and cell activation in polymicrobial sepsis. In: Update in Intensive Care and Emergency Medicine, Vol. 31. Editors: Marshal, J.C., Cohen, J., Vincent, J.L. Springer-Verlag, Berlin, Germany, pg. 226-246.
Angele, M.K., Schwacha, M.G., Ayala, A., Chaudry, I.H. 1999. The immunoinflammatory response to hemorrhage. In: Sepsis and Multiple Organ Dysfunction. Editors: Deitch, E.A., Windsor and J.L. Vincent. Harcourt Brace & Co. Ltd., London, U.K., pg. 117-126.
Ayala, A., Chaudry, I.H. 1998. Anti-cytokine strategies in peritonitis. Is local, intra-abdominal, therapy possible? In: Cytokines and the Abdominal Surgeon, Editor: M. Schein, Medical Intelligence Unit; R.G. Landes Company, Austin, TX. Pg.245-271.
Angele, M.K., Ayala, A., Chaudry, I.H. 1998. Cytokine in experimental peritonitis. In: Cytokines and the Abdominal Surgeon, Editor: M. Schein, Medical Intelligence Unit; R.G. Landes Company, Austin, TX. Pg.107-116.
Zellweger, R., Ayala, A., Chaudry, I.H. 1998. Predisposing factors: effect of sex, nutritional factors and age on the immunity following shock and sepsis. In: Cytokines in Severe Sepsis and Septic Shock. Editors: H. Redl and G. Schlag, Birkhauser Publishing Ltd., Basel, Switzerland, pg. 57-77.
Zellweger, R., Ayala, A., Wang, P., Chaudry, I.H. 1998. Immunomodulation following shock and sepsis. In: Cytokines in Severe Sepsis and Septic Shock. Editors: H. Redl and G. Schlag, Birkhauser Publishing Ltd., Basel, Switzerland, pg. 313-295.
Chaudry, I.H., Wichmann, M.W., Ayala, A. 1997. Immunological alterations following hemorrhagic shock: considerations for resuscitation with blood substitutes. In: Fundamental Principles and Clinical Applications of Red Blood Cell Substitutes, Editors, R. Rabinovici, G. Feuerstein, A.S. Rudolph, Marcel-Dekker, New York, pg.165-188.
Ayala, A., Wang, P., Chaudry, I.H. 1996. Hemorrhage induced alteration in macrophage signal transduction. In Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches, Editor, E. Faist, Pabst, Berlin 84-98.
Chaudry, I.H., Ayala, A., Wang, P. 1996. Early indicator of hepatocellular dysfunction in sepsis and hemorrhage. In Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches, Editor, E. Faist, Pabst, Berlin 935-947.
Chaudry, I.H., Wang, P., Ayala, A. 1996. Hepatic and splenic macrophage response to shock. In Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches, Editor, E. Faist, Pabst, Berlin 130-141.
Chaudry, I.H., Zellweger, R., Ayala, A. 1995. The role of bacterial translocation in kupffer cell immune function following hemorrhage. In Bacterial Endotoxins: Lipopolysaccharides, From Genes to Therapy, Editor, E. Faist, Wiley-Liss, Inc., New York, pg 209-218.
Chaudry, I.H., Ayala, A., Meldrum, D., and W. Ertel. 1993. Hemorrhage-induced alterations in cell-mediated immune function. In Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches, Editor, E. Faist, Springer-Verlag, Berlin, 149-159.
Stephan, R.N., Ayala, A., Chaudry, I.H. 1993. Monocyte and lymphocyte responses following trauma. In Pathophysiology of Shock, Sepsis and Organ Failure, Editor, G. Schlag and H. Redl, Springer-Verlag, Berlin, 131-139.
BOOK:
Chaudry, I.H., Ayala, A. Immunologic Aspects of Hemorrhage." Medical Intelligence Unit; R.G. Landes Company, Austin, TX, October, 1992.| Year | Degree | Institution |
|---|---|---|
| 1985 | PhD | Cleveland State University |
| 1978 | MS | Cleveland State University |
| 1976 | BS | Bowling Green State University |
| Research Associate | Michigan State University, Surgery | 1988-1989 | East Lansing, MI |
| Postdoctoral Fellow | Michigan State University, microbiology | 1985-1988 | East Lansing, MI |
Selected as the 2024 "Legacy Awardee" of the Society of Leukocyte Biology (SLB)
Elected “Fellow”-American Association for the Advancement of Science (AAAS), 2022
Recipient of an NIH-NIGMS - Maximizing Investigators' Research Award-MIRA (2016)
Recipient of an AM-'Ad eundem' Honary Degree in Science & Training from Brown Univ. (2014)
Recipient of the Shock Society's - Distinguished Service Award (2011)
Recipient of the Shock Society's - Scientific Achievement Award (2007)
Surgical Infection Society - Joseph Susman Awardee (1994)
selected as:
SIS Recorder/Council Member (2005-07)
Society of Leukocyte Biology- Councilor (2011-2013) (by appoinment)
Society of Leukocyte Biology- Co-Program Chariman (2013) (by appoinment)
Elected as:
Shock Society- President (2004-05), Treasurer (2002-04), Sci. Program Chair. (2001)
Society of Leukocyte Biology- Councilor (2011-2013) (by appoinment)
| Name | Title |
|---|---|
| Albina, Jorge | Professor Emeritus of Surgery |
| Brossay, Laurent | Charles A. and Helen B. Stuart Professor of Medical Science, Professor of Molecular Microbiology and Immunology |
| Chung, Chun-Shiang | Assistant Professor Emerita (Research) of Surgery |
| Cioffi, William | Professor Emeritus of Surgery |
| De Paepe, Monique | Professor of Pathology and Laboratory Medicine |
| Gregory, Stephen | Associate Professor of Medicine (Research) |
| Harrington, Elizabeth | Associate Dean for Graduate Studies, Professor of Medicine |
| Heffernan, Daithi | Associate Professor of Surgery |
| Jamieson, Amanda | Esther Elizabeth Brintzenhoff Associate Professor of Molecular Microbiology and Immunology, Pathobiology Graduate Program Co-Director |
| Lefort, Craig | Associate Professor of Surgery (Research) |
| Lomas-Neira, Joanne | Assistant Professor of Surgery (Research) |
| Lu, Qing | Associate Professor of Medicine |
| Monaghan, Sean | Associate Professor of Surgery |
| Opal, Steven | Clinical Professor of Medicine |
| Reichner, Jonathan | Professor of Surgery (Research) |
| Rounds, Sharon | Associate Dean for Translational Science, Professor of Medicine, Professor of Pathology and Laboratory Medicine |
| Tyrka, Audrey | Mary E. Zucker Professor of Psychiatry and Human Behavior, Professor of Psychiatry and Human Behavior, Chair of Psychiatry and Human Behavior |
| Zhuang, Shougang | Professor of Medicine (Research) |
American Society of Investigative Pathology
American Association for the Advancement of Science
American Association of Immunologists
International Cytokine Society
Shock Society
Surgical Infection Society
Society of Critical Care Medicine
Society of Leukocyte Biology
National Research Mentoring Network
| Director, Division of Surgical Research. RI Hospital/Brown University, 2023- |
| Senior Research Scientist. Rhode Island Hospital, 2000-Present |
| Research Scientist. Rhode Island Hospital, 1996-2000 |
IMSD Training Module-Spring 2023
Crit. Reading Sci. Pubs.
Bio296
Dir. Res./Grad. Independent Study
Bio285
Intro. to Pathobiol. Res.-overview lect.
Bio710
Med. Student Independent Study
Bio284
Topics in Pathiobiology: Immunopathology
Bio 195/196
Undergrad. Independent Study
