Dr. Tyrka is Mary E. Zucker Professor and Chair, of the Department of Psychiatry and Human Behavior. She received her MD and PhD in medicine and psychology through a combined program at the University of Pennsylvania in 1999. Dr. Tyrka completed psychiatry residency training at Brown and further research training in clinical neuroscience at the Mood Disorders Research Program and Laboratory for Clinical Neuroscience at Butler Hospital. Dr. Tyrka is Co-Director of the Center for Stress, Trauma, and Resilience (STAR), which includes the STAR COBRE Center and a STAR Research Postdoctoral Fellowship T32 program. Internationally known for her groundbreaking work on early adversity, Dr. Tyrka has made discoveries of neuroendocrine, epigenetic, and biological aging processes that are now widely understood to underlie stress-associated mental and physical health conditions. She has also contributed to pharmacologic, behavioral, and neuromodulation treatments trials for depression and is an attending psychiatrist in the Butler Hospital Transcranial Magnetic Stimulation Clinic. A dedicated mentor and leader in research training, Dr. Tyrka is PI of our NIMH-funded R25 Research Training Program for physician scientists in psychiatry training. The Department of Psychiatry and Human Behavior is committed to measurable policies and practices that foster diversity, equity, inclusion and belonging, and promote anti-racism within our education, research, and clinical care settings and the community at large. A member of the Community Advisory Board of Sojourner House, Dr. Tyrka is also a painter and mixed-media artist, and she contributes the proceeds from her art toward their mission to support people affected by domestic and sexual violence.
| Parade SH, Huffhines L, Daniels TE, Stroud LR, Nugent NR, Tyrka AR. "A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches." Translational Psychiatry, vol. 11, no. 1, 2021, pp. 134. |
| Marquez FD, Risica PM, Mathis KJ, Sullivan A, Gobin AP, Tyrka AR. "Do measures of healthy eating differ in survivors of early adversity?." Appetite, vol. 162, 2021, pp. 105180. |
| Daniels TE, Sadovnikoff AI, Ridout KK, Lesseur C, Marsit CJ, Tyrka AR. "Associations of maternal diet and placenta leptin methylation." Molecular and cellular endocrinology, vol. 505, 2020, pp. 110739. |
| Coe JL, Parade SH, Seifer R, Frank L, Tyrka AR. "Household Chaos Moderates Indirect Pathways Involving Domestic Violence, Parenting Practices, and Behavior Problems among Preschool Children." Journal of Family Violence, vol. 35, no. 5, 2020, pp. 405-416. |
| Dichtel LE, Carpenter LL, Nyer M, Mischoulon D, Kimball A, Deckersbach T, Dougherty DD, Schoenfeld DA, Fisher L, Cusin C, Dording C, Trinh NH, Pedrelli P, Yeung A, Farabaugh A, Papakostas GI, Chang T, Shapero BG, Chen J, Cassano P, Hahn EM, Rao EM, Brady RO Jr, Singh RJ, Tyrka AR, Price LH, Fava M, Miller KK. "Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study." American Journal of Psychiatry, vol. 177, no. 10, 2020, pp. 965-973. |
| Ridout, Kathryn K., Coe, Jesse L., Parade, Stephanie H., Marsit, Carmen J., Kao, Hung-Teh, Porton, Barbara, Carpenter, Linda L., Price, Lawrence H., Tyrka, Audrey R. "Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress." Psychoneuroendocrinology, vol. 116, 2020, pp. 104632. |
| Coe, Jesse L., Micalizzi, Lauren, Josefson, Brittney, Parade, Stephanie H., Seifer, Ronald, Tyrka, Audrey R. "Sex Differences in Associations between Early Adversity, Child Temperament, and Behavior Problems." International Journal of Behavioral Development, vol. 44, no. 6, 2020, pp. 490-504. |
| Daniels TE, Olsen EM, Tyrka AR. "Stress and Psychiatric Disorders: The Role of Mitochondria." Annual review of clinical psychology, vol. 16, 2020, pp. 165-186. |
| Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M. "Accelerating research on biological aging and mental health: Current challenges and future directions." Psychoneuroendocrinology, vol. 106, 2019, pp. 293-311. |
| Ridout KK, Parade SH, Kao HT, Magnan S, Seifer R, Porton B, Price LH, Tyrka AR. "Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study." Psychoneuroendocrinology, vol. 107, 2019, pp. 261-269. |
| Ridout KK, Parade SH, Kao HT, Magnan S, Seifer R, Porton B, Price LH, Tyrka AR. "Corrigendum to "Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study" [Psychoneuroendocrinology 107 (2019) 261-269]." Psychoneuroendocrinology, vol. 110, 2019, pp. 104466. |
| Zandvakili A, Philip NS, Jones SR, Tyrka AR, Greenberg BD, Carpenter LL. "Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study." Journal of Affective Disorders, vol. 252, 2019, pp. 47-54. |
| Carpenter LL, Conelea C, Tyrka AR, Welch ES, Greenberg BD, Price LH, Niedzwiecki M, Yip AG, Barnes J, Philip NS. "5 Hz Repetitive transcranial magnetic stimulation for posttraumatic stress disorder comorbid with major depressive disorder." Journal of affective disorders, vol. 235, 2018, pp. 414-420. |
| Ridout KK, Levandowski M, Ridout SJ, Gantz L, Goonan K, Palermo D, Price LH, Tyrka AR. "Early life adversity and telomere length: a meta-analysis." Molecular Psychiatry, vol. 23, no. 4, 2018, pp. 858-871. |
| Welch ES, Weigand A, Hooker JE, Philip NS, Tyrka AR, Press DZ, Carpenter LL. "Feasibility of Computerized Cognitive-Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression." Neuromodulation: Technology at the Neural Interface, vol. 22, no. 8, 2018, pp. 898-903. |
| Laferton JAC, Vijapura S, Baer L, Clain AJ, Cooper A, Papakostas G, Price LH, Carpenter LL, Tyrka AR, Fava M, Mischoulon D. "Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression." Frontiers in Psychiatry, vol. 9, 2018, pp. 424. |
| Conelea CA, Philip NS, Yip AG, Barnes JL, Niedzwiecki MJ, Greenberg BD, Tyrka AR, Carpenter LL. "Response to Letter to the Editor regarding "Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic outcomes for younger versus older patients"." Journal of Affective Disorders, vol. 225, 2018, pp. 773-774. |
| Novick AM, Levandowski ML, Laumann LE, Philip NS, Price LH, Tyrka AR. "The effects of early life stress on reward processing." Journal of Psychiatric Research, vol. 101, 2018, pp. 80-103. |
| Uebelacker LA, Tremont G, Gillette LT, Epstein-Lubow G, Strong DR, Abrantes AM, Tyrka AR, Tran T, Gaudiano BA, Miller IW. "Adjunctive yoga v. health education for persistent major depression: a randomized controlled trial." Psychological Medicine, vol. 47, no. 12, 2017, pp. 1-13. |
| Parade SH, Parent J, Rabemananjara K, Seifer R, Marsit CJ, Yang BZ, Zhang H, Tyrka AR. "Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity." Development and Psychopathology, vol. 29, no. 5, 2017, pp. 1627-1634. |
| Parent J, Parade SH, Laumann LE, Ridout KK, Yang BZ, Marsit CJ, Seifer R, Tyrka AR. "Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment." Development and Psychopathology, vol. 29, no. 5, 2017, pp. 1635-1648. |
| Philip, Noah S., Barredo, Jennifer, van ’t Wout-Frank, Mascha, Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder." Biological Psychiatry, vol. 83, no. 3, 2017, pp. 263-272. |
| Parade, Stephanie H., Novick, Andrew M., Parent, Justin, Seifer, Ronald, Klaver, Samantha J., Marsit, Carmen J., Gobin, Asi Polly, Yang, Bao-Zhu, Tyrka, Audrey R. "Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers." Development and Psychopathology, vol. 29, no. 5, 2017, pp. 1619-1626. |
| Conelea CA, Philip NS, Yip AG, Barnes JL, Niedzwiecki MJ, Greenberg BD, Tyrka AR, Carpenter LL. "Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic treatment outcomes for younger versus older patients." Journal of Affective Disorders, vol. 217, 2017, pp. 42-47. |
| Tyrka, Audrey R., Parade, Stephanie H., Price, Lawrence H., Kao, Hung-Teh, Porton, Barbara, Philip, Noah S., Welch, Emma S., Carpenter, Linda L. "Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology." Biological Psychiatry, vol. 79, no. 2, 2016, pp. 78-86. |
| Tyrka AR, Ridout KK, Parade SH. "Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults." Dev Psychopathol, vol. 28, no. 4pt2, 2016, pp. 1319-1331. |
| Levandowski ML, Tractenberg SG, de Azeredo LA, De Nardi T, Rovaris DL, Bau CH, Rizzo LB, Maurya PK, Brietzke E, Tyrka AR, Grassi-Oliveira R. "Crack cocaine addiction, early life stress and accelerated cellular aging among women." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 71, 2016, pp. 83-9. |
| Ridout KK, Ridout SJ, Price LH, Sen S, Tyrka AR. "Depression and telomere length: A meta-analysis." Journal of affective disorders, vol. 191, 2016, pp. 237-47. |
| Philip NS, Tyrka AR, Albright SE, Sweet LH, Almeida J, Price LH, Carpenter LL. "Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity." Journal of Psychiatric Research, vol. 79, 2016, pp. 93-100. |
| Parade SH, Ridout KK, Seifer R, Armstrong DA, Marsit CJ, McWilliams MA, Tyrka AR. "Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links With Internalizing Behavior Problems." Child Dev, vol. 87, no. 1, 2016, pp. 86-97. |
| Tyrka AR, Parade SH, Welch ES, Ridout KK, Price LH, Marsit C, Philip NS, Carpenter LL. "Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders." Translational psychiatry, vol. 6, no. 7, 2016, pp. e848. |
| Ostlund, Brendan D., Conradt, Elisabeth, Crowell, Sheila E., Tyrka, Audrey R., Marsit, Carmen J., Lester, Barry M. "Prenatal Stress, Fearfulness, and the Epigenome: Exploratory Analysis of Sex Differences in DNA Methylation of the Glucocorticoid Receptor Gene." Frontiers in behavioral neuroscience, vol. 10, 2016, pp. 147. |
| Ridout KK, Carpenter LL, Tyrka AR. "The Cellular Sequelae of Early Stress: Focus on Aging and Mitochondria." Neuropsychopharmacology, vol. 41, no. 1, 2016, pp. 388-9. |
| Ganança, Licínia, Oquendo, Maria A., Tyrka, Audrey R., Cisneros-Trujillo, Sebastian, Mann, J. John, Sublette, M. Elizabeth. "The role of cytokines in the pathophysiology of suicidal behavior." Psychoneuroendocrinology, vol. 63, 2016, pp. 296-310. |
| Philip, Noah S., Carpenter, S. Louisa, Ridout, Samuel J., Sanchez, George, Albright, Sarah E., Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "5Hz Repetitive transcranial magnetic stimulation to left prefrontal cortex for major depression." Journal of affective disorders, vol. 186, 2015, pp. 13-7. |
| Dougherty DD, Rezai AR, Carpenter LL, Howland RH, Bhati MT, O'Reardon JP, Eskandar EN, Baltuch GH, Machado AD, Kondziolka D, Cusin C, Evans KC, Price LH, Jacobs K, Pandya M, Denko T, Tyrka AR, Brelje T, Deckersbach T, Kubu C, Malone DA Jr. "A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression." Biological Psychiatry, vol. 78, no. 4, 2015, pp. 240-248. |
| Tyrka, Audrey R., Parade, Stephanie H., Valentine, Thomas R., Eslinger, Nicole M., Seifer, Ronald. "Adversity in preschool-aged children: Effects on salivary interleukin-1β." Dev Psychopathol, vol. 27, no. 02, 2015, pp. 567-576. |
| Tyrka, Audrey R., Carpenter, Linda L., Kao, Hung-Teh, Porton, Barbara, Philip, Noah S., Ridout, Samuel J., Ridout, Kathryn K., Price, Lawrence H. "Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults." Experimental Gerontology, vol. 66, 2015, pp. 17-20. |
| Tyrka, Audrey R., Ridout, Kathryn K., Parade, Stephanie H., Paquette, Alison, Marsit, Carmen J., Seifer, Ronald. "Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)." Dev Psychopathol, vol. 27, no. 4pt2, 2015, pp. 1637-1645. |
| Tyrka AR, Ridout KK, Parade SH, Paquette A, Marsit CJ, Seifer R. "Childhood maltreatment and methylation of FK506 binding protein 5 gene (FKBP5)." Dev Psychopathol, vol. 27, no. 4 Pt 2, 2015, pp. 1637-45. |
| Philip, Noah S., Sweet, Lawrence H., Tyrka, Audrey R., Carpenter, S. Louisa, Albright, Sarah E., Price, Lawrence H., Carpenter, Linda L. "Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task." Brain Imaging and Behavior, vol. 10, no. 1, 2015, pp. 124-35. |
| Sarris J, Price LH, Carpenter LL, Tyrka AR, Ng CH, Papakostas GI, Jaeger A, Fava M, Mischoulon D. "Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial." Pharmacopsychiatry, vol. 48, no. 4-5, 2015, pp. 141-144. |
| Tyrka, Audrey R., Parade, Stephanie H., Eslinger, Nicole M., Marsit, Carmen J., Lesseur, Corina, Armstrong, David A., Philip, Noah S., Josefson, Brittney, Seifer, Ronald. "Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children." Dev Psychopathol, vol. 27, no. 02, 2015, pp. 577-85. |
| McCarthy MJ, Tyrka AR. "The Acta Psychiatrica Scandinavica Trainee Advisory Board: education, mentoring, and experience with the editorial process." Acta psychiatrica Scandinavica, vol. 132, no. 6, 2015, pp. 429-30. |
| Kaufman J, Gelernter J, Hudziak JJ, Tyrka AR, Coplan JD. "The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children." Journal of the American Academy of Child & Adolescent Psychiatry, vol. 54, no. 8, 2015, pp. 617-25. |
| Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L, Dording CM, Clain AJ, Durham K, Walker R, Ludington E, Fava M. "A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder." J. Clin. Psychiatry, vol. 75, no. 4, 2014, pp. 370-6. |
| Mischoulon, David, Price, Lawrence H., Carpenter, Linda L., Tyrka, Audrey R., Papakostas, George I., Fava, Maurizio. "Dr Mischoulon and Colleagues Reply." J. Clin. Psychiatry, 2014, pp. e1329-e1329. |
| Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Fava M. "Dr. Mischoulon and colleagues reply." J. Clin. Psychiatry, vol. 75, no. 11, 2014, pp. e1328-9. |
| Philip NS, Valentine TR, Sweet LH, Tyrka AR, Price LH, Carpenter LL. "Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments." Journal of Psychiatric Research, vol. 52, 2014, pp. 63-9. |
| Ridout, Kathryn K., Parade, Stephanie H., Seifer, Ronald, Price, Lawrence H., Gelernter, Joel, Feliz, Paloma, Tyrka, Audrey R. "Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers." Dev Psychopathol, vol. 26, no. 4pt2, 2014, pp. 1277-1287. |
| Philip NS, Sweet LH, Tyrka AR, Price LH, Bloom RF, Carpenter LL. "Decreased default network connectivity is associated with early life stress in medication-free healthy adults." European Neuropsychopharmacology, vol. 23, no. 1, 2013, pp. 24-32. |
| Philip NS, Sweet LH, Tyrka AR, Price LH, Carpenter LL, Kuras YI, Clark US, Niaura RS. "Early life stress is associated with greater default network deactivation during working memory in healthy controls: a preliminary report." Brain Imaging and Behavior, vol. 7, no. 2, 2013, pp. 204-12. |
| Philip NS, Kuras YI, Valentine TR, Sweet LH, Tyrka AR, Price LH, Carpenter LL. "Regional homogeneity and resting state functional connectivity: associations with exposure to early life stress." Psychiatry Research, vol. 214, no. 3, 2013, pp. 247-53. |
| Tracie Shea M, Reddy MK, Tyrka AR, Sevin E. "Risk factors for post-deployment posttraumatic stress disorder in national guard/reserve service members." Psychiatry Research, vol. 210, no. 3, 2013, pp. 1042-8. |
| Price LH, Kao HT, Burgers DE, Carpenter LL, Tyrka AR. "Telomeres and early-life stress: an overview." Biological Psychiatry, vol. 73, no. 1, 2013, pp. 15-23. |
| Tyrka AR, Burgers DE, Philip NS, Price LH, Carpenter LL. "The neurobiological correlates of childhood adversity and implications for treatment." Acta psychiatrica Scandinavica, vol. 128, no. 6, 2013, pp. 434-47. |
| Gawuga, C.E., Tyrka, A.R., Price, L.H., Carpenter, L.L. "145. Temporal associations between IL-6 and cortisol production in response to acute psychosocial stress." Brain, Behavior, and Immunity, vol. 26, 2012, pp. S40. |
| Tyrka AR, Walters OC, Price LH, Anderson GM, Carpenter LL. "Altered response to neuroendocrine challenge linked to indices of the metabolic syndrome in healthy adults." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, vol. 44, no. 7, 2012, pp. 543-9. |
| Carpenter LL, Gawuga CE, Tyrka AR, Price LH. "C-reactive protein, early life stress, and wellbeing in healthy adults." Acta psychiatrica Scandinavica, vol. 126, no. 6, 2012, pp. 402-10. |
| Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. "Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults." PLoS ONE, vol. 7, no. 1, 2012, pp. e30148. |
| Tyrka AR, Lee JK, Graber JA, Clement AM, Kelly MM, DeRose L, Warren MP, Brooks-Gunn J. "Neuroendocrine predictors of emotional and behavioral adjustment in boys: longitudinal follow-up of a community sample." Psychoneuroendocrinology, vol. 37, no. 12, 2012, pp. 2042-6. |
| Strong DR, Haber SN, Tyrka AR, Bernier JA, Rassmussen SA, Greenberg BD. "Reversible increase in smoking after withdrawal of ventral capsule/ventral striatum deep brain stimulation in a depressed smoker." Journal of Addiction Medicine, vol. 6, no. 1, 2012, pp. 94-5. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "The nicotinic acetylcholine receptor as a target for antidepressant drug development." TheScientificWorldJournal, vol. 2012, 2012, pp. 104105. |
| Carpenter LL, Tyrka AR, Lee JK, Tracy AP, Wilkinson CW, Price LH. "A placebo-controlled study of sertraline's effect on cortisol response to the dexamethasone/corticotropin-releasing hormone test in healthy adults." Psychopharmacology, vol. 218, no. 2, 2011, pp. 371-9. |
| Carpenter LL, Shattuck TT, Tyrka AR, Geracioti TD, Price LH. "Effect of childhood physical abuse on cortisol stress response." Psychopharmacology, vol. 214, no. 1, 2011, pp. 367-75. |
| Nugent NR, Tyrka AR, Carpenter LL, Price LH. "Gene-environment interactions: early life stress and risk for depressive and anxiety disorders." Psychopharmacology, vol. 214, no. 1, 2011, pp. 175-96. |
| Cui D, Zhang H, Yang BZ, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. "Variation in NGFB is associated with primary affective disorders in women." Am. J. Med. Genet., vol. 156B, no. 4, 2011, pp. 401-12. |
| Amin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilomäki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landrø NI, Zvartau E, Gelernter J, Epperson CN, Räsänen P, Siironen J, Lappalainen J. "A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls." Am. J. Med. Genet., vol. 153B, no. 1, 2010, pp. 332-5. |
| Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. "Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults." Neuropsychopharmacology, vol. 35, no. 13, 2010, pp. 2617-23. |
| Tyrka AR, Kelly MM, Graber JA, DeRose L, Lee JK, Warren MP, Brooks-Gunn J. "Behavioral adjustment in a community sample of boys: links with basal and stress-induced salivary cortisol concentrations." Psychoneuroendocrinology, vol. 35, no. 8, 2010, pp. 1167-77. |
| Tyrka, A. "C.10.01 Gene–environment interactions – role in depressive and anxiety disorders." European Neuropsychopharmacology, vol. 20, 2010, pp. S644. |
| Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL. "Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging." Biological Psychiatry, vol. 67, no. 6, 2010, pp. 531-4. |
| Tyrka, Audrey R., Price, Lawrence H., Kao, Hung-Teh, Porton, Barbara, Carpenter, Linda L. "In Response to “No Correlation Between Childhood Maltreatment and Telomere Length”." Biological Psychiatry, vol. 68, no. 6, 2010, pp. e23-e24. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature." Psychopharmacology, vol. 212, no. 1, 2010, pp. 1-12. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era." Expert opinion on pharmacotherapy, vol. 11, no. 5, 2010, pp. 709-22. |
| Schoedl AF, Costa MC, Mari JJ, Mello MF, Tyrka AR, Carpenter LL, Price LH. "The clinical correlates of reported childhood sexual abuse: an association between age at trauma onset and severity of depression and PTSD in adults." Journal of child sexual abuse, vol. 19, no. 2, 2010, pp. 156-70. |
| Mello MF, Faria AA, Mello AF, Carpenter LL, Tyrka AR, Price LH. "[Childhood maltreatment and adult psychopathology: pathways to hypothalamic-pituitary-adrenal axis dysfunction]." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 31 Suppl 2, 2009, pp. S41-8. |
| Tyrka AR, Wyche MC, Kelly MM, Price LH, Carpenter LL. "Childhood maltreatment and adult personality disorder symptoms: influence of maltreatment type." Psychiatry Research, vol. 165, no. 3, 2009, pp. 281-7. |
| Malone, Donald A., Dougherty, Darin D., Rezai, Ali R., Carpenter, Linda L., Friehs, Gerhard M., Eskandar, Emad N., Rauch, Scott L., Rasmussen, Steven A., Machado, Andre G., Kubu, Cynthia S., Tyrka, Audrey R., Price, Lawrence H., Stypulkowski, Paul H., Giftakis, Jonathon E., Rise, Mark T., Malloy, Paul F., Salloway, Stephen P., Greenberg, Benjamin D. "Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression." Biological Psychiatry, vol. 65, no. 4, 2009, pp. 267-275. |
| Carpenter LL, Ross NS, Tyrka AR, Anderson GM, Kelly M, Price LH. "Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls." Psychoneuroendocrinology, vol. 34, no. 8, 2009, pp. 1208-13. |
| Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH. "Effect of childhood emotional abuse and age on cortisol responsivity in adulthood." Biological Psychiatry, vol. 66, no. 1, 2009, pp. 69-75. |
| Tyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL. "Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity." Biological Psychiatry, vol. 66, no. 7, 2009, pp. 681-5. |
| Mello, Marcelo F., Faria, Alvaro A., Mello, Andrea F., Carpenter, Linda L., Tyrka, Audrey R., Price, Lawrence H. "Maus-tratos na infância e psicopatologia no adulto: caminhos para a disfunção do eixo hipotálamo-pituitária-adrenal." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 31, 2009. |
| Philip, Noah S., Carpenter, Linda L., Tyrka, Audrey R., Whiteley, Laura B., Price, Lawrence H. "Varenicline augmentation in depressed smokers: an 8-week, open-label study." J. Clin. Psychiatry, vol. 70, no. 7, 2009, pp. 1026-1031. |
| Philip NS, Carpenter LL, Tyrka AR, Price LH. "Augmentation of antidepressants with atypical antipsychotics: a review of the current literature." Journal of Psychiatric Practice, vol. 14, no. 1, 2008, pp. 34-44. |
| Tyrka AR, Wier L, Price LH, Ross N, Anderson GM, Wilkinson CW, Carpenter LL. "Childhood parental loss and adult hypothalamic-pituitary-adrenal function." Biological Psychiatry, vol. 63, no. 12, 2008, pp. 1147-54. |
| Tyrka AR, Wier L, Price LH, Ross NS, Carpenter LL. "Childhood parental loss and adult psychopathology: effects of loss characteristics and contextual factors." International journal of psychiatry in medicine, vol. 38, no. 3, 2008, pp. 329-344. |
| Tyrka AR, Wier LM, Price LH, Rikhye K, Ross NS, Anderson GM, Wilkinson CW, Carpenter LL. "Cortisol and ACTH responses to the Dex/CRH test: influence of temperament." Hormones and behavior, vol. 53, no. 4, 2008, pp. 518-25. |
| Carpenter LL, Bayat L, Moreno F, Kling MA, Price LH, Tyrka AR, Kinkead B, Owens MJ, Nemeroff CB. "Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy." Psychiatry Research, vol. 157, no. 1-3, 2008, pp. 123-9. |
| Rikhye K, Tyrka AR, Kelly MM, Gagne GG Jr, Mello AF, Mello MF, Price LH, Carpenter LL. "Interplay between childhood maltreatment, parental bonding, and gender effects: impact on quality of life." Child Abuse & Neglect, vol. 32, no. 1, 2008, pp. 19-34. |
| Philip NS, Mello K, Carpenter LL, Tyrka AR, Price LH. "Patterns of quetiapine use in psychiatric inpatients: an examination of off-label use." Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, vol. 20, no. 1, 2008, pp. 15-20. |
| Kelly MM, Tyrka AR, Anderson GM, Price LH, Carpenter LL. "Sex differences in emotional and physiological responses to the Trier Social Stress Test." Journal of Behavior Therapy and Experimental Psychiatry, vol. 39, no. 1, 2008, pp. 87-98. |
| Kelly MM, Tyrka AR, Price LH, Carpenter LL. "Sex differences in the use of coping strategies: predictors of anxiety and depressive symptoms." Depression and Anxiety, vol. 25, no. 10, 2008, pp. 839-46. |
| Mello AF, Juruena MF, Pariante CM, Tyrka AR, Price LH, Carpenter LL, Del Porto JA. "[Depression and stress: is there an endophenotype?]." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 29 Suppl 1, 2007, pp. S13-8. |
| Price LH, Tyrka AR. "Adjunctive antidepressant treatment for bipolar depression." New England Journal of Medicine, vol. 357, no. 6, 2007, pp. 614; author reply 615-6. |
| Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, Anderson GM, Wilkinson CW, Price LH. "Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment." Biological Psychiatry, vol. 62, no. 10, 2007, pp. 1080-7. |
| Mello, Andrea Feijo, Juruena, Mario Francisco, Pariante, Carmine M, Tyrka, Audrey R, Price, Lawrence H, Carpenter, Linda L, Del Porto, Jose Alberto. "Depressão e estresse: existe um endofenótipo?." Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), vol. 29, 2007, pp. s13-s18. |
| Tyrka AR, Wier LM, Anderson GM, Wilkinson CW, Price LH, Carpenter LL. "Temperament and response to the Trier Social Stress Test." Acta psychiatrica Scandinavica, vol. 115, no. 5, 2007, pp. 395-402. |
| Grover KE, Carpenter LL, Price LH, Gagne GG, Mello AF, Mello MF, Tyrka AR. "The relationship between childhood abuse and adult personality disorder symptoms." Journal of personality disorders, vol. 21, no. 4, 2007, pp. 442-7. |
| Tyrka AR, Carpenter LL, Carvalho JP, Price LH. "Biomarkers in the human stress system: do they signal risk for depression?." Medicine and health, Rhode Island, vol. 89, no. 5, 2006, pp. 180-2. |
| Wier, Lauren M., Tavares, Sandra B., Tyrka, Audrey R., Price, Lawrence H., Carpenter, Linda L. "Levetiracetam-Induced Depression in a Healthy Adult." J. Clin. Psychiatry, vol. 67, no. 07, 2006, pp. 1156. |
| Wier LM, Tavares SB, Tyrka AR, Price LH, Carpenter LL. "Levetiracetam-induced depression in a healthy adult." J. Clin. Psychiatry, vol. 67, no. 7, 2006, pp. 1159-60. |
| Carpenter LL, Schecter JM, Tyrka AR, Mello AF, Mello MF, Haggarty R, Price LH. "Open-Label Tiagabine Monotherapy for Major Depressive Disorder With Anxiety." J. Clin. Psychiatry, vol. 67, no. 01, 2006, pp. 66-71. |
| Tyrka, Audrey R, Price, Lawrence H, Mello, Marcelo F, Mello, Andrea F, Carpenter, Linda L. "Psychotic major depression: a benefit-risk assessment of treatment options." Drug safety : an international journal of medical toxicology and drug experience, vol. 29, no. 6, 2006, pp. 491-508. |
| Tyrka AR, Mello AF, Mello MF, Gagne GG, Grover KE, Anderson GM, Price LH, Carpenter LL. "Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults." Psychoneuroendocrinology, vol. 31, no. 9, 2006, pp. 1036-45. |
| Carpenter LL, Friehs GM, Tyrka AR, Rasmussen S, Price LH, Greenberg BD. "Vagus nerve stimulation and deep brain stimulation for treatment resistant depression." Medicine and health, Rhode Island, vol. 89, no. 4, 2006, pp. 137, 140-1. |
| Carpenter LL, Milosavljevic N, Schecter JM, Tyrka AR, Price LH. "Augmentation With Open-Label Atomoxetine for Partial or Nonresponse to Antidepressants." J. Clin. Psychiatry, vol. 66, no. 10, 2005, pp. 1234-1238. |
| Carpenter LL, Schecter JM, Underwood JA, Tyrka AR, Price LH. "Service expectations and clinical characteristics of patients receiving psychiatric emergency services." PS, vol. 56, no. 6, 2005, pp. 743-5. |
| Carpenter LL, Tyrka AR, McDougle CJ, Malison RT, Owens MJ, Nemeroff CB, Price LH. "Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects." Neuropsychopharmacology, vol. 29, no. 4, 2004, pp. 777-84. |
| Carpenter LL, Heninger GR, Malison RT, Tyrka AR, Price LH. "Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression." Journal of affective disorders, vol. 79, no. 1-3, 2004, pp. 285-9. |
| Tyrka AR, Carpenter LL, McDougle CJ, Kirwin PD, Owens MJ, Nemeroff CB, Strong DR, Price LH. "Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults." Biological Psychiatry, vol. 56, no. 7, 2004, pp. 531-4. |
| Graber JA, Tyrka AR, Brooks-Gunn J. "How similar are correlates of different subclinical eating problems and bulimia nervosa?." Journal of Child Psychology and Psychiatry, vol. 44, no. 2, 2003, pp. 262-73. |
| Carpenter LL, Heninger GR, McDougle CJ, Tyrka AR, Epperson CN, Price LH. "Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania." Psychiatry Research, vol. 112, no. 3, 2002, pp. 257-62. |
| Tyrka AR, Waldron I, Graber JA, Brooks-Gunn J. "Prospective predictors of the onset of anorexic and bulimic syndromes." The International journal of eating disorders, vol. 32, no. 3, 2002, pp. 282-90. |
| Tyrka AR, Cannon TD, Haslam N, Mednick SA, Schulsinger F, Schulsinger H, Parnas J. "The latent structure of schizotypy: I. Premorbid indicators of a taxon of individuals at risk for schizophrenia-spectrum disorders." Journal of Abnormal Psychology, vol. 104, no. 1, 1995, pp. 173-83. |
| Tyrka A, Smith GP. "SCH23390, but not raclopride, decreases intake of intraorally infused 10% sucrose in adult rats." Pharmacology Biochemistry and Behavior, vol. 45, no. 1, 1993, pp. 243-6. |
| Miesner J, Smith GP, Gibbs J, Tyrka A. "Intravenous infusion of CCKA-receptor antagonist increases food intake in rats." The American journal of physiology, vol. 262, no. 2 Pt 2, 1992, pp. R216-9. |
| Tyrka A, Gayle C, Smith GP. "Raclopride decreases sucrose intake of rat pups in independent ingestion tests." Pharmacology Biochemistry and Behavior, vol. 43, no. 3, 1992, pp. 863-9. |
| Weller A, Corp ES, Tyrka A, Ritter RC, Brenner L, Gibbs J, Smith GP. "Trypsin inhibitor and maternal reunion increase plasma cholecystokinin in neonatal rats." Peptides, vol. 13, no. 5, 1992, pp. 939-41. |
| Tyrka A, Smith GP. "Potency of SCH 23390 for decreasing sucrose intake in rat pups depends on mode of ingestion." Pharmacology Biochemistry and Behavior, vol. 39, no. 4, 1991, pp. 955-61. |
| Smith GP, Tyrka A, Gibbs J. "Type-A CCK receptors mediate the inhibition of food intake and activity by CCK-8 in 9- to 12-day-old rat pups." Pharmacology Biochemistry and Behavior, vol. 38, no. 1, 1991, pp. 207-10. |
| Ridout, Samuel J., Ridout, Kathryn K., Kao, Hung-Teh, Carpenter, Linda L., Philip, Noah S., Tyrka, Audrey R., Price, Lawrence H. "Telomeres, early-life stress and mental illness." Advances in psychosomatic medicine, vol. 34, 1900, pp. 92-108. |
Dr. Tyrka's research is focused on understanding the effects of childhood trauma and mechanisms of risk and resilience for developing mental health and related health conditions. In addition to psychiatric disorders including major depression, post-traumatic stress disorder (PTSD), and substance use disorders, stress and trauma increase risk for medical conditions such as diabetes, cardiovascular disease and metabolic syndrome. Dr. Tyrka studies children and adults with early adversity and trauma to understand the developmental, behavioral, metabolic, neuroendocrine, neuroimmune, and pathways of risk for mood and anxiety disorders, accelerated biological aging and related health conditions. The goal of her work is to identify and understand mechanisms of risk and resilience necessary for targeted prevention and treatment development. Dr. Tyrka also collaborates on studies investigating inflammatory and molecular mechanisms of behavioral treatments (exercise, yoga) for major depression and perinatal depression. Dr. Tyrka has served as co-investigator of several studies of new treatments for depression, including novel pharmacologic (e.g., Esketamine) and neurostimulation (e.g., DBS, TMS, tDCS) approaches to the treatment of major depression and treatment resistant depression.
1. National Institute of General Medical Sciences Medical Scientist Training Program, role: Training Grant Recipient, 8/93-8/94.
2. 5 F30 MH10819 Predoctoral National Research Service Award, “Neuropsychological Indicators of Risk for Schizophrenia,” role: Principal Investigator, 9/94-5/00.
3. NARSAD (Young Investigator Award), “Hypothalamic-Pituitary-Adrenal Function in Adults with a History of Childhood Parental Loss,” role: Principal Investigator; 6/03-5/05, $60,000.
4. Janssen Pharmaceutica Faculty Development Award in Psychopharmacology, role: Principal Investigator, 5/18/03, $25,000.
5. RSGPB PBP-103382 American Cancer Society, “Improving Smoking Cessation in Smokers with
Depressive Symptoms”, role: Study Physician, 7/02-6/04
6. Medtronic, Inc., “Electrical Stimulation of the Anterior Limb of the Internal Capsule to Treat Major Depressive Disorder,” role: Co-Investigator, 10/02-9/04, $315,000.
7. K23MH067947 Mentored Patient-Oriented Research Career Development Award, “Risk for Depression, Stress, and Neuroendocrine Function,” role: Principal Investigator; 12/03-11/08, $905,000.
8. Pfizer, Inc. “Sertraline Treatment and Cortisol Response to the DEX/CRH Test”, Investigator-Initiated, role: Co-Investigator, 1/04-11/06, $300,684.
9. United States Department of the Interior, “Perceived Early Life Stress and DEX/CRH Test Response as Predictors of Psychological Sequelae following Exposure of Healthy Adults to War Stress,” role: Co-Investigator, 7/04-6/05, $40,000
10. UCB Pharma, Inc. “Keppra Treatment and Cortisol Response to the DEX/CRH Test in Healthy Subjects,” Investigator-Initiated, role: Co-Investigator, 6/04-5/07, $111,624.
11. NCCAM/NIMH AT001742, "Double-blind, placebo-controlled study of SAMe vs. escitalopram in MDD," role: Study Physician, 4/04 - 3/09, $1,087,938.
12. United States Department of Defense, “Biomarkers of risk for post-traumatic stress disorder (PTSD),” role: Principal Investigator, 4/01/07-4/01/10, $409,390.
13. Cyberonics, Inc. “Randomized Comparison of Outcomes in Patients with Treatment-Resistant Depression Who Receive VNS Therapy Administered at Different Amounts of Electrical Charge” role: Co-Investigator; 11/1/07-12/1/10; $230,000.
14. Medtronic, Inc. “RECLAIM Deep Brain Stimulation (DBS) Clinical Study for Treatment- Resistant Depression.” Multi-Site; role: Sub-Investigator 4/16/2009-5/1/2012, $329,280.
15. R01 MH0687670 “DEX/CRH Response: Mood/Anxiety Disorder Endophenotype? Phase 2.” role: Co-Investigator, 12/08-11/13, $3,514,780.
16. R01 MH083704 “Childhood Maltreatment: Biomarkers of Risk and Resilience,” role: Principal Investigator, 12/09-11/14, $2,863,342.
17. R01 NR012005 “RCT of Hatha Yoga for Persistent Depression,” role: Co-Investigator, 2/11 - 01/15, $1,718,041.
18. R21 MH091508 “Childhood Maltreatment: Epigenetic Modulation of the Glucocorticoid Receptor,” role: Principal Investigator, 4/08/11-3/31/13, $393,156.
19. R01MH068767 - 08W1 Supplement to “DEX/CRH Response: Mood/Anxiety Disorder Endophenotype? Phase 2.” Telomere Shortening in Relation to Early-Life Stress, role: Co-Investigator, 5/8/12-4/30/13, $60,000.
20. R01 MH083704-Supplement to “Childhood Maltreatment: Biomarkers of Risk and Resilience,” role: Principal Investigator, 07/29/12-11/30/2014, $185,143.
21. R34 MH099310 “Testosterone Augmentation in Women,” role: Co-Investigator, 6/30/13-6/30/15, $633,150.
22. HHSN2712011000061 “Rapidly Acting Treatments for Treatment-Resistant Depression (RAPID),” role: Co-Investigator, 4/1/14-3/31/16, $341,269.
23. Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award “Developmental Response to Early Stress: Neural Mechanisms of Cognitive and Behavioral Effects,” role: Co Principal Investigator, 1/1/14-12/31/14, $40,000.
24. 1 R01 MH101107 “Early Life Stress: Epigenetic Regulation of Endocrine and Immune Pathways,” role: Principal Investigator, 4/1/2014-3/31/2019, $2,639,488.
25. 1 R01 NR014540-01A1 (Battle, PI) “RCT of a Tailored Walking Program to Reduce Stress Among Pregnant Women,” role: Co-Investigator, 9/17/14-9/16/19, 2,358,850.
26. R01MH105379-01 (Nugent, PI) “Biomarkers, Social, and Affective Predictors of Suicidal Thoughts and Behaviors in Adolescents”, role: Co-Investigator, 3/1/15-2/28/19, $3,230,458.
27. R25MH101076 “Promoting Research Training During Psychiatry Residency,” role: Principal Investigator, 7/1/13-6/30/18, $989,310.
28. R25MH101076 S1 Supplement to “Promoting Research Training During Psychiatry Residency” to support the National Neuroscience Curriculum Initiative. role: Principal Investigator, 7/1/13-6/30/18, $989,310.
29. TACO / The White Family Foundation Grant to fund purchase of a spectrophotometer, Principal Investigator, 1/1/2016, $5,000.
30. Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award “Molecular Mechanisms of the Impact of Early Adversity on Neuronal Development: Focus on Mitochondria,” role: Co Principal Investigator, 5/1/16-4/30/17, $40,000.
31. R01HD081868-01A1 (Battle, PI) “Efficacy of a Prenatal Yoga Intervention for Antenatal Depression,” role: Co-Investigator, 11/1/15-6/30/20.
32. R01HD086487-01 “Risk Profiles and Mechanisms of Disease in Maltreated Children,” role: Principal Investigator, 9/21/16-5/31/21, $2,962,164.
33. F31HD088020-01A1 (Huffhines, PI) “Biological Indicators of Trauma in Foster Youth: The Role of Social Support,” role: Co-Mentor, 4/25/17-4/24/19, $76,488.
34. Roddy Holden Kinzel Foundation equipment grant “Childhood Adversity and Mitochondrial Function,” Principal Investigator, 12/1/17, $10,000.
35. Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award “Molecular Mechanisms of the Impact of Early Adversity on Neuronal Development: Focus on Mitochondria, Phase II” role: Co Principal Investigator, 5/1/17-4/30/18, $40,000.
36. Ida Ballou Littlefield Foundation equipment grant “Early Life Stress and Mitochondrial Function,” Principal Investigator, 1/17/18, $7,500.
37. R25MH101076-05S2 Supplement to “Promoting Research Training During Psychiatry Residency” to support a summer research fellowship in psychiatry for medical students from under-represented minority groups, role: Principal Investigator, 6/21/18-8/03/18, $10,433.
38. R01HD095837 (Parade, PI) “Longitudinal Examination of DNA Methylation in Maltreated Children,” role: Co-Investigator, 9/1/18-8/31/23.
39. P20 GM130452 (Greenberg, PI) ”COBRE Center for Neuromodulation (CCN),” role: Associate Director, Administrative Core, 2/28/2019-2/27/2024, $10,223,884
40. F32HD100020 (Huffhines, PI) “Emotional and Physiological Regulation Linking Child Maltreatment to Health Risk,” role: Co-Mentor, 6/28/20-6/27/22.
41. K23AT0111173-01 “Developing an Internet-Delivered, Mindfulness-Based Intervention to Reduce HIV Risk and Promote Mental and Sexual Health Among Young Adult MSM,” role: Co-Mentor, 9/1/20-8/31/25.
42. R25MH101076-06A1 “Promoting Research Training During Psychiatry Residency,” role: Principal Investigator, 7/1/20-6/30/25.
43. T32HD101392 “Research Training in Childhood Stress, Trauma, and Resilience,” role: Multiple Principal Investigator, 5/01/20-4/30/25.
44. 2R25MH101076-06A1S1 Supplement to “Promoting Research Training During Psychiatry Residency,” to support a summer research fellowship in psychiatry for medical students from under-represented minority groups role: Principal Investigator, 7/1/20-6/30/25, $12,285.
45. Hasbro / Bradley Pilot Clinical Research Awards “Childhood Adversity, Mitochondrial DNA Deletions, and Metabolic Syndrome,” role: Multiple Principal Investigator, 4/1/21-3/31/22, $25,000.
46. 3R25MH101076-06A1S1 Supplement to “Promoting Research Training During Psychiatry Residency,” to support a summer research fellowship in psychiatry for medical students from under-represented minority groups role: Principal Investigator, 7/1/20-6/30/25, $12,285.
47. P20GM139767 (Stroud, PI) “COBRE for Stress, Trauma, and Resilience (STAR),” role: Co-Director, 09/15/2021 - 07/31/2026, $11,077,551.
48. 2R25MH101076-06A1S2 Supplement to “Promoting Research Training During Psychiatry Residency,” to support a summer research fellowship in psychiatry for medical students from under-represented minority groups, role: Principal Investigator, 6/1/22-7/31/23.
49. R21AG077332-01A1 “Mechanisms of Accelerated Aging: Stress, Health Behaviors, and the Role of Mitochondria”, role: Principal Investigator, 12/1/22-11/30/24. $413,458.
| Year | Degree | Institution |
|---|---|---|
| 1999 | PhD | University of Pennsylvania |
| 1999 | MD | University of Pennsylvania |
| 1988 | BA | State University of New York at Purchase |
PREDOCTORAL HONORS AND AWARDS
1988 B.A., Summa Cum Laude, State University of New York College at Purchase
1988 Award for Outstanding Undergraduate Research, State University of New York
1994 Robert M. Toll Psychiatry Research Prize, University of Pennsylvania
1999 AMA Rock Sleyster Memorial Scholarship
1999 Kenneth E. Appel Psychiatry Award, University of Pennsylvania School of
Medicine
POSTGRADUATE HONORS AND AWARDS
2002 The American College of Psychiatrists 2002 Laughlin Fellowship Recipient.
2002 First Prize, Resident Research, Sixth Annual Research Symposium, Brown University School of Medicine Department of Psychiatry and Human Behavior
2003 American Psychiatric Association Research Colloquium for Junior Investigators, Participant and Travel Award Recipient
2003 NIMH Mentored Patient-Oriented Research Career Development Award
2003 Janssen Psychiatry Resident Award of Excellence
2003 NARSAD Young Investigator Award
2003 Janssen Pharmaceutica Faculty Development Award in Psychopharmacology
2003 NIH Clinical Research Loan Repayment Program
2004 American College of Neuropsychopharmacology Young Investigator Travel Award
2005 Future Leaders in Psychiatry Symposium Travel Award
2007, 2008, 2009, 2010 Citation, Best Doctors in America (Best Doctors, Inc)
2007 Outstanding Teaching Award in General Psychiatry, Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior
2009 The DBSA 2009 Gerald L. Klerman Young Investigator Award
2014 Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award, Co-Awardees Tyrka and Amso
2016 Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award, Co-Awardees Tyrka and Bath
2016 Psychiatry Research Mentor Award, Warren Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior
2017 Brown Institute for Brain Science / Norman Prince Neurosciences Institute New Frontiers Award, Co-Awardees Tyrka and Bath
2018 Psychiatry Education Award, Warren Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior
2022 Faculty Mentoring Award, Warren Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior
| Name | Title |
|---|---|
| Abrantes, Ana | Professor of Psychiatry and Human Behavior |
| Armey, Michael | Associate Professor of Psychiatry and Human Behavior (Research) |
| Ayala, Alfred | Professor of Surgery (Research) |
| Battle, Cynthia | Professor of Psychiatry and Human Behavior |
| Belenky, Peter | Associate Professor of Molecular Microbiology and Immunology |
| Bertone, Paul | Associate Professor of Medicine (Research) |
| Bock, Beth | Professor of Psychiatry and Human Behavior, Professor of Behavioral and Social Sciences |
| Brick, Leslie Ann | Associate Professor of Psychiatry and Human Behavior (Research) |
| Carpenter, Linda | Professor of Psychiatry and Human Behavior |
| Chung, Chun-Shiang | Assistant Professor Emerita (Research) of Surgery |
| De La Monte, Suzanne | Professor of Neurosurgery, Professor of Pathology and Laboratory Medicine |
| Dennery, Phyllis | Sylvia Kay Hassenfeld Professor of Pediatrics, Professor of Molecular Biology, Cell Biology and Biochemistry, Chair of Pediatrics |
| Dunsiger, Shira | Associate Professor of Biostatistics (Research), Associate Professor of Psychiatry and Human Behavior (Research), Associate Professor of Behavioral and Social Sciences (Research) |
| Evans, Erin | Associate Professor of Psychiatry and Human Behavior |
| Festa, Elena | Senior Lecturer in Cognitive and Psychological Sciences |
| Fukuda, Andrew | Assistant Professor of Psychiatry and Human Behavior |
| Gaudiano, Brandon | Professor of Psychiatry and Human Behavior, Professor of Behavioral and Social Sciences |
| Greenberg, Benjamin | Professor of Psychiatry and Human Behavior |
| Guthrie, Tracey | Professor of Psychiatry and Human Behavior, Clinician Educator, Assistant Dean for Diversity in the Division of Biology and Medicine, Professor of Medical Science, Clinician Educator |
| Huffhines, Lindsay | Assistant Professor of Psychiatry and Human Behavior (Research) |
| Hunt, Jeffrey | Professor of Psychiatry and Human Behavior |
| Jelalian, Elissa | Professor of Psychiatry and Human Behavior, Professor of Pediatrics |
| Jones, Rich | Professor of Psychiatry and Human Behavior, Professor of Neurology |
| Jones, Stephanie | Professor of Neuroscience |
| Kao, Hung-Teh | Associate Professor of Psychiatry and Human Behavior (Research) |
| Kavanaugh, Brian | Assistant Professor of Psychiatry and Human Behavior |
| Koinis-Mitchell, Daphne | Professor of Psychiatry and Human Behavior and Pediatrics (Research) |
| Kudinova, Anastacia | Assistant Professor of Psychiatry and Human Behavior (Research) |
| Kunicki, Zachary | Assistant Professor of Psychiatry and Human Behavior |
| Lester, Barry | Professor of Psychiatry and Human Behavior, Professor of Pediatrics, Director of the Center for the Study of Children at Risk |
| Lewis-de los Angeles, William | Assistant Professor of Pediatrics, Clinician Educator |
| Loucks, Eric | Professor of Epidemiology, Associate Professor of Medicine, Professor of Behavioral and Social Sciences |
| Malloy, Paul | Professor Emeritus of Psychiatry and Human Behavior |
| Marsit, Carmen | Adjunct Professor of Epidemiology |
| McGeary, John | Professor of Psychiatry and Human Behavior |
| McQuaid, Elizabeth | Professor of Pediatrics, Professor of Psychiatry and Human Behavior |
| Nugent, Nicole | Professor of Psychiatry and Human Behavior, Professor of Emergency Medicine, Professor of Pediatrics |
| Parade, Stephanie | Associate Professor of Psychiatry and Human Behavior |
| Parent, Justin | Associate Professor of Psychiatry and Human Behavior |
| Philip, Noah | Professor of Psychiatry and Human Behavior |
| Porton, Barbara | Assistant Professor of Psychiatry and Human Behavior (Research) |
| Price, Lawrence | Professor of Psychiatry and Human Behavior |
| Rasmussen, Steven | Professor of Psychiatry and Human Behavior |
| Risica, Patricia | Associate Professor of Behavioral and Social Sciences, Director of the Undergraduate Public Health Concentration, Associate Professor of Epidemiology |
| Rounds, Sharon | Associate Dean for Translational Science, Professor of Medicine, Professor of Pathology and Laboratory Medicine |
| Salloway, Stephen | Professor of Psychiatry and Human Behavior, Professor of Neurology |
| Stroud, Laura | Professor of Psychiatry and Human Behavior, Professor of Obstetrics and Gynecology, Professor of Behavioral and Social Sciences |
| Sun, Shufang | Assistant Professor of Behavioral and Social Sciences, Assistant Professor of Psychiatry and Human Behavior, Associate Director of the Mindfulness Center |
| Uebelacker, Lisa | Professor of Psychiatry and Human Behavior |
| Vargas, Sara | Assistant Professor of Psychiatry and Human Behavior (Research) |
| Vergara-Lopez, Chrystal | Assistant Professor of Psychiatry and Human Behavior |
| Whiteley, Laura | Associate Professor of Psychiatry and Human Behavior |
| Zand Vakili, Amin | Assistant Professor of Psychiatry and Human Behavior |
Director, Trainee Editorial Board, Acta Psychiatrica Scandinavica, 2007-2016
Editorial Board Member, Acta Psychiatrica Scandinavica, 2007-2016
Editorial Board Member, Development and Psychopathology, 2011-
Scientific Advisory Board Member, Depression Bipolar Support Alliance, 2009-
American College of Neuropsychopharmacology (ACNP), Program Committee Member, 2011-2015
American College of Neuropsychopharmacology (ACNP), Travel Awardee Mentor, 2013-
Society for Biological Psychiatry, Training and Education Committee, Mentor, 2013-
American Psychiatric Association (APA) Workgroup on Research Training, Mentor for Research Colloquium for Junior Investigators 2014
External Referee, Faculty Promotion Review, Department of Psychiatry, Yale University School of Medicine, 2015
American College of Neuropsychopharmacology (ACNP), Travel Awardee Mentor, 2015, 2017
External Referee, Faculty Promotion Review, Department of Psychiatry, University of Massachusetts Medical School, 2016
American College of Neuropsychopharmacology (ACNP), Women’s Task Force, 2017-
American College of Neuropsychopharmacology (ACNP), Travel Awardee Mentor, 2015, 2017
External Referee, Faculty Promotion Review, Department of Psychiatry, University of Massachusetts Medical School, 2016
Chair, Data Safety Monitoring Board. R01HL127695 Initiating and Maintaining Physical Activity in Depressed Individuals, 2016-2021.
American College of Neuropsychopharmacology (ACNP), Women’s Task Force, 2017-
American College of Neuropsychopharmacology (ACNP), Co-Chair, Women’s Task Force, 2019-2020
American College of Neuropsychopharmacology (ACNP), Chair, Women’s Task Force, 2020-2021
American College of Neuropsychopharmacology (ACNP), past Chair, Women’s Task Force, 2021-2022
American College of Neuropsychopharmacology (ACNP), Member, Diversity and Inclusion Committee, 2021-2022
External Advisory Board Member, Yale University School of Medicine Neuroscience Research Training Program, 2021-
External Advisory Board Member, MGH McLean Physician Scientist Training Program, 2022-
American College of Neuropsychopharmacology (ACNP), Member, Women’s Committee, 2023-
Executive Leadership in Academic Medicine (ELAM), Institute for Women’s Health and Leadership, Drexel University College of Medicine, 2021-2022
| American Board of Psychiatry and Neurology | 2014-2015 | ||
| Certification | American Board of Psychiatry and Neurology, Psychiatry | 2004- | |
| Medical License | Rhode Island | 2003- |
Seminar Leader, Interviewing Seminar, Brown Medical School Department of Psychiatry and Human Behavior, PG1 Residents, 2004-2019
Introduction to Psychiatric Literature, PGY 1 Residents, 2003-2004
Mood Disorders Psychopharmacology lectures, PGY 1-4 Residents, 2003-
Mood Disorders Psychopathology lectures, PGY 1-4 Residents 2003-
Grant Reviewer, Post-doctoral fellows grantsmanship workshop 2004-2006
Morbidity and Mortality Conference Preceptor, PGY 1-4, 2007
Course Director and Instructor, Principles of Biostatistics, T32 Post-Doctoral Fellows, 2006-2008
Module Coordinator, Mood Disorders Module, Brown Medical School Department of Psychiatry and Human Behavior, Psychiatry Residency Program, 2012-2017
Module Co-Coordinator, Trauma Module, Brown Medical School Department of Psychiatry and Human Behavior, Psychiatry Residency Program, 2017-
Co-Director NIMH R25 Research Training Program “Promoting Research Training During Psychiatry Residency,” 9/1/15-6/30/17
Director NIMH R25 Research Training Program “Promoting Research Training During Psychiatry Residency,” 7/1/17-
Director, Summer Research Fellowship for Under-Represented Minority Medical Students 2018-
Lecturer, Brown University Neuroscience Department “Bench to Bedside” Lecture Series, April 2018
Co-Director, Postdoctoral Research T32 Training Program in Stress, Trauma, and Resilience, 2020-
Co-Director, COBRE on Stress, Trauma, and Resilience, 2021-Lecturer, Alpert Medical School of Brown University, Brain Sciences Course, “Neurobiology of Trauma and Stress,” 2019-
