Craig T. LefortAssistant Professor of Surgery (Research)
Dr. Lefort is an Assistant Professor in the Department of Surgery, Division of Surgical Research. He received his BS in Biomedical Engineering from Columbia University in 2001 and his Ph.D. in the same field from the University of Rochester in 2007. He completed postdoctoral work in Immunology at the University of Rochester and at La Jolla Institute for Allergy & Immunology.
During infection or injury, white blood cells (leukocytes) must exit from the circulation to reach sites in the tissue where they are needed to mount an immune response. My lab's focus is on the neutrophil, a type of innate immune cell that is the first to mobilize from the circulation to mount the inflammatory response. The recruitment of neutrophils occurs by a cascade of interactions with the endothelial cell lining of the blood vessel wall that precedes their migration into the tissue. We use biophysical and molecular engineering methods to dissect the mechanisms of leukocyte capture, rolling, arrest, adhesion stabilization and intravascular migration. Our research also uses CRISPR-based genome-scale screening to identify novel aspects of neutrophil function and thereby develop strategies for combating drug-resistant bacterial and fungal infections.
R35GM124911, NIH/NIGMS, 2017-2022: "Selective modulation of neutrophils in critical illness"
R03AI130526, NIH/NIAID, 2017-2018: "A murine model of Pseudomonas aeruginosa pneumonia secondary to hemorrhagic shock"
Oh-Zopfi Pediatric Research Pilot Grant, Women & Infants Hospital, 2017-2018: "A Genetic Screen to Identify Mechanisms of Neutrophil Phagocytosis of Candida"
Pilot Project, CardioPulmonary Vascular Biology COBRE, 2015-2016: "Integrin activation regulates neutrophil trafficking during bacterial pneumonia"
Scientist Development Grant, American Heart Association, 2012-2016: "Mechanisms of LFA-1 Conformational Activation in Neutrophils"