Dr. Aliotta is an Associate Professor of Medicine at the Alpert Medical School of Brown University. He attended Tufts Medical School and completed a Residency in Internal Medicine at the Beth Israel Deaconess Medical Center and a Fellowship in Pulmonary and Critical Care Medicine at the Alpert Medical School of Brown University. Dr. Aliotta joined the faculty of Rhode Island Hospital and the Miriam Hospital in 2006 and served as the Associate Program Director of the Brown Pulmonary and Critical Care Medicine Fellowship. He is currently the Medical Director of Respiratory Therapy and the Director of the Medical Intensive Care Unit at Rhode Island Hospital.
| Corl KA, Dado C, Agarwal A, Azab N, Amass T, Marks SJ, Levy MM, Merchant RC, Aliotta J. "A modified Montpellier protocol for intubating intensive care unit patients is associated with an increase in first-pass intubation success and fewer complications." Journal of Critical Care, vol. 44, 2018, pp. 191-195. |
| Aliotta JM, Pereira M, Wen S, Dooner MS, Del Tatto M, Papa E, Cheng Y, Goldberg L, Ventetuolo CE, Liang O, Klinger JR, Quesenberry PJ. "Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model." STEM CELLS Translational Medicine, vol. 6, no. 7, 2017, pp. 1595-1606. |
| Wen S, Dooner M, Cheng Y, Papa E, Del Tatto M, Pereira M, Deng Y, Goldberg L, Aliotta J, Chatterjee D, Stewart C, Carpanetto A, Collino F, Bruno S, Camussi G, Quesenberry P. "Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells." Leukemia, vol. 30, no. 11, 2016, pp. 2221-2231. |
| Aliotta JM, Pereira M, Sears EH, Dooner MS, Wen S, Goldberg LR, Quesenberry PJ. "Lung-derived exosome uptake into and epigenetic modulation of marrow progenitor/stem and differentiated cells." Journal of Extracellular Vesicles, vol. 4, 2015, pp. 26166. |
| Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen CC, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M. "Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium." Journal of Extracellular Vesicles, vol. 4, 2015, pp. 27575. |
| Quesenberry PJ, Aliotta J, Deregibus MC, Camussi G. "Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming." Stem cell research & therapy, vol. 6, 2015, pp. 153. |
| Quesenberry PJ, Goldberg LR, Aliotta JM, Dooner MS, Pereira MG, Wen S, Camussi G. "Cellular phenotype and extracellular vesicles: basic and clinical considerations." Stem Cells and Development, vol. 23, no. 13, 2014, pp. 1429-36. |
| Quesenberry PJ, Goldberg L, Aliotta J, Dooner M. "Marrow Hematopoietic Stem Cells Revisited: They Exist in a Continuum and are Not Defined by Standard Purification Approaches; Then There are the Microvesicles." Frontiers in Oncology, vol. 4, 2014, pp. 56. |
| Goldberg LR, Dooner MS, Johnson KW, Papa EF, Pereira MG, Del Tatto M, Adler DM, Aliotta JM, Quesenberry PJ. "The murine long-term multi-lineage renewal marrow stem cell is a cycling cell." Leukemia, vol. 28, no. 4, 2014, pp. 813-22. |
| Aliotta JM, Pereira M, Amaral A, Sorokina A, Igbinoba Z, Hasslinger A, El-Bizri R, Rounds SI, Quesenberry PJ, Klinger JR. "Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice." Cardiovascular research, vol. 100, no. 3, 2013, pp. 354-62. |
| Quesenberry PJ, Dooner MS, Goldberg LR, Aliotta JM, Pereira M, Amaral A, Del Tatto MM, Hixson DC, Ramratnam B. "A new stem cell biology: the continuum and microvesicles." Transactions of the American Clinical and Climatological Association, vol. 123, 2012, pp. 152-66; discussion 166. |
| Sears EH, Aliotta JM, Klinger JR. "Partial anomalous pulmonary venous return presenting with adult-onset pulmonary hypertension." Pulmonary Circulation, vol. 2, no. 2, 2012, pp. 250-5. |
| Aliotta JM, Lee D, Puente N, Faradyan S, Sears EH, Amaral A, Goldberg L, Dooner MS, Pereira M, Quesenberry PJ. "Progenitor/stem cell fate determination: interactive dynamics of cell cycle and microvesicles." Stem Cells and Development, vol. 21, no. 10, 2012, pp. 1627-38. |
| Li M, Aliotta JM, Asara JM, Tucker L, Quesenberry P, Lally M, Ramratnam B. "Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells." PROTEOMICS, vol. 12, no. 13, 2012, pp. 2203-11. |
| Aliotta JM, Pereira M, Li M, Amaral A, Sorokina A, Dooner MS, Sears EH, Brilliant K, Ramratnam B, Hixson DC, Quesenberry PJ. "Stable cell fate changes in marrow cells induced by lung-derived microvesicles." Journal of Extracellular Vesicles, vol. 1, 2012. |
| Del Tatto M, Ng T, Aliotta JM, Colvin GA, Dooner MS, Berz D, Dooner GJ, Papa EF, Hixson DC, Ramratnam B, Aswad BI, Sears EH, Reagan J, Quesenberry PJ. "Marrow cell genetic phenotype change induced by human lung cancer cells." Experimental hematology, vol. 39, no. 11, 2011, pp. 1072-80. |
| Aliotta JM. "Tumor exosomes: a novel biomarker?." Journal of gastrointestinal oncology, vol. 2, no. 4, 2011, pp. 203-5. |
| Quesenberry PJ, Aliotta JM. "Cellular phenotype switching and microvesicles." Advanced Drug Delivery Reviews, vol. 62, no. 12, 2010, pp. 1141-8. |
| Li M, Aliotta JM, Asara JM, Wu Q, Dooner MS, Tucker LD, Wells A, Quesenberry PJ, Ramratnam B. "Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture." Journal of Biological Chemistry, vol. 285, no. 9, 2010, pp. 6285-97. |
| Aliotta JM, Pereira M, Johnson KW, de Paz N, Dooner MS, Puente N, Ayala C, Brilliant K, Berz D, Lee D, Ramratnam B, McMillan PN, Hixson DC, Josic D, Quesenberry PJ. "Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription." Experimental hematology, vol. 38, no. 3, 2010, pp. 233-45. |
| Renzulli JF 2nd, Del Tatto M, Dooner G, Aliotta J, Goldstein L, Dooner M, Colvin G, Chatterjee D, Quesenberry P. "Microvesicle induction of prostate specific gene expression in normal human bone marrow cells." The Journal of Urology, vol. 184, no. 5, 2010, pp. 2165-71. |
| Quesenberry PJ, Dooner MS, Aliotta JM. "Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles." Experimental hematology, vol. 38, no. 7, 2010, pp. 581-92. |
| Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW 2nd, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. "Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report." Am J Respir Crit Care Med, vol. 182, no. 12, 2010, pp. 1554-62. |
| Fritzell JA Jr, Mao Q, Gundavarapu S, Pasquariello T, Aliotta JM, Ayala A, Padbury JF, De Paepe ME. "Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice." American Journal of Respiratory Cell and Molecular Biology, vol. 40, no. 5, 2009, pp. 575-87. |
| Aliotta JM, Keaney PJ, Warburton RR, DelTatto M, Dooner MS, Passero MA, Quesenberry PJ, Klinger JR. "Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension." Stem Cells and Development, vol. 18, no. 5, 2009, pp. 773-82. |
| Dooner MS, Aliotta JM, Pimentel J, Dooner GJ, Abedi M, Colvin G, Liu Q, Weier HU, Johnson KW, Quesenberry PJ. "Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle." Stem Cells and Development, vol. 17, no. 2, 2008, pp. 207-19. |
| Quesenberry PJ, Aliotta JM. "The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles." Stem cell reviews and reports, vol. 4, no. 3, 2008, pp. 137-47. |
| Aliotta JM, Sanchez-Guijo FM, Dooner GJ, Johnson KW, Dooner MS, Greer KA, Greer D, Pimentel J, Kolankiewicz LM, Puente N, Faradyan S, Ferland P, Bearer EL, Passero MA, Adedi M, Colvin GA, Quesenberry PJ. "Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation." STEM CELLS, vol. 25, no. 9, 2007, pp. 2245-56. |
| Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K. "The stem cell continuum: cell cycle, injury, and phenotype lability." Annals of the New York Academy of Sciences, vol. 1106, 2007, pp. 20-9. |
| Puente NA, Aliotta JM, Passero MA. "Update on idiopathic pulmonary fibrosis: the role of gamma interferon and cytokines." Medicine and health, Rhode Island, vol. 90, no. 2, 2007, pp. 43-5. |
| Aliotta JM, Keaney P, Passero M, Dooner MS, Pimentel J, Greer D, Demers D, Foster B, Peterson A, Dooner G, Theise ND, Abedi M, Colvin GA, Quesenberry PJ. "Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype." Experimental hematology, vol. 34, no. 2, 2006, pp. 230-41. |
| Aliotta JM, Passero M, Meharg J, Klinger J, Dooner MS, Pimentel J, Quesenberry PJ. "Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration." Journal of cellular physiology, vol. 204, no. 3, 2005, pp. 725-41. |
| Quesenberry P, Abedi M, Dooner M, Colvin G, Sanchez-Guijo FM, Aliotta J, Pimentel J, Dooner G, Greer D, Demers D, Keaney P, Peterson A, Luo L, Foster B. "The marrow cell continuum: stochastic determinism." Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, vol. 43, no. 4, 2005, pp. 187-90. |
| Quesenberry PJ, Colvin GA, Abedi M, Dooner G, Dooner M, Aliotta J, Keaney P, Luo L, Demers D, Peterson A, Foster B, Greer D. "The stem cell continuum." Annals of the New York Academy of Sciences, vol. 1044, 2005, pp. 228-35. |
| Colvin GA, Lambert JF, Abedi M, Dooner MS, Demers D, Moore BE, Greer D, Aliotta JM, Pimentel J, Cerny J, Lum LG, Quesenberry PJ. "Differentiation hotspots: the deterioration of hierarchy and stochasm." Blood Cells, Molecules, and Diseases, vol. 32, no. 1, 2004, pp. 34-41. |
| Quesenberry PJ, Abedi M, Aliotta J, Colvin G, Demers D, Dooner M, Greer D, Hebert H, Menon MK, Pimentel J, Paggioli D. "Stem cell plasticity: an overview." Blood Cells, Molecules, and Diseases, vol. 32, no. 1, 2004, pp. 1-4. |
| Xu SY, Xiao JP, Ettwiller L, Holden M, Aliotta J, Poh CL, Dalton M, Robinson DP, Petronzio TR, Moran L, Ganatra M, Ware J, Slatko B, Benner J. "Cloning and expression of the ApaLI, NspI, NspHI, SacI, ScaI, and SapI restriction-modification systems in Escherichia coli." Molecular & general genetics : MGG, vol. 260, no. 2-3, 1998, pp. 226-31. |
| Sears LE, Zhou B, Aliotta JM, Morgan RD, Kong H. "BaeI, another unusual BcgI-like restriction endonuclease." Nucleic acids research, vol. 24, no. 18, 1996, pp. 3590-2. |
| Aliotta JM, Pelletier JJ, Ware JL, Moran LS, Benner JS, Kong H. "Thermostable Bst DNA polymerase I lacks a 3'-->5' proofreading exonuclease activity." Genetic analysis : biomolecular engineering, vol. 12, no. 5-6, 1996, pp. 185-95. |
Active:
1. 1R01 HL103726 - Genetic Information Transfer to Hematopoietic Cells: Role of Microvesicles
Agency: NIH/NHLBI
PI: Peter Quesenberry, MD
Role: Co-investigator
04/01/11 - 3/30/16
$158,538 (direct costs/year)
Effort: 1.2 calendar months
2. 1UH2 TR000880 - Regulation of renal and bone marrow injury by extracellular vesicle non-coding RNA
Agency: NIH/NIDDK
PI: Peter Quesenberry, MD
Role: Co-Investigator
07/01/13 - 6/30/18
$300,000 (direct costs/year)
Effort: 0.3 calendar months
3. 5P20 GM103652 (Ventetuolo PI) - Sex hormones and pulmonary vascular and right ventricular dysfunction
Agency: NIH/NIGMS
PI: Sharon Rounds, MD; COBRE project leader Corey Ventetuolo, MD
07/01/14-06/30/19
$270,439 (direct costs/year)
Effort: 0.24 calendar months
Completed:
1. 5K08 HL086868 - Injured Lung and its Influence on Bone Marrow Cell Phenotype
Agency: NIH/NHLBI
PI: Jason Aliotta, MD
1/4/08 - 12/31/12
$ 117,475 (direct costs/year)
Effort: 9 calendar months
2. 5P20GM103468 - New Directions in Clinical and Basic Research COBRE
Agency: NIH/NIGMS
PI: Peter Quesenberry, MD
Role: Project Leader
9/30/09 - 6/30/14
$ 103,251 (direct costs/year)
Effort: 6 calendar months
| Year | Degree | Institution |
|---|---|---|
| 1999 | MD | Tufts University |
| 1993 | BS | Tufts University |
| Fellow | The Warren Alpert Medical School of Brown University, pulmonary and critical care medicine | 2002-2005 | Providence, RI |
| Intern; Resident | Beth Israel Deaconess Medical Center, internal medicine | 1999-2002 | Boston, MA |
-Warren Alpert Medical School of Brown University Department of Medicine Beckwith Family Award for Outstanding Teaching. 2015
-Warren Alpert Medical School of Brown University Department of Medicine Attending Teaching Award. 2013.
-Dean’s Teaching Excellence Award, Pulmonary Pathophysiology Small Group, Warren Alpert Medical School of Brown University, 2007, 2008, 2009, 2010
| Name | Title |
|---|---|
| Klinger, James | Professor of Medicine |
| Quesenberry, Peter | Paul Calabresi, M.D. Professor of Oncology, Professor of Medicine |
| Rounds, Sharon | Associate Dean for Translational Science, Professor of Medicine, Professor of Pathology and Laboratory Medicine |
| Ventetuolo, Corey | Associate Professor of Medicine, Associate Professor of Health Services, Policy and Practice |
| Certification | American Board of Internal Medicine, Critical care medicine | 2015-Present | #215147 |
| Certification | American Board of Internal Medicine, Pulmonary disease | 2014-2024 | #215147 |
| Certification | American Board of Internal Medicine, Internal medicine | 2012-2024 | #215147 |
| Medical License | Rhode Island | 2005-2016 |
| Staff Physician. Women & Infants Hospital of Rhode Island, 2015-2016 |
| Staff Physician. The Miriam Hospital, 2006-2016 |
| Staff Physician. Rhode Island Hospital, 2006-2016 |
