Joseph Lau, MD is Professor in the Center for Evidence-based Medicine within the School of Public Health and co-director of the Agency for Healthcare Research and Quality (AHRQ) designated Evidence-based Practice Center (EPC) at Brown. Prior to his current position, he was professor of medicine and professor of clinical and translational science at the Institute for Clinical Research and Health Policy Studies at Tufts Medical Center. He directed the Tufts EPC from 1997 until 2012 and led the production of over 80 evidence reports, technology assessments, and comparative effectiveness reviews under contract with the AHRQ. He has served as a member of an FDA advisory committee, and as a member of an FAO/WHO workshop. He served as a member on two IOM committees including framework to evaluate the safety of dietary supplements and standards for clinical practice guidelines. He received his MD from Tufts University School of Medicine and completed a fellowship in clinical decision making and medical computer science at the New England Medical Center.
|Concannon, Thomas W., Fuster, Melissa, Saunders, Tully, Patel, Kamal, Wong, John B., Leslie, Laurel K., Lau, Joseph. "Concannon TW, Fuster M, Saunders T, Patel K, Wong JB, Leslie LK, Lau J. A systematic review of stakeholder engagement in comparative effectiveness and patient-centered outcomes research. J Gen Intern Med 2014; DOI: 10.1007/s11606-014-2878-x." J GEN INTERN MED, 2014.|
|Dacks PA, Andrieu S, Blacker D, Carman AJ, Green AM, Grodstein F, Henderson VW, James BD, Lane RF, Lau J, Lin PJ, Reeves BC, Shah RC, Vellas B, Yaffe K, Yurko-Mauro K, Shineman DW, Bennett DA, Fillit HM. "Dementia Prevention: Optimizing the use of observational data for personal, clinical, and public health decision-making." J Prev Alz Dis, vol. 1, 2014, pp. 117-123.|
|Hatfield, Daniel P, Sweeney, Kathryn P, Lau, Joseph, Lichtenstein, Alice H. "Critical assessment of high-circulation print newspaper coverage of the Institute of Medicine report Dietary Reference Intakes for Calcium and Vitamin D." Public Health Nutrition, vol. 17, no. 08, 2013, pp. 1868-1876.|
|Yu, Winifred W., Schmid, Christopher H., Lichtenstein, Alice H., Lau, Joseph, Trikalinos, Thomas A. "Empirical evaluation of meta-analytic approaches for nutrient and health outcome dose-response data." Research Synthesis Methods, 2013, pp. n/a-n/a.|
|Dahabreh, I. J., Schmid, C. H., Lau, J., Varvarigou, V., Murray, S., Trikalinos, T. A. "Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer." American Journal of Epidemiology, vol. 177, no. 12, 2013, pp. 1317-25.|
|Earley, A., Lau, J., Uhlig,, K. "Haphazard reporting of deaths in clinical trials: a review of cases of ClinicalTrials.gov records and matched publications-a cross-sectional study." BMJ Open, vol. 3, no. 1, 2013, pp. e001963-e001963.|
|Rao, Madhu, Concannon, Thomas W, Iovin, Ramon, Yu, Winifred W, Chan, Jeffrey A, Lypas, Georgios, Terasawa, Teruhiko, Gaylor, James M, Kong, Lina, Rausch, Andrew C, Lau, Joseph, Kitsios, Georgios D. "Identification of topics for comparative effectiveness systematic reviews in the field of cancer imaging." Journal of comparative effectiveness research, vol. 2, no. 5, 2013, pp. 483-495.|
|Wallace, Byron C, Dahabreh, Issa J, Schmid, Christopher H, Lau, Joseph, Trikalinos, Thomas A. "Modernizing the systematic review process to inform comparative effectiveness: tools and methods." Journal of comparative effectiveness research, vol. 2, no. 3, 2013, pp. 273-82.|
|paulus JK, Dahabreh IJ, Balk EM, Avendano EE, Lau J, Ip S. "Opportunities and challenges in using studies without a control group in comparative effectiveness reviews." Research Synthesis Methods, vol. 5, no. 2, 2013, pp. 152-161.|
|Dahabreh IJ, Chung M, Kitsios GD, Terasawa T, Raman G, Tatsioni A, Tobar A, Lau J, Trikalinos TA, Schmid CH. "Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009." Research Synthesis Methods, vol. 4, no. 3, 2013, pp. 242-55.|
|Patel, K., Hadar, N., Lee, J., Siegel, B. A., Hillner, B. E., Lau, J. "The Lack of Evidence for PET or PET/CT Surveillance of Patients with Treated Lymphoma, Colorectal Cancer, and Head and Neck Cancer: A Systematic Review." Journal of Nuclear Medicine, vol. 54, no. 9, 2013, pp. 1518-1527.|
|Trikalinos TA, Moorthy D, Chung M, Yu WW, Lee J, Lichtenstein AH, Lau J. "Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations." American Journal of Kidney Diseases, vol. 65, no. 1, 2012, pp. 16-29.|
|Fu R, Gartlehner G, Grant M, Shamliyan T, Sedrakyan A, Wilt TJ, Griffith L, Oremus M, Raina P, Ismaila A, Santaquida P, Lau J, Trikalinos T. "Conducting quantitative synthesis when comparing medical interventions: AHRQ and the Effective Health Care Program." J Clin Epidemiol, vol. 64, 2011, pp. 1187-1197.|
|Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., Terrin, N., Jones, D. R., Lau, J., Carpenter, J., Rucker, G., Harbord, R. M., Schmid, C. H., Tetzlaff, J., Deeks, J. J., Peters, J., Macaskill, P., Schwarzer, G., Duval, S., Altman, D. G., Moher, D., Higgins, J. P. T. "Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials." BMJ, vol. 343, no. jul22 1, 2011, pp. d4002-d4002.|
|Zhang, L., Axelsson, I., Chung, M., Lau, J. "Dose Response of Inhaled Corticosteroids in Children With Persistent Asthma: A Systematic Review." Pediatrics, vol. 127, no. 1, 2010, pp. 129-138.|
|Chung M, Balk EM, Ip S, Lee J, Terasawa T, Raman G, Trikalinos TA, Lichtenstein AH, Lau J. "Systematic Review to Support the Development of Nutrient Reference Intake Values: Challenges and Solutions." Am J Clin Nutr, vol. 92, 2010, pp. 273-276.|
|Terasawa T, Balk EM, Chung M, Garlitski AC, Alsheikh-Ali AA, Lau J, Ip S. "Comparative effectiveness of radiofrequency catheter ablation for atrial fibrillation: A Systematic Review." Ann Intern Med, vol. 151, 2009, pp. 191-202.|
|Russell R, Chung M, Balk EM, Atkinson S, Giovannucci EL, Ip S, Lichtenstein AH, Mayne ST, Raman G, Ross AC, Trikalinos TA, West KP Jr, Lau J. "Opportunities and challenges in conducting systematic reviews to support development of nutrient reference values: Vitamin A as an example." The American journal of clinical nutrition, vol. 89, no. 3, 2009, pp. 728-33.|
|Abernethy AP, Raman G, Balk EM, Hammond JM, Orlando LA, Wheeler JL, Lau J, McCrory DC. "Reliability of compendia methods for off-label oncology indications." Ann Intern Med, vol. 150, 2009, pp. 336-343.|
|Balk EM, Armour TA, Newberry SJ, Lichtenstein AH, Yetley EA, Schachter HM, Moher D, MacLean CH, Lau J. "A collaborative effort to apply the evidence-based review process to the field of nutrition: Challenges, benefits, and lessons learned." Am J Clin Nutr, vol. 85, 2007, pp. 1448-1456.|
|Amori RE, Lau J, Pittas A. "Systematic review of randomized controlled trials on the efficacy and safety of incretin therapy in type 2 diabetes." JAMA, vol. 298, 2007, pp. 194-206.|
|Lau J, Ioannidis JPA, Terrin N, Schmid CH, Olkin I. "The case of the misleading funnel plot." BMJ, vol. 333, 2006, pp. 597-600.|
|Tatsioni A, Zarin DA, Aronson N, Samson DJ, Flamm CR, Schmid C, Lau J. "Challenges in Systematic Reviews of Diagnostic Technologies." Ann Intern Med, vol. 142, 2005, pp. 1048-1055.|
|Terrin N, Schmid CH, Lau J. "In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias." J Clin Epidemiol, vol. 2005, 2005, pp. 894-901.|
|Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Kim C, Lau J. "Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis." Arch Intern Med, vol. 164, 2004, pp. 1395-1404.|
|Schmid CH, Stark PC, Berlin JA , Landais P and Lau J. "Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors." J Clin Epidemiol, vol. 57, 2004, pp. 683-697.|
|Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y, and Bornstein SR. "The Clinically Inapparent Adrenal Mass: Update in Diagnosis and Management." Endocr Rev, vol. 25, 2004, pp. 309-340.|
|Levey AS, Coresh J, Balk E, Kausz AT, Levein A, Steffes MW, Hoggs RJ, Perrone RD, Lau J, Eknoyan G. "NKF-K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification and Stratification." Ann Intern Med, vol. 139, 2003, pp. 137-147.|
|Balk EM, Bonis P, Moskowitz H, Schmid CH, Ioannidis JPA, Wang C, Lau J. "Correlation of quality measures with estimates of treatment in meta-analyses of randomized trials." JAMA, vol. 287, 2002, pp. 2973-2982.|
|Ioannidis JPA, Lau J. "Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses." Proc Nat Acad Sci, vol. 98, 2001, pp. 831-836.|
|Ioannidis JPA, Lau J. "Randomized evidence on interventions to reduce medical errors: an attempted overview and recommendations for future research." J GEN INTERN MED, vol. 16, 2001, pp. 325-334.|
|Ioannidis JPA, Lau J. "Reporting of the safety of medications in randomized trials is neglected: an evaluation of 7 medical areas." JAMA, vol. 285, 2001, pp. 437-443.|
|Engels EA, Schmid CH, Terrin N, Olkin I, Lau J. "Heterogeneity and statistical significant in meta-analysis: an empirical study of 125 meta-analyses." Stat Med, vol. 19, 2000, pp. 1707-1728.|
|Schmid CH, Lau J, McIntosh M, Cappelleri JC. "An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis of clinical trials." Stat Med, vol. 17, 1998, pp. 1923-1942.|
|Ioannidis JPA, Cappelleri JC, Lau J. "Issues in comparisons between meta-analyses and large trials." JAMA, vol. 279, 1998, pp. 1089-1093.|
|Lau J, Ioannidis JPA, Schmid CH. "Summing up evidence: One answer is not always enough." The Lancet, vol. 351, 1998, pp. 123-127.|
|Ballantyne JC, Carr DB, deFerranti SD, Suarez T, Lau J, Chalmers TC, Angelillo IF, Mosteller F. "The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials." Anesth Analg, vol. 86, 1998, pp. 598-612.|
|Zucker DR, Schmid CH, McIntosh MW, D'Agnostino RB, Selker HP, Lau J. "Combining single patient (N-of-1) trials to estimate population-based treatment effects and to evaluate individual patient response to treatment." J Clin Epidemiol, vol. 50, 1997, pp. 401-410.|
|Lau J, Ioannidis JPA, Schmid CH. "Quantitative synthesis in systematic reviews." Ann Intern Med, vol. 127, 1997, pp. 820-826.|
Barza M, Ioannidis JPA, Cappelleri JC, Lau J.
"Efficacy and toxicity of single daily dose vs. multi-dose aminoglycoside: a meta-analysis." BMJ, vol. 312, 1996, pp. 338-345.
|Cappelleri JC, Ioannidis JPA, deFerranti SD, Schmid CH, Aubert M, Chalmers TC, Lau J. "Large trials versus meta-analyses of smaller trials: How do their results compare?." JAMA, vol. 276, 1996, pp. 1332-1338.|
|Berkey CS, Mosteller F, Lau J, Antman EM. "Uncertainty of the first instance of significance in random-effects cumulative meta-analysis." Controlled Clin Trials, vol. 17, 1996, pp. 357-371.|
|Antman EM. Lau J. Kupelnick B. Mosteller F. Chalmers TC. "A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction." JAMA, vol. 268, 1992, pp. 240-248.|
Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC.
"Clinical implications of cumulative meta-analyses of randomized control trials: Acute myocardial infarction as an example." N Engl J Med, vol. 327, 1992, pp. 248-254.
Develop Patient Centered Outcomes Scholars for Comparative Effectiveness Research. AHRQ K12 HS022998. Role: PI; Period: 8/1/14 - 7/31/19
Innovative Training to Improve CER PCOR Systematic Review Production and Uptake. AHRQ R25 HS023299. Role: Investigator (PI: Christopher Schmid, PhD). Period: 6/1/14 - 5/31/19
Brown Evidence-based Practice Center IV. AHRQ contract No. HHSA-290-2012-00012-I. Role: Co-director. Periord: 9/1/2012 - 8/31/-2017.
Systematic Review Data Repository (SRDR). AHRQ Contract No. HHSA-290-2012-00012-I, Task Order #3. Role: PI. Period: 2/1/2013- 1/31/2018
Evidence-based Complementary and Alternative Medicine. NCCAM 2R24AT001293. Role: PI of subcontractor to Brown from Univ. Maryland (PI: Brian Berman). Period: Dec 1, 2012 – Dec 1, 2017
Develop, test and disseminate a new technology to modernize data abstractions in PCOR systematic reviews. PCORI grant; Role: PI subcontract (PI: Tianjing Li, Johns Hopkins); Period: Dec 2014 - Nov 2017.
Publication on cumulative meta-analysis (Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC. Clinical implications of cumulative meta-analyses of randomized control trials: Acute myocardial infarction as an example. N Engl J Med. 1992;327:248-54) was included in a proposed 27-articles canon of the western medical literature by the editor of the Lancet (Horton R. A manifesto for reading medicine. Lancet. 1997;349:872-74).
Faculty Recognition Award, Sackler School of Graduate Biomedical Sciences, Tufts University 2000.
Distinguished Faculty Award. Tufts University School of Medicine, 2003.
Elected member, Association of American Physicians, 2006.
Elected member, Society for Research synthesis Methodology, 2006.
Lau J, Ioannidis JPA, Terrin N, Schmid CH, Olkin I. The case of the misleading funnel plot. BMJ 2006;333:597-600. [recognized by Faculty of 1000 Medicine as a “must read” article. Faculty of 1000 Medicine: evaluations for Lau J et al BMJ 2006 Sep 16 333 (7568) :597-600 http://www.f1000medicine.com/article/id/1043014/evaluation.]
Ingram Olkin Award for lifetime achievement in research synthesis methodology. Society for Research Synthesis Methodology, Seattle, WA, July 14, 2009.
National Award for Career Achievement and Contribution to Clinical and Translational Science award. Society for Clinical Translational Science. April 6, 2010.
Profile: Joseph Lau: mastering the meta-analysis. Lancet 2012;379: 403.
Cappelleri JC, Ingerick M. A conversation with Joseph Lau (historical perspective). Res Synth Method 2014; DOI: 10.1002/jrsm.1116.
|Balk, Ethan||Associate Professor of Health Services, Policy and Practice (Research)|
|Dahabreh, Issa||Adjunct Associate Professor of Epidemiology|
|Gatsonis, Constantine||Henry Ledyard Goddard University Professor of Statistical Sciences, Director of Statistical Sciences, Professor of Biostatistics|
|Mor, Vincent||Florence Pirce Grant University Professor, Professor of Health Services, Policy and Practice|
|Schmid, Christopher||Professor of Biostatistics, Chair of Biostatistics|
|Trikalinos, Thomas||Professor of Health Services, Policy and Practice, Director of the Center for Evidence Synthesis in Health|
|Wilson, Ira||Professor of Health Services, Policy and Practice, Professor of Medicine, Chair of Health Services, Policy and Practice|
Society for Research Synthesis Methodology
PHP2415, Introduction to Evidence-based Medicine, given at the School of Public Health
Workshops in systematic review within Brown and at external venues on request.
Seminars on comparative effectiveneess research methods for AHRQ funded K12 scholars within CEBM.