Christopher H Schmid
Christopher H Schmid
Professor of Biostatistics
Overview
Christopher H. Schmid, PhD is Professor of Biostatistics and former Chair of the Department of Biostatistics and a founding member of the Center for Evidence Synthesis in Health in the Brown School of Public Health. He is Fellow of the American Statistical Association (ASA), elected member of the Society for Research Synthesis Methodology, Founding Editor of the journal Research Synthesis Methods, statistical editor for the American Journal of Kidney Diseases and former Chair of the Section on Health Policy Statistics at ASA. He directs the Biostatistics, Epidemiology and Research Design (BERD), Core of Advance-RI Clinical and Translational Research.
His research focuses on methods and applications for meta-analysis, particularly Bayesian methods and software, on predictive models derived from combining data from different sources and on clinical trials, particularly N-of-1 trials, single person multiple crossover studies. He has published extensively on meta-regression and multivariate methods, including network meta-analysis and combining N-of-1 studies.
Dr. Schmid also has coauthored a large number of applications in collaboration with medical and public health scientists. He has published in all the leading general medical journals and in many top subspecialty journals as well.
Dr. Schmid helped develop Institute of Medicine national standards for systematic reviews. Before moving to Brown, Dr. Schmid was on the faculty of Tufts University School of Medicine from 1992-2012. He served as Director of the Biostatistics Research Center at Tufts Medical Center and as Associate Director of the Clinical and Translational Science program. He directed the Brown Biostatistics Masters Program from 2012-2016. Dr. Schmid holds a PhD in Statistics from Harvard University (1991) and a BA in Mathematics from Haverford College (1983). He consults extensively with government, academia and industry and has served on many data safety monitoring and grant review committees including the AHRQ Health Care Research Training Study Section, the FDA Drug Safety and Risk Management Advisory Committee and the Scientific Advisory Committee of the Cochrane Collaboration.
Brown Affiliations
Research Areas
Bangladesh | biostatistics | clinical prediction rules | clinical trials | diagnostic tests | meta-analysis | N-of-1 studies | network meta-analysis | Peru | predictive models | Professional education | Puerto Rico | Statistics Education | systematic review | United States | West Africa
On the Web
Advance CTR Center for Evidence Synthesis in Health Department of BiostatisticsPublications Visualize it
| Qu K, Gainey M, Kanekar SS, Nasrim S, Nelson EJ, Garbern SC, Monjory M, Alam NH, Levine AC, Schmid CH. "Comparing the predictive discrimination of machine learning models for ordinal outcomes: A case study of dehydration prediction in patients with acute diarrhea." PLOS digital health, vol. 4, no. 5, 2025, pp. e0000820. |
| Quintana AN, Schmid CH, Qu K, Gainey M, Nasrin S, Monjory M, Nelson EJ, Alam NH, Levine AC. "Evaluating clinical utility of multi-category outcome risk prediction models." medRxiv : the preprint server for health sciences, 2025. |
| Koukounas KG, Dixit MN, Thorsness R, Patzer RE, Wilk AS, Drewry KM, Mehrotra R, Rivera-Hernandez M, Meyers DJ, Kim D, Shah AD, Schmid CH, Trivedi AN. "Performance of Dialysis Facilities after Health-Equity Scoring Incentive." New England Journal of Medicine, vol. 392, no. 16, 2025, pp. 1657-1659. |
| Duan R, Tong J, Lin L, Levine L, Sammel M, Stoddard J, Li T, Schmid CH, Chu H, Chen Y. "PALM: PATIENT-CENTERED TREATMENT RANKING VIA LARGE-SCALE MULTIVARIATE NETWORK META-ANALYSIS." Ann. Appl. Stat., vol. 17, no. 1, 2023, pp. 815-837. |
| Selker HP, Cohen T, D'Agostino RB, Dere WH, Ghaemi SN, Honig PK, Kaitin KI, Kaplan HC, Kravitz RL, Larholt K, McElwee NE, Oye KA, Palm ME, Perfetto E, Ramanathan C, Schmid CH, Seyfert-Margolis V, Trusheim M, Eichler HG. "A Useful and Sustainable Role for N-of-1 Trials in the Healthcare Ecosystem." Clinical pharmacology and therapeutics, vol. 112, no. 2, 2022, pp. 224-232. |
| Schmid C, Yang J. "Bayesian Models for N-of-1 Trials." Harvard data science review, vol. 2022, no. SI3, 2022. |
| Levine AC, Barry MA, Gainey M, Nasrin S, Qu K, Schmid CH, Nelson EJ, Garbern SC, Monjory M, Rosen R, Alam NH. "Correction: Derivation of the first clinical diagnostic models for dehydration severity in patients over five years with acute diarrhea." PLOS Neglected Tropical Diseases, vol. 16, no. 12, 2022, pp. e0011026. |
| Marcus GM, Modrow MF, Schmid CH, Sigona K, Nah G, Yang J, Chu TC, Joyce S, Gettabecha S, Ogomori K, Yang V, Butcher X, Hills MT, McCall D, Sciarappa K, Sim I, Pletcher MJ, Olgin JE. "Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial." JAMA Cardiology, vol. 7, no. 2, 2022, pp. 167-174. |
| Lee, J. Austin, Qu, Kexin, Gainey, Monique, Kanekar, Samika S., Barry, Meagan A., Nasrin, Sabiha, Alam, Nur H., Schmid, Christopher H., Levine, Adam C. "Continuous diagnostic models for volume deficit in patients with acute diarrhea." Tropical Medicine and Health, vol. 49, no. 1, 2021, pp. 70. |
| Rubenstein, Dana, Sokolovsky, Alexander W., Aston, Elizabeth R., Nollen, Nicole L., Schmid, Christopher H., Rice, Myra, Pulvers, Kim, Ahluwalia, Jasjit S. "Predictors of smoking reduction among African American and Latinx smokers in a randomized controlled trial of JUUL e-cigarettes." Addictive Behaviors, vol. 122, 2021, pp. 107037. |
| Aert, Robbie C. M., Schmid, Christopher H., Svensson, David, Jackson, Dan. "Study specific prediction intervals for random‐effects meta‐analysis: A tutorial." Research Synthesis Methods, 2021. |
| Khan MS, Khan AR, Khan AI, Seo M, Yasmin F, Usman MS, Moustafa A, Schmid CH, Kalra A, Ikram S. "Comparison of revascularization strategies in patients with acute coronary syndrome and multivessel coronary disease: A systematic review and network meta-analysis." Catheterization and Cardiovascular Interventions, vol. 96, no. 4, 2020, pp. E447-E454. |
| Zgodic A, Schmid CH, Olkin I, Trikalinos TA. "Different evidence summaries have implications for contextualizing findings of meta-analysis of diagnostic tests." American Journal of Kidney Diseases, vol. 109, 2019, pp. 51-61. |
| Kravitz RL, Schmid CH, Sim I. "Finding Benefit in n-of-1 Trials-Reply." JAMA Internal Medicine, vol. 179, no. 3, 2019, pp. 455. |
| Wang L, Rouse B, Marks-Anglin A, Duan R, Shi Q, Quach K, Chen Y, Cameron C, Schmid CH, Li T. "Rapid network meta-analysis using data from Food and Drug Administration approval packages is feasible but with limitations." American Journal of Kidney Diseases, vol. 114, 2019, pp. 84-94. |
| Schmid CH. "Contribution to the discussion of "When should meta-analysis avoid making hidden normality assumptions?." Biometrical journal. Biometrische Zeitschrift, vol. 60, no. 6, 2018, pp. 1087-1088. |
| Schmid CH. "Discussion of "quantifying publication bias in meta-analysis" by Lin et al." Biometrics, vol. 74, no. 3, 2018, pp. 797-799. |
| Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I. "Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial." JAMA Internal Medicine, vol. 178, no. 10, 2018, pp. 1368-1377. |
| Wang, Chenchen, Schmid, Christopher H, Fielding, Roger A, Harvey, William F, Reid, Kieran F, Price, Lori Lyn, Driban, Jeffrey B, Kalish, Robert, Rones, Ramel, McAlindon, Timothy. "Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial." BMJ, vol. 360, 2018, pp. k851. |
| Jap J, Saldanha IJ, Smith BT, Lau J, Schmid CH, Li T, Data Abstraction Assistant Investigators. "Features and functioning of Data Abstraction Assistant, a software application for data abstraction during systematic reviews." Research Synthesis Methods, 2018. |
| Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL. "Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study." JMIR mHealth and uHealth, vol. 6, no. 10, 2018, pp. e10291. |
| Chen Y, Liu Y, Chu H, Ting Lee ML, Schmid CH. "A simple and robust method for multivariate meta-analysis of diagnostic test accuracy." Statistics in Medicine, vol. 36, no. 1, 2017, pp. 105-121. |
| Dahabreh I, Kent D, Trikalinos T and Schmid CH. "Heterogeneity of Treatment Effects." Methods in Comparative Effectiveness Research, edited by SC Morton and C Gatsonis, New York, Chapman & Hall, 2017, pp. 227-271. |
| Wallace, Byron C., Lajeunesse, Marc J., Dietz, George, Dahabreh, Issa J., Trikalinos, Thomas A., Schmid, Christopher H., Gurevitch, Jessica. "OpenMEE : Intuitive, open-source software for meta-analysis in ecology and evolutionary biology." Methods in Ecology and Evolution, vol. 8, no. 8, 2017, pp. 941-947. |
| Schmid CH. "Outcome Reporting Bias: A Pervasive Problem in Published Meta-analyses." American Journal of Kidney Diseases, vol. 69, no. 2, 2017, pp. 172-174. |
| Porcino AJ, Punja S, Chan AW, Kravitz R, Orkin A, Ravaud P, Schmid CH, Vohra S. "Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines." Systematic reviews, vol. 6, no. 1, 2017, pp. 132. |
| Lau J, Morton SC, Trikalinos TA and Schmid CH. "Systematic Reviews with Study-Level and Individual Patient-Level Data." Methods in Comparative Effectiveness Research, edited by SC Morton and C Gatsonis, New York, Chapman & Hall, 2017, pp. 301-339. |
| Landsittel DP, Kessler L, Schmid CH, Marantz P, Suarez-Almazor ME. "Training in patient-centered outcomes research for specific researcher communities." Journal of clinical and translational science, vol. 1, no. 5, 2017, pp. 278-284. |
| Dahabreh, Issa J., Trikalinos, Thomas A., Lau, Joseph, Schmid, Christopher H. "Univariate and bivariate likelihood-based meta-analysis methods performed comparably when marginal sensitivity and specificity were the targets of inference." Journal of Clinical Epidemiology, vol. 83, 2017, pp. 8-17. |
| Rothstein H, Schmid C, Shrier I. "2016 Bulletin." Research Synthesis Methods, vol. 7, no. 1, 2016, pp. 5. |
| Schmid, Christopher H. "An interview with Constantine Gatsonis." Health Services and Outcomes Research Methodology, vol. 16, no. 4, 2016, pp. 187-212. |
| Wang C, Schmid CH, Iversen MD, Harvey WF, Fielding RA, Driban JB, Price LL, Wong JB, Reid KF, Rones R, McAlindon T. "Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial." Annals of Internal Medicine, vol. 165, no. 2, 2016, pp. 77-86. |
| Inker LA, Mondal H, Greene T, Masaschi T, Locatelli F, Schena FP, Katafuchi R, Appel GB, Maes BD, Li PK, Praga M, Del Vecchio L, Andrulli S, Manno C, Gutierrez E, Mercer A, Carroll KJ, Schmid CH, Levey AS. "Early Change in Urine Protein as a Surrogate End Point in Studies of IgA Nephropathy: An Individual-Patient Meta-analysis." American Journal of Kidney Diseases, vol. 68, no. 3, 2016, pp. 392-401. |
| Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T. "Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial." Systematic reviews, vol. 5, no. 1, 2016, pp. 196. |
| Levine AC, Glavis-Bloom J, Modi P, Nasrin S, Atika B, Rege S, Robertson S, Schmid CH, Alam NH. "External validation of the DHAKA score and comparison with the current IMCI algorithm for the assessment of dehydration in children with diarrhoea: a prospective cohort study." The Lancet. Global health, vol. 4, no. 10, 2016, pp. e744-51. |
| Schmid CH. "Heterogeneity: multiplicative, additive or both?." Research Synthesis Methods, 2016. |
| Schmid, Christopher H. "Increased mortality for white middle-aged Americans not fully explained by causes suggested." Proceedings of the National Academy of Sciences, vol. 113, no. 7, 2016, pp. E814-E814. |
| Norris SL, Zhang X, Avenell A, Gregg E, Brown T, Schmid CH, Lau J. "Long-term non-pharmacological weight loss interventions for adults with type 2 diabetes mellitus." Sao Paulo medical journal = Revista paulista de medicina, vol. 134, no. 2, 2016, pp. 184. |
| Punja S, Nikles CJ, Senior H, Mitchell G, Schmid CH, Heussler H, Witmans M, Vohra S. "Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol for a randomized controlled trial." Trials, vol. 17, 2016, pp. 375. |
| Punja S, Xu D, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S. "N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis." American Journal of Kidney Diseases, vol. 76, 2016, pp. 65-75. |
| Schmid, CH. "Review of Introduction to Scientific Programming and Simulation Using R (2nd ed) by O. Jones, R. Maillardet and A. Robinson." Journal of the American Statistical Association, vol. 111, 2016, pp. 443-444. |
| Whiting P, Savović J, Higgins JP, Caldwell DM, Reeves BC, Shea B, Davies P, Kleijnen J, Churchill R, ROBIS group. "ROBIS: A new tool to assess risk of bias in systematic reviews was developed." American Journal of Kidney Diseases, vol. 69, 2016, pp. 225-34. |
| Tate RL, Perdices M, Rosenkoetter U, Shadish W, Vohra S, Barlow DH, Horner R, Kazdin A, Kratochwill T, McDonald S, Sampson M, Shamseer L, Togher L, Albin R, Backman C, Douglas J, Evans JJ, Gast D, Manolov R, Mitchell G, Nickels L, Nikles J, Ownsworth T, Rose M, Schmid CH, Wilson B. "The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement." Journal of school psychology, vol. 56, 2016, pp. 133-42. |
| Tate RL, Perdices M, Rosenkoetter U, Shadish W, Vohra S, Barlow DH, Horner R, Kazdin A, Kratochwill T, McDonald S, Sampson M, Shamseer L, Togher L, Albin R, Backman C, Douglas J, Evans JJ, Gast D, Manolov R, Mitchell G, Nickels L, Nikles J, Ownsworth T, Rose M, Schmid CH, Wilson B. "The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement." The American Journal of Occupational Therapy, vol. 70, no. 4, 2016, pp. 7004320010p1-11. |
| Tate RL, Perdices M, Rosenkoetter U, Shadish W, Vohra S, Barlow DH, Horner R, Kazdin A, Kratochwill T, McDonald S, Sampson M, Shamseer L, Togher L, Albin R, Backman C, Douglas J, Evans JJ, Gast D, Manolov R, Mitchell G, Nickels L, Nikles J, Ownsworth T, Rose M, Schmid CH, Wilson B. "The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement." Physical Therapy, vol. 96, no. 7, 2016, pp. e1-e10. |
| Tate RL, Perdices M, Rosenkoetter U, Shadish W, Vohra S, Barlow DH, Horner R, Kazdin A, Kratochwill T, McDonald S, Sampson M, Shamseer L, Togher L, Albin R, Backman C, Douglas J, Evans JJ, Gast D, Manolov R, Mitchell G, Nickels L, Nikles J, Ownsworth T, Rose M, Schmid CH, Wilson B. "The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement." American Journal of Kidney Diseases, vol. 73, 2016, pp. 142-52. |
| Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, McDonald, Skye, Togher, Leanne, Shadish, William, Horner, Robert, Kratochwill, Thomas, Barlow, David H., Kazdin, Alan, Sampson, Margaret, Shamseer, Larissa, Vohra, Sunita. "The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016: Explanation and elaboration." Archives of Scientific Psychology, vol. 4, no. 1, 2016, pp. 10-31. |
| Punja S, Schmid CH, Hartling L, Urichuk L, Nikles CJ, Vohra S. "To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD." American Journal of Kidney Diseases, vol. 76, 2016, pp. 76-81. |
| Jin M, Li H, Schmid CH and Wallace BC. "Using Electronic Medical Records and Physician Data to Improve Information Retrieval for Evidence-Based Care." 2016, pp. 61-64. |
| Wang, Chenchen, McAlindon, Timothy, Fielding, Roger A, Harvey, William F, Driban, Jeffrey B, Price, Lori Lyn, Kalish, Robert, Schmid, Anna, Scott, Tammy M, Schmid, Christopher H. "A novel comparative effectiveness study of Tai Chi versus aerobic exercise for fibromyalgia: study protocol for a randomized controlled trial." Trials, vol. 16, no. 1, 2015. |
| Bannuru, Raveendhara R., Schmid, Christopher H., Kent, David M., Vaysbrot, Elizaveta E., Wong, John B., McAlindon, Timothy E. "Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis." Annals of Internal Medicine, vol. 162, no. 1, 2015, pp. 46. |
| Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. "Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis." Annals of Internal Medicine, vol. 162, no. 1, 2015, pp. 46-54. |
| Vohra, S., Shamseer, L., Sampson, M., Bukutu, C., Schmid, C. H., Tate, R., Nikles, J., Zucker, D. R., Kravitz, R., Guyatt, G., Altman, D. G., Moher, D. "CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement." BMJ, vol. 350, no. may14 17, 2015, pp. h1738-h1738. |
| Vohra S, Shamseer L, Sampson M, Bukutu C, Schmid CH, Tate R, Nikles J, Zucker DR, Kravitz R, Guyatt G, Altman DG, Moher D, CENT Group. "CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement." BMJ, vol. 350, 2015, pp. h1738. |
| Vohra S, Shamseer L, Sampson M, Bukutu C, Schmid CH, Tate R, Nikles J, Zucker DR, Kravitz R, Guyatt G, Altman DG, Moher D, CENT Group. "CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement." American Journal of Kidney Diseases, vol. 76, 2015, pp. 9-17. |
| Shamseer, L., Sampson, M., Bukutu, C., Schmid, C. H., Nikles, J., Tate, R., Johnston, B. C., Zucker, D., Shadish, W. R., Kravitz, R., Guyatt, G., Altman, D. G., Moher, D., Vohra, S. "CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration." BMJ, vol. 350, no. may14 15, 2015, pp. h1793-h1793. |
| Shamseer L, Sampson M, Bukutu C, Schmid CH, Nikles J, Tate R, Johnston BC, Zucker D, Shadish WR, Kravitz R, Guyatt G, Altman DG, Moher D, Vohra S, CENT group. "CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration." American Journal of Kidney Diseases, vol. 76, 2015, pp. 18-46. |
| Shamseer L, Sampson M, Bukutu C, Schmid CH, Nikles J, Tate R, Johnston BC, Zucker D, Shadish WR, Kravitz R, Guyatt G, Altman DG, Moher D, Vohra S, CENT Group. "CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration." BMJ, vol. 350, 2015, pp. h1793. |
| Bannuru RR, McAlindon TE, Sullivan MC, Wong JB, Kent DM, Schmid CH. "Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials." Annals of Internal Medicine, vol. 163, no. 5, 2015, pp. 365-72. |
| Levine AC, Glavis-Bloom J, Modi P, Nasrin S, Rege S, Chu C, Schmid CH, Alam NH. "Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh." Global health, science and practice, vol. 3, no. 3, 2015, pp. 405-18. |
| Bannuru, R.R., Wong, J.B., Kent, D.M., Schmid, C.H., McAlindon, T.E. "Intra-articular corticosteroids may be a cost-effective strategy for short-term management of knee osteoarthritis." Osteoarthritis and Cartilage, vol. 23, 2015, pp. A392-A394. |
| Stewart GB, Schmid CH. "Lessons from meta-analysis in ecology and evolution: the need for trans-disciplinary evidence synthesis methodologies." Research Synthesis Methods, vol. 6, no. 2, 2015, pp. 109-110. |
| Miligkos, Michael, Bannuru, Raveendhara R., Alkofide, Hadeel, Kher, Sucharita R., Schmid, Christopher H., Balk, Ethan M. "Leukotriene-Receptor Antagonists Versus Placebo in the Treatment of Asthma in Adults and Adolescents." Annals of Internal Medicine, vol. 163, no. 10, 2015, pp. 756. |
| Wagner M, Earley AK, Webster AC, Schmid CH, Balk EM, Uhlig K. "Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients." The Cochrane database of systematic reviews, no. 12, 2015, pp. CD007746. |
| Stewart LA, Clarke M, Rovers M, Riley RD, Simmonds M, Stewart G, Tierney JF, PRISMA-IPD Development Group. "Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data: the PRISMA-IPD Statement." JAMA, vol. 313, no. 16, 2015, pp. 1657-65. |
| Mengersen K, McGree JM and Schmid CH. "Statistical Analysis of N-of-1 Trials." The Essential Guide to N-of-1 Trials in Health, edited by J Nikles and G Mitchell, New York, Springer, 2015, pp. 135-153. |
| Mengersen K, McGree JM and Schmid CH. "Systematic Review and Meta-analysis Using N-of-1 Trials." The Essential Guide to N-of-1 Trials in Health, edited by J Nikles and G Mitchell, New York, Springer, 2015, pp. 211-232. |
| Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. "The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial." Trials, vol. 16, 2015, pp. 67. |
| Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, Mulrow C, Catalá-López F, Gøtzsche PC, Dickersin K, Boutron I, Altman DG, Moher D. "The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations." Annals of Internal Medicine, vol. 162, no. 11, 2015, pp. 777-84. |
| Halladay CW, Trikalinos TA, Schmid IT, Schmid CH, Dahabreh IJ. "Using data sources beyond PubMed has a modest impact on the results of systematic reviews of therapeutic interventions." American Journal of Kidney Diseases, vol. 68, no. 9, 2015, pp. 1076-84. |
| Trikalinos TA, Hoaglin DC, Schmid CH. "An empirical comparison of univariate and multivariate meta-analyses for categorical outcomes." Statistics in Medicine, vol. 33, no. 9, 2014, pp. 1441-59. |
| Wang, Chenchen, Iversen, Maura D, McAlindon, Timothy, Harvey, William F, Wong, John B, Fielding, Roger A, Driban, Jeffrey B, Price, Lori, Rones, Ramel, Gamache, Tressa, Schmid, Christopher H. "Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial." BMC Complementary and Alternative Medicine, vol. 14, no. 1, 2014, pp. 333. |
| Nikolakopoulou A, Chaimani A, Veroniki AA, Vasiliadis HS, Schmid CH, Salanti G. "Characteristics of networks of interventions: a description of a database of 186 published networks." PLoS ONE, vol. 9, no. 1, 2014, pp. e86754. |
| Kravitz RL, Duan N, eds, and the DEcIDE Methods Center N-of-1 Guidance Panel (Duan N, Eslick I, Gabler NB, Kaplan HC, Kravitz RL, Larson EB, Pace WD, Schmid CH, Sim I, Vohra S). Design and Implementation of N-of-1 Trials: A User’s Guide. Agency for Healthcare Research and Quality, 2014. |
| Bannuru, R.R., Schmid, C.H., Sullivan, M.C., Kent, D.M., Wong, J.B., McAlindon, T.E. "Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis." Osteoarthritis and Cartilage, vol. 22, 2014, pp. S24-S25. |
| Jessani S, Levey AS, Bux R, Inker LA, Islam M, Chaturvedi N, Mariat C, Schmid CH, Jafar TH. "Estimation of GFR in South Asians: a study from the general population in Pakistan." American Journal of Kidney Diseases, vol. 63, no. 1, 2014, pp. 49-58. |
| Wallace BC, Schmid CH, Lau J and Trikalinos TA. "Evidence-Based Medicine and Meta-Analysis: Modernizing Evidence Synthesis." Clinical Decision Support: The Road to Broad Adoption, 2nd edition, edited by RA Greenes, New York, Academic Press, 2014, pp. 339-361. |
| Inker LA, Lambers Heerspink HJ, Mondal H, Schmid CH, Tighiouart H, Noubary F, Coresh J, Greene T, Levey AS. "GFR decline as an alternative end point to kidney failure in clinical trials: a meta-analysis of treatment effects from 37 randomized trials." American Journal of Kidney Diseases, vol. 64, no. 6, 2014, pp. 848-59. |
| Trikalinos, Thomas A., Hoaglin, David C., Small, Kevin M., Terrin, Norma, Schmid, Christopher H. "Methods for the joint meta-analysis of multiple tests." Research Synthesis Methods, vol. 5, no. 4, 2014, pp. 294-312. |
| Hutton B, Salanti G, Chaimani A, Caldwell DM, Schmid C, Thorlund K, Mills E, Catalá-López F, Turner L, Altman DG, Moher D. "The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions for improvement." PLoS ONE, vol. 9, no. 3, 2014, pp. e92508. |
| Schmid CH and Mengersen K. "Bayesian meta-analyses." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 145-173. |
| Schmid, Christopher H., Trikalinos, Thomas A., Olkin, Ingram. "Bayesian network meta-analysis for unordered categorical outcomes with incomplete data." Research Synthesis Methods, vol. 5, no. 2, 2013, pp. 162-185. |
| Chaimani A, Vasiliadis HS, Pandis N, Schmid CH, Welton NJ, Salanti G. "Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study." International journal of epidemiology, vol. 42, no. 4, 2013, pp. 1120-31. |
| Trikalinos TA, Hoaglin DC, Schmid CH. Empirical and Simulation-Based Comparison of Univariate and Multivariate Meta-Analysis for Binary Outcomes. 2013. |
| Yu, Winifred W., Schmid, Christopher H., Lichtenstein, Alice H., Lau, Joseph, Trikalinos, Thomas A. "Empirical evaluation of meta-analytic approaches for nutrient and health outcome dose-response data." Research Synthesis Methods, 2013, pp. n/a-n/a. |
| Trikalinos TA, Hoaglin DC, Small KM, Schmid CH. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests. 2013. |
| Dahabreh, I. J., Schmid, C. H., Lau, J., Varvarigou, V., Murray, S., Trikalinos, T. A. "Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer." American Journal of Epidemiology, vol. 177, no. 12, 2013, pp. 1317-25. |
| Mengersen K and Schmid CH. "Maximum likelihood approaches to meta-analysis." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 125-144. |
| Mengersen K, Gurevitch J and Schmid CH. "Meta-analysis of primary data." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 300-312. |
| Wallace BC, Dahabreh IJ, Schmid CH, Lau J, Trikalinos TA. "Modernizing the systematic review process to inform comparative effectiveness: tools and methods." Journal of comparative effectiveness research, vol. 2, no. 3, 2013, pp. 273-82. |
| Beidleman BA, Tighiouart H, Schmid CH, Fulco CS, Muza SR. "Predictive models of acute mountain sickness after rapid ascent to various altitudes." Medicine & Science in Sports & Exercise, vol. 45, no. 4, 2013, pp. 792-800. |
| Trikalinos TA, Trow P and Schmid CH. "Simulation-based Comparison of Methods for Meta-Analysis of Proportions and Rates." AHRQ Methods Research Report. AHRQ Publication No. 13-EHC066-EF, 2013. |
| Duan N, Kravitz RL, Schmid CH. "Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research." American Journal of Kidney Diseases, vol. 66, no. 8 Suppl, 2013, pp. S21-8. |
| Schmid CH, Stewart G, Rothstein H and Gurevitch J. "Software for meta-analysis." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 174-191. |
| Mengersen K, Schmid CH, Jennions MD and Gurevitch J. "Statistical models and approaches to inference for meta-analysis." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 89-107. |
| Mengersen K, Jennions MD and Schmid CH. "Statistical models for the meta-analysis of non-independent data." Handbook of Meta-Analysis in Ecology and Evolution, edited by J Koricheva, J Gurevitch and K Mengersen, Princeton, NJ, Princeton University Press, 2013, pp. 255-283. |
| Dahabreh IJ, Chung M, Kitsios GD, Terasawa T, Raman G, Tatsioni A, Tobar A, Lau J, Trikalinos TA, Schmid CH. "Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009." Research Synthesis Methods, vol. 4, no. 3, 2013, pp. 242-55. |
| Schmid A, McAlindon T, Schmid CH and Wang C. "The Influence of Tai Chi Exercise on Proprioception in Patients with Knee Osteoarthritis: Results from a Pilot Randomized Controlled Trial." International Journal of Integrative Medicine, vol. 1, 2013, pp. 37. |
| Trikalinos TA, Dahabreh IJ, Wallace BC, Schmid CH and Lau J. Towards a Framework for Communicating Confidence in Methodological Recommendations for Systematic Reviews and Meta-Analyses. 2013. |
| Padala S, Tighiouart H, Inker LA, Contreras G, Beck GJ, Lewis J, Steffes M, Rodby RA, Schmid CH, Levey AS. "Accuracy of a GFR estimating equation over time in people with a wide range of kidney function." American Journal of Kidney Diseases, vol. 60, no. 2, 2012, pp. 217-24. |
| Dahabreh IJ, Trikalinos TA, Lau J, Schmid C. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy. 2012. |
| Wallace BC, Dahabreh IJ, Trikalinos TA, Lau J, Trow P and Schmid CH. "Closing the Gap Between Methodologists and End-Users: R as a Computational Back-end." Journal of Statistical Software, vol. 49, 2012, pp. 5. |
| Dahabreh IJ, Chung M, Kitsios GD, Terasawa T, Raman G, Tatsioni A, Tobar A, Lau J, Trikalinos TA, Schmid CH. Comprehensive Overview of Methods and Reporting of Meta-Analyses of Test Accuracy. 2012. |
| Jansen JP, Schmid CH, Salanti G. "Directed acyclic graphs can help understand bias in indirect and mixed treatment comparisons." American Journal of Kidney Diseases, vol. 65, no. 7, 2012, pp. 798-807. |
| Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS, CKD-EPI Investigators. "Estimating glomerular filtration rate from serum creatinine and cystatin C." New England Journal of Medicine, vol. 367, no. 1, 2012, pp. 20-9. |
| Zintzaras E, Doxani C, Mprotsis T, Schmid CH and Hadjigeorgiou GM. "Network analysis of randomized controlled trials in multiple sclerosis." Clinical Therapeutics, vol. 34, 2012, pp. 857-869. |
| Inker LA, Wyatt C, Creamer R, Hellinger J, Hotta M, Leppo M, Levey AS, Okparavero A, Graham H, Savage K, Schmid CH, Tighiouart H, Wallach F, Krishnasami Z. "Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals." JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 61, no. 3, 2012, pp. 302-9. |
| Salanti G, Schmid CH. "Research Synthesis Methods special issue on network meta-analysis: introduction from the editors." Research Synthesis Methods, vol. 3, no. 2, 2012, pp. 69-70. |
| Gatsonis C, Carlos R, Gareen I, Gorelick J, Kessler L, Lau J, Rutter C, Schmid C, Tosteson ANA, Trikalinos T. "Standards in the Design, Conduct and Evaluation of Diagnostic Testing For Use in Patient Centered Outcomes Research." Patient Centered Outcomes Research Institute, 2012. |
| Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA. "Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining." Genet Med, vol. 14, no. 7, 2012, pp. 663-9. |
| Askling J, Fahrbach K, Nordstrom B, Ross S, Schmid CH and Symmons D. "Cancer risk with tumor necrosis factor (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept and infliximab using patient level data." Pharmacoepidemiology and Drug Safety, vol. 20, 2011, pp. 119-130. |
| Tangri N, Stevens LA, Schmid CH, Zhang YL, Beck GJ, Greene T, Coresh J, Levey AS. "Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate." Kidney International, vol. 79, no. 4, 2011, pp. 471-7. |
| Stevens LA, Claybon MA, Schmid CH, Chen J, Horio M, Imai E, Nelson RG, Van Deventer M, Wang HY, Zuo L, Zhang YL, Levey AS. "Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities." Kidney International, vol. 79, no. 5, 2011, pp. 555-62. |
| Committee on Standards for Systematic Review of Comparative Effectiveness Research. Finding What Works in Health Care: Standards for Systematic Reviews. edited by J Eden, L Levit, A Berg and S Morton, Institute of Medicine of the National Academies, 2011. |
| Kitsios GD, Dahabreh IJ, Trikalinos TA, Schmid CH, Huggins GS, Kent DM. "Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies." Circulation: Cardiovascular Genetics, vol. 4, no. 1, 2011, pp. 58-67. |
| Gordon CE, Uhlig K, Schmid CH, Levey AS, Wong JB. "Long-term viral negativity after interferon for chronic hepatitis C virus infection in hemodialysis." Clinical journal of the American Society of Nephrology : CJASN, vol. 6, no. 9, 2011, pp. 2226-34. |
| Deo A, Schmid CH, Earley A, Lau J, Uhlig K. "Loss to analysis in randomized controlled trials in CKD." American Journal of Kidney Diseases, vol. 58, no. 3, 2011, pp. 349-55. |
| Li T, Puhan MA, Vedula SS, Singh S, Dickersin K and the Ad Hoc Network Meta-analysis Methods Meeting Working Group. "Network meta-analysis-highly attractive but more methodological research is needed." BMC Medicine, vol. 9, 2011, pp. 79. |
| Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, Carpenter J, Rücker G, Harbord RM, Schmid CH, Tetzlaff J, Deeks JJ, Peters J, Macaskill P, Schwarzer G, Duval S, Altman DG, Moher D, Higgins JP. "Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials." BMJ, vol. 343, 2011, pp. d4002. |
| Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE. "Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--meta-analysis." Osteoarthritis and Cartilage, vol. 19, no. 6, 2011, pp. 611-9. |
| Bannuru, R.R., Natov, N.S., Dasi, U.R., Schmid, C.H., McAlindon, T.E. "540 THERAPEUTIC TRAJECTORY FOLLOWING INTRA-ARTICULAR HYALURONIC ACID INJECTION IN KNEE OSTEOARTHRITIS: META-ANALYSIS." Osteoarthritis and Cartilage, vol. 18, 2010, pp. S242-S243. |
| Wang C, Schmid CH, Rones R, Kalish R, Yinh J, Goldenberg DL, Lee Y, McAlindon T. "A randomized trial of tai chi for fibromyalgia." New England Journal of Medicine, vol. 363, no. 8, 2010, pp. 743-54. |
| Stevens LA, Schmid CH, Greene T, Zhang YL, Beck GJ, Froissart M, Hamm LL, Lewis JB, Mauer M, Navis GJ, Steffes MW, Eggers PW, Coresh J, Levey AS. "Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2." American Journal of Kidney Diseases, vol. 56, no. 3, 2010, pp. 486-95. |
| Stevens LA, Schmid CH, Zhang YL, Coresh J, Manzi J, Landis R, Bakoush O, Contreras G, Genuth S, Klintmalm GB, Poggio E, Rossing P, Rule AD, Weir MR, Kusek J, Greene T, Levey AS. "Development and validation of GFR-estimating equations using diabetes, transplant and weight." Nephrol. Dial. Transplant., vol. 25, no. 2, 2010, pp. 449-57. |
| Zucker DR, Deo A, Schmid CH. "Dialysis research and N-of-1 trials: made for each other?." American Journal of Kidney Diseases, vol. 55, no. 4, 2010, pp. 635-8. |
| Lipsey MW, Schmid CH. "From the Editors." Research Synthesis Methods, vol. 1, no. 1, 2010, pp. 1. |
| Zucker DR, Ruthazer R, Schmid CH. "Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations." American Journal of Kidney Diseases, vol. 63, no. 12, 2010, pp. 1312-23. |
| Wallace BC, Trikalinos TA, Lau J, Brodley C, Schmid CH. "Semi-automated screening of biomedical citations for systematic reviews." BMC Bioinformatics, vol. 11, 2010, pp. 55. |
| Wang C, Bannuru R, Ramel J, Kupelnick B, Scott T, Schmid CH. "Tai Chi on psychological well-being: systematic review and meta-analysis." BMC Complementary and Alternative Medicine, vol. 10, 2010, pp. 23. |
| Bannuru, R.R., Natov, N.S., Obadan, I.E., Schmid, C.H., McAlindon, T.E. "501 RELATIVE EFFICACY OF HYALURONIC ACID VERSUS CORTICOSTEROIDS IN THE TREATMENT OF KNEE OSTEOARTHRITIS: META-ANALYSIS." Osteoarthritis and Cartilage, vol. 17, 2009, pp. S269-S270. |
| Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). "A new equation to estimate glomerular filtration rate." Annals of Internal Medicine, vol. 150, no. 9, 2009, pp. 604-12. |
| Marques, A., Shaw, P., Schmid, C. H., Steere, A., Kaplan, R. F., Hassett, A., Shapiro, E., Wormser, G. P., Fallon, B. A., Petkova, E., Keilp, J. G., Slavov, I., Maloney, E. L., Halperin, J. J., Fallon, B. A., Szantyr, B. M., Halperin, J. J., Maloney, E. "A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH." Neurology, vol. 72, no. 4, 2009, pp. 383-386. |
| Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS, Chronic Kidney Disease Epidemiology Collaboration. "Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations." American Journal of Kidney Diseases, vol. 54, no. 1, 2009, pp. 33-42. |
| Stevens LA, Schmid CH, Greene T, Li L, Beck GJ, Joffe MM, Froissart M, Kusek JW, Zhang YL, Coresh J, Levey AS. "Factors other than glomerular filtration rate affect serum cystatin C levels." Kidney International, vol. 75, no. 6, 2009, pp. 652-60. |
| Gordon CE, Uhlig K, Lau J, Schmid CH, Levey AS, Wong JB. "Interferon for hepatitis C virus in hemodialysis--an individual patient meta-analysis of factors associated with sustained virological response." Clinical journal of the American Society of Nephrology : CJASN, vol. 4, no. 9, 2009, pp. 1449-58. |
| Wallace BC, Schmid CH, Lau J, Trikalinos TA. "Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data." BMC medical research methodology, vol. 9, 2009, pp. 80. |
| Stoycheff N, Stevens LA, Schmid CH, Tighiouart H, Lewis J, Atkins RC, Levey AS. "Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition." American Journal of Kidney Diseases, vol. 54, no. 5, 2009, pp. 840-9. |
| Wang C, Schmid CH, Hibberd PL, Kalish R, Roubenoff R, Rones R, McAlindon T. "Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial." Arthritis and rheumatism, vol. 61, no. 11, 2009, pp. 1545-53. |
| Bannuru RR, Natov NS, Obadan IE, Price LL, Schmid CH, McAlindon TE. "Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis." Arthritis and rheumatism, vol. 61, no. 12, 2009, pp. 1704-11. |
| Wang, C., Schmid, C., Hibberd, P., Kalish, R., Roubenoff, R., Rones, R., Okparavero, A., McAlindon, T. "A46 TAI CHI IS EFFECTIVE IN TREATING KNEE OSTEOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL." Osteoarthritis and Cartilage, vol. 16, 2008, pp. S32-S33. |
| Wang C, de Pablo P, Chen X, Schmid C, McAlindon T. "Acupuncture for pain relief in patients with rheumatoid arthritis: a systematic review." Arthritis and rheumatism, vol. 59, no. 9, 2008, pp. 1249-56. |
| Drees M, Snydman DR, Schmid CH, Barefoot L, Hansjosten K, Vue PM, Cronin M, Nasraway SA, Golan Y. "Antibiotic exposure and room contamination among patients colonized with vancomycin-resistant enterococci." Infection Control & Hospital Epidemiology, vol. 29, no. 8, 2008, pp. 709-15. |
| Quach LA, Wanke CA, Schmid CH, Gorbach SL, Mwamburi DM, Mayer KH, Spiegelman D, Tang AM. "Drug use and other risk factors related to lower body mass index among HIV-infected individuals." Drug and Alcohol Dependence, vol. 95, no. 1-2, 2008, pp. 30-6. |
| Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J, Rossert J, Van Lente F, Bruce RD 3rd, Zhang YL, Greene T, Levey AS. "Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD." American Journal of Kidney Diseases, vol. 51, no. 3, 2008, pp. 395-406. |
| Stevens LA, Zhang Y, Schmid CH. "Evaluating the performance of equations for estimating glomerular filtration rate." Journal of nephrology, vol. 21, no. 6, 2008, pp. 797-807. |
| Eggleston K, Shen YC, Lau J, Schmid CH, Chan J. "Hospital ownership and quality of care: what explains the different results in the literature?." Health economics, vol. 17, no. 12, 2008, pp. 1345-62. |
| Gordon CE, Uhlig K, Lau J, Schmid CH, Levey AS, Wong JB. "Interferon treatment in hemodialysis patients with chronic hepatitis C virus infection: a systematic review of the literature and meta-analysis of treatment efficacy and harms." American Journal of Kidney Diseases, vol. 51, no. 2, 2008, pp. 263-77. |
| Rasmussen SA, Chu SY, Kim SY, Schmid CH, Lau J. "Maternal obesity and risk of neural tube defects: a metaanalysis." American Journal of Obstetrics and Gynecology, vol. 198, no. 6, 2008, pp. 611-9. |
| Chu, S.Y., Kim, S.Y., Lau, J., Schmid, C.H., Dietz, P.M., Callaghan, W.M., Curtis, K.M. "Maternal Obesity and Risk of Stillbirth: A Meta-analysis." Obstetric Anesthesia Digest, vol. 28, no. 2, 2008, pp. 70-71. |
| Rao SR, Graubard BI, Schmid CH, Morton SC, Louis TA, Zaslavsky A and Finkelstein DM. "Meta-Analysis of Survey Data: Application to Health Services Research." Health Services and Outcomes Research Methodology, vol. 8, 2008, pp. 98-114. |
| Drees M, Snydman DR, Schmid CH, Barefoot L, Hansjosten K, Vue PM, Cronin M, Nasraway SA, Golan Y. "Prior environmental contamination increases the risk of acquisition of vancomycin-resistant enterococci." Clinical Infectious Diseases, vol. 46, no. 5, 2008, pp. 678-85. |
| Rhee MS, Schmid CH, Stevens LA, Forrester JE. "Risk factors for proteinuria in HIV-infected and -uninfected Hispanic drug users." American Journal of Kidney Diseases, vol. 52, no. 4, 2008, pp. 683-90. |
| Wang C, Schmid CH, Hibberd PL, Kalish R, Roubenoff R, Rones R, Okparavero A, McAlindon T. "Tai Chi for treating knee osteoarthritis: designing a long-term follow up randomized controlled trial." BMC Musculoskeletal Disorders, vol. 9, 2008, pp. 108. |
| Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples LA, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. "Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene." Hypertension, vol. 49, no. 5, 2007, pp. 1000-6. |
| McAlindon T, Formica M, Schmid CH, Fletcher J. "Changes in barometric pressure and ambient temperature influence osteoarthritis pain." The American Journal of Medicine, vol. 120, no. 5, 2007, pp. 429-34. |
| Hagadorn, J I, Richardson, D K, Schmid, C H, Cole, C H. "Cumulative illness severity and progression from moderate to severe retinopathy of prematurity." Journal of perinatology : official journal of the California Perinatal Association, vol. 27, no. 8, 2007, pp. 502-509. |
| Prata MM, Dos Santos JP, Hegbrant J, Schmid CH, Pereira BJ, Wald R. "Dose requirements among hemodialysis patients treated with darbepoetin-alpha or epoetin-beta." Nephron. Clinical practice, vol. 107, no. 2, 2007, pp. c50-5. |
| Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, Rahman M, Deysher AE, Zhang YL, Schmid CH, Levey AS. "Evaluation of the modification of diet in renal disease study equation in a large diverse population." Journal of the American Society of Nephrology, vol. 18, no. 10, 2007, pp. 2749-57. |
| Shen YC, Eggleston K, Lau J, Schmid CH. "Hospital ownership and financial performance: what explains the different findings in the empirical literature?." INQUIRY: The Journal of Health Care Organization, Provision, and Financing, vol. 44, no. 1, 2007, pp. 41-68. |
| Stevens LA, Manzi J, Levey AS, Chen J, Deysher AE, Greene T, Poggio ED, Schmid CH, Steffes MW, Zhang YL, Van Lente F, Coresh J. "Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database." American Journal of Kidney Diseases, vol. 50, no. 1, 2007, pp. 21-35. |
| Chu SY, Kim SY, Schmid CH, Dietz PM, Callaghan WM, Lau J, Curtis KM. "Maternal obesity and risk of cesarean delivery: a meta-analysis." Obesity Reviews, vol. 8, no. 5, 2007, pp. 385-94. |
| Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, Dietz PM. "Maternal obesity and risk of gestational diabetes mellitus." Diabetes Care, vol. 30, no. 8, 2007, pp. 2070-6. |
| Chu SY, Kim SY, Lau J, Schmid CH, Dietz PM, Callaghan WM, Curtis KM. "Maternal obesity and risk of stillbirth: a metaanalysis." American Journal of Obstetrics and Gynecology, vol. 197, no. 3, 2007, pp. 223-8. |
| Uhlig K, Menon V, Schmid CH. "Recommendations for reporting of clinical research studies." American Journal of Kidney Diseases, vol. 49, no. 1, 2007, pp. 3-7. |
| Kourtis AP, Schmid CH, Jamieson DJ, Lau J. "Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis." AIDS, vol. 21, no. 5, 2007, pp. 607-15. |
| Hagadorn JI, Furey AM, Nghiem T-H, Schmid CH, Phelps DL, Pillers DM and Cole CH. "Achieved Versus Intended Pulse Oximeter Saturation in Infants Less Than 28 Weeks Gestation: The AVIOx Study." Pediatrics, vol. 118, 2006, pp. 1574-1582. |
| Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH, Housman DE, Mendelsohn ME, Ordovas JM. "Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study." Atherosclerosis, vol. 185, no. 1, 2006, pp. 210-8. |
| Eggleston K, Shen Y-C, Lau J, Schmid CH and Chan J. "Hospital Ownership and Quality of Care: What Explains the Different Results?." 2006. |
| Zucker DR, Ruthazer R, Schmid CH, Feuer JM, Fischer PA, Kieval RI, Mogavero N, Rapoport RJ, Selker HP, Stotsky SA, Winston E, Goldenberg DL. "Lessons learned combining N-of-1 trials to assess fibromyalgia therapies." The Journal of Rheumatology, vol. 33, no. 10, 2006, pp. 2069-77. |
| Lau J, Ioannidis JP, Terrin N, Schmid CH, Olkin I. "The case of the misleading funnel plot." BMJ, vol. 333, no. 7568, 2006, pp. 597-600. |
| Klempner MS, Wormser GH, Wade K, Trevino RP, Tang J, Kaslow RA, Schmid C. "A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease." The Journal of Infectious Diseases, vol. 192, no. 6, 2005, pp. 1010-3. |
| Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ. "Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women." American Journal of Hypertension, vol. 18, no. 11, 2005, pp. 1388-95. |
| Tatsioni A, Zarin DA, Aronson N, Samson DJ, Flamm CR, Schmid C, Lau J. "Challenges in systematic reviews of diagnostic technologies." Annals of Internal Medicine, vol. 142, no. 12 Pt 2, 2005, pp. 1048-55. |
| JAFAR, T, ISLAM, M, POULTER, N, HATCHER, J, SCHMID, C, LEVEY, A, CHATURVEDI, N. "Children in South Asia have higher body mass adjusted blood pressure levels than Caucasian children in the United States -a comparative study." American Journal of Hypertension, vol. 18, no. 5, 2005, pp. A109-A109. |
| Jafar TH, Islam M, Poulter N, Hatcher J, Schmid CH, Levey AS, Chaturvedi N. "Children in South Asia have higher body mass-adjusted blood pressure levels than white children in the United States: a comparative study." Circulation, vol. 111, no. 10, 2005, pp. 1291-7. |
| Olsen IE, Richardson DK, Schmid CH, Ausman LM, Dwyer JT. "Dietitian Involvement in the Neonatal Intensive Care Unit: More Is Better." Journal of the American Dietetic Association, vol. 105, 2005, pp. 1224-1230. |
| Wang C, Roubenoff R, Lau J, Kalish R, Schmid CH, Tighiouart H, Rones R, Hibberd PL. "Effect of Tai Chi in adults with rheumatoid arthritis." Rheumatology (Oxford, England), vol. 44, no. 5, 2005, pp. 685-7. |
| Shen Y-C, Eggleston K, Lau J and Schmid C. "Hospital Ownership and Financial Performance: A Qunatitative Research Review." 2005. |
| Terrin N, Schmid CH, Lau J. "In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias." American Journal of Kidney Diseases, vol. 58, no. 9, 2005, pp. 894-901. |
| Norris SL, Zhang X, Avenell A, Gregg E, Bowman B, Schmid CH, Lau J. "Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: a review." American Journal of Preventive Medicine, vol. 28, no. 1, 2005, pp. 126-39. |
| Norris SL, Zhang X, Avenell A, Gregg E, Brown TJ, Schmid CH, Lau J. "Long-term non-pharmacologic weight loss interventions for adults with type 2 diabetes." The Cochrane database of systematic reviews, no. 2, 2005, pp. CD004095. |
| Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Lau J. "Long-term non-pharmacological weight loss interventions for adults with prediabetes." The Cochrane database of systematic reviews, no. 2, 2005, pp. CD005270. |
| Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Lau J. "Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus." The Cochrane database of systematic reviews, no. 1, 2005, pp. CD004096. |
| Norris, None, Zhang, None, Avenell, None, Gregg, None, Schmid, None, Lau, None. "Pharmakotherapie zur Gewichtsabnahme bei Erwachsenen mit Typ-2-Diabetes mellitus." PRAXIS, vol. 94, no. 41, 2005, pp. 1606-1606. |
| Jafar TH, Chaturvedi N, Hatcher J, Khan I, Rabbani A, Khan AQ, Portman R, Schmid CH, Levey AS. "Proteinuria in South Asian children: prevalence and determinants." Pediatric Nephrology, vol. 20, no. 10, 2005, pp. 1458-65. |
| Jafar TH, Schmid CH, Levey AS. "Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan." Journal of the American Society of Nephrology, vol. 16, no. 5, 2005, pp. 1413-9. |
| Jafar TH, Stark PC, Schmid CH, Strandgaard S, Kamper AL, Maschio G, Becker G, Perrone RD, Levey AS, ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group. "The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease." Kidney International, vol. 67, no. 1, 2005, pp. 265-71. |
| Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME, Housman DE. "Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level." Human molecular genetics, vol. 14, no. 16, 2005, pp. 2405-13. |
| Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D. "Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study." Journal of hypertension, vol. 23, no. 12, 2005, pp. 2193-200. |
| Gill CJ, Sabin L, Schmid CH. "Why clinicians are natural bayesians." BMJ, vol. 330, no. 7499, 2005, pp. 1080-3. |
| Schmid CH, Cappelleri JC, Lau J. "Bayesian methods to improve sample size approximations." Methods in enzymology, vol. 383, 2004, pp. 406-27. |
| Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Kim C, Lau J. "Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis." Arch Intern Med, vol. 164, no. 13, 2004, pp. 1395-404. |
| Jafar TH, Levey AS, White FM, Gul A, Jessani S, Khan AQ, Jafary FH, Schmid CH, Chaturvedi N. "Ethnic differences and determinants of diabetes and central obesity among South Asians of Pakistan." Diabetic medicine : a journal of the British Diabetic Association, vol. 21, no. 7, 2004, pp. 716-23. |
| Norris SL, Zhang X, Avenell A, Gregg E, Bowman B, Serdula M, Brown TJ, Schmid CH, Lau J. "Long-term effectiveness of lifestyle and behavioral weight loss interventions in adults with type 2 diabetes: a meta-analysis." The American Journal of Medicine, vol. 117, no. 10, 2004, pp. 762-74. |
| Schmid CH, Stark PC, Berlin JA, Landais P, Lau J. "Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors." American Journal of Kidney Diseases, vol. 57, no. 7, 2004, pp. 683-97. |
| Fleming RV, Marques AR, Klempner MS, Schmid CH, Dally LG, Martin DS, Philipp MT. "Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis." European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, vol. 23, no. 8, 2004, pp. 615-8. |
| Terrin N, Schmid CH, Lau J, Olkin I. "Adjusting for publication bias in the presence of heterogeneity." Statistics in Medicine, vol. 22, no. 13, 2003, pp. 2113-26. |
| Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE and Levy D. "Association between estrogen receptor a gene variation and cardiovascular disease." JAMA, vol. 290, 2003, pp. 2263-2270. |
| Kaplan RF, Trevino RP, Johnson GM, Levy L, Dornbush R, Hu LT, Evans J, Weinstein A, Schmid CH and Klempner MS. "Cognitive Function in Post-treatment Lyme Disease: Do additional antibiotics help?." Neurology, vol. 60, 2003, pp. 1916-1922. |
| Schmid CH, Landa M, Jafar TH, Giatras I, Karim T, Reddy M, Stark PC, Levey AS, Angiotensin-Converting Enzyme Inhibition in Progressive Renal Disease (AIPRD) Study Group. "Constructing a database of individual clinical trials for longitudinal analysis." Controlled clinical trials, vol. 24, no. 3, 2003, pp. 324-40. |
| Jafar TH, Chaturvedi N, Gul A, Khan AQ, Schmid CH, Levey AS. "Ethnic differences and determinants of proteinuria among South Asian subgroups in Pakistan." Kidney International, vol. 64, no. 4, 2003, pp. 1437-44. |
| Jafar TH, Levey AS, Jafary FH, White F, Gul A, Rahbar MH, Khan AQ, Hattersley A, Schmid CH, Chaturvedi N. "Ethnic subgroup differences in hypertension in Pakistan." Journal of hypertension, vol. 21, no. 5, 2003, pp. 905-12. |
| Terrin N, Schmid CH, Griffith JL, D'Agostino RB, Selker HP. "External validity of predictive models: a comparison of logistic regression, classification trees, and neural networks." American Journal of Kidney Diseases, vol. 56, no. 8, 2003, pp. 721-9. |
| Schmid CH, Brown EN and Ogren JM. "Modeling Daily Growth in children." 2003, pp. 3698-3705. |
| Stark PC, Levey AS and Schmid CH. "Predictors of Change in Glomerular Filtration Rate Among Nondiabetic Patients with Chronic Kidney Disease." 2003, pp. 4047-4049. |
| Jafar TH, Stark PC, Schmid CH, Landa M, Maschio G, de Jong PE, de Zeeuw D, Shahinfar S, Toto R, Levey AS, AIPRD Study Group. "Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis." Annals of Internal Medicine, vol. 139, no. 4, 2003, pp. 244-52. |
| Nguyen DP, Schmid CH, Klerman EB, Adler G and Brown EN. "Stochastic Deconvolution of Neuroendocrine Hormone Rhythms." ASA Proceedings of the Joint Statistical Meetings, 2003, pp. 3025-3032. |
| Olsen IE, Richardson DK, Schmid CH, Ausman LM, Dwyer JT. "The impact of early transfer bias in a growth study among neonatal intensive care units." American Journal of Kidney Diseases, vol. 56, no. 10, 2003, pp. 998-1005. |
| Jafar TH, Schmid CH, Stark PC, Toto R, Remuzzi G, Ruggenenti P, Marcantoni C, Becker G, Shahinfar S, De Jong PE, De Zeeuw D, Kamper AL, Strangaard S, Levey AS. "The rate of progression of renal disease may not be slower in women compared with men: a patient-level meta-analysis." Nephrol. Dial. Transplant., vol. 18, no. 10, 2003, pp. 2047-53. |
| Selker HP, Raitt MH, Schmid CH, Laks MM, Beshansky JR, Griffith JL, Califf RM, Selvester RH, Maynard C, D'Agostino RB, Weaver WD. "Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarction." The American Journal of Cardiology, vol. 91, no. 3, 2003, pp. 280-6. |
| Balk EM, Bonis PA, Moskowitz H, Schmid CH, Ioannidis JP, Wang C, Lau J. "Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials." JAMA, vol. 287, no. 22, 2002, pp. 2973-82. |
| Jafar TH, Schmid CH, Levey AS. "Effect of angiotensin-converting enzyme inhibitors on progression of nondiabetic renal disease." Annals of Internal Medicine, vol. 137, no. 4, 2002, pp. 298-9. |
| Jaber BL, Lau J, Schmid CH, Karsou SA, Levey AS, Pereira BJ. "Effect of biocompatibility of hemodialysis membranes on mortality in acute renal failure: a meta-analysis." Clinical Nephrology, vol. 57, no. 4, 2002, pp. 274-82. |
| Berlin JA, Santanna J, Schmid CH, Szczech LA, Feldman HI, Anti-Lymphocyte Antibody Induction Therapy Study Group. "Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head." Statistics in Medicine, vol. 21, no. 3, 2002, pp. 371-87. |
| Olsen IE, Richardson DK, Schmid CH, Ausman LM and Dwyer JT. "Intersite Differences in Weight Growth Velocity of Extremely Premature Infants." Pediatrics, vol. 110, 2002, pp. 1125-1132. |
| Kent DM, Schmid CH, Lau J, Selker HP. "Is primary angioplasty for some as good as primary angioplasty for all?." J GEN INTERN MED, vol. 17, no. 12, 2002, pp. 887-94. |
| Norris SL, Lau J, Smith SJ, Schmid CH, Engelgau MM. "Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control." Diabetes Care, vol. 25, no. 7, 2002, pp. 1159-71. |
| Jafar TH, Schmid CH, Landa M, Giatras I, Toto R, Remuzzi G, Maschio G, Brenner BM, Kamper A, Zucchelli P, Becker G, Himmelmann A, Bannister K, Landais P, Shahinfar S, de Jong PE, de Zeeuw D, Lau J, Levey AS. "Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data." Annals of Internal Medicine, vol. 135, no. 2, 2001, pp. 73-87. |
| Klempner MS, Schmid CH, Hu L, Steere AC, Johnson G, McCloud B, Noring R, Weinstein A. "Intralaboratory reliability of serologic and urine testing for Lyme disease." The American Journal of Medicine, vol. 110, no. 3, 2001, pp. 217-9. |
| Schmid CH. "Marginal and dynamic regression models for longitudinal data." Statistics in Medicine, vol. 20, no. 21, 2001, pp. 3295-311. |
| Schmid CH, Griffith JL, Terrin N and D’Agostino RB Sr. "Predictive Performance of Missing Data Methods for Logistic Regression, Classification Trees and Neural Networks." Journal of Statistical Computation and Simulation, vol. 71, 2001, pp. 115-140. |
| Jafar TH, Stark PC, Schmid CH, Landa M, Maschio G, Marcantoni C, de Jong PE, de Zeeuw D, Shahinfar S, Ruggenenti P, Remuzzi G, Levey AS, AIPRD Study Group. Angiotensin-Converting Enzymne Inhibition and Progression of Renal Disease. "Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease." Kidney International, vol. 60, no. 3, 2001, pp. 1131-40. |
| Klempner MS, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, Norton D, Levy L, Wall D, McCall J, Kosinski M, Weinstein A. "Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease." New England Journal of Medicine, vol. 345, no. 2, 2001, pp. 85-92. |
| Schmid CH. "Using Bayesian Inference to Perform Meta-Analysis." Evaluation and the Health Professions, vol. 24, 2001, pp. 165-189. |
| Schmid CH, Brown EN. "Bayesian hierarchical models." Methods in enzymology, vol. 321, 2000, pp. 305-30. |
| Athienites NV, Miskulin DC, Fernandez G, Bunnapradist S, Simon G, Landa M, Schmid CH, Greenfield S, Levey AS, Meyer KB. "Comorbidity assessment in hemodialysis and peritoneal dialysis using the index of coexistent disease." Semin Dial, vol. 13, no. 5, 2000, pp. 320-6. |
| Arbo MD, Snydman DR, Wong JB, Goldberg HS, Schmid CH, Pauker SG. "Cytomegalovirus immune globulin after liver transplantation: a cost-effectiveness analysis." Clinical transplantation, vol. 14, no. 1, 2000, pp. 19-27. |
| Engels EA, Schmid CH, Terrin N, Olkin I, Lau J. "Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses." Statistics in Medicine, vol. 19, no. 13, 2000, pp. 1707-28. |
| Balakrishnan VS, Schmid CH, Jaber BL, Natov SN, King AJ, Pereira BJ. "Interleukin-1 receptor antagonist synthesis by peripheral blood mononuclear cells: a novel predictor of morbidity among hemodialysis patients." Journal of the American Society of Nephrology, vol. 11, no. 11, 2000, pp. 2114-21. |
| Ioannidis JP, Schmid CH, Lau J. "Meta-analysis in hematology and oncology." Hematology/oncology clinics of North America, vol. 14, no. 4, 2000, pp. 973-91. |
| Schmid CH and Brown EN. "A Probability Model for Saltatory Growth." Saltation and Stasis in Human Growth and Development: Evidence, Methods and Theory, edited by M Lampl, Smith-Gordon, 1999, pp. 121-131. |
| Kaplan MM, Schmid C, Provenzale D, Sharma A, Dickstein G, McKusick A. "A prospective trial of colchicine and methotrexate in the treatment of primary biliary cirrhosis." Gastroenterology, vol. 117, no. 5, 1999, pp. 1173-80. |
| Engels EA, Ellis CA, Supran SE, Schmid CH, Barza M, Schenkein DP, Koc Y, Miller KB, Wong JB. "Early infection in bone marrow transplantation: quantitative study of clinical factors that affect risk." Clinical Infectious Diseases, vol. 28, no. 2, 1999, pp. 256-66. |
| Schmid CH. "Exploring Heterogeneity in Randomized Trials via Meta-Analysis." vol. 33, 1999, pp. 211-224. |
| Wazer DE, Jabro G, Ruthazer R, Schmid C, Safaii H, Schmidt-Ullrich RK. "Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation." Radiation oncology investigations, vol. 7, no. 2, 1999, pp. 111-7. |
| Natov SN, Lau JY, Ruthazer R, Schmid CH, Levey AS, Pereira BJ. "Hepatitis C virus genotype does not affect patient survival among renal transplant candidates. The New England Organ Bank Hepatitis C Study Group." Kidney International, vol. 56, no. 2, 1999, pp. 700-6. |
| Schmid CH, Whiting G, Cory D, Ross SD and Chalmers TC. "Omeprazole Plus Antibiotics in the Eradication of Helicobacter pylori Infection: A Meta-Regression Analysis of Randomized, Controlled Trials." American journal of therapeutics, vol. 6, 1999, pp. 25-36. |
| Schmid CH. "Regression Models for Longitudinal Data with Missing Covariate Values." Proceedings of the Section on Statistics in Epidemiology, American Statistical Association, 1999, pp. 25-34. |
| Stason WB, Schmid CH, Niedzwiecki D, Whiting GW, Caubet JF, Cory D, Luo D, Ross SD, Chalmers TC. "Safety of nifedipine in angina pectoris: a meta-analysis." Hypertension, vol. 33, no. 1, 1999, pp. 24-31. |
| Schmid CH, Lau J, McIntosh MW, Cappelleri JC. "An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis of clinical trials." Statistics in Medicine, vol. 17, no. 17, 1998, pp. 1923-42. |
| Levey AS, Schmid CH, Lau J. "Antilymphocyte antibodies, renal transplantation, and meta-analysis." Annals of Internal Medicine, vol. 128, no. 10, 1998, pp. 863-5. |
| King AJ, Kehayias JJ, Roubenoff R, Schmid CH, Pereira BJ. "Cytokine production and nutritional status in hemodialysis patients." The International journal of artificial organs, vol. 21, no. 1, 1998, pp. 4-11. |
| Pereira BJ, Natov SN, Bouthot BA, Murthy BV, Ruthazer R, Schmid CH, Levey AS. "Effects of hepatitis C infection and renal transplantation on survival in end-stage renal disease. The New England Organ Bank Hepatitis C Study Group." Kidney International, vol. 53, no. 5, 1998, pp. 1374-81. |
| Wazer DE, Schmidt-Ullrich RK, Ruthazer R, Schmid CH, Graham R, Safaii H, Rothschild J, McGrath J, Erban JK. "Factors determining outcome for breast-conserving irradiation with margin-directed dose escalation to the tumor bed." International Journal of Radiation Oncology*Biology*Physics, vol. 40, no. 4, 1998, pp. 851-8. |
| Balakrishnan VS, Jaber BL, Natov SN, Cendoroglo M, King AJ, Schmid CH, Pereira BJ. "Interleukin-1 receptor antagonist synthesis by peripheral blood mononuclear cells in hemodialysis patients." Kidney International, vol. 54, no. 6, 1998, pp. 2106-12. |
| Ioannidis JPA, Schmid CH and Lau J. "Meta-Analysis Approaches for Epidemiologic Research on Asbestos." Current Asbestos Issues: Volume 18 of the Sourcebook for Asbestos Diseases, edited by GA Peters and BJ Peters, Charlottsville, VA, Lexis Law Publishing, 1998, pp. 93-116. |
| Schmid CH and Griffith JL. "Multivariate Classification Rules: Calibration and Discrimination." Encyclopedia of Biostatistics, New York, John Wiley and Sons, 1998, pp. 2844-2850. |
| Schmid CH. "Nuisance Parameters." Encyclopedia of Biostatistics, New York, John Wiley and Sons, 1998, pp. 3079-3080. |
| Ettinger LM, Hijazi ZM, Geggel RL, Supran SE, Cao Q and Schmid CH. "Peripheral pulmonary artery stenosis: Acute and mid-term results of high pressure balloon angioplasty." Journal of interventional cardiology, vol. 11, 1998, pp. 337-344. |
| Murthy BV, Muerhoff AS, Desai SM, Natov SN, Bouthot BA, Ruthazer R, Schmid CH, Levey AS, Mushahwar IK, Pereira BJ. "Predictors of GBV-C infection among patients referred for renal transplantation." Kidney International, vol. 53, no. 6, 1998, pp. 1769-74. |
| Natov SN, Lau JY, Bouthot BA, Murthy BV, Ruthazer R, Schmid CH, Levey AS, Pereira BJ. "Serologic and virologic profiles of hepatitis C infection in renal transplant candidates. New England Organ Bank Hepatitis C Study Group." American Journal of Kidney Diseases, vol. 31, no. 6, 1998, pp. 920-7. |
| Lau J, Ioannidis JP, Schmid CH. "Summing up evidence: one answer is not always enough." The Lancet, vol. 351, no. 9096, 1998, pp. 123-7. |
| Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. "Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group." New England Journal of Medicine, vol. 339, no. 4, 1998, pp. 209-15. |
| Schmid CH, D'Agostino RB, Griffith JL, Beshansky JR, Selker HP. "A logistic regression model when some events precede treatment: the effect of thrombolytic therapy for acute myocardial infarction on the risk of cardiac arrest." American Journal of Kidney Diseases, vol. 50, no. 11, 1997, pp. 1219-29. |
| Zucker DR, Schmid CH, McIntosh MW, D'Agostino RB, Selker HP, Lau J. "Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment." American Journal of Kidney Diseases, vol. 50, no. 4, 1997, pp. 401-10. |
| Wazer DE, Kramer B, Schmid C, Ruthazer R, Ulin K, Schmidt-Ullrich R. "Factors determining outcome in patients treated with interstitial implantation as a radiation boost for breast conservation therapy." International Journal of Radiation Oncology*Biology*Physics, vol. 39, no. 2, 1997, pp. 381-93. |
| Rhodes J, Warner KG, Fulton DR, Romero BA, Schmid CH and Marx GR. "Fate of Mitral Regurgitation Following Repair of Atrioventricular Septal Defects." American Journal of Cardiology, vol. 80, 1997, pp. 1194-1197. |
| Murthy BV, Muerhoff AS, Desai SM, Lund J, Schmid CH, Levey AS, Mushahwar IK, Pereira BJ. "GB hepatitis agent in cadaver organ donors and their recipients." Transplantation, vol. 63, no. 3, 1997, pp. 346-51. |
| Murthy BV, Muerhoff AS, Desai SM, Yamaguchi J, Mushahwar IK, Schmid CH, Levey AS, Pereira BJ. "Impact of pretransplantation GB virus C infection on the outcome of renal transplantation." Journal of the American Society of Nephrology, vol. 8, no. 7, 1997, pp. 1164-73. |
| Griffith JL, Schmid CH, Terrin N and D’Agostino RB Sr. "Impact of Sample Size and Outcome Prevalence on the Predictive Performance of Logistic Regression, Classification Trees and Neural Networks." 1997, pp. 259-264. |
| Tunis SR, Sheinhait IA, Schmid CH, Bishop DJ and Ross SD. "Lansoprazole Compared with Histamine2-Receptor Antagonists in Healing Gastric Ulcers: A Meta-Analysis." Clinical Therapeutics, vol. 19, 1997, pp. 743-757. |
| Bouthot BA, Murthy BV, Schmid CH, Levey AS, Pereira BJ. "Long-term follow-up of hepatitis C virus infection among organ transplant recipients: implications for policies on organ procurement." Transplantation, vol. 63, no. 6, 1997, pp. 849-53. |
| D’Agostino RB Sr., Griffith JL, Schmid CH and Terrin N. "Measures for Evaluating Model Performance." Proceedings of the Biometrics Section, American Statistical Association, 1997, pp. 253-258. |
| Selker HP, Griffith JL, Beshansky JR, Schmid CH, Califf RM, D'Agostino RB, Laks MM, Lee KL, Maynard C, Selvester RH, Wagner GS, Weaver WD. "Patient-specific predictions of outcomes in myocardial infarction for real-time emergency use: a thrombolytic predictive instrument." Annals of Internal Medicine, vol. 127, no. 7, 1997, pp. 538-56. |
| Lafayette RA, Paré G, Schmid CH, King AJ, Rohrer RJ, Nasraway SA. "Pretransplant renal dysfunction predicts poorer outcome in liver transplantation." Clinical Nephrology, vol. 48, no. 3, 1997, pp. 159-64. |
| Lau J, Ioannidis JP, Schmid CH. "Quantitative synthesis in systematic reviews." Annals of Internal Medicine, vol. 127, no. 9, 1997, pp. 820-6. |
| Stason WB, Schmid CH, Niedzwiecki D, Whiting G, Cory D, Luo D, Caubet JF, Sheinhait I, Freedman R, Ross SD and Chalmers TC. "Safety of Nifedipine in Patients with Hypertension: A Meta-Analysis." Hypertension, vol. 30, 1997, pp. 7-14. |
| Schmid CH, Griffith JL, Terrin N and D’Agostino RB Sr. "Synthesizing the Treatment of Missing Data in Logistic Regression, Classification Trees and Neural Networks." Proceedings of the Biometrics Section, American Statistical Association, 1997, pp. 265-269. |
| Wazer DE, Morr J, Erban JK, Schmid CH, Ruthazer R, Schmidt-Ullrich RK. "The effects of postradiation treatment with tamoxifen on local control and cosmetic outcome in the conservatively treated breast." Cancer, vol. 80, no. 4, 1997, pp. 732-40. |
| Terrin N, Griffith JL, Schmid CH and D’Agostino RB Sr. "The Impact of Outliers and Distortions on the Predictive Performance of Logistic Regression, Classification Trees and Neural Networks." Proceedings of the Biometrics Section, American Statistical Association, 1997, pp. 270-275. |
| Wazer DE, Schmidt-Ullrich RK, Schmid CH, Ruthazer R, Kramer B, Safaii H, Graham R. "The value of breast lumpectomy margin assessment as a predictor of residual tumor burden." International Journal of Radiation Oncology*Biology*Physics, vol. 38, no. 2, 1997, pp. 291-9. |
| Schmid CH and Brown EN. "A Hierarchical Bayes Model for Human Growth." Proceedings of the Section on Bayesian Statistics, American Statistical Association, 1996, pp. 146-151. |
| Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C. "A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia." Arthritis and rheumatism, vol. 39, no. 11, 1996, pp. 1852-9. |
| Wazer DE, Gage I, Homer MJ, Krosnick SH, Schmid C. "Age-related differences in patients with nonpalpable breast carcinomas." Cancer, vol. 78, no. 7, 1996, pp. 1432-7. |
| Schmid CH. "An EM Algorithm Fitting First-Order Conditional Autoregressive Models to Longitudinal Data." Journal of the American Statistical Association, vol. 91, 1996, pp. 1322-1330. |
| Nocton JJ, Bloom BJ, Rutledge BJ, Persing DH, Logigian EL, Schmid CH and Steere AC. "Detection of Borrelia Burgdorferi DNA by Polymerase Chain Reaction in Cerebrospinal Fluid in Lyme Neuroborreliosis." The Journal of Infectious Diseases, vol. 174, 1996, pp. 623-627. |
| Lakshmipathy N, Bokesch PM, Cowen DE, Lisman SR, Schmid CH. "Environmental tobacco smoke: a risk factor for pediatric laryngospasm." Anesthesia and analgesia, vol. 82, no. 4, 1996, pp. 724-7. |
| Ioannidis JP, Cappelleri JC, Schmid CH, Lau J. "Impact of epidemic and individual heterogeneity on the population distribution of disease progression rates. An example from patient populations in trials of human immunodeficiency virus infection." American Journal of Epidemiology, vol. 144, no. 11, 1996, pp. 1074-85. |
| Pereira BJ, Natov SN, Sundaram S, Schmid CH, Trabelsi FR, Strom JA, King AJ. "Impact of single use versus reuse of cellulose dialyzers on clinical parameters and indices of biocompatibility." Journal of the American Society of Nephrology, vol. 7, no. 6, 1996, pp. 861-70. |
| Cappelleri JC, Ioannidis JP, Schmid CH, de Ferranti SD, Aubert M, Chalmers TC, Lau J. "Large trials vs meta-analysis of smaller trials: how do their results compare?." JAMA, vol. 276, no. 16, 1996, pp. 1332-8. |
| Stason W, Schmid CH, Caubet JF, Kupelnick B, Cory D, Whiting G, Chalmers TC, Ross SD. "Searching for signals: mortality and cardiovascular events in published randomized control trials of nifedipine in ischemic heart disease and hypertension." Journal of hypertension. Supplement : official journal of the International Society of Hypertension, vol. 14, no. 2, 1996, pp. S5-7. |
| Pereira BJ, Wright TL, Schmid CH, Levey AS. "A controlled study of hepatitis C transmission by organ transplantation. The New England Organ Bank Hepatitis C Study Group." The Lancet, vol. 345, no. 8948, 1995, pp. 484-7. |
| Goldenberg DL, Mossey CJ and Schmid CH. "A Model to Assess Severity and Impact of Fibromyalgia." Journal of Rheumatology, vol. 22, 1995, pp. 2313-2318. |
| Schmid CH, Cappelleri JC and Lau J. "Bayesian Methods to Improve Sample Size Approximations." Proceedings of the Section on Bayesian Statistics, American Statistical Association, 1995, pp. 89-94. |
| Lau J, Schmid CH, Chalmers TC. "Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care." American Journal of Kidney Diseases, vol. 48, no. 1, 1995, pp. 45-57; discussion 59-60. |
| Werner-Wasik M, Schmid CH, Bornstein LE, Madoc-Jones H. "Increased risk of second malignant neoplasms outside radiation fields in patients with cervical carcinoma." Cancer, vol. 75, no. 9, 1995, pp. 2281-5. |
| Werner-Wasik M, Schmid CH, Bornstein L, Ball HG, Smith DM, and Madoc-Jones H. "Prognostic Factors for Local and Distant Recurrence in Stage I and II Cervical Carcinoma." Int. J. Radiation Oncology Biol. Phys., vol. 32, 1995, pp. 1309-1317. |
| Maynard C, Selker HP, Beshansky JR, Griffith JL, Schmid CH, Califf RM, D'Agostino RB, Laks MM, Lee KL, Wagner GS. "The exclusion of women from clinical trials of thrombolytic therapy: implications for developing the thrombolytic predictive instrument database." Medical decision making : an international journal of the Society for Medical Decision Making, vol. 15, no. 1, 1995, pp. 38-43. |
| Periera BJ, Wright TL, Schmid CH, Levey AS. "The impact of pretransplantation hepatitis C infection on the outcome of renal transplantation." Transplantation, vol. 60, no. 8, 1995, pp. 799-805. |
| Goldenberg DL, Kaplan KH, Nadeau MG, Brodeur C, Smith S and Schmid CH. "A Controlled Study of a Stress-Reduction, Cognitive-Behavioral Treatment Program in Fibromyalgia." Journal of Musculoskeletal Pain, vol. 2, 1994, pp. 53-66. |
| Fink JC, Schmid CH, Selker HP. "A decision aid for referring patients with systolic murmurs for echocardiography." J GEN INTERN MED, vol. 9, no. 9, 1994, pp. 479-84. |
| Schmid CH. "A State-Space Model for Longitudinal Regression." Proceedings of the 26th Symposium on the Interface, 1994, pp. 125-129. |
| Bry JD, Belkin M, O'Donnell TF Jr, Mackey WC, Udelson JE, Schmid CH, Safran DG. "An assessment of the positive predictive value and cost-effectiveness of dipyridamole myocardial scintigraphy in patients undergoing vascular surgery." Journal of vascular surgery, vol. 19, no. 1, 1994, pp. 112-21; discussion 121-4. |
| Brown EN and Schmid CH. "Application of the Kalman Filter to Computational Problems in Statistics." Methods in Enzymology Volume 240: Numerical Computer Methods Part B, edited by ML Johnson and L Brand, New York, Academic Press, 1994, pp. 171-181. |
| Wazer DE, Erban JK, Robert NJ, Smith TJ, Marchant DJ, Schmid C, DiPetrillo T, Schmidt-Ullrich R. "Breast conservation in elderly women for clinically negative axillary lymph nodes without axillary dissection." Cancer, vol. 74, no. 3, 1994, pp. 878-83. |
| Schmid CH, Segal M and Rosner B. "Incorporating Measurement Error in the Estimation of Autoregressive Models for Longitudinal Data." Journal of Statistical Planning and Inference, vol. 42, 1994, pp. 1-18. |
| Selker HP, Beshansky JR, Schmid CH, Griffith JL, Longstreth WT Jr, O'Connor CM, Caplan LR, Massey EW, D'Agostino RB, Laks MM. "Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results." Circulation, vol. 90, no. 4, 1994, pp. 1657-61. |
| Kaelin CM, Smith TJ, Homer MJ, Taback B, Azurin D, Schmid CH and Weld L. "Safety, Accuracy, and Diagnostic Yield of Needle Localization Biopsy of the Breast Performed Using Local Anesthesia." Journal of the American College of Surgeons, vol. 179, 1994, pp. 267-272. |
| Pereira BJG, Wright TL, Schmid CH, Bryan CF, Cheung RC, Cooper ES, Hsu H, Kelly MK, Light JA, Norman DJ, Van Thiel DH, Werner BG, Wright CE, and Levey AS. "Screening and Confirmatory Testing of Cadaver Organ Donors for Hepatitis C Virus Infection: A U.S. National Collaborative Study." Kidney International, vol. 46, 1994, pp. 886-892. |
| Graham RA, Homer MJ, Sigler CJ, Safaii H, Schmid CH, Marchant DJ, Smith TJ. "The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma." American Journal of Roentgenology, vol. 162, no. 1, 1994, pp. 33-6. |
| Steere AC, Levin RE, Molloy PJ, Kalish RA, Abraham JH 3rd, Liu NY, Schmid CH. "Treatment of Lyme arthritis." Arthritis and rheumatism, vol. 37, no. 6, 1994, pp. 878-88. |
| Schmid CH, Rosner B. "A Bayesian approach to logistic regression models having measurement error following a mixture distribution." Statistics in Medicine, vol. 12, no. 12, 1993, pp. 1141-53. |
| Rhodes J, Udelson JE, Marx GR, Schmid CH, Konstam MA, Hijazi ZM, Bova SA and Fulton DR. "A New Noninvasive Method for the Estimation of Peak dP/dt." Circulation, vol. 88, 1993, pp. 2693-2699. |
| Schmidt-Ullrich RK, Wazer DE, DiPetrillo T, Marchant DJ, Smith TJ, Safaii H, Schmid C, Homer MJ. "Breast conservation therapy for early stage breast carcinoma with outstanding 10-year locoregional control rates: a case for aggressive therapy to the tumor bearing quadrant." International Journal of Radiation Oncology*Biology*Physics, vol. 27, no. 3, 1993, pp. 545-52. |
| DeGroot AS, McGowen K, Schieb RG, Schmid CH, Lieberman J and Wyler DJ. "T Cell Responses to Mycobacterium tuberculosis Antigens in the HIV-Infected Host." Vaccines 93, Cold Spring Harbor, NY, Cold Spring Harbor Press, 1993, pp. 251-257. |
| Schmid CH. "Value Splitting: Taking the Data Apart." Fundamentals of Exploratory Analysis of Variance, edited by DC Hoaglin, F Mosteller and JW Tukey, New York, John Wiley and Sons, 1991, pp. 72-113. |
Research
Research Overview
My research focuses on methods for the quantitative synthesis of information from observational and experimental studies and through meta-analysis. My team develops methods and software for meta-analysis of two or more treatments, for N-of-1 studies and for predictive models. My research seeks to develop and apply tools to further the health of patients and to design and carry out research studies to develop new treatments and new methods of delivering them. I am involved in many different clinical trials and development of predictive models.
Research Statement
My major research interests include development and application of Bayesian models for clinical research, development of statistical methods and computational tools for meta-analysis and N-of-1 studies and methods for developing, testing and applying predictive models. I see many opportunities for advancing the science of comparative effectiveness research in the coming years and believe that these will be fruitful research opportunities for both biostatistics graduate students and other collaborators in medicine, public health and other scientific disciplines doing systematic reviews. My research in meta-analysis and evidence synthesis takes place in the Center for Evidence Synthesis in Health. Our focus there revolves around the development of research methods and software tools.
In multivariate meta-analysis, I have a current focus in methods, applications and software for network meta-analysis, a method for synthesizing data from studies that involve different combinations of treatments or different diagnostic modalities. This method has become a key tool in comparing and ranking the effectiveness of a class of treatments and therefore of high profile in clinical research. I have been involved in the development of guidelines and reporting standards for systematic reviews and meta-analysis, including those for analyses of individual participant data, network meta-analysis and N-of-1 studies.
N-of-1 studies are single patient multiple crossover trials to compare two or more treatments. They are very patient-centered because the studies are designed by patients working with their clinicians. This enables them to choose their own outcomes, interventions and study protocols. I am working to develop a mobile application that will enable users to design their own studies and enter and analyze their own data. I am building software that will automate real-time Bayesian analysis of the trial data according to user specifications and that will provide user-friendly summaries of the results to help users decide which treatment works best and how likely it is to be best. Another piece of software will enable calcuation of power and sample size for trial designs that allow users to model the tradeoff between recruiting more participants vs. running trials longer.
I am also working with a team that is using regression and machine learning to apply models for predicting the amount of dehydration of patients based on clinical presentation and patient-reported symptoms for children and adults presenting at a hospital in Bangladesh.
I also direct the Biostatistics, Epidemiology and Study Design Key Component of the Rhode Island Center for Clinical and Translational Science, a large state-wide program to develop infrastructure in clinical research and to provide educational tools and consultative services to junior researchers. This program is a joint project of Brown University School of Public Health, the Brown Alpert Medical School, Lifespan and Care New England hospital networks, the Rhode Island Quality Institute and the University of Rhode Island. This will provide many opportunities for students to become involved with research.
Funded Research
Research Grants
Current
Title: Translational Approaches for Pathogens of Human Significance
Funding Source: NIH/NIGMS P20 GM156688
Total Costs: $12,500,000
Funding Period: 2025-2030
Role: Senior Statistician/Investigator (PI: Jennifer Friedman and Jonathan Kurtis)
Title: External Validation and Implementation of a Novel Mobile Health Application for Acute Diarrhea Management across the Lifespan
Funding Source: NIH/NIDDK 2R01 DK116163-06A1
Total Costs: $2,600,000
Funding Period: 2024-2028
Role: Senior Statistician/Investigator (PI: Adam Levine)
Title: Impact of Randomized Payment Incentives on Disparities in Home Dialysis and Kidney Transplantation
Funding Source: NIH/ NIMHD R01 MD017080
Total Costs: $ 3,500,000 (sub $201,000)
Funding Period: 2021-2026
Role: Senior Statistician/Investigator (PI: Amal Trivedi and Rachel Patzer)
Title: RI-Center for Clinical and Translational Science
Funding Source: NIH/NIGMS 2U54GM115677
Total Costs: $20,000,000 (sub $810,000)
Funding Period: 2021-2026
Role: Subcontract PI and Director of Biostatistics, Epidemiology, and Research Design Core (PI: Sharon Rounds)
Title: Effect of PDE5 Inhibitor on Respiratory Symptoms in COPD Complicated by Pulmonary Hypertension
Funding Source: VA Office of Research and Development Clinical Science I01CX002543-01
Total Costs: $2,000,000
Funding Period: 2024-2029
Role: Senior Statistician/Investigator (PI: Sharon Rounds)
Title: An intervention to improve HIV pre-exposure prophylaxis initiation, adherence and linkage to care for recently incarcerated men who inject drugs
Funding Source: NIH K23 DA054003
Total Costs: $1,000,000
Funding Period: 2022-2027
Role: Faculty Mentor (PI: Matthew Murphy)
Title: Developing Computational Nosologies of Posttraumatic Stress Disorder (PTSD)
Funding Source: VA IK2 CX002115
Total Costs: $1,383,436
Funding Period: 2021-2026
Role: Faculty Mentor (PI: Amin Zand Vakili)
Title: Moi-Brown Partnership for HIV Biostatistics Training
Funding Source: NIH Fogarty International Center 2D43TW010050
Total Costs: $1,500,894
Funding Period: 2021-2026
Role: Faculty Mentor (PI: Joseph Hogan)
Title: A Novel N-of-1 Randomized, Controlled, Clinical Trial to Assess the Effect of Blenderized Tube Feeds on Esophagogastric Physiology
Funding Source: NIH K23 DK133679
Total Costs: $1,000,000
Funding Period: 2022-2027
Role: Consultant (PI: Bridget Hron)
Title: Optimizing Dialysis Care in Skilled Nursing Facilities: Implementation and Outcomes of On-Site Dialysis
Funding Source: Advance RI-CTR Mentored Research Award
Total Costs: $285,000
Funding Period: 2024-2026
Role: Mentor (PI: Ankur Shah)
Scholarly Work
Courses/Workshops/Webinars
National
- “Making Predictive Instruments.” Society for General Internal Medicine, Washington, DC, May 1996.
- “Making Predictive Instruments.” Society for General Internal Medicine, Washington, DC, May 1997.
- “ Meta-Analysis” Medical Decision Making, Cambridge, MA, October 1998.
- Statistical Basis of Meta-Analysis.” National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, May 2005.
- Modern Metaanalysis. 6th International Conference on Health Policy Research, Boston, MA, October 2005.
- “Basic Statistical Concepts for the Medical Researcher.” American College of Rheumatology Annual Meeting, Boston MA, November 2007.
- “Issues When Trying to Adjust for Confounders in Meta-Analyses of Observational Data.“ Drug Information Association, May 2009.
- “Comparative Effectiveness Research: Meta-Analysis.” Tufts University, Boston MA, 2011.
- “Bayesian Methods for Multivariate Meta-Analysis.” Eli Lilly and Company, Indianapolis, IN, June 2011.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, Miami FL, August 2011.
- “Network Meta-Analysis.” Workshop given at 9th International Conference on Health Policy Statistics, Cleveland, OH, October 2011.
- “Institute of Medicine Standards on Systematic Reviews.” Webinar for Guidelines International North America, February, 2012.
- “OpenMetaAnalyst software for diagnostic test accuracy studies.” Learning Network, Evidence-Based Practice Center program, Agency for Healthcare Research and Quality, May 2012.
- “Meta-analysis combining individual participant level data (IPD) and aggregated data (AD).” International Society of Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual International Meeting, Washington DC, June 2012.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, San Diego, CA, July 2012.
- “Meta Analysis with Multivariate Data.” ASA Biopharmaceutical Section FDA-Industry Statistics Workshop, Washington DC, September 2012.
- “Introduction to Meta-Analysis.” Global Clinical Scholars Research Training Program, Harvard Medical School, Boston MA, June 2014.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, Boston, MA, Aug 2014.
- “N-of-1 Trials.” Webinar for Health Policy Statistics Section of American Statistical Association, Sept 2014.
- “Network Meta-Analysis for Comparative Effectiveness in Safety Studies.” Eli Lilly, April 2015.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, Seattle, WA, Aug 2015.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Centers for Disease Control, Atlanta, GA, Aug 2015.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Medtronic, Minneapolis, MN, Oct 2015.
- “Network Meta-Analysis.” American Statistical Association Connecticut Chapter, West Haven CT, March, 2016.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, Chicago, IL, Aug 2016.
- “How to Be an Informed Consumer of Systematic Reviews.” Centers for Disease Control, Atlanta, GA, Feb 2017.
- “Meta-Analysis and Network Meta-Analysis: Combining the Results of Multiple Studies.” Centers for Disease Control, Atlanta, GA, Mar 2017.
- “Network Meta-Analysis.” Joint Statistical Meetings, Baltimore, MD, July 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” Webinar given to Washington University students attending course Intermediate Methods in Clinical Research, March 2018.
- “Network Meta-Analysis for Various Study Designs: Stepping Outside the Randomized Controlled Trials Comfort Zone Into the Real World.” ISPOR, Baltimore, MD, May 2018.
- “Meta-Analysis and Combining the Results of Multiple Studies.” Centers for Disease Control, Atlanta, GA, Oct 2018.
- “Network Meta-Analysis.” Centers for Disease Control, Atlanta, GA, Oct 2018.
- “Network Meta-Analysis.” North Texas Chapter of the American Statistical Association, Dallas, TX, Nov 2018.
- “Meta-Analysis: Combining Results of Multiple Studies.” San Antonio Chapter of the American Statistical Association, San Antonio, TX, Nov 2018.
- “Systematic Review Workshop.” Advance-RI CTR, Providence RI, March 2019.
- “Introduction to Evidence Synthesis.” Hawaii Chapter of the American Statistical Association, Honolulu, HI, June 2019.
- “Meta-Analysis: Combining Results of Multiple Studies.” Hawaii Chapter of the American Statistical Association, Honolulu, HI, June 2019.
- “Meta-Analysis and Combining the Results of Multiple Studies.” Centers for Disease Control, Atlanta, GA, Oct 2019.
- “Network Meta-Analysis.” Centers for Disease Control, Atlanta, GA, Oct 2019.
- “Combining Information from Different Studies with Meta-Analysis and Network Meta-Analysis.” Deming Conference, Atlantic City NJ, Dec 2019.
- “Combining Results of Studies Using Meta-Analysis.” Medtronic, October 2022.
- “Combining Information from Different Studies with Meta-Analysis and Network Meta-Analysis.” Deming Conference, Philadelphia, PA, Dec 2022.
- “N-of-1 Trials for Personalized Healthcare.” Deming Conference, Philadelphia, PA, Dec 2022.
- “Use of Meta-Analyses in Nutrition Research and Policy: Planning of Meta-Analysis. Webinar sponsored by National Academies of Sciences, Engineering and Medicine, Sept 2023.
- “N-of-1 Trials for Personalized Healthcare.” Graybill Conference, Ft. Collins, CO, June 2024.
- “N-of-1 Trials for Personalized Healthcare.” Harvard Catalyst, Boston, MA, October 2024.
- “Using N-of-1 Trials to Personalize Diet Interventions”, Webinar sponsored by NIH Office of Dietary Supplements, March 2025.
- “Leadership in Esametry: Within-Individual Statistics of N-of-1 Trials and Single-Case Designs.” Webinar sponssored by COPSS-NISS Leadership, April 2026.
International
- “Introductory Biostatistics.” Portuguese Society of Nephrology, Porto, Portugal, July 2001.
- “Introductory Biostatistics.” Portuguese Society of Nephrology, Porto, Portugal, March 1997.
- “The Design of Studies for Medical Research: Common Errors in Statistics and How to Avoid Them.” Pre-Congress Satellite XXI Portuguese Congress of Nephrology, Vilamoura, Portugal, May 2007.
- “Introductory Biostatistics.” Consultation of Investment in Health Promotion, Hanoi, Vietnam, June 2008.
- “Heterogeneity, Meta-Regression and Statistical Models.” Italian Cochrane Center. Milan, Italy, March 2011.
- “Comparing multiple treatments 1: Overview or intervention review.” 20th Cochrane Collaboration Colloquium, Auckland, New Zealand, October 2012.
- “Meta-Analysis: Combining the Results of Multiple Studies.” Joint Statistical Meetings, Montreal, Canada, Aug 2013.
- “Network Meta-Analysis.” Southern Ontario Regional Association of the Statistical Society of Canada and the Southern Ontario Chapter of the American Statistical Association, Toronto, Canada, June 2018.
Invited Presentations
National
- “A Probability Model for Saltatory Growth.” Colloquium given to the Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, September 1997.
- “An Empirical Study of the Effect of the Control Rate as a Predictor of Treatment Efficacy in Meta-Analysis of Clinical Trials.” 1997 International Conference on Health Policy Research, Crystal City, VA, December 1997.
- “Exploring Heterogeneity in Randomized Trials via Meta-Analysis.” 1998 Drug Information Association Conference on Global Statistical Challenges and Strategies in the Pharmaceutical Industry, Hilton Head, SC, March 1998.
- “Regression Models for Longitudinal Data with Missing Covariate Values.” American Statistical Association, Baltimore, August 1999.
- “Marginal and Dynamic Regression Models for Longitudinal Data.” Epidemiology Methods Working Group, Harvard School of Public Health, January 2000.
- “Introduction to Meta-Analysis.” Eunice Kennedy Shriver Center, Waltham MA, May 2000.
- “Exploring Heterogeneity in Randomized Trials With Meta-Analysis”. Rand, Santa Monica, November 2000.
- “Exploring Heterogeneity in Randomized Trials with Meta-Analysis” Merck Institute on Aging, Washington DC, June 2001.
- “Using Bayesian Models to Perform Meta-Analysis” Bartlett International workshop on Statistical Design and Analysis, Philadelphia, November 2001.
- “Using the Control Rate to Explore Heterogeneity of Treatment Effects in Clinical Trials” American Statistical Association, New York, August 2002.
- “Modeling Daily Growth in Children.” Yale University Biostatistics Colloquium, New Haven, October 2002.
- “Using Meta-Analysis to Explore Differences in Study Effects.” Ninth Annual Biopharmaceutical Applied Statistics Symposium, Savannah, December 2002.
- “Combining N-of-1 Studies to Improve Treatment for Individual Patients.” Center for Health Quality, Outcomes & Economics Research, Bedford, MA, December 2003.
- “Using Meta-Regression to Explore Treatment Heterogeneity.” US Cochrane Center, Brown University, Providence RI, April 2004.
- “Using Bayesian Models to Perform Meta-Analysis.” Harvard University, Boston, MA, April 2004.
- “The State of the Art in Diagnostic Test Meta-Analysis.” American Statistical Association, Toronto, August 2004.
- “Basics of Combining Data in a Meta-Analysis.” Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, October 2004.
- “Exploring Heterogeneity in Study Results Through Meta-Analysis.” Statistics group, Roche Labs, Nutley, NJ, November 2004.
- “Systematic Review/Meta-analysis Workshop” Sanofi-Aventis pharmaceuticals, Bridgewater, NJ, September 2005.
- “Statistical Methods for Diagnostic Tests.” International Chinese Statistical Association, Storrs, CT, June 2006.
- “The State of the Art in Diagnostic Test Meta-Analysis.” Center for Medicare and Medicaid Services, Baltimore MD, October 2006.
- “Testing the Accuracy of Diagnostic Tests Through Meta-Analysis.” Epidemiology Methods Working Group, Harvard School of Public Health, Cambridge MA, March, 2007.
- “Putting Together a Strong Clinical Study.” Fourth International Meeting Ten Years of the US-Russian Program in Prosthetics and Rehabilitation, Stoughton MA, June 2007.
- “What If I’d Known Then What I Know Now? Re-evaluating Diagnostic Test Meta-Analyses With New Statistical Models.” 7th International Conference on Health Policy Statistics, Philadelphia PA, January 2008.
- “Random-Effects Meta-Analyses For Outcomes With Three or More Mutually Exclusive Categorical Responses.” Midwest Biopharmaceutical Statistics Workshop, Muncie IN, May 2008.
- “Bayesian Meta-analysis.” Pfizer Research and Development, New London CT, June 2008.
- “State of the art and science’ associated with the use of statistical models used in the meta-analysis of clinical data”. Massachusetts Biotechnology Council, Cambridge MA, June 2008.
- “Empirical Study of Bayesian Methods for Meta-Analyses of Diagnostic Test Data Using a Large Database of Studies in the Medical Literature.” American Statistical Association, Denver, August 2008.
- Issues When Trying to Adjust for Confounders in Meta-Analyses of Observational Data.“ Drug Information Association/FDAPHrMA Drug Safety Conference, Arlington, VA October 2008.
- “Multiple-treatments meta-analysis for categorical outcomes.” 8th International Conference on Health Policy Statistics, Washington DC, January 2010.
- “Multiple-treatments meta-analysis for categorical outcomes.” Massachusetts General Hospital Biostatistics Center, Boston MA, February 2010.
- “Multiple-treatments meta-analysis.” Johns Hopkins University Center for Clinical Trials, Baltimore, MD, March 2010.
- “Bayesian Meta-Analysis” Pfizer, New York, NY, April 2010.
- “Multiple Treatments Meta-Analysis for Comparative Effectiveness.” ACRT/SCTS Joint Annual Meeting, Clinical and Translational Research and Education Meeting , Washington DC, April, 2010.
- “Bayesian Analysis Using BUGS.” Network Meta-analysis Methods Meeting and Workshop. Baltimore, MD, May 2010.
- “Multiple-treatments, Multiple Outcomes and Multiple Followup Times.” Network Meta-analysis Methods Meeting and Workshop. Baltimore, MD, May 2010.
- “Interpreting Multiple Results to the Same Query.” Expert Workshop: Statistical and Epidemiological Issues in Active Medical Product Surveillance. Brookings Institution, Washington DC, February 2011.
- “Multiple-treatments meta-analysis for categorical outcomes.” Eastern North American Region of the International Biometric Society (ENAR). Miami, Florida, March 2011.
- “Modernizing knowledge synthesis and integration for comparative effectiveness.” ACRT/SCTS Joint Annual Meeting, Clinical and Translational Research and Education Meeting , Washington DC, April 2011.
- “Proposed National Standards for Reviews of Health Care Evidence.” Joint Statistical Meetings, Miami FL, July 2011.
- “Introductory Overview Lecture: Evidence-Based Medicine and Statistics.” Joint Statistical Meetings, Miami FL, August 2011.
- “Network Meta-Analysis for Comparative Effectiveness.” Starr Lecture at Brown University, Providence RI, October 2011.
- “IOM Standards on Systematic Reviews.” International Life Sciences Institute meeting, Phoenix, AZ, January 2012.
- “Exploring a Network of Treatments with Direct and Indirect Comparisons.” Fourth DEcIDE Symposium on Comparative Effectiveness Research Methods, Rockville MD, June 2012.
- “Bayesian Methods for Multivariate Meta-Analysis of Treatment Networks with Incomplete Data.” Joint Statistical Meetings, San Diego, CA, July 2012.
- “Bayesian Network Meta-Analysis for Unordered Categorical Outcomes With Incomplete Data.” DIMACS Workshop on Analysis of Information from Diverse Sources, Rutgers University, New Brunswick NJ, May 2013.
- “N-of-1 Trials: A Tool for Making Patient-Centered Treatment Decisions.” International Chinese Statistics Association, Bethesda, MD, June, 2013.
- “Multivariate Techniques for Combining Information.” 10th International Conference on Health Policy Statistics, Chicago, IL, October 2013.
- “N of 1 Studies.” University of Massachusetts Medical Center Dept. of Quantitative Health Sciences, Worcester, MA, February 2014.
- “Bayesian Network Meta-Analysis for Categorical Outcomes.” Eastern North American Region of the International Biometric Society (ENAR). Baltimore, MD, March 2014.
- “Meta-Analysis of Diagnostic Test Accuracy Comparisons: Network Methods.” Eastern North American Region of the International Biometric Society (ENAR). Baltimore, MD, March 2014.
- “N-of-1 Trials.” American Statistical Association Connecticut Chapter, Danbury CT, March, 2014.
- “Network Meta-Analysis for Comparative Effectiveness in Safety Studies.” DIA/FDA Statistics Forum, Bethesda MD, April 2014.
- “Network Meta-Analysis.” Department of Industrial and Systems Engineering, Georgia Institute of Technology Atlanta GA, December 2014.
- “Large-Scale Comparison of Univariate and Multivariate Meta-Analysis for Categorical Outcomes.” 11th International Conference on Health Policy Statistics, Providence, RI, October 2015.
- "N of 1 Trials for Personalized Decision Making." Department of Computer Science and Statistics, University of Rhode Island, Kingston RI, April 2016.
- “N-of-1 Trials.” TMJ Association, Bethesda, MD, Sept 2016.
- "N of 1 Trials for Personalized Decision Making." Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, November 2016.
- "N of 1 Trials for Personalized Decision Making." Center for Clinical Trials and Evidence Seminar Series, Johns Hopkins University, Baltimore, MD, December 2016.
- “Hierarchical Models for Combining N-of-1 Trials.” Eastern North American Region of the International Biometric Society (ENAR), Washington DC, March 2017.
- “N-of-1 Trials.” NIH Individualizing Treatment – Broadening the Framework for Urinary Incontinence Research meeting, Bethesda MD, March 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” U Penn Department of Biostatistics, Epidemiology and Informatics, Philadelphia, PA, June 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” International Chinese Statistics Association, Chicago, IL, June 2017.
- Discussant for “Meta-Analysis Has Moved Beyond Its Original Niche as a Method to Provide a Summary of the Average Effect of an Intervention on an Outcome”. Joint Statistical Meetings, Baltimore, MD, Aug 2017.
- “N-of-1 Trials for Making Personalized Treatment Decisions with Personalized Designs Using Self-Collected Data.” U Rochester Department of Biostatistics and Computational Biology Colloquium, October 2017.
- “N-of-1 Trials for Making Personalized Treatment Decisions with Personalized Designs Using Self-Collected Data.” NYU Workshop on Single Case Designs and Beyond, New York, NY, November 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” 12th International Conference on Health Policy Statistics, Charleston, SC, January 2018.
- “N-of-1 Trials for Making Personalized Treatment Decisions.” Eastern North American Region of the International Biometric Society (ENAR), Atlanta, GA, March 2018.
- “Network Meta-Analysis.” Dartmouth Interdisciplinary Network Research Group, Hanover, NH, December 2018.
- “Design and Analytic Tools for Personalizing Healthcare Experiments.” Eastern North American Region of the International Biometric Society (ENAR), Philadelphia, PA, March 2019.
- “N-of-1 Trials: Estimating Individual Treatment Effects.” Washington University Department of Biostatistics. Saint Louis, MO, April 2019.
- “N-of-1 Trials: Estimating Individual Treatment Effects.” Washington University Department of Anesthesiology. Saint Louis, MO, April 2019.
- “The Evidence Synthesis Academy: Educating the Public about Evidence Synthesis.” Presidential Address to the Society for Research Synthesis Methodology. Chicago, IL, July 2019.
- “Incorporating Information from a Network of Personalized Trials to Facilitate Individualized Treatment Choice.” Joint Statistical Meetings, Denver, CO, Aug 2019.
- “Design and Analytic Tools for Personalizing Healthcare Experiments.” Population Science Group Meeting, Joint Program in Cancer Biology, Brown Medical School, Aug 2019.
- “Design and Analytic Tools for Personalizing Healthcare Experiments Using N-of-1 Designs.” Keynote Address to Pfizer Global Statistics Conference. October 2020.
- “Design and Analytic Tools for Personalizing Healthcare Experiments Using N-of-1 Designs.” Grand rounds given to Division of Nephrology, Rhode Island Hospital, December 2020.
- “Statistical Considerations in the Choice of Fixed or Random Intercepts for Meta-Analytic Models.” Eastern North American Region of the International Biometric Society (ENAR), Virtual, March 2021.
- “Personalized, patient-driven research: A multicenter N-of-1 trial of dietary management of Crohn’s Disease”, Learning Health Networks Research Conference: Accelerating Patient-Centered Outcomes Research, Virtual, June 2021.
- “Personalizing Healthcare Experiments Using N-of-1 Designs”, Advance-CTR Translational Research Seminar Series, Virtual, September 2021.
- “Personalizing Healthcare Experiments Using N-of-1 Designs”, New England Statistics Symposium, Providence, RI, October 2021.
- “Bayesian Methods for Meta-Analysis of N-of-1 Trials”, International Conference on Advances in Interdisciplinary Statistics and Combinatorics, Virtual, October 2021.
- “The Statistician is the Clinical Investigator’s Best Friend.” Talk given to West Virginia CTSI Principal Investigator Academy, Virtual, September 2022.
- “Bayesian Models for Combining N-of-1 Trials.” Talk given to International Conference on Health Policy Statistics, Scottsdale AZ, Jan 2023.
- “Validating a Predictive Model”, Advance-CTR Translational Research Seminar Series, February 2023.
- “N-of-1 Trials for Personalized Healthcare”, Thomas R Ten Have Symposium on Statistics in Mental Health, Boston MA, June 2023.
- “The Statistician is the Clinical Investigator’s Best Friend.” North East Regional IDeA Conference, Wilmington, DE, August 2023.
- “N-of-1 Trials for Personalized Healthcare.” Vincent Armenio Memorial Lecture, Roger Williams Medical Center, Providence RI May 2025.
- “N-of-1 Trials for Personalized Healthcare.” Virtual Talk to UMass Chan Department of Population and Quantitative Health Sciences Research Methods Meeting, Worcester, MA, March 2026.
- “AI and Data Driven Approaches to Modern Challenges in Evidence Synthesis.” Discussion at Eastern North American Region of the International Biometric Society (ENAR), Indianapolis, IN, March 2026.
- “Designing Personalized Trials to Estimate Individual Treatment Effects.” Eastern North American Region of the International Biometric Society (ENAR), Indianapolis, IN, March 2026.
International
- “Exploring Heterogeneity in Clinical Trials With Meta-Analysis.” Bayer International Clinical Datapool Meeting, Wuppertal, Germany, June 1998.
- “Estimating Treatment-Covariate Interactions Using Meta-Regression and Individual Patient Data. ” 16thCochrane Collaboration Colloquium, Freiburg, Germany, October 2008.
- “Meta-Analysis of Clinical Trials: Strengths and Weaknesses.” 11th Cardiology Conference of Central Greece. Larissa, Greece, October 2008.
- “Meta-analysis of Clinical Trials: Strengths and Weaknesses.” Halkidiki, Greece, July 2009.
- “Semi-automated abstract screening for systematic reviews using support vector machines.” University of York, Centre for Reviews and Dissemination, York, United Kingdom, March 2010.
- “Institute of Medicine Perspective on Systematic Reviews.” Registering Systematic Review Portocols: An International Initiative. Vancouver, Canada, February 2011.
- “Multinomial Network Meta-Analysis”. University of Ioannina, Greece, September 2011.
- “A Conversation on Standards for Systematic Reviews.” 19th Cochrane Collaboration Colloquium, Madrid, Spain, October 2011.
- “Hierarchical Models for Combining N-of-1 Trials.” University of Bristol Dept of Community Health, Bristol, UK, April 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” Statistical Society of Canada, Winnipeg, Canada, June 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” Joint Conference on Biometrics & Biopharmaceutical Statistics (CEN-ISBS Vienna 2017) Vienna, Austria, August 2017.
- “Hierarchical Models for Combining N-of-1 Trials.” Tenth International Conference of the European Research Consortium for Informatics and Mathematics Working Group on Computational and Methodological Statistics, London, UK, December 2017.
- “N-of-1 Trials for Making Personalized Treatment Decisions.” Karolinska Institute, Stockholm, Sweden, April 2018.
- “N-of-1 Trials for Making Personalised Treatment Decisions with Personalised Designs Using Self-Collected Data.” Royal Statistical Society South West Local Group Meeting, Plymouth, UK, July 2018.
- “Statistical Models for Combining N-of-1 Trials with Application to the PREEMPT Study” part of panel on Small Data and N-Of-1 Trials. Joint Statistical Meetings, Vancouver, CA, Aug 2018.
- “Design and Analytic Tools for Personalizing Healthcare Experiments.” Keynote address to Deutsch Gesellschaft fur Medizinische Informatik, Biometrie und Epidemiologie, Dortmund, Germany, Sept 2019
- “N-of-1 Trials for Personalized Healthcare”, Talk given to Centre for Physical Activity Research, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark, June 2023.
- “Using Bayesian methods to analyze data from N-of-1 trials”, Recent Methods in Meta-Analysis Symposium, Goettingen, Germany, August 2024.
Other Presentations
National
- “Incorporating Measurement Error in the Estimation of Autoregressive Models for Longitudinal Data.” Joint Statistical Meetings, Anaheim, CA, August 1990.
- “A Bayesian Approach to Logistic Regression Models Having Measurement Error Following a Mixture Distribution.” Joint Statistical Meetings, Boston, MA, August 1992.
- “A Logistic Regression Model for the Effect of Thrombolytic Therapy on the Risk of Cardiac Arrest When Some Outcomes Precede Treatment.” American Federation for Clinical Research, Washington DC, May 1993.
- “Applying Bayesian Meta-Regression to the Study of Thrombolytic Therapy.” American Federation for Clinical Research, Baltimore, MD, May 1994.
- “A State-Space Model for Longitudinal Regression.” Twenty-Sixth Symposium on the Interface, Research Triangle Park, NC, June 1994.
- “Measuring the Impact of the Control Rate in Meta-Analysis of Clinical Trials.” Sixteenth Annual Meeting of the Society for Clinical Trials, Seattle, Washington, April-May 1995.
- “Bayesian Methods to Improve Sample Size Approximations.” Joint Statistical Meetings, Orlando, FL, August 1995.
- “A Hierarchical Model for Human Growth.” Joint Statistical Meetings, Chicago, IL, August 1996.
- “Synthesizing the Treatment of Missing Data in Logistic Regression, Classification Trees and Neural Networks.” Joint Statistical Meetings, Anaheim, CA, August 1997.
- “Modeling Growth in Kids” Presentation to Summer Seminar Lecture Series in Clinical Care Research, New England Medical Center, July 2000.
- “Exploring Heterogeneity in Randomized Trials With Meta-Analysis.” American Statistical Association, Indianapolis, August 2000.
- “Saltatory Growth in Children.” Summer Seminar Lecture Series in Clinical Care Research, New England Medical Center, Boston, July 2001.
- “Modeling Daily Growth in Children.” Summer Seminar Lecture Series in Clinical Care Research, New England Medical Center, Boston, July 2002.
- “Modeling Daily Growth in Children.” Joint Statistical Meetings, San Francisco, August 2003.
- “Predictors of Change in Glomerular Filtration Rate Among Nondiabetic Patients with Chronic Kidney Disease.” Joint Statistical Meetings, San Francisco, August 2003.
- “The State of the Art in Metaanalyses of Diagnostic Tests.” 6th International Conference on Health Policy Research, Boston, MA, October 2005.
- “Random-Effects Meta-Analyses For Outcomes With Three or More Mutually Exclusive Categorical Responses.” Society for Research Synthesis Methodology Annual Meeting, Chicago, IL, July 2007.
- “Meta-Analyst Software” Society for Research Synthesis Methodology, Seattle, WA, July 2009.
- “The Statistician as an Expert Witness”. American Statistical Association, Washington DC, August 2009.
- “Bayesian Network Meta-Analysis for Unordered Categorical Outcomes With Incomplete Data.” Society for Research Synthesis Methodology, Providence, RI, June 2013.
- “How question formulation motivates different approaches to research synthesis.” Society for Research Synthesis Methodology, Nashville, TN, July 2015.
- “An Empirical Comparison of Univariate and Multivariate Meta-Analyses for Categorical Outcomes.” Joint Statistical Meetings, Seattle, WA, Aug 2015.
- “Application of Bayesian meta-analytic models to analysis of a series of N-of-1 trials for comparing two new diets to usual diet in treatment of children with inflammatory bowel disease.” Society for Research Synthesis Methodology, Portland, OR (virtual), July 2022.
- “Experiences with Large Series of Individual Trials for Personalized Health.” Joint Statistical Meetings, Washington DC, Aug 2022.
- “N of 1 Trials for Personalized Healthcare.” Talk given to Internal Resident Research Track, Brown Alpert Medical School, Nov 2023.
International
- “Survey of Diagnostic Test Meta-Analyses.” 12th Cochrane Collaboration Colloquium, Ottawa, Canada, October 2004.
- “Evaluating Heterogeneity in Studies of Diagnostic Test Accuracy.” 14th Cochrane Collaboration Colloquium, Dublin, Ireland, October 2006.
- “Empirical Study of Bayesian Methods for Meta-Analyses of Diagnostic Test Data Using a Large Database of Studies in the Medical Literature.” Society for Research Synthesis Methodology, Corfu, Greece, July 2008.
- “Multiple-treatments meta-analysis for categorical outcomes.” Society for Research Synthesis Methodology, Cartagena, Spain, July 2010.
- “Multiple-treatments meta-analysis for categorical outcomes.” 18th Cochrane Collaboration Colloquium, Keystone, Colorado, October 2010.
- “Finding What Works in Health Care: Standards for Systematic Reviews.” Society for Research Synthesis Methodology, Ottawa, Canada, July 2011.
- “Methods and reporting of meta-analyses of test accuracy.” Society for Research Synthesis Methodology, Aix-en-Provence, France, June 2012.
- “Empirical assessment of methods for the meta-analysis of test accuracy studies.” Society for Research Synthesis Methodology, Aix-en-Provence, France, June 2012.
- “Methods for the joint meta-analysis of several medical tests.” Society for Research Synthesis Methodology, Aix-en-Provence, France, June 2012.
- “Towards Modernizing the Systematic Review Pipeline: Efficient Updating via Data Mining.” 20th Cochrane Collaboration Colloquium, Auckland, New Zealand, October 2012.
- “Methods for the Joint Meta-Analysis of Multiple Tests.” 20th Cochrane Collaboration Colloquium, Auckland, New Zealand, October 2012.
- “An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Performance.” 20th Cochrane Collaboration Colloquium, Auckland, New Zealand, October 2012.
- “Network Meta-Analysis of Categorical Outcomes With Incomplete Data.” Joint Statistical Meetings, Montreal, Canada, Aug 2013.
- “Opportunities and Challenges in conducting a series of N-of-1 studies”. Society for Research Synthesis Methodology, York UK, July 2014.
- “Top Ten Things I Hate to See When Reviewing Applied Meta-Analyses: We need to do a better job of teaching our field.” Society for Research Synthesis Methodology, Florence, IT, July 2016.
- “Hierarchical Models for Combining N-of-1 Trials.” Society for Research Synthesis Methodology, Montreal, CA, July 2017.
- “Free and open-access online systematic review curriculum for broad audiences.” Cochrane Colloquium, Edinburgh, UK, Sept 2018.
- “Using Experimental Design Principles to Design Simulations.” Society for Research Synthesis Methodology, Paris, France, July 2023.
- “Considerations for accurately estimating variance components in Bayesian multilevel models for meta-analysis of N-of-1 trials.” Joint Statistical Meetings, Toronto, CA, Aug 2023.
- “Considerations in Bayesian Estimations for meta-analysis of RCTs.” Society for Research Synthesis Methodology, Amsterdam, The Netherlands, July 2024.
- “Designing personalized trials to estimate individual treatment effects.” Western North American Region of the International Biometric Society (WNAR), Whistler, CA, June 2025.
Background
Education and Training
| Year | Degree | Institution |
|---|---|---|
| 1991 | PhD | Harvard University |
Honors and Awards
2000 Drug Information Association Donald E. Francke Award (best paper of year)
2006 Elected member, Society for Research Synthesis Methodology
2010 Fellow, American Statistical Association
2010 Dean's Outstanding Sackler Faculty Mentor Award, Tufts Medical School
2010 Tufts University School of Medicine Distinguished Faculty Award
2021 Taylor and Francis Best Science and Medical Handbook (Handbook of Meta-Analysis)
2023 Fellow, Society for Research Synthesis Methodology (SRSM)
2023 Shadish Recognition for Extraordinary Service, SRSM
AffiliationsVisualize it
Collaborators
| Name | Title |
|---|---|
| Ahluwalia, Jasjit | Professor of Behavioral and Social Sciences, Professor of Medicine |
| Aluisio, Adam | Associate Professor of Emergency Medicine |
| Balk, Ethan | Professor of Health Services, Policy and Practice |
| Barry, Meagan | Assistant Professor of Emergency Medicine |
| Bohlen, Lauren | Assistant Professor of Behavioral and Social Sciences |
| Bourjeily, Ghada | Professor of Health Services, Policy and Practice, Professor of Medicine |
| Chiang, Silvia | Associate Professor of Pediatrics |
| Dunsiger, Shira | Associate Professor of Behavioral and Social Sciences, Associate Professor of Biostatistics, Associate Professor of Psychiatry and Human Behavior |
| Friedman, Jennifer | Professor of Epidemiology, Professor of Pediatrics |
| Garbern, Stephanie | Associate Professor of Emergency Medicine |
| Gatsonis, Constantine | Professor of Biostatistics |
| Genisca, Alicia | Associate Professor of Emergency Medicine, Associate Professor of Pediatrics |
| Hubbard, Rebecca | Carl Kawaja and Wendy Holcombe Professor of Public Health, Director of School of Public Health |
| Lee, Youjin | Manning Assistant Professor of Biostatistics |
| Levine, Adam | Associate Dean of Biology and Medicine, Perri Peltz and Eric Ruttenberg Professor of the Practice of Human Rights, Professor of Emergency Medicine, and Director of the Center for Global Health Equity |
| Liu, Tao | Professor of Biostatistics, Director of the Online Master’s Program in Biostatistics |
| Marcus, Bess | Professor of Behavioral and Social Sciences |
| Mende, Ulrike | Professor of Medicine |
| Meyers, David | Associate Professor of Health Services, Policy and Practice, Director of the Doctoral Program in Health Services Research, Associate Director of the Center for Advancing Health Policy through Research |
| Moitra, Ethan | Professor of Psychiatry and Human Behavior |
| Mor, Vincent | Florence Pirce Grant University Professor of Health Services, Policy and Practice, Professor of Health Services, Policy and Practice |
| Moretti, Katelyn | Associate Professor of Emergency Medicine |
| Murphy, Matthew | Assistant Professor of Medicine, Assistant Professor of Behavioral and Social Sciences |
| Paul, Alice | Director of Biostatistics, Associate Professor of Biostatistics |
| Rivera-Hernandez, Maricruz | Associate Professor of Health Services, Policy and Practice |
| Rosen, Rochelle | Professor of Psychiatry and Human Behavior, Professor of Behavioral and Social Sciences |
| Rounds, Sharon | Associate Dean for Translational Science, Professor of Pathology and Laboratory Medicine, Professor of Medicine |
| Sauerbrun-Cutler, May-Tal | Assistant Professor of Obstetrics and Gynecology, Clinician Educator |
| Shah, Ankur | Associate Professor of Medicine |
| Steingrimsson, Jon | Associate Professor of Biostatistics |
| Trikalinos, Thomas | Professor of Health Services, Policy and Practice, Director of the Center for Evidence Synthesis in Health |
| Trivedi, Amal | Professor of Health Services, Policy and Practice, Professor of Medicine |
| Van Wart, Audra | Director of University Postdoctoral Affairs, Associate Dean for Training and Program Development, Division of Biology and Medicine, Associate Professor |
| Veroniki, Argie | Associate Professor of Biostatistics, Associate Professor of Health Services, Policy and Practice |
Affiliations
American Statistical Association
Society for Research Synthesis Methodology
Society for Research Synthesis Methodology
Teaching
Teaching Overview
Biostatistics
Meta-analysis/Systematic review
Predictive Models
Statistical Learning
Clinical Trials
Data Analysis
Teaching
| DATA 2020 - Probability, Statistics, and Machine Learning: Advanced Methods |
| PHP 0100 - First year seminar: Statistics is everywhere |
| PHP 1510 - Principles of Biostatistics and Data Analysis |
| PHP 2514 - Applied Generalized Linear Models |
| PHP 2550 - Practical Data Analysis |
| PHP 2590 - Design of Experiments |
| PHP 2690H - Design of Experiments |
| PHP 2690J - Meta-Analysis: Synthesizing Evidence From Different Data Sources |