Kaley (Kaleen) Hayes, PharmD, PhD is a pharmacoepidemiologist whose research mission is to optimize the use of medications for chronic conditions in older adults using rigorous real-world evidence. She is also an Investigator with the Providence VA Medical Center.
Dr. Hayes conducts research using advanced pharmacoepidemiologic designs and causal inference methods to study outcomes among older patients with osteoporosis, dementia, cardiovascular conditions, and other chronic diseases. Her work also examines the impacts of policy changes on medication and health services use.
Her research has been supported by multiple project grants from the National Institute on Aging and the Canadian Institutes for Health Research. She has authored over 50 peer-reviewed publications and has been awarded over 6.4M USD in research funding as Principal Investigator.
Dr. Hayes received her Doctor of Pharmacy degree from the University of Pittsburgh and her PhD in Epidemiology at the University of Toronto.
Ko D, Lee Y, Kim DH, Shah SJ, Hayes KN, Zullo AR, Berry SD. "Antiplatelet and Anticoagulant Use in Nursing Home Residents With Atrial Fibrillation." JAMA Internal Medicine, 2024. |
Cupp MA, Berry SD, Hayes KN, Daiello LA, Ko D, Riester MR, Zullo AR. "Cholinesterase Inhibitor Initiation Does Not Increase the Risk of Fall-Related Injury in Older Adults Treated with Beta-blockers: a self-controlled case series design." The Journals of Gerontology: Series A, 2024. |
Riester MR, Zullo AR, Joshi R, Daiello LA, Hayes KN, Ko D, Kim DH, Munshi M, Berry SD. "Comparative safety and cardiovascular effectiveness of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in nursing homes." Diabetes, obesity & metabolism, vol. 26, no. 8, 2024, pp. 3403-3417. |
Harris DA, Chachlani P, Hayes KN, McCarthy EP, Wen KJ, Deng Y, Zullo AR, Djibo DA, McMahill-Walraven CN, Smith-Ray RL, Gravenstein S, Mor V. "COVID-19 and Influenza Vaccine Coadministration Among Older U.S. Adults." American Journal of Preventive Medicine, vol. 67, no. 1, 2024, pp. 67-78. |
Wen K, Harris DA, Chachlani P, Hayes KN, McCarthy E, Zullo AR, Smith-Ray RL, Singh T, Djibo DA, McMahill-Walraven CN, Hiris J, Conti RM, Gruber J, Mor V. "COVID-19 Vaccines: Moderna And Pfizer-BioNTech Use Varied By Urban, Rural Counties." Health Affairs, vol. 43, no. 5, 2024, pp. 659-665. |
Hayes KN, Cupp MA, Joshi R, Riester MR, Beaudoin FL, Zullo AR. "Differences in opioid prescriptions by race among U.S. older adults with a hip fracture transitioning to community care." Journal of the American Geriatrics Society, 2024. |
Berry SD, Hayes K, Lee Y, Zhang Y, Kim DH, Ko D, Kiel DP, Daielo L, Zhang T, Zullo AR. "Fall risk and cardiovascular outcomes of first-line antihypertensive medications in nursing home residents." Journal of the American Geriatrics Society, vol. 72, no. 3, 2024, pp. 682-692. |
Hayes KN, Oganisian A, Kiel DP. "Improving the value and interpretation of observational studies comparing treatment effects of osteoporosis medications depends on standardized reporting of methods." J Bone Miner Res, vol. 39, no. 7, 2024, pp. 807-809. |
Shakya I, Zullo AR, Hayes KN, Joshi R, Berry SD. "Risk factors for urinary tract infections among nursing home residents initiating sodium-glucose cotransporter-2 inhibitors." Journal of the American Geriatrics Society, vol. 72, no. 9, 2024, pp. 2878-2881. |
Tat DP, Zullo AR, Mor V, Hayes KN. "Sliding Scale Insulin Use in Nursing Homes Before and After Onset of the COVID-19 Pandemic." Journal of the American Medical Directors Association, vol. 25, no. 3, 2024, pp. 459-464. |
Zhang T, Zullo AR, Hayes KKN, Kim DH, Lee Y, Daiello LA, Kiel DP, Berry SD. "Use of Diabetes Medications before and after a Heart Failure-Related Hospitalization among Nursing Home Residents." Journal of the American Medical Directors Association, vol. 25, no. 3, 2024, pp. 454-458. |
Riester MR, Zhang Y, Hayes KN, Beaudoin FL, Zullo AR. "Use of electronic health record data to examine administrations of pro re nata analgesics during hip fracture post-acute care." Pharmacoepidemiology and Drug Safety, vol. 33, no. 6, 2024, pp. e5846. |
Hayes KN, Berry SD, Munshi MN, Zullo AR. "Adoption of sodium-glucose cotransporter-2 inhibitors among prescribers caring for nursing home residents." Journal of the American Geriatrics Society, vol. 71, no. 8, 2023, pp. 2585-2592. |
Hayes KN, Zhang T, Kim DH, Daiello LA, Lee Y, Kiel DP, Berry SD, Zullo AR. "Benefits and Harms of Standard Versus Reduced-Dose Direct Oral Anticoagulant Therapy for Older Adults With Multiple Morbidities and Atrial Fibrillation." Journal of the American Heart Association, vol. 12, no. 21, 2023, pp. e029865. |
Morin SN, Feldman S, Funnell L, Giangregorio L, Kim S, McDonald-Blumer H, Santesso N, Ridout R, Ward W, Ashe MC, Bardai Z, Bartley J, Binkley N, Burrell S, Butt D, Cadarette SM, Cheung AM, Chilibeck P, Dunn S, Falk J, Frame H, Gittings W, Hayes K, Holmes C, Ioannidis G, Jaglal SB, Josse R, Khan AA, McIntyre V, Nash L, Negm A, Papaioannou A, Ponzano M, Rodrigues IB, Thabane L, Thomas CA, Tile L, Wark JD, Osteoporosis Canada 2023 Guideline Update Group. "Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update." CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, vol. 195, no. 39, 2023, pp. E1333-E1348. |
Harris DA, Hayes KN, Zullo AR, Mor V, Chachlani P, Deng Y, McCarthy EP, Djibo DA, McMahill-Walraven CN, Gravenstein S. "Comparative Risks of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Older US Adults." JAMA Network Open, vol. 6, no. 8, 2023, pp. e2326852. |
Zullo AR, Riester MR, Hayes KN, Munshi MN, Berry SD. "Comparative safety of sulfonylureas among U.S. nursing home residents." Journal of the American Geriatrics Society, vol. 71, no. 4, 2023, pp. 1047-1057. |
Hayes KN, Harris DA, Zullo AR, Djibo DA, Smith-Ray RL, Taitel MS, Singh TG, McMahill-Walraven C, Chachlani P, Wen KJ, McCarthy EP, Gravenstein S, McCurdy S, Baird KE, Moran D, Fenson D, Deng Y, Mor V. "Data resource profile: COVid VAXines effects on the aged (COVVAXAGE)." International journal of population data science, vol. 8, no. 6, 2023, pp. 2170. |
Riester MR, Beaudoin FL, Joshi R, Hayes KN, Cupp MA, Berry SD, Zullo AR. "Evaluation of post-acute care and one-year outcomes among Medicare beneficiaries with hip fractures: a retrospective cohort study." BMC Medicine, vol. 21, no. 1, 2023, pp. 232. |
Hayes KN, Cadarette SM, Burden AM. "Methodological guidance for the use of real-world data to measure exposure and utilization patterns of osteoporosis medications." Bone reports, vol. 20, 2023, pp. 101730. |
Cupp MA, Beaudoin FL, Hayes KN, Riester MR, Berry SD, Joshi R, Zullo AR. "Post-Acute Care Setting After Hip Fracture Hospitalization and Subsequent Opioid Use in Older Adults." Journal of the American Medical Directors Association, vol. 24, no. 7, 2023, pp. 971-977.e4. |
Hayes KN, Harris DA, Zullo AR, Chachlani P, Wen KJ, Smith-Ray RL, Djibo DA, McCarthy EP, Pralea A, Singh TG, McMahill-Walraven C, Taitel MS, Deng Y, Gravenstein S, Mor V. "Racial and ethnic disparities in COVID-19 booster vaccination among U.S. older adults differ by geographic region and Medicare enrollment." Frontiers in public health, vol. 11, 2023, pp. 1243958. |
Zhang Y, Hayes KN, Riester MR, Silva JBB, Cupp MA, Lee Y, Zullo AR. "Trends in COVID-19-Related Medication Use in US Nursing Homes, 2018-2022." Journal of the American Medical Directors Association, vol. 24, no. 8, 2023, pp. 1120-1126.e1. |
Hayes KN, Brown KA, Cheung AM, Kim SA, Juurlink DN, Cadarette SM. "Comparative Fracture Risk During Osteoporosis Drug Holidays After Long-Term Risedronate Versus Alendronate Therapy : A Propensity Score-Matched Cohort Study." Annals of Internal Medicine, vol. 175, no. 3, 2022, pp. 335-343. |
Schneider T, Gomes T, Hayes KN, Suda KJ, Tadrous M. "Comparisons of Insulin Spending and Price Between Canada and the United States." Mayo Clinic proceedings, vol. 97, no. 3, 2022, pp. 573-578. |
Hayes, Kaleen N., Mor, Vincent, Zullo, Andrew R. "Electronic Health Records to Rapidly Assess Biosimilar Uptake: An Example Using Insulin Glargine in a Large U.S. Nursing Home Cohort." Frontiers in Pharmacology, vol. 13, 2022, pp. 855598. |
Hofmeister M, Sivakumar A, Clement F, Hayes KN, Law M, Guertin JR, Neville HL, Tadrous M. "Trends in Canadian prescription drug purchasing: 2001-2020." Journal of pharmaceutical policy and practice, vol. 15, no. 1, 2022, pp. 20. |
Hundal, Anisha K., Watterson, Taylor L., Hayes, Kaleen N. "Addressing the Challenges of Precepting Students Enrolled in Remote Research Advanced Pharmacy Practice Experiences." American Journal of Pharmaceutical Education, vol. 85, no. 5, 2021, pp. 8311. |
Tadrous, Mina, Shakeri, Ahmad, Hayes, Kaleen N., Neville, Heather L., Houlihan, Joanne, Clement, Fiona, Guertin, Jason R., Law, Michael R., Gomes, Tara. "Canadian Trends and Projections in Prescription Drug Purchases: 2001–2023." Canadian Journal of Health Technologies, vol. 1, no. 11, 2021. |
Cadarette, Suzanne M., Maclure, Malcolm, Delaney, J. A. Chris, Whitaker, Heather J., Hayes, Kaleen N., Wang, Shirley V., Tadrous, Mina, Gagne, Joshua J., Consiglio, Giulia P., Hallas, Jesper. "Control yourself: ISPE‐endorsed guidance in the application of self‐controlled study designs in pharmacoepidemiology." Pharmacoepidemiology and Drug Safety, vol. 30, no. 6, 2021, pp. 671-684. |
Hayes KN, Winter EM, Cadarette SM, Burden AM. "Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making." Journal of Clinical Medicine, vol. 10, no. 5, 2021, pp. 1140. |
Hayes, Kaleen N., Burkard, Theresa, Weiler, Stefan, Tadrous, Mina, Burden, Andrea M. "Global adverse events reported for direct-acting antiviral therapies for the treatment of hepatitis C." European Journal of Gastroenterology & Hepatology, vol. Publish Ahead of Print, 2021. |
Hayes, Kaleen N., Gomes, Tara, Tadrous, Mina. "Greater than the Sum: Applying Daily-Dose Equivalents to Antipsychotic Prescription Claims to Study Real-World Effects." Frontiers in Pharmacology, vol. 12, 2021. |
Makari, Joy, Dagenais, Joseph, Tadrous, Mina, Jennings, Sarah, Rahmaan, Israa, Hayes, Kaleen. "Hospital pharmacist discharge care is independently associated with reduced risk of readmissions for patients with chronic obstructive pulmonary disease: A propensity-matched cohort study." Canadian Pharmacists Journal / Revue des Pharmaciens du Canada, 2021, pp. 171516352110611. |
Hayes, Kaleen N., Hundal, Anisha K., Cadarette, Suzanne M. "Observational study methods used to assess pharmacotherapy effects of type 2 diabetes on fracture risk." JBI Evidence Synthesis, vol. Publish Ahead of Print, 2021. |
Hayes, K.N., He, N., Brown, K.A., Cheung, A.M., Juurlink, D.N., Cadarette, S.M. "Over half of seniors who start oral bisphosphonate therapy are exposed for 3 or more years: novel rolling window approach and patterns of use." Osteoporosis International, vol. 32, no. 7, 2021, pp. 1413-1420. |
Hayes, Kaleen N., Baschant, Ulrike, Hauser, Barbara, Burden, Andrea M., Winter, Elizabeth M. "When to Start and Stop Bone-Protecting Medication for Preventing Glucocorticoid-Induced Osteoporosis." Frontiers in Endocrinology, vol. 12, 2021. |
Hayes, Kaleen N, Giannakeas, Vasily, Wong, Andy Kin On. "Bisphosphonate Use Is Protective of Radiographic Knee Osteoarthritis Progression Among those With Low Disease Severity and Being Non‐Overweight: Data From the Osteoarthritis Initiative." Journal of Bone and Mineral Research, vol. 35, no. 12, 2020, pp. 2318-2326. |
Kirisci, Levent, Tarter, Ralph E., Reynolds, Maureen, Hayes, Kaleen N., Cochran, Gerald, Vanyukov, Michael. "Derivation and assessment of the opioid use disorder severity scale: prediction of health, psychological and social adjustment problems." The American Journal of Drug and Alcohol Abuse, vol. 46, no. 6, 2020, pp. 699-707. |
Hayes, Kaleen N, Giannakeas, Vasily, Wong, Andy Kin On. "Response to: Challenges to the Possible Use of Bisphosphonates in Early‐Stage Osteoarthritis." Journal of Bone and Mineral Research, vol. 36, no. 4, 2020, pp. 815-816. |
Hayes, Kaleen N., Nakhla, Nardine R., Tadrous, Mina. "Further Evidence to Monitor Long-term Proton Pump Inhibitor Use." JAMA Network Open, vol. 2, no. 11, 2019, pp. e1916184. |
Hayes KN, Ban JK, Athanasiadis G, Burden AM, Cadarette SM. "Time trends in oral bisphosphonate initiation in Ontario, Canada over 20 years reflect drug policy and healthcare delivery changes." Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 30, no. 11, 2019, pp. 2311-2319. |
Hayes, Kaleen N., Pan, Ingrid, Kunkel, Alyssa, McGivney, Melissa Somma, Thorpe, Carolyn T. "Evaluation of targeted human papillomavirus vaccination education among undergraduate college students." Journal of American College Health, vol. 67, no. 8, 2018, pp. 781-789. |
Year | Degree | Institution |
---|---|---|
2021 | PhD | University of Toronto |
2017 | PharmD | University of Pittsburgh |
Name | Title |
---|---|
Beaudoin, Francesca | Academic Dean of School of Public Health, Professor of Epidemiology, Professor of Emergency Medicine |
Gravenstein, Stefan | David S. Greer Professor of Geriatric Medicine, Director, Division of Geriatrics and Palliative Care, Professor of Health Services, Policy and Practice |
McConeghy, Kevin | Adjunct Assistant Professor of the Practice of Health Services, Policy and Practice |
Mor, Vincent | Florence Pirce Grant University Professor of Health Services, Policy and Practice, Professor of Health Services, Policy and Practice |
Zhang, Tingting | Assistant Professor of Health Services, Policy and Practice |
Zullo, Andrew | Associate Professor of Epidemiology, Associate Professor of Health Services, Policy and Practice |
PHP 2440 - Introduction to Pharmacoepidemiology |