Dr. Mende attended Medical School at the University of Hamburg in Germany, followed by postdoctoral training in the Department of Pharmacology at the University of Hamburg and in the Cardiovascular Division of Brigham and Women's Hospital and Harvard Medical School. She launched a career as an independent scientist and principal investigator at Brigham and Women's Hospital/Harvard Medical School. Dr. Mende was then recruited by Rhode Island Hospital and Brown Medical School to help establish a new Cardiovascular Research Center. Her research focuses on cell signaling in heart cells under normal and pathophysiological conditions. Her work has been funded by the American Heart Association (AHA) and the National Institutes of Health (NIH), where she has also been serving as grant reviewer for many years.
| Zhang, Peng, Kofron, Celinda M., Mende, Ulrike Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart. Life sciences. 2015; 129 : 35-41. |
| Chichger, Havovi, Vang, Alexander, O'Connell, Kelly A., Zhang, Peng, Mende, Ulrike, Harrington, Elizabeth O., Choudhary, Gaurav PKC δ and βII Regulate Angiotensin II Mediated Fibrosis through p38: A Mechanism of RV Fibrosis in Pulmonary Hypertension.. AJP: Lung Cellular and Molecular Physiology. 2015; 308 (8) : L827-36. |
| Zhang P, Mende U Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart.. Trends in cardiovascular medicine. 2014; 24 (2) : 85-93. |
| Zhang P, Su J, Mende U Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences.. American Journal of Physiology - Heart and Circulatory Physiology. 2012; 303 (12) : H1385-96. |
| Desroches BR, Zhang P, Choi BR, King ME, Maldonado AE, Li W, Rago A, Liu G, Nath N, Hartmann KM, Yang B, Koren G, Morgan JR, Mende U Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells.. American Journal of Physiology - Heart and Circulatory Physiology. 2012; 302 (10) : H2031-H2042. |
| Park-Windhol C, Zhang P, Zhu M, Su J, Chaves L Jr, Maldonado AE, King ME, Rickey L, Cullen D, Mende U Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2.. PLoS ONE. 2012; 7 (7) : e40048. |
| Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.. PLoS ONE. 2012; 7 (12) : e52667. |
| Mackiewicz U, Czarnowska E, Brudek M, Pająk B, Duda M, Emanuel K, Csanyi G, Fedorowicz A, Grochal E, Tyrankiewicz U, Skórka T, Mende U, Lewartowski B, Chłopicki S Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy.. Journal of Molecular and Cellular Cardiology. 2012; 52 (5) : 978-87. |
| Pinz I, Zhu M, Mende U, Ingwall JS An improved isolation procedure for adult mouse cardiomyocytes.. Cell biochemistry and biophysics. 2011; 61 (1) : 93-101. |
| Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.. Circulation journal : official journal of the Japanese Circulation Society. 2011; 75 (10) : 2333-42. |
| Zhang P, Su J, King ME, Maldonado AE, Park C, Mende U Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses.. American Journal of Physiology - Heart and Circulatory Physiology. 2011; 301 (1) : H147-56. |
| Zhang P, Mende U Regulators of G-protein signaling in the heart and their potential as therapeutic targets.. Circulation research. 2011; 109 (3) : 320-33. |
| Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.. Journal of Molecular and Cellular Cardiology. 2011; 50 (6) : 1000-7. |
| Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.. Heart rhythm : the official journal of the Heart Rhythm Society. 2009; 6 (1) : 78-84. |
| Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, Goto K, Mende U, Kubota I Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.. Circulation journal : official journal of the Japanese Circulation Society. 2008; 72 (2) : 309-17. |
| Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.. American Journal of Physiology - Heart and Circulatory Physiology. 2008; 294 (3) : H1335-47. |
| Drelicharz L, Kozlovski V, Skorka T, Heinze-Paluchowska S, Jasinski A, Gebska A, Guzik T, Olszanecki R, Wojnar L, Mende U, Csanyi G, Chlopicki S NO and PGI(2) in coronary endothelial dysfunction in transgenic mice with dilated cardiomyopathy.. Basic research in cardiology. 2008; 103 (5) : 417-30. |
| Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Liao R, Jain MK Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.. Proceedings of the National Academy of Sciences. 2007; 104 (17) : 7074-9. |
| Anger T, Klintworth N, Stumpf C, Daniel WG, Mende U, Garlichs CD RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.. Journal of biochemistry and molecular biology. 2007; 40 (6) : 899-910. |
| Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.. Proceedings of the National Academy of Sciences. 2006; 103 (39) : 14525-30. |
| Hao J, Michalek C, Zhang W, Zhu M, Xu X, Mende U Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.. Journal of Molecular and Cellular Cardiology. 2006; 41 (1) : 51-61. |
| Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, Gach A, Cui L, Liao R, Mende U Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.. Journal of Biological Chemistry. 2006; 281 (9) : 5811-20. |
| Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Ribeiro RS, Gereben B, Bianco AC, Mende U, Larsen PR Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.. Molecular endocrinology (Baltimore, Md.). 2004; 18 (7) : 1840-9. |
| Anger T, Zhang W, Mende U Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo.. Journal of Biological Chemistry. 2004; 279 (6) : 3906-15. |
| Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.. Science. 2003; 299 (5611) : 1410-3. |
| Gehrmann J, Meister M, Maguire CT, Martins DC, Hammer PE, Neer EJ, Berul CI, Mende U Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits.. American Journal of Physiology - Heart and Circulatory Physiology. 2002; 282 (2) : H445-56. |
| Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.. Journal of Clinical Investigation. 2002; 109 (8) : 1013-20. |
| Mende U, Semsarian C, Martins DC, Kagen A, Duffy C, Schoen FJ, Neer EJ Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype.. Journal of Molecular and Cellular Cardiology. 2001; 33 (8) : 1477-91. |
| Greif GJ, Sodickson DL, Bean BP, Neer EJ, Mende U Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o).. Journal of Neurophysiology. 2000; 83 (2) : 1010-8. |
| Mende U, Kagen A, Meister M, Neer EJ Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q).. Circulation research. 1999; 85 (11) : 1085-91. |
| Mende U, Zagrovic B, Cohen A, Li Y, Valenzuela D, Fishman MC, Neer EJ Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity.. Journal of neuroscience research. 1998; 54 (2) : 263-72. |
| Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, Neer EJ Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.. Proceedings of the National Academy of Sciences. 1998; 95 (23) : 13893-8. |
| Valenzuela D, Han X, Mende U, Fankhauser C, Mashimo H, Huang P, Pfeffer J, Neer EJ, Fishman MC G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.. Proceedings of the National Academy of Sciences. 1997; 94 (5) : 1727-32. |
| Eschenhagen T, Mende U, Diederich M, Hertle B, Memmesheimer C, Pohl A, Schmitz W, Scholz H, Steinfath M, Böhm M, Michel MC, Brodde OE, Raap A Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia.. Circulation. 1996; 93 (4) : 763-71. |
| Li Y, Mende U, Lewis C, Neer EJ Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cells.. Biochem. J.. 1996; 318 ( Pt 3) : 1071-7. |
| Bartel S, Stein B, Eschenhagen T, Mende U, Neumann J, Schmitz W, Krause EG, Karczewski P, Scholz H Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts.. Molecular and Cellular Biochemistry. 1996; 157 (1-2) : 171-9. |
| Stokke M, Hagelin EM, Mende U, Brørs O Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.. Pharmacology & toxicology. 1996; 78 (1) : 28-36. |
| Eschenhagen T, Diederich M, Kluge SH, Magnussen O, Mene U, Müller F, Schmitz W, Scholz H, Weil J, Sent U Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy.. Journal of Molecular and Cellular Cardiology. 1995; 27 (1) : 357-70. |
| Jakob H, Sigmund M, Eschenhagen T, Mende U, Patten M, Schmitz W, Scholz H, Schulte am Esch J, Steinfath M, Hanrath P Effect of captopril on myocardial beta-adrenoceptor density and Gi alpha-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy.. European journal of clinical pharmacology. 1995; 47 (5) : 389-94. |
| Boluyt MO, Long X, Eschenhagen T, Mende U, Schmitz W, Crow MT, Lakatta EG Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart.. The American journal of physiology. 1995; 269 (2 Pt 2) : H638-47. |
| Mende U, Schmidt CJ, Yi F, Spring DJ, Neer EJ The G protein gamma subunit. Requirements for dimerization with beta subunits.. Journal of Biological Chemistry. 1995; 270 (26) : 15892-8. |
| Böhm M, Eschenhagen T, Gierschik P, Larisch K, Lensche H, Mende U, Schmitz W, Schnabel P, Scholz H, Steinfath M Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure.. Journal of Molecular and Cellular Cardiology. 1994; 26 (2) : 133-49. |
| von Schrenck T, Mackensen B, Mende U, Schmitz W, Sievers J, Mirau S, Raedler A, Greten H Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction.. Naunyn-Schmiedeberg's archives of pharmacology. 1994; 349 (4) : 346-54. |
| Stein B, Mende U, Neumann J, Schmitz W, Scholz H Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes.. Journal of Molecular and Cellular Cardiology. 1993; 25 (6) : 655-9. |
| Eschenhagen T, Mende U, Schmitz W, Scholz H [Changes in gene expression in terminal myocardial failure].. Zeitschrift fur Kardiologie. 1992; 81 Suppl 4 : 33-40. |
| Eschenhagen T, Mende U, Nose M, Schmitz W, Scholz H, Haverich A, Hirt S, Döring V, Kalmár P, Höppner W Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.. Circulation research. 1992; 70 (4) : 688-96. |
| Mende U, Eschenhagen T, Geertz B, Schmitz W, Scholz H, Schulte am Esch J, Sempell R, Steinfath M Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart.. Naunyn-Schmiedeberg's archives of pharmacology. 1992; 345 (1) : 44-50. |
| Eschenhagen T, Mende U, Diederich M, Nose M, Schmitz W, Scholz H, Schulte am Esch J, Warnholtz A, Schäfer H Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart.. Molecular pharmacology. 1992; 42 (5) : 773-83. |
| Schmitz W, Eschenhagen T, Mende U, Müller FU, Neumann J, Scholz H Phosphodiesterase inhibition and positive inotropy in failing human myocardium.. Basic research in cardiology. 1992; 87 Suppl 1 : 65-71. |
| Bethke T, Eschenhagen T, Klimkiewicz A, Kohl C, von der Leyen H, Mehl H, Mende U, Meyer W, Neumann J, Rosswag S Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts.. Arzneimittel-Forschung. 1992; 42 (4) : 437-45. |
| Steinfath M, Danielsen W, von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Reich T, Schmitz W, Scholz H Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.. British Journal of Pharmacology. 1992; 105 (2) : 463-9. |
| Eschenhagen T, Mende U, Nose M, Schmitz W, Scholz H, Schulte am Esch J, Sempell R, Warnholtz A, Wüstel JM Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium.. Basic research in cardiology. 1992; 87 Suppl 1 : 51-64. |
| Eschenhagen T, Mende U, Schmitz W, Scholz H, Schulte am Esch J, Sempell R, Warnholtz A, Wüstel JM Beta-adrenoceptor stimulation-induced increase in cardiac Gi-protein expression and in carbachol sensitivity.. European heart journal. 1991; 12 Suppl F : 127-31. |
| Bethke T, Klimkiewicz A, Kohl C, von der Leyen H, Mehl H, Mende U, Meyer W, Neumann J, Schmitz W, Scholz H Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts.. Journal of cardiovascular pharmacology. 1991; 18 (3) : 386-97. |
| Eschenhagen T, Mende U, Nose M, Schmitz W, Scholz H, Warnholtz A, Wüstel JM Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart.. Naunyn-Schmiedeberg's archives of pharmacology. 1991; 343 (6) : 609-15. |
| von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Schmitz W, Scholz H, Starbatty J, Stein B, Wenzlaff H Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.. Naunyn-Schmiedeberg's archives of pharmacology. 1991; 344 (1) : 90-100. |
| Schmitz W, Eschenhagen T, Mende U, Müller FU, Scholz H The role of alpha 1-adrenergic and muscarinic receptors in cardiac function.. European heart journal. 1991; 12 Suppl F : 83-7. |
| Böhm M, Mende U, Schmitz W, Scholz H Cardiac alpha-receptors and cardiac hypertrophy in genetic predisposition to hypertension.. American Heart Journal. 1986; 112 (6) : 1347-9. |
| Böhm M, Mende U, Schmitz W, Scholz H Does an impaired adenosine mediated feedback control play a role in the development of hereditary dystrophic cardiomyopathy?. Cardiovascular research. 1986; 20 (8) : 568-73. |
| Böhm M, Mende U, Schmitz W, Scholz H Increased responsiveness to stimulation of alpha- but not beta-adrenoceptors in the hereditary cardiomyopathy of the Syrian hamster. Intact adenosine- and cholinoceptor-mediated isoprenaline antagonistic effect.. European journal of pharmacology. 1986; 128 (3) : 195-203. |
| Böhm M, Mende U, Schmitz W, Scholz H Increased sensitivity to alpha-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats.. Naunyn-Schmiedeberg's archives of pharmacology. 1986; 333 (3) : 284-9. |
Current Research Funding:
Title: Advancing Experimental Models top Study Intercellular Communication of Cardiac Cells
Grant/Source: R21 HL113918-01A1; NIH/NHLBI
Dates: 01/16/2013 - 12/31/2015 (NCE)
Amount: $137,500 per year (direct)
Role: Principal Investigator
Title: Regulation of Gq Signaling in Cardiac Fibroblasts and its Role in Cardiac Remodeling
Grant/Source: R01 HL114784-01A1; NIH/NHLBI
Dates: 09/01/2013 - 05/31/2017
Amount: $303,031 per year (direct)
Role: Principal Investigator
Title: A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the Organ
Source: R01 HL110791-01A1; NHLBI
Dates: 08/01/2013 - 05/31/2018
Amount: Partial salary support
Role: Co-Investigator (PI: Dr. G. Koren)
Title: Endothelial Injury and Repair: CardioPulmonary Vascular Biology COBRE
Source: P20 GM103652-01A1; NIH/NIGMS
Dates: 09/20/2013 - 05/31/2018
Amount: Partial salary support
Role: Faculty Mentor (PI: Dr. S. Round; Project PI: Dr. P. Zhang)
Title: Functional Integration of Aligned Engineered Cardiac Tissue in Infarcted Heart
Source: DEANS Award; Brown University
Dates: 11/01/2014 – 12/31/2015
Amount: $80,000
Role: Co-PI (with Dr. K. Coulombe)
| Year | Degree | Institution |
|---|---|---|
| 1988 | MD | University of Hamburg |
| Research Fellow | Harvard Medical School, Brigham and Women's Hospital, cardiovascular basic science | 1992-1995 | Boston, MA |
| Research Fellow | University of Hamburg, pharmacology | 1988-1992 | Germany |
| Name | Title |
|---|---|
| Choi, Bum-Rak | Associate Professor of Medicine (Research) |
| Coulombe, Kareen | Assistant Professor of Engineering, Assistant Professor of Molecular Pharmacology, Physiology and Biotechnology |
| Hoffman-Kim, Diane | Associate Professor of Medical Science, Associate Professor of Engineering |
| Koren, Gideon | Professor of Medicine |
| Morgan, Jeffrey | Professor of Medical Science, Professor of Engineering |
International Society for Heart Research
American Society for Biochemistry and Molecular Biology
American Heart Association
German Society of Heart and Circulation Research
American Physiological Society
