B.S. Syracuse University
Ph.D. Harvard University
Post Doctoral Fellow Massachusetts Institute of Technology
and Whitehead Institute for Biomedical Research
|Wilks BT, Evans EB, Nakhla MN, Morgan JR Directing fibroblast self-assembly to fabricate highly-aligned, collagen-rich matrices.. Acta Biomaterialia. 2018; 81 : 70-79.|
|Ip, Blanche C., Cui, Francis, Wilks, Benjamin T., Murphy, John, Tripathi, Anubhav, Morgan, Jeffrey R. Perfused Organ Cell-Dense Macrotissues Assembled from Prefabricated Living Microtissues. Advanced Biosystems/Advanced Biosystems. 2018; 2 (8) : 1800076.|
|Leary E, Rhee C, Wilks BT, Morgan JR Quantitative Live-Cell Confocal Imaging of 3D Spheroids in a High-Throughput Format.. SLAS TECHNOLOGY: Translating Life Sciences Innovation/SLAS TECHNOLOGY: Translating Life Sciences Innovation. 2018; 23 (3) : 231-242.|
|Schell, Jacquelyn Y., Wilks, Benjamin T., Patel, Mohak, Franck, Christian, Chalivendra, Vijaya, Cao, Xuan, Shenoy, Vivek B., Morgan, Jeffrey R. Harnessing cellular-derived forces in self-assembled microtissues to control the synthesis and alignment of ECM. Biomaterials. 2016; 77 : 120-129.|
|Susienka MJ, Wilks BT, Morgan JR Quantifying the kinetics and morphological changes of the fusion of spheroid building blocks.. Biofabrication. 2016; 8 (4) : 045003.|
|Ip BC, Cui F, Tripathi A, Morgan JR The bio-gripper: a fluid-driven micro-manipulator of living tissue constructs for additive bio-manufacturing.. Biofabrication. 2016; 8 (2) : 025015.|
|Curran, Sean, Achilli, Toni-Marie, Leary, Elizabeth, Wilks, Benjamin T., Vantangoli, Marguerite M., Boekelheide, Kim, Morgan, Jeffrey R. A 3D spheroid system to evaluate inhibitors of the ABCG2 transporter in drug uptake and penetration. Technology. 2015; 03 (01) : 54-63.|
|Curran, Sean, Vantangoli, Marguerite M., Boekelheide, Kim, Morgan, Jeffrey R. Architecture of Chimeric Spheroids Controls Drug Transport.. Cancer Microenvironment. 2015; 8 (2) : 101-109.|
|Blakely, Andrew M., Manning, Kali L., Tripathi, Anubhav, Morgan, Jeffrey R. Bio-Pick, Place, and Perfuse: A New Instrument for Three-Dimensional Tissue Engineering. Tissue engineering. Part C, Methods. 2015; 21 (7) : 737-746.|
|Blakely AM, Manning KL, Tripathi A, Morgan JR Bio-Pick, Place, and Perfuse: A New Instrument for Three-Dimensional Tissue Engineering.. Tissue engineering. Part C, Methods. 2015; 21 (7) : 737-46.|
|Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane A, Boekelheide K Into the depths: Techniques for in vitro three-dimensional microtissue visualization.. BioTechniques. 2015; 59 (5) : 279-86.|
|Dingle, Yu-Ting L., Boutin, Molly E., Chirila, Anda M., Livi, Liane L., Labriola, Nicholas R., Jakubek, Lorin M., Morgan, Jeffrey R., Darling, Eric M., Kauer, Julie A., Hoffman-Kim, Diane Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies . Tissue Engineering Part C: Methods/Tissue engineering. Part C, Methods. 2015; 21 (12) : 1274-1283.|
|Dingle YT, Boutin ME, Chirila AM, Livi LL, Labriola NR, Jakubek LM, Morgan JR, Darling EM, Kauer JA, Hoffman-Kim D Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies.. Tissue engineering. Part C, Methods. 2015; 21 (12) : 1274-83.|
|Svoronos AA, Tejavibulya N, Schell JY, Shenoy VB, Morgan JR Micro-mold design controls the 3D morphological evolution of self-assembling multicellular microtissues.. Tissue engineering. Part A. 2014; 20 (7-8) : 1134-44.|
|Achilli TM, McCalla S, Meyer J, Tripathi A, Morgan JR Multilayer Spheroids To Quantify Drug Uptake and Diffusion in 3D. Mol. Pharmaceutics. 2014; 11 (7) : 2071-81.|
|Shenoy, Vivek B., Wang, Hailong, Svoronos, Alexander A., Boudou, Thomas, Morgan, Jeffrey R., Chen, Christopher S. Necking and Failure of Constrained Contractile 3D Microtissues Induced by Cell Derived Tension. Biophysical Journal. 2014; 106 (2) : 614a-615a.|
|Patel RS, Chang A, Lysaght MJ, Morgan JR Control of the timing and dosage of IGF-I delivery from encapsulated cells.. Journal of tissue engineering and regenerative medicine. 2013; 7 (6) : 470-8.|
|Wang, H., Svoronos, A. A., Boudou, T., Sakar, M. S., Schell, J. Y., Morgan, J. R., Chen, C. S., Shenoy, V. B. Necking and failure of constrained 3D microtissues induced by cellular tension.. Proceedings of the National Academy of Sciences. 2013; 110 (52) : 20923-20928.|
|Wang, Hailong, Svoronos, Alexander A., Boudou, Thomas, Morgan, Jeffrey R., Chen, Christopher S., Shenoy, Vivek B. Necking and Failure of Constrained Contractile 3D Microtissues: Role of Geometry and Stiffness. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. 2013;|
|Achilli TM, Meyer J, Morgan JR Advances in the formation, use and understanding of multi-cellular spheroids.. Expert opinion on biological therapy. 2012; 12 (10) : 1347-60.|
|Desroches BR, Zhang P, Choi BR, King ME, Maldonado AE, Li W, Rago A, Liu G, Nath N, Hartmann KM, Yang B, Koren G, Morgan JR, Mende U Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells.. American Journal of Physiology - Heart and Circulatory Physiology. 2012; 302 (10) : H2031-H2042.|
|Youssef J, Chen P, Shenoy VB, Morgan JR Mechanotransduction is enhanced by the synergistic action of heterotypic cell interactions and TGF- 1. The FASEB Journal. 2012; 26 (6) : 2522-2530.|
|Bao BA, Lai CP, Naus CC, Morgan JR Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton.. Journal of Biological Chemistry. 2012; 287 (11) : 8407-16.|
|Ho DN, Kohler N, Sigdel A, Kalluri R, Morgan JR, Xu C, Sun S Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticles.. Theranostics. 2012; 2 (1) : 66-75.|
|Achilli TM, McCalla S, Tripathi A, Morgan JR Quantification of the kinetics and extent of self-sorting in three dimensional spheroids.. Tissue engineering. Part C, Methods. 2012; 18 (4) : 302-9.|
|Robins JC, Morgan JR, Krueger P, Carson SA Bioengineering anembryonic human trophoblast vesicles.. Reproductive sciences (Thousand Oaks, Calif.). 2011; 18 (2) : 128-35.|
|Bao B, Jiang J, Yanase T, Nishi Y, Morgan JR Connexon-mediated cell adhesion drives microtissue self-assembly.. The FASEB Journal. 2011; 25 (1) : 255-64.|
|Holt B, Tripathi A, Morgan JR Designing polyHEMA substrates that mimic the viscoelastic response of soft tissue.. Journal of Biomechanics. 2011; 44 (8) : 1491-8.|
|Tejavibulya N, Youssef J, Bao B, Ferruccio TM, Morgan JR Directed self-assembly of large scaffold-free multi-cellular honeycomb structures.. Biofabrication. 2011; 3 (3) : 034110.|
|Youssef, J., Nurse, A. K., Freund, L. B., Morgan, J. R. Quantification of the forces driving self-assembly of three-dimensional microtissues.. Proceedings of the National Academy of Sciences. 2011; 108 (17) : 6993-8.|
|Leonard EF, Morgan JR, Nerem RM In remembrance: Michael J. Lysaght, 1942-2009.. Tissue engineering. Part A. 2010; 16 (3) : 767-8.|
|Krotz SP, Robins JC, Ferruccio TM, Moore R, Steinhoff MM, Morgan JR, Carson S In vitro maturation of oocytes via the pre-fabricated self-assembled artificial human ovary.. Journal of assisted reproduction and genetics. 2010; 27 (12) : 743-50.|
|Jarrell JD, Dolly B, Morgan JR Rapid screening, in vitro study of metal oxide and polymer hybrids as delivery coatings for improved soft-tissue integration of implants.. Journal of Biomedical Materials Research Part A. 2010; 92 (3) : 1094-104.|
|Livoti CM, Morgan JR Self-assembly and tissue fusion of toroid-shaped minimal building units.. Tissue engineering. Part A. 2010; 16 (6) : 2051-61.|
|Patel RS, Temu TM, Jeanbart L, Morgan JR, Lysaght MJ A localizable, biological-based system for the delivery of bioactive IGF-1 utilizing microencapsulated genetically modified human fibroblasts.. ASAIO Journal. 2009; 55 (3) : 259-65.|
|Jarrell JD, Dolly B, Morgan JR Controlled release of vanadium from titanium oxide coatings for improved integration of soft tissue implants.. Journal of Biomedical Materials Research Part A. 2009; 90 (1) : 272-81.|
|Rago AP, Dean DM, Morgan JR Controlling cell position in complex heterotypic 3D microtissues by tissue fusion.. Biotechnology and Bioengineering. 2009; 102 (4) : 1231-41.|
|Rago AP, Chai PR, Morgan JR Encapsulated arrays of self-assembled microtissues: an alternative to spherical microcapsules.. Tissue engineering. Part A. 2009; 15 (2) : 387-95.|
|Dean DM, Rago AP, Morgan JR Fibroblast elongation and dendritic extensions in constrained versus unconstrained microtissues.. Cell motility and the cytoskeleton. 2009; 66 (3) : 129-41.|
|Xu, Chenjie, Xie, Jin, Ho, Don, Wang, Chao, Kohler, Nathan, Walsh, Edward G., Morgan, Jeffrey R., Chin, Y. Eugene, Sun, Shouheng Au-Fe3O4 dumbbell nanoparticles as dual-functional probes.. Angew. Chem. Int. Ed. Engl.. 2008; 47 (1) : 173-176.|
|Dean DM, Morgan JR Cytoskeletal-mediated tension modulates the directed self-assembly of microtissues.. Tissue engineering. Part A. 2008; 14 (12) : 1989-97.|
|Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids.. Journal of Biological Chemistry. 2008; 283 (19) : 13021-30.|
|Rago AP, Napolitano AP, Dean DM, Chai PR, Morgan JR Miniaturization of an Anoikis assay using non-adhesive micromolded hydrogels.. Cytotechnology. 2008; 56 (2) : 81-90.|
|Holt, Brian, Tripathi, Anubhav, Morgan, Jeffrey Viscoelastic response of human skin to low magnitude physiologically relevant shear. Journal of Biomechanics. 2008; 41 (12) : 2689-2695.|
|Aaron RK, Morgan JR Biohybrid limbs: new materials and new properties.. Medicine and health, Rhode Island. 2007; 90 (1) : 4-6.|
|Napolitano AP, Chai P, Dean DM, Morgan JR Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels.. Tissue engineering. 2007; 13 (8) : 2087-94.|
|Sobral, C.S., Ferreira, L.M., Morgan, J., Filho, A.G. Experimental burn model using human keratinocytes cultured over collagen matrix. Burns. 2007; 33 (1) : S140.|
|Sobral CS, Gragnani A, Cao X, Morgan JR, Ferreira LM Human keratinocytes cultured on collagen matrix used as an experimental burn model.. Journal of burns and wounds. 2007; 7 : e6.|
|Sobral, C.S., Gragnani, A., Morgan, J., Ferreira, L.M. Inhibition of proliferation of Pseudomonas aeruginosa by KGF in an experimental burn model using human cultured keratinocytes. Burns. 2007; 33 (5) : 613-620.|
|Jarrell JD, Eun TH, Samale M, Briant C, Sheldon BW, Morgan JR Metal oxide coated cell culture arrays for rapid biological screening. Journal of Biomedical Materials Research Part A. 2007; 83 (3) : 853-860.|
|Lohmueller, J., Cumbers, J., Schmidt, M., Hickey, B., Lattanzi, V., Brodsky, A.S., Morgan, J., Tam, L.-K., Urabe, H., Neretti, N., Lemon, J., Gao, A., Goldstein, P., Jaklenec, A., Kaka, A., Haberstroh, K., Palmore, T., Gagnon, J., Wessel, G. Progress toward construction and modelling of a tri-stable toggle switch in E. coli. IET Synthetic Biology. 2007; 1 (1) : 25-28.|
|Sobral, C.S., Ferreira, L.M., Morgan, J., Cao, X., Ipolito, M.Z., Filho, A.G. Pseudomonas aeruginosa proliferation is diminished by KGF in experimental burn model using genetically modified keratinocytes. Burns. 2007; 33 (1) : S121.|
|Dean, D. M., Napolitano, A. P., Youssef, J., Morgan, J. R. Rods, tori, and honeycombs: the directed self-assembly of microtissues with prescribed microscale geometries. The FASEB Journal. 2007; 21 (14) : 4005-12.|
|Napolitano, Anthony, Dean, Dylan, Man, Alan, Youssef, Jacquelyn, Ho, Don, Rago, Adam, Lech, Matthew, Morgan, Jeffrey Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels. BioTechniques. 2007; 43 (4) : 494-500.|
|Napolitano AP, Dean DM, Man AJ, Youssef J, Ho DN, Rago AP, Lech MP, Morgan JR Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels.. BioTechniques. 2007; 43 (4) : 494, 496-500.|
|Campaner, A.B., Cusik, J., Bruder, J., Sobral, C., Morgan, J., Filho, A.G., Ferreira, L.M. Upregulation of TGF-â1 expression may be necessary but is not sufficient for excessive scarring. Burns. 2007; 33 (1) : S124.|
|Dabiri G, Campaner A, Morgan JR, Van De Water L A TGF-beta1-dependent autocrine loop regulates the structure of focal adhesions in hypertrophic scar fibroblasts.. Journal of Investigative Dermatology. 2006; 126 (5) : 963-70.|
|Aaron RK, Herr HM, Ciombor DM, Hochberg LR, Donoghue JP, Briant CL, Morgan JR, Ehrlich MG Horizons in prosthesis development for the restoration of limb function.. Journal of the American Academy of Orthopaedic Surgeons. 2006; 14 (10 Spec No.) : S198-204.|
|Paek, Hyun J., Campaner, Anelisa B., Kim, Jennifer L., Golden, Louis, Aaron, Roy K., Ciombor, Deborah M., Morgan, Jeffrey R., Lysaght, Michael J. Microencapsulated Cells Genetically Modified to Overexpress Human Transforming Growth Factor-1: Viability and Functionality in Allogeneic and Xenogeneic Implant Models. Tissue engineering. 2006; 0 (0) : 060802052515003.|
|Paek HJ, Campaner AB, Kim JL, Golden L, Aaron RK, Ciombor DM, Morgan JR, Lysaght MJ Microencapsulated cells genetically modified to overexpress human transforming growth factor-beta1: viability and functionality in allogeneic and xenogeneic implant models.. Tissue engineering. 2006; 12 (7) : 1733-9.|
|Campaner AB, Ferreira LM, Gragnani A, Bruder JM, Cusick JL, Morgan JR Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring.. Journal of Investigative Dermatology. 2006; 126 (5) : 1168-76.|
|Paek HJ, Campaner AB, Kim JL, Aaron RK, Ciombor DM, Morgan JR, Lysaght MJ In vitro characterization of TGF-beta1 release from genetically modified fibroblasts in Ca(2+)-alginate microcapsules.. ASAIO Journal. 2005; 51 (4) : 379-84.|
|Paek, Hyun J, Campaner, Anelisa B, Morgan, Jeffrey R, Aaron, Roy K, Ciombor, Deborah M, Lysaght, Michael J IN-VIVO CHARACTERIZATION OF BIOLOGICAL CONTROLLED-RELEASE DEVICE FOR IN-SITU DELIVERY OF TGF-??1 FOR ORTHOPEDIC TISSUE ENGINEERING. ASAIO Journal. 2005; 51 (2) : 17A.|
|Paek, H.J., Moise, L.J., Morgan, J.R., Lysaght, M.J. Origin of Insulin Secreted from Islet-Like Cell Clusters Derived from Murine Embryonic Stem Cells. Cloning and Stem Cells. 2005; 7 (4) : 226-231.|
|Paek HJ, Morgan JR, Lysaght MJ Sequestration and synthesis: the source of insulin in cell clusters differentiated from murine embryonic stem cells.. STEM CELLS. 2005; 23 (7) : 862-7.|
|Paek, Hyun J, Moise, Leonard J, Morgan, Jeffrey R, Lysaght, Michael J SOURCE OF INSULIN SECRETED BY ISLET-LIKE CELL CLUSTERS (ILCCs) DERIVED FROM MURINE EMBRYONIC STEM (mES) CELLS. ASAIO Journal. 2005; 51 (2) : 6A.|
|Erdag G, Morgan JR Allogeneic versus xenogeneic immune reaction to bioengineered skin grafts.. Cell transplantation. 2004; 13 (6) : 701-12.|
|Davis HE, Rosinski M, Morgan JR, Yarmush ML Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation.. Biophysical Journal. 2004; 86 (2) : 1234-42.|
|Gragnani, Alfredo, Morgan, Jeffrey R., Ferreira, Lydia Masako Experimental model of cultured skin graft. Acta Cirurgica Brasileira. 2004; 19 : 4-10.|
|ERDAG, G FGF-7 Expression Enhances the Performance of Bioengineered Skin. Molecular therapy : the journal of the American Society of Gene Therapy. 2004; 10 (1) : 76-85.|
|Hamoen KE, Erdag G, Cusick JL, Rakhorst HA, Morgan JR Genetically modified skin substitutes. Preparation and use.. Methods in molecular medicine. 2002; 69 : 203-17.|
|Erdag G, Morgan JR Interleukin-1alpha and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts.. Annals of Surgery. 2002; 235 (1) : 113-24.|
|Davis HE, Morgan JR, Yarmush ML Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes.. Biophysical chemistry. 2002; 97 (2-3) : 159-72.|
|Hamoen KE, Morgan JR Transient hyperproliferation of a transgenic human epidermis expressing hepatocyte growth factor.. Cell transplantation. 2002; 11 (4) : 385-95.|
|Le Doux, Joseph M., Landazuri, Natalia, Yarmush, Martin L., Morgan, Jeffrey R. Complexation of Retrovirus with Cationic and Anionic Polymers Increases the Efficiency of Gene Transfer. Human gene therapy. 2001; 12 (13) : 1611-1621.|
The Morgan lab has devised a new method for culturing cells in three dimensions (3D) and is using this technology to answer fundamental questions in three synergistic areas: 3D tissue engineering , 3D cell-cell mechanics and 3D drug transport . These areas are relevant to important medical needs including the shortage of organs for transplantation, the lack of effective treatments for fibrosis, multi-drug resistance in cancer and the quest to find new and less toxic drugs while reducing the use of animals in research. It has been widely recognized that cells cultured in 2D do not adequately mimic native tissues and organs and in recent years the field of tissue engineering has developed new methods for growing cells in 3D. The Morgan lab invented the 3D PetriDish®, now commercially available Microtissues, Inc (Sigma-Aldrich) to grow cells in 3D using micro-molded agarose gels. Unlike most methods in tissue engineering that attach cells to a scaffold, cells attach to each other in the 3D PetriDish®. Cells are seeded into micro-molded nonadhesive agarose gels where they self-assemble 3D multi-cellular microtissues of varying sizes and shapes from simple spheroids to more complex honeycomb structures in typically 24 hours. Like native tissue, cell density is high and cell-cell interactions such as mechanics and signaling are maximized. The Morgan Lab as well as many others has shown that this platform technology works for many different cell types including primary cells, cancer cell lines and stem cells.
In 3D tissue engineering , the Morgan lab has shown that micro-molds can produce microtissues in complex shapes such as toroids and honeycombs and that these microtissues will fuse to one another when placed in close contact. These structures with their open lumens that mimic an element of the vasculature are intriguing and we are investigating whether these microtissues can be used as building blocks to fabricate larger tissues and eventually organs.
In 3D cell-cell mechanics , the Morgan lab is making microtissues with various shapes such as loop ended dogbones, rods, and toroids-on-cones to investigate the mechanical forces that cells exert on one another in the context of a 3D multi-cellular microtissue. We have used the toroid-on-cone assay to quantify the work performed by a multi-cellular toroid as it contracts up the cone and shown that mixtures of fibroblasts and hepatocytes exert surprisingly high levels of force; a result relevant to fibrosis.
In 3D drug transport , the Morgan lab is using 3D spheroids to quantify the uptake and diffusion of various drugs through the multiple layers of cells as well as the role of drug efflux pumps that pump drugs out of cells. Drug transport is of fundamental importance to the efficacy and toxicity of all drugs and so is of great interest to the pharmaceutical industry. Moreover, some of these efflux pumps are upregulated in cancer which can lead to multi-drug resistance, an important clinical problem in need of new and more effective inhibitors.
Blakely, A.M., Manning, K.L., Tripathi, A. and Morgan, J.R. Bio-Pick, Place and Perfuse: A New Instrument for 3D Tissue Engineering. Tissue Eng. In Press.
Curran, S., Achilli, T-M, Leary, E., Wilks, B., Vantangoli, M.M., Boekelheide, K., and Morgan, J.R. A 3D Spheroid System to Evaluate Inhibitors of the ABCG2 Transporter in Drug Uptake and Penetration. TECHNOLOGY 3: 54-63, 2015
Achilli, T-M, McCalla, S., Meyer, J., Tripathi, A., Morgan, J.R. Multilayer Spheroids to Quantify Drug Uptake and Diffusion in 3D. Molecular Pharmaceutics, 11: 2071-2081, 2014. PMCID# PMC4096226
Svoronos, A. A., Tejavibulya, N., Schell, J.Y., Shenoy, V.B. and Morgan, J.R. Micro-mold Design Controls the 3D Morphological Evolution of Self-assembling Multi-cellular Microtissues. Tissue Eng. 20: 1134-1144, 2014.
Wang, H., Svoronos, A. A., Boudou, T., Chen, S. C., Morgan, J.R, and Shenoy V.B. Necking and Failure of Constrained Contractile 3D Microtissues: Role of Geometry and Stiffness. Proc. Nat'l. Acad. Sci. USA. 110(52): 20923-20928, 2013.
Desroches, B.R., Zhang, P., Choi, B., Maldonado, A.E., Rago, A., Liu, G.X. Nath, N., King, M.E., Hartmann, K.M., Yang, B., Koren, G., Morgan, J.R. and Mende U. Functional Scaffold-free Cardiac Microtissues: A Novel Model for the Investigation of Heart Cells. Am J Physiol. Heart Circ. Physiol 302: H22031-H220442, 2012.
Youssef, J., Chen, P., Shenoy, V.B. and Morgan, J.R. Mechano-Transduction is Enhanced by the Synergistic Action of Heterotypic Cell Interactions and TGF-B1. FASEB J. 26: 2522-2530, 2012. PMID: 22375018 [PubMed - as supplied by publisher].
Ho, D.N., Kohler, N., Sigdel, A., Killuri, R., Morgan, J.R., Xu, C., Sun, S.S. Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles. Theranostics. 2: 66-75, 2012. PMCID: PMC3263517.
Achilli, T-M., McCalla, S., Tripathi, A. and Morgan, J.R. Quantification of the Kinetics and Extent of Self-sorting in Three Dimensional Spheroids. Tissue Eng. 18: 302-309, 2012. PMCID: PMC3312373.
Bao, B.A., Lai, C.P.K., Naus, C.C., and Morgan, J.R. Pannexin 1 Drives Multicellular Compaction Via a Signaling Cascade that Upregulates Cytoskeletal Function. J. Biol Chem. 287: 8407-8416, 2012. PMCID: PMC3318751.
Tejavibulya, N., Youssef, J., Bao, B., Ferruccio, T-M and Morgan, J.R. Directed Self-Assembly of Large Scaffold-free Multi-cellular Honeycomb Structures. Biofabrication 3, 1-9, 2011. PMCID: PMC3176969.
Youssef, J., Nurse, A., Freund, L.B. and Morgan, J.R. Quantification of the Forces Driving Self-assembly of 3D Micro-tissues. Proc. Nat'l. Acad. Sci. USA. 108: 6993-6998, 2011. PMCID: PMC3084067.
Bao, B., Jiang, J. Yanase, T., Nishi, Y., and Morgan, J.R. Connexon-mediated Cell Adhesion Drives Microtissue Self-assembly. FASEB J. 25: 255-264, 2011. PMCID: PMC3005422.
Robins, J.C., Morgan, J.R., Krueger, P. Carson, S.A. Bioengineering Anembryonic Human Trophoblast Vesicles. Reproductive Sciences 18: 128-135, 2011. PMID: 20978180.
Krotz, S.F., Robins, J.C., Ferruccio, T-M., Moore, R., Steinhoff, M.M., Morgan, J.R. and Carson, S. In Vitro Maturation of Oocytes via Pre-fabricated Self-assembled Artificial Human Ovary. J. of Assisted Reproduction and Genetics.27: 743-750, 2010. PMCID: PMC2997950.
Livoti, C.M., and Morgan, J.R. Self-Assembly and Tissue Fusion of Toroid-Shaped Minimal Building Units. Tissue Eng. 16: 2051-2061, 2010. PMCID: PMC2949232.
Dean, D.M. and Morgan, J.R. Fibroblast Elongation and Dendritic Extensions in Constrained Versus Unconstrained Microtissues. Cell Motility and the Cytoskeleton 66: 129-141, 2009. PMID: 19170224.
Rago, A.P., Dean, D.M., Morgan, J.R. Controlling Cell Position in Complex Heterotypic 3D Microtissues by Tissue Fusion. Biotech. & Bioeng. 102: 1231-1241, 2009. PMID: 19012266.
Rago, A.P., Chai, P., Morgan, J.R. Encapsulated Arrays of Self-Assembled Micro-tissues: An Alternative to Spherical Microcapsules. Tissue Eng. 15: 387-395, 2009. PMID: 19193131.
Dean, D.M. and Morgan, J.R. Cytoskeletal-Mediated Tension Modulates the Directed Self-assembly of Microtissues. Tissue Eng. 14: 1989-1997, 2008. PMID: 18673088.
Barbone, D., Yang, T-M, Morgan, J.R., Gaudino, G., Broaddus, V.C. mTOR Contributes to the Acquired Multicellular Apoptotic Resistance of Human Malignant Mesothelioma Spheroids. J. Biol. Chem. 283: 13021-13030, 2008. PMCID: PMC2259263.
Dean, D.M., Napolitano, A.P., Youssef, J., Morgan, J.R. Rods, Tori and Honeycombs. The Directed Self-Assembly of Microtissues with Prescribed Microscale Geometries. FASEB J. 21: 4005-4012, 2007. PMID: 17627028.
Napolitano, A.P., Chai, P., Dean, D.M., Morgan, J.R. Dynamics of the Self-Assembly of Complex Cellular Aggregates on Micro-Molded Non-Adhesive Hydrogels. Tissue Eng. 13: 2087-2094, 2007. PMID: 17518713.
1977 Departmental Award for Outstanding Achievement in Biology, Syracuse University, Syracuse, NY
1978 National Research Service Award in Viral Oncology
1983-1986 Damon Runyon Walter Winchell Postdoctoral Fellowship
1986-1988 Cancer Research Institute Postdoctoral Fellowship
1996 La Roche-Posay International Foundation Prize
1996 European Association of Plastic Surgeons Honorary Lecture
2014 Editorial board member of TECHNOLOGY
2015 Fellow, National Academy of Inventors
2016 Fellow, Amercian Institute of Medical and Biological Engineering
|Boekelheide, Kim||Professor of Medical Science, Director of Superfund Research|
|Hurt, Robert||Professor of Engineering|
|Kane, Agnes||Professor of Medical Science|
|Mathiowitz, Edith||Professor of Medical Science, Graduate Program Director for the Biotechnology Graduate Program, Professor of Engineering|
|Tripathi, Anubhav||Professor of Engineering, Professor of Molecular Pharmacology, Physiology and Biotechnology, Director of Biomedical Engineering|
|BIOL 2089 - The Importance of Intellectual Property in Biotechnology|
|BIOL 2167 - In Vitro Models for Disease|
|BIOL 2180 - Experiential Learning Industry, ELI|
|BIOL 2240 - Biomedical Engineering and Biotechnology Seminar|