Kim Boekelheide is Professor of Pathology and Laboratory Medicine at the Brown University School of Medicine. He received his B.A. from Harvard University, and M.D. and Ph.D. from Duke University. His research examines fundamental molecular mechanisms by which environmental and occupational toxicants induce testicular injury. Current projects include the development of novel in vitro approaches to safety assessment, use of xenotransplantation approaches for human-relevant toxicity testing, and the discovery of sperm molecular biomarkers that reflect testicular injury. He is Associate Director of the Brown University Superfund Research Program and Associate Director of the Center to Advance Predictive Biology. His research has been continuously funded by the National Institute of Environmental Health Sciences since 1985 and he has received several awards including a Burroughs Wellcome Toxicology Scholar Award (1994-1999) and the Lifetime Achievement Award from the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology (2015)
| Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K. "All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. I: Altered seminiferous cord maturation and testicular cell fate." Toxicological Sciences, vol. 167, no. 1, 2018, pp. 546-558. |
| Dere E, Anderson LM, Huse SM, Spade DJ, McDonnell-Clark E, Madnick SJ, Hall SJ, Camacho L, Lewis SM, Vanlandingham MM, Boekelheide K. "Effects of continuous bisphenol A exposure from early gestation on 90 day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study." Toxicology and Applied Pharmacology, vol. 347, 2018, pp. 1-9. |
| Bianchi E, Stermer A, Boekelheide K, Sigman M, Hall SJ, Reyes G, Dere E, Hwang K. "High-quality human and rat spermatozoal RNA isolation for functional genomic studies." Andrology, vol. 6, no. 2, 2018, pp. 374-383. |
| Spade DJ, Bai CY, Lambright C, Conley JM, Boekelheide K, Gray LE. "Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells." Toxicology Letters, vol. 290, 2018, pp. 55-61. |
| Dere, Edward, Spade, Daniel J., Hall, Susan J., Altemus, Aimee, Smith, James D., Phillips, Jonathan A., Moffit, Jeffrey S., Blanchard, Kerry T., Boekelheide, Kim. "Identification of sperm mRNA biomarkers associated with testis injury during preclinical testing of pharmaceutical compounds." Toxicology and Applied Pharmacology, vol. 320, 2017, pp. 1-7. |
| Pendse SN, Maertens A, Rosenberg M, Roy D, Fasani RA, Vantangoli MM, Madnick SJ, Boekelheide K, Fornace AJ, Odwin SA, Yager JD, Hartung T, Andersen ME, McMullen PD. "Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity." Archives of toxicology, vol. 91, no. 4, 2017, pp. 1749-1762. |
| Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T. "Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function." Scientific reports, vol. 6, 2016, pp. 33011. |
| Dere, Edward, Wilson, Shelby K., Anderson, Linnea M., Boekelheide, Kim. "From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure." Toxicological Sciences, vol. 153, no. 2, 2016, pp. 327-340. |
| Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T. "Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function." Scientific reports, vol. 6, 2016, pp. 28994. |
| Bianchi E, Boekelheide K, Sigman M, Lamb DJ, Hall SJ, Hwang K. "Ghrelin ameliorates adhesions in a postsurgical mouse model." Journal of Surgical Research, vol. 201, no. 1, 2016, pp. 226-234. |
| Bianchi E, Boekelheide K, Sigman M, Lamb DJ, Hall SJ, Hwang K. "Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway." PLOS ONE, vol. 11, no. 4, 2016, pp. e0153968. |
| Dere E, Huse S, Hwang K, Sigman M, Boekelheide K. "Intra- and inter-individual differences in human sperm DNA methylation." Andrology, vol. 4, no. 5, 2016, pp. 832-42. |
| Vantangoli, Marguerite M., Wilson, Shelby, Madnick, Samantha J., Huse, Susan M., Boekelheide, Kim. "Morphologic effects of estrogen stimulation on 3D MCF-7 microtissues." Toxicology Letters, vol. 248, 2016, pp. 1-8. |
| Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. "The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions." Environ Health Perspect, vol. 124, no. 11, 2016, pp. 1671-1682. |
| Curran, Sean, Achilli, Toni-Marie, Leary, Elizabeth, Wilks, Benjamin T., Vantangoli, Marguerite M., Boekelheide, Kim, Morgan, Jeffrey R. "A 3D spheroid system to evaluate inhibitors of the ABCG2 transporter in drug uptake and penetration." Technology, vol. 03, no. 01, 2015, pp. 54-63. |
| Saffarini CM, McDonnell-Clark EV, Amin A, Boekelheide K. "A Human Fetal Prostate Xenograft Model of Developmental Estrogenization." International Journal of Toxicology, vol. 34, no. 2, 2015, pp. 119-28. |
| Curran, Sean, Vantangoli, Marguerite M., Boekelheide, Kim, Morgan, Jeffrey R. "Architecture of Chimeric Spheroids Controls Drug Transport." Cancer Microenvironment, vol. 8, no. 2, 2015, pp. 101-109. |
| Saffarini, Camelia M., McDonnell-Clark, Elizabeth V., Amin, Ali, Huse, Susan M., Boekelheide, Kim. "Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model." PLoS ONE, vol. 10, no. 3, 2015, pp. e0122290. |
| Spade DJ, Hall SJ, Wilson S, Boekelheide K. "Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism." Biology of Reproduction, vol. 93, no. 5, 2015, pp. 110-110. |
| Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane A, Boekelheide K. "Into the depths: Techniques for in vitro three-dimensional microtissue visualization." BioTechniques, vol. 59, no. 5, 2015, pp. 279-86. |
| De Paepe ME, Chu S, Hall SJ, McDonnell-Clark E, Heger NE, Schorl C, Mao Q, Boekelheide K. "Intussusceptive-like angiogenesis in human fetal lung xenografts: Link with bronchopulmonary dysplasia-associated microvascular dysangiogenesis?." Experimental lung research, vol. 41, no. 9, 2015, pp. 477-88. |
| Vantangoli, Marguerite M., Madnick, Samantha J., Huse, Susan M., Weston, Paula, Boekelheide, Kim. "MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels." PLoS ONE, vol. 10, no. 8, 2015, pp. e0135426. |
| Huse SM, Gruppuso PA, Boekelheide K, Sanders JA. "Patterns of gene expression and DNA methylation in human fetal and adult liver." BMC genomics, vol. 16, no. 1, 2015, pp. 981. |
| Bouhifd M, Andersen ME, Baghdikian C, Boekelheide K, Crofton KM, Fornace AJ Jr, Kleensang A, Li H, Livi C, Maertens A, McMullen PD, Rosenberg M, Thomas R, Vantangoli M, Yager JD, Zhao L, Hartung T. "The human toxome project." ALTEX, vol. 32, no. 2, 2015, pp. 112-24. |
| Rider CV, Boekelheide K, Catlin N, Gordon CJ, Morata T, Selgrade MK, Sexton K, Simmons JE. "Cumulative risk: toxicity and interactions of physical and chemical stressors." Toxicological Sciences, vol. 137, no. 1, 2014, pp. 3-11. |
| Spade DJ, Hall SJ, Saffarini CM, Huse SM, McDonnell EV, Boekelheide K. "Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay." Toxicological Sciences, vol. 138, no. 1, 2014, pp. 148-60. |
| Thompson MR, Burdon A, Boekelheide K. "Practice-based evidence informs environmental health policy and regulation: a case study of residential lead-soil contamination in Rhode Island." Science of The Total Environment, vol. 468-469, 2014, pp. 514-22. |
| Hwang, K., Bianchi, E., Sigman, M., Lamb, D.J., Boekelheide, K. "Special research presentation: defining the role of ghrelin in wound healing and the inflammatory response in the post-operative setting." Fertility and Sterility, vol. 102, no. 3, 2014, pp. e2. |
| Catlin, N. R., Huse, S. M., Boekelheide, K. "The Stage-specific Testicular Germ Cell Apoptotic Response to Low-dose Radiation and 2,5-hexanedione Combined Exposure. II: qRT-PCR Array Analysis Reveals Dose Dependent Adaptive Alterations in the Apoptotic Pathway." Toxicologic Pathology, vol. 42, no. 8, 2014, pp. 1229-1237. |
| Catlin, N. R., Huse, S. M., Boekelheide, K. "The Stage-specific Testicular Germ Cell Apoptotic Response to Low-dose X-irradiation and 2,5-hexanedione Combined Exposure. I: Validation of the Laser Capture Microdissection Method for qRT-PCR Array Application." Toxicologic Pathology, vol. 42, no. 8, 2014, pp. 1221-1228. |
| Spade, Daniel J., McDonnell, Elizabeth V., Heger, Nicholas E., Sanders, Jennifer A., Saffarini, Camelia M., Gruppuso, Philip A., De Paepe, Monique E., Boekelheide, Kim. "Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues." Birth Defects Res B, vol. 101, no. 6, 2014, pp. 410-422. |
| Chapin RE, Boekelheide K, Cortvrindt R, van Duursen MB, Gant T, Jegou B, Marczylo E, van Pelt AM, Post JN, Roelofs MJ, Schlatt S, Teerds KJ, Toppari J, Piersma AH. "Assuring safety without animal testing: the case for the human testis in vitro." Reproductive toxicology (Elmsford, N.Y.), vol. 39, 2013, pp. 63-8. |
| Dere E, Anderson LM, Hwang K, Boekelheide K. "Biomarkers of chemotherapy-induced testicular damage." Fertility and Sterility, vol. 100, no. 5, 2013, pp. 1192-202. |
| Stephens ML, Andersen M, Becker RA, Betts K, Boekelheide K, Carney E, Chapin R, Devlin D, Fitzpatrick S, Fowle JR 3rd, Harlow P, Hartung T, Hoffmann S, Holsapple M, Jacobs A, Judson R, Naidenko O, Pastoor T, Patlewicz G, Rowan A, Scherer R, Shaikh R, Simon T, Wolf D, Zurlo J. "Evidence-based toxicology for the 21st century: opportunities and challenges." ALTEX, vol. 30, no. 1, 2013, pp. 74-103. |
| Saffarini CM, McDonnell EV, Amin A, Spade DJ, Huse SM, Kostadinov S, Hall SJ, Boekelheide K. "Maturation of the developing human fetal prostate in a rodent xenograft model." The Prostate, vol. 73, no. 16, 2013, pp. 1761-75. |
| Thompson MR, Boekelheide K. "Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factors." Environmental Research, vol. 121, 2013, pp. 23-30. |
| Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. "SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures." Toxicological Sciences, vol. 136, no. 2, 2013, pp. 265-73. |
| Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F. "The current status of biomarkers for predicting toxicity." Expert Opinion on Drug Metabolism & Toxicology, vol. 9, no. 11, 2013, pp. 1391-408. |
| Davis M, Boekelheide K, Boverhof DR, Eichenbaum G, Hartung T, Holsapple MP, Jones TW, Richard AM, Watkins PB. "The new revolution in toxicology: the good, the bad, and the ugly." Annals of the New York Academy of Sciences, vol. 1278, 2013, pp. 11-24. |
| Stephens ML, Barrow C, Andersen ME, Boekelheide K, Carmichael PL, Holsapple MP, Lafranconi M. "Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop." Toxicological Sciences, vol. 125, no. 2, 2012, pp. 327-34. |
| Heger NE, Hall SJ, Sandrof MA, McDonnell EV, Hensley JB, McDowell EN, Martin KA, Gaido KW, Johnson KJ, Boekelheide K. "Human fetal testis xenografts are resistant to phthalate-induced endocrine disruption." Environ Health Perspect, vol. 120, no. 8, 2012, pp. 1137-43. |
| Saffarini CM, Heger NE, Yamasaki H, Liu T, Hall SJ, Boekelheide K. "Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice." Journal of andrology, vol. 33, no. 3, 2012, pp. 505-13. |
| Campion S, Catlin N, Heger N, McDonnell EV, Pacheco SE, Saffarini C, Sandrof MA, Boekelheide K. "Male reprotoxicity and endocrine disruption." EXS, vol. 101, 2012, pp. 315-60. |
| Campion SN, Catlin N, Houseman EA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K. "Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure." Reproductive toxicology (Elmsford, N.Y.), vol. 33, no. 3, 2012, pp. 382-9. |
| Johnson KJ, Heger NE, Boekelheide K. "Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent." Toxicological Sciences, vol. 129, no. 2, 2012, pp. 235-48. |
| Pacheco SE, Anderson LM, Boekelheide K. "Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting." Journal of andrology, vol. 33, no. 5, 2012, pp. 811-6. |
| Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM. "Predicting later-life outcomes of early-life exposures." Environ Health Perspect, vol. 120, no. 10, 2012, pp. 1353-61. |
| Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K. "Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust." Environ Health Perspect, vol. 120, no. 12, 2012, pp. 1711-9. |
| Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW. "SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice." The FASEB Journal, vol. 26, no. 2, 2012, pp. 555-66. |
| Boekelheide K, Schuppe-Koistinen I. "SOT/EUROTOX Debate: Biomarkers from Blood and Urine Will Replace Traditional Histopathological Evaluation to Determine Adverse Response." Toxicological Sciences, 2012. |
| Boekelheide K, Schuppe-Koistinen I. "SOT/EUROTOX debate: biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses." Toxicological Sciences, vol. 129, no. 2, 2012, pp. 249-55. |
| Pacheco SE, Anderson LM, Sandrof MA, Vantangoli MM, Hall SJ, Boekelheide K. "Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat." PLoS ONE, vol. 7, no. 8, 2012, pp. e44280. |
| Blaauboer BJ, Boekelheide K, Clewell HJ, Daneshian M, Dingemans MM, Goldberg AM, Heneweer M, Jaworska J, Kramer NI, Leist M, Seibert H, Testai E, Vandebriel RJ, Yager JD, Zurlo J. "The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans." ALTEX, vol. 29, no. 4, 2012, pp. 411-25. |
| Koistinen, I. Schuppe, Boekelheide, K. "Biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses." Toxicology Letters, vol. 205, 2011, pp. S1. |
| Andersen ME, Clewell HJ, Carmichael PL, Boekelheide K. "Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?"." ALTEX, vol. 28, no. 3, 2011, pp. 175-82. |
| Boekelheide K. "Commentary on "incidence and nature of testicular toxicity findings…"." Birth Defects Res B, vol. 92, no. 6, 2011, pp. 501-3. |
| Thanos CG, Bintz BE, Goddard M, Boekelheide K, Hall S, Emerich DF. "Functional modulation of choroid plexus epithelial clusters in vitro for tissue repair applications." Cell transplantation, vol. 20, no. 11-12, 2011, pp. 1659-72. |
| Pacheco SE, Houseman EA, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. "Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm." PLoS ONE, vol. 6, no. 6, 2011, pp. e20280. |
| Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME. "Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways." PLoS ONE, vol. 6, no. 6, 2011, pp. e20887. |
| Boekelheide K, Andersen ME. "A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift." ALTEX, vol. 27, no. 4, 2010, pp. 243-52. |
| Yamasaki H, Sandrof MA, Boekelheide K. "Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis." Toxicological Sciences, vol. 117, no. 2, 2010, pp. 449-56. |
| Campion SN, Houseman EA, Sandrof MA, Hensley JB, Sui Y, Gaido KW, Wu Z, Boekelheide K. "Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways." Toxicological Sciences, vol. 117, no. 2, 2010, pp. 457-65. |
| Campion SN, Sandrof MA, Yamasaki H, Boekelheide K. "Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis." Toxicological Sciences, vol. 117, no. 2, 2010, pp. 466-74. |
| Krewski D, Acosta D Jr, Andersen M, Anderson H, Bailar JC 3rd, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S Jr, Kelsey KT, Kerkvliet NI, Li AA, McCray L, Meyer O, Patterson RD, Pennie W, Scala RA, Solomon GM, Stephens M, Yager J, Zeise L. "Toxicity testing in the 21st century: a vision and a strategy." Journal of toxicology and environmental health. Part B, Critical reviews, vol. 13, no. 2-4, 2010, pp. 51-138. |
| Boekelheide K, Campion SN. "Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects." Toxicological Sciences, vol. 114, no. 1, 2010, pp. 20-4. |
| Paul E, Cronan R, Weston PJ, Boekelheide K, Sedivy JM, Lee SY, Wiest DL, Resnick MB, Klysik JE. "Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death." Mammalian genome : official journal of the International Mammalian Genome Society, vol. 20, no. 2, 2009, pp. 92-108. |
| Boekelheide K, Kleymenova E, Liu K, Swanson C, Gaido KW. "Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate." Microscopy research and technique, vol. 72, no. 8, 2009, pp. 629-38. |
| Thanos CG, Emerich DF, Bintz BE, Goddard M, Mills J, Jensen R, Lombardi M, Hall S, Boekelheide K. "Secreted products from the porcine choroid plexus accelerate the healing of cutaneous wounds." Cell transplantation, vol. 18, no. 12, 2009, pp. 1395-409. |
| Boekelheide K, Sigman M. "Is gene therapy for the treatment of male infertility feasible?." Nature clinical practice. Urology, vol. 5, no. 11, 2008, pp. 590-3. |
| Chapin RE, Adams J, Boekelheide K, Gray LE Jr, Hayward SW, Lees PS, McIntyre BS, Portier KM, Schnorr TM, Selevan SG, Vandenbergh JG, Woskie SR. "NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A." Birth Defects Res B, vol. 83, no. 3, 2008, pp. 157-395. |
| Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K. "Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction." Cellular signalling, vol. 20, no. 1, 2008, pp. 1-9. |
| Bryant BH, Yamasaki H, Sandrof MA, Boekelheide K. "Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat." Toxicologic Pathology, vol. 36, no. 4, 2008, pp. 552-9. |
| Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR. "The mouse polyubiquitin gene Ubb is essential for meiotic progression." Molecular and Cellular Biology, vol. 28, no. 3, 2008, pp. 1136-46. |
| Moffit JS, Bryant BH, Hall SJ, Boekelheide K. "Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis." Toxicologic Pathology, vol. 35, no. 5, 2007, pp. 719-27. |
| Gaido KW, Hensley JB, Liu D, Wallace DG, Borghoff S, Johnson KJ, Hall SJ, Boekelheide K. "Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone." Toxicological Sciences, vol. 97, no. 2, 2007, pp. 491-503. |
| Moffit JS, Boekelheide K, Sedivy JM, Klysik J. "Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury." Journal of andrology, vol. 28, no. 6, 2007, pp. 883-90. |
| Boekelheide, K. "Mixed Messages." Toxicological Sciences, vol. 99, no. 1, 2007, pp. 1-2. |
| Rasoulpour RJ, Boekelheide K. "NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis." Biology of Reproduction, vol. 76, no. 2, 2007, pp. 279-85. |
| Bryant BH, Boekelheide K. "Time-dependent changes in post-mortem testis histopathology in the rat." Toxicologic Pathology, vol. 35, no. 5, 2007, pp. 665-71. |
| Emerich DF, Thanos CG, Goddard M, Skinner SJ, Geany MS, Bell WJ, Bintz B, Schneider P, Chu Y, Babu RS, Borlongan CV, Boekelheide K, Hall S, Bryant B, Kordower JH. "Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys." Neurobiology of disease, vol. 23, no. 2, 2006, pp. 471-80. |
| Kavlock R, Barr D, Boekelheide K, Breslin W, Breysse P, Chapin R, Gaido K, Hodgson E, Marcus M, Shea K, Williams P. "NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 22, no. 3, 2006, pp. 291-399. |
| Rasoulpour RJ, Boekelheide K. "The Sycp1-Cre transgenic mouse and male germ cell inhibition of NF-kappa b." Journal of andrology, vol. 27, no. 6, 2006, pp. 729-33. |
| Kleymenova E, Swanson C, Boekelheide K, Gaido KW. "Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact." Biology of Reproduction, vol. 73, no. 3, 2005, pp. 482-90. |
| Boekelheide K, Schoenfeld HA, Hall SJ, Weng CC, Shetty G, Leith J, Harper J, Sigman M, Hess DL, Meistrich ML. "Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure." Journal of andrology, vol. 26, no. 2, 2005, pp. 222-34. |
| Beall SA, Boekelheide K, Johnson KJ. "Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity." Journal of andrology, vol. 26, no. 4, 2005, pp. 529-38. |
| Boekelheide K. "Mechanisms of toxic damage to spermatogenesis." Journal of the National Cancer Institute. Monographs, no. 34, 2005, pp. 6-8. |
| Rasoulpour RJ, Boekelheide K. "NF-kappaB is activated in the rat testis following exposure to mono-(2-ethylhexyl) phthalate." Biology of Reproduction, vol. 72, no. 2, 2005, pp. 479-86. |
| Bercovitch RS, Januario JA, Terry SF, Boekelheide K, Podis AD, Dupuy DE, Bercovitch LG. "Testicular microlithiasis in association with pseudoxanthoma elasticum." Radiology, vol. 237, no. 2, 2005, pp. 550-4. |
| Augustine LM, Markelewicz RJ Jr, Boekelheide K, Cherrington NJ. "Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier." Drug metabolism and disposition: the biological fate of chemicals, vol. 33, no. 1, 2005, pp. 182-9. |
| Markelewicz RJ Jr, Hall SJ, Boekelheide K. "2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules." Toxicological Sciences, vol. 80, no. 1, 2004, pp. 92-100. |
| Boekelheide K. "Cracking the nut." Toxicological Sciences, vol. 81, no. 1, 2004, pp. 1-2. |
| Boekelheide K, Darney SP, Daston GP, David RM, Luderer U, Olshan AF, Sanderson WT, Willhite CC, Woskie S, NTP Center for the Evaluation of Risks to Human Reproduction Bromopropanes Expert Panel. "NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane." Reproductive toxicology (Elmsford, N.Y.), vol. 18, no. 2, 2004, pp. 189-217. |
| Boekelheide K, Fleming SL, Allio T, Embree-Ku ME, Hall SJ, Johnson KJ, Kwon EJ, Patel SR, Rasoulpour RJ, Schoenfeld HA, Thompson S. "2,5-hexanedione-induced testicular injury." Annual review of pharmacology and toxicology, vol. 43, 2003, pp. 125-47. |
| Hixon ML, Boekelheide K. "Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium." Journal of andrology, vol. 24, no. 6, 2003, pp. 891-8. |
| Rasoulpour RJ, Schoenfeld HA, Gray DA, Boekelheide K. "Expression of a K48R mutant ubiquitin protects mouse testis from cryptorchid injury and aging." The American Journal of Pathology, vol. 163, no. 6, 2003, pp. 2595-603. |
| Fleming SL, Shank PR, Boekelheide K. "gamma-Tubulin overexpression in Sertoli cells in vivo. II: Retention of spermatids, residual bodies, and germ cell apoptosis." Biology of Reproduction, vol. 69, no. 1, 2003, pp. 322-30. |
| Fleming SL, Shank PR, Boekelheide K. "gamma-Tubulin overexpression in Sertoli cells in vivo: I. Localization to sites of spermatid head attachment and alterations in Sertoli cell microtubule distribution." Biology of Reproduction, vol. 69, no. 1, 2003, pp. 310-21. |
| McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M. "The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis." Molecular and Cellular Biology, vol. 23, no. 1, 2003, pp. 38-54. |
| Embree-Ku M, Boekelheide K. "Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction." Experimental Biology and Medicine, vol. 227, no. 7, 2002, pp. 545-53. |
| Johnson KJ, Boekelheide K. "Dynamic testicular adhesion junctions are immunologically unique. I. Localization of p120 catenin in rat testis." Biology of Reproduction, vol. 66, no. 4, 2002, pp. 983-91. |
| Johnson KJ, Boekelheide K. "Dynamic testicular adhesion junctions are immunologically unique. II. Localization of classic cadherins in rat testis." Biology of Reproduction, vol. 66, no. 4, 2002, pp. 992-1000. |
| Embree-Ku M, Venturini D, Boekelheide K. "Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis." Biology of Reproduction, vol. 66, no. 5, 2002, pp. 1456-61. |
| Embree-Ku M, Boekelheide K. "FasL deficiency enhances the development of tumors in p53+/- mice." Toxicologic Pathology, vol. 30, no. 6, 2002, pp. 705-13. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 453-87. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 529-653. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 655-78. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 679-708. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 489-527. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 709-19. |
| Kavlock R, Boekelheide K, Chapin R, Cunningham M, Faustman E, Foster P, Golub M, Henderson R, Hinberg I, Little R, Seed J, Shea K, Tabacova S, Tyl R, Williams P, Zacharewski T. "NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate." Reproductive toxicology (Elmsford, N.Y.), vol. 16, no. 5, 2002, pp. 721-34. |
| Schoenfeld HA, Hall SJ, Boekelheide K. "Continuously proliferative stem germ cells partially repopulate the aged, atrophic rat testis after gonadotropin-releasing hormone agonist therapy." Biology of Reproduction, vol. 64, no. 4, 2001, pp. 1273-82. |
| Boekelheide K, Schoenfeld HA. "Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury." Systems Biology of RNA Binding Proteins, vol. 500, 2001, pp. 421-8. |
| Roehl HH, Leibbrandt ME, Greengard JS, Kamantigue E, Glass WG, Giedlin M, Boekelheide K, Johnson DE, Jolly DJ, Sajjadi NC. "Analysis of testes and semen from rabbits treated by intravenous injection with a retroviral vector encoding the human factor VIII gene: no evidence of germ line transduction." Human gene therapy, vol. 11, no. 18, 2000, pp. 2529-40. |
| Johnson KJ, Patel SR, Boekelheide K. "Multiple cadherin superfamily members with unique expression profiles are produced in rat testis." Endocrinology, vol. 141, no. 2, 2000, pp. 675-83. |
| Boekelheide, Kim, Fleming, Shawna L., Johnson, Kamin J., Patel, Sutchin R., Schoenfeld, Heidi A. "Role of Sertoli Cells in Injury-Associated Testicular Germ Cell Apoptosis." Proceedings of the Society for Experimental Biology and Medicine, vol. 225, no. 2, 2000, pp. 105-115. |
| Boekelheide K, Fleming SL, Johnson KJ, Patel SR, Schoenfeld HA. "Role of Sertoli cells in injury-associated testicular germ cell apoptosis." Proceedings of the Society for Experimental Biology and Medicine, vol. 225, no. 2, 2000, pp. 105-15. |
| Richburg JH, Nañez A, Williams LR, Embree ME, Boekelheide K. "Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand." Endocrinology, vol. 141, no. 2, 2000, pp. 787-93. |
| Fox RA, Sigman M, Boekelheide K. "Transmembrane versus soluble stem cell factor expression in human testis." Journal of andrology, vol. 21, no. 4, 2000, pp. 579-85. |
| Varmuza S, Jurisicova A, Okano K, Hudson J, Boekelheide K, Shipp EB. "Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene." Developmental Biology, vol. 205, no. 1, 1999, pp. 98-110. |
| Lee J, Richburg JH, Shipp EB, Meistrich ML, Boekelheide K. "The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis." Endocrinology, vol. 140, no. 2, 1999, pp. 852-8. |
| Boekelheide K. "Toxicologists: have we been honest with the public?"." Toxicological Sciences, vol. 46, no. 2, 1998, pp. 418-9. |
| Boekelheide K, Lee J, Shipp EB, Richburg JH, Li G. "Expression of Fas system-related genes in the testis during development and after toxicant exposure." Toxicology Letters, vol. 102-103, 1998, pp. 503-8. |
| Blanchard KT, Lee J, Boekelheide K. "Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression." Endocrinology, vol. 139, no. 1, 1998, pp. 236-44. |
| Blanchard KT, Boekelheide K. "Adenovirus-mediated gene transfer to rat testis in vivo." Biology of Reproduction, vol. 56, no. 2, 1997, pp. 495-500. |
| Jiang C, Hall SJ, Boekelheide K. "Cloning and characterization of the 5' flanking region of the stem cell factor gene in rat Sertoli cells." Gene, vol. 185, no. 2, 1997, pp. 285-90. |
| Jiang C, Hall SJ, Boekelheide K. "Development and characterization of a prepubertal rat Sertoli cell line, 93RS2." Journal of andrology, vol. 18, no. 4, 1997, pp. 393-9. |
| Costa SL, Boekelheide K, Vanderhyden BC, Seth R, McBurney MW. "Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor alpha 1." Biology of Reproduction, vol. 56, no. 4, 1997, pp. 985-90. |
| Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA. "Selective protein covalent binding and target organ toxicity." Toxicology and Applied Pharmacology, vol. 143, no. 1, 1997, pp. 1-12. |
| Lee J, Richburg JH, Younkin SC, Boekelheide K. "The Fas system is a key regulator of germ cell apoptosis in the testis." Endocrinology, vol. 138, no. 5, 1997, pp. 2081-8. |
| Allard EK, Blanchard KT, Boekelheide K. "Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats." Biology of Reproduction, vol. 55, no. 1, 1996, pp. 185-93. |
| Blanchard KT, Allard EK, Boekelheide K. "Fate of germ cells in 2,5-hexanedione-induced testicular injury. I. Apoptosis is the mechanism of germ cell death." Toxicology and Applied Pharmacology, vol. 137, no. 2, 1996, pp. 141-8. |
| Allard EK, Boekelheide K. "Fate of germ cells in 2,5-hexanedione-induced testicular injury. II. Atrophy persists due to a reduced stem cell mass and ongoing apoptosis." Toxicology and Applied Pharmacology, vol. 137, no. 2, 1996, pp. 149-56. |
| Johnson KJ, Hall ES, Boekelheide K. "Kinesin localizes to the trans-Golgi network regardless of microtubule organization." European journal of cell biology, vol. 69, no. 3, 1996, pp. 276-87. |
| Richburg JH, Boekelheide K. "Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes." Toxicology and Applied Pharmacology, vol. 137, no. 1, 1996, pp. 42-50. |
| Hall ES, Hall SJ, Boekelheide K. "2,5-Hexanedione exposure alters microtubule motor distribution in adult rat testis." Fundamental and applied toxicology : official journal of the Society of Toxicology, vol. 24, no. 2, 1995, pp. 173-82. |
| Redenbach DM, Hall ES, Boekelheide K. "Distribution of Sertoli cell microtubules, microtubule-dependent motors, and the Golgi apparatus before and after tight junction formation in developing rat testis." Microscopy research and technique, vol. 32, no. 6, 1995, pp. 504-19. |
| Allard EK, Hall SJ, Boekelheide K. "Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione." Biology of Reproduction, vol. 53, no. 1, 1995, pp. 186-92. |
| Redenbach DM, Boekelheide K. "Microtubules are oriented with their minus-ends directed apically before tight junction formation in rat Sertoli cells." European journal of cell biology, vol. 65, no. 2, 1994, pp. 246-57. |
| Redenbach DM, Richburg JH, Boekelheide K. "Microtubules with altered assembly kinetics have a decreased rate of kinesin-based transport." Cell motility and the cytoskeleton, vol. 27, no. 1, 1994, pp. 79-87. |
| McBurney MW, Staines WA, Boekelheide K, Parry D, Jardine K, Pickavance L. "Murine PGK-1 promoter drives widespread but not uniform expression in transgenic mice." Developmental dynamics : an official publication of the American Association of Anatomists, vol. 200, no. 4, 1994, pp. 278-93. |
| Richburg JH, Redenbach DM, Boekelheide K. "Seminiferous tubule fluid secretion is a Sertoli cell microtubule-dependent process inhibited by 2,5-hexanedione exposure." Toxicology and Applied Pharmacology, vol. 128, no. 2, 1994, pp. 302-9. |
| Boekelheide K, Lee JW, Hall SJ, Rhind NR, Zaret KS. "A tumorigenic murine Sertoli cell line that is temperature-sensitive for differentiation." The American Journal of Pathology, vol. 143, no. 4, 1993, pp. 1159-68. |
| Allard EK, Johnson KJ, Boekelheide K. "Colchicine disrupts the cytoskeleton of rat testis seminiferous epithelium in a stage-dependent manner." Biology of Reproduction, vol. 48, no. 1, 1993, pp. 143-53. |
| Johnson KJ, Boekelheide K. "Visualization of Golgi complexes and spermatogonial cohorts of viable, intact seminiferous tubules." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, vol. 41, no. 2, 1993, pp. 299-306. |
| Redenbach DM, Boekelheide K, Vogl AW. "Binding between mammalian spermatid-ectoplasmic specialization complexes and microtubules." European journal of cell biology, vol. 59, no. 2, 1992, pp. 433-48. |
| Boekelheide K, Arcila ME, Eveleth J. "cis-diamminedichloroplatinum (II) (cisplatin) alters microtubule assembly dynamics." Toxicology and Applied Pharmacology, vol. 116, no. 1, 1992, pp. 146-51. |
| Hall ES, Eveleth J, Jiang C, Redenbach DM, Boekelheide K. "Distribution of the microtubule-dependent motors cytoplasmic dynein and kinesin in rat testis." Biology of Reproduction, vol. 46, no. 5, 1992, pp. 817-28. |
| Hall ES, Hall SJ, Boekelheide K. "Sertoli cells isolated from adult 2,5-hexanedione-exposed rats exhibit atypical morphology and actin distribution." Toxicology and Applied Pharmacology, vol. 117, no. 1, 1992, pp. 9-18. |
| Ashman JB, Hall ES, Eveleth J, Boekelheide K. "Tau, the neuronal heat-stable microtubule-associated protein, is also present in the cross-linked microtubule network of the testicular spermatid manchette." Biology of Reproduction, vol. 46, no. 1, 1992, pp. 120-9. |
| Johnson KJ, Hall ES, Boekelheide K. "2,5-Hexanedione exposure alters the rat Sertoli cell cytoskeleton. I. Microtubules and seminiferous tubule fluid secretion." Toxicology and Applied Pharmacology, vol. 111, no. 3, 1991, pp. 432-42. |
| Hall ES, Eveleth J, Boekelheide K. "2,5-Hexanedione exposure alters the rat Sertoli cell cytoskeleton. II. Intermediate filaments and actin." Toxicology and Applied Pharmacology, vol. 111, no. 3, 1991, pp. 443-53. |
| Boekelheide K, Hall SJ. "2,5-hexanedione exposure in the rat results in long-term testicular atrophy despite the presence of residual spermatogonia." Journal of andrology, vol. 12, no. 1, 1991, pp. 18-26. |
| Boekelheide K, Eveleth J, Neely MD, Sioussat TM. "Microtubule assembly is altered following covalent modification by the n-hexane metabolite 2,5-hexanedione." Systems Biology of RNA Binding Proteins, vol. 283, 1991, pp. 433-42. |
| Sioussat TM, Miller FJ, Boekelheide K. "2,5-Hexanedione-treated tubulin microinjected into sea urchin zygotes induces mitotic abnormalities." Toxicology and Applied Pharmacology, vol. 104, no. 1, 1990, pp. 36-46. |
| Boekelheide K, Eveleth J, Hall SJ. "Experimental cryptorchidism protects against long-term 2,5-hexanedione-induced testicular germ cell loss in the rat." Journal of andrology, vol. 11, no. 2, 1990, pp. 105-12. |
| Neely MD, Erickson HP, Boekelheide K. "HMW-2, the Sertoli cell cytoplasmic dynein from rat testis, is a dimer composed of nearly identical subunits." Journal of Biological Chemistry, vol. 265, no. 15, 1990, pp. 8691-8. |
| Sioussat TM, Boekelheide K. "Selection of a nucleation-promoting element following chemical modification of tubulin." Biochemistry, vol. 28, no. 10, 1989, pp. 4435-43. |
| Boekelheide K, Neely MD, Sioussat TM. "The Sertoli cell cytoskeleton: a target for toxicant-induced germ cell loss." Toxicology and Applied Pharmacology, vol. 101, no. 3, 1989, pp. 373-89. |
| Boekelheide K, Anthony DC, Giangaspero F, Gottfried MR, Graham DG. "Aliphatic diketones: influence of dicarbonyl spacing on amine reactivity and toxicity." Chemical Research in Toxicology, vol. 1, no. 4, 1988, pp. 200-3. |
| Boekelheide K. "Rat testis during 2,5-hexanedione intoxication and recovery. I. Dose response and the reversibility of germ cell loss." Toxicology and Applied Pharmacology, vol. 92, no. 1, 1988, pp. 18-27. |
| Boekelheide K. "Rat testis during 2,5-hexanedione intoxication and recovery. II. Dynamics of pyrrole reactivity, tubulin content, and microtubule assembly." Toxicology and Applied Pharmacology, vol. 92, no. 1, 1988, pp. 28-33. |
| Neely MD, Boekelheide K. "Sertoli cell processes have axoplasmic features: an ordered microtubule distribution and an abundant high molecular weight microtubule-associated protein (cytoplasmic dynein)." The Journal of cell biology, vol. 107, no. 5, 1988, pp. 1767-76. |
| Boekelheide K, Eveleth J. "The rate of 2,5-hexanedione intoxication, not total dose, determines the extent of testicular injury and altered microtubule assembly in the rat." Toxicology and Applied Pharmacology, vol. 94, no. 1, 1988, pp. 76-83. |
| Boekelheide K. "2,5-Hexanedione alters microtubule assembly. I. Testicular atrophy, not nervous system toxicity, correlates with enhanced tubulin polymerization." Toxicology and Applied Pharmacology, vol. 88, no. 3, 1987, pp. 370-82. |
| Boekelheide K. "2,5-Hexanedione alters microtubule assembly. II. Enhanced polymerization of crosslinked tubulin." Toxicology and Applied Pharmacology, vol. 88, no. 3, 1987, pp. 383-96. |
| Boekelheide K, Eveleth J, Tatum AH, Winkelman JW. "Microtubule assembly inhibition by porphyrins and related compounds." Photochemistry and photobiology, vol. 46, no. 5, 1987, pp. 657-61. |
| Graham DG, Anthony DC, Szakál-Quin G, Gottfried MR, Boekelheide K. "Covalent crosslinking of neurofilaments in the pathogenesis of n-hexane neuropathy." Neurotoxicology, vol. 6, no. 4, 1985, pp. 55-63. |
| Anthony DC, Boekelheide K, Graham DG. "The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings." Toxicology and Applied Pharmacology, vol. 71, no. 3, 1983, pp. 362-71. |
| Anthony DC, Boekelheide K, Anderson CW, Graham DG. "The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking." Toxicology and Applied Pharmacology, vol. 71, no. 3, 1983, pp. 372-82. |
| Graham DG, Anthony DC, Boekelheide K. "In vitro and in vivo studies of the molecular pathogenesis of n-Hexane neuropathy." Neurobehavioral toxicology and teratology, vol. 4, no. 6, 1982, pp. 629-34. |
| Blumenkopf B, Boekelheide K. "Neck paraganglioma with a pituitary adenoma. Case report." Journal of Neurosurgery, vol. 57, no. 3, 1982, pp. 426-9. |
| Graham DG, Anthony DC, Boekelheide K, Maschmann NA, Richards RG, Wolfram JW, Shaw BR. "Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking." Toxicology and Applied Pharmacology, vol. 64, no. 3, 1982, pp. 415-22. |
| Boekelheide K, Graham DG, Mize PD, Koo EH. "Melanocytotoxicity and the mechanism of activation of gamma-L-glutaminyl-4-hydroxybenzene." Journal of Investigative Dermatology, vol. 75, no. 4, 1980, pp. 322-7. |
| Boekelheide K, Graham DG, Mize PD, Jeffs PW. "The metabolic pathway catalyzed by the tyrosinase of Agaricus bisporus." Journal of Biological Chemistry, vol. 255, no. 10, 1980, pp. 4766-71. |
| Boekelheide K, Graham DG, Mize PD, Vogel FS. "The role of gamma-glutamyl transpeptidase in the nephrotoxicity of an Agaricus bisporus metabolite." The American Journal of Pathology, vol. 100, no. 3, 1980, pp. 651-62. |
| Vogel FS, Kemper LA, Boekelheide K, Graham DG, Jeffs PW. "Intracellular activation of gamma-L-glutaminyl-4-hydroxybenzene by tyrosinase, a mechanism for selective cytotoxicity against melanocarcinoma." Cancer Research, vol. 39, no. 5, 1979, pp. 1490-3. |
| Boekelheide K, Patt SL, Weisz G, Baldo JH, Sykes BD. "Lysozyme catalysis: kinetics of the hydrolysis of cell wall oligosaccharides." Canadian journal of biochemistry, vol. 57, no. 6, 1979, pp. 785-88. |
| Boekelheide K, Graham DG, Mize PD, Anderson CW, Jeffs PW. "Synthesis of gamma-L-glutaminyl-[3,5-3H]4-hydroxybenzene and the study of reactions catalyzed by the tyrosinase of Agaricus bisporus." Journal of Biological Chemistry, vol. 254, no. 23, 1979, pp. 12185-91. |
| Patt SL, Baldo JH, Boekelheide K, Weisz G, Sykes BD. "The nuclear magnetic resonance determination of the conformation of saccharides bound in subsite D of lysozyme." Canadian journal of biochemistry, vol. 56, no. 6, 1978, pp. 624-9. |
My career has been devoted to understanding how environmental and occupational chemicals affect mammals at the biochemical, cellular, and molecular level. In the laboratory, much of this effort has been devoted to studying how the mammalian testis functions and the underlying mechanisms responsible for toxicant-induced testicular dysfunction. Hormones, paracrine signaling factors, signal transduction processes, and intracellular response pathways are the key cellular and molecular regulators of this wonderfully complex system responsible for spermatogenesis.
More broadly, as a member of the National Academy of Sciences committee that produced the report entitled "Toxicity Testing in the Twenty-first Century: A Vision and a Strategy," I have thought long and hard about toxicity testing, and I know that a transformative change is inevitable. We currently rely on 20th century technologies that are too slow, too expensive, and fail to take advantage of the ongoing revolution in biology. With the new technologies and bioinformatics tools now being developed, we can shift the paradigm of toxicity testing, characterize the responsible toxicity pathways, and develop a robust mechanistic explanation of toxicant action. I helped to establish the Center to Advance Predictive Biology to develop the needed in vitro models and techniques to transform toxicity testing. Advocating for the best science, I use of human tissue xenotransplantation approaches to enhance the human relevance of our research effort, which is focused on understanding the fetal basis of later life diseases. This has involved intense investigation of epigenetic responses to toxicant exposure.
As Director of the Superfund research Program at Brown University (2005-2016), I strongly promoted the value of developing academic-government-community partnerships to enhance the value and relevance of our work. My project in the Superfund addresses deficiencies in the current methods used to monitor environmental and occupational exposures that target testicular function which rely on serum hormones and semen parameters (sperm count, motility and morphology). These traditional assessments of testicular function are insensitive and highly variable. My project identifies sperm molecular biomarkers by exploring fundamental processes in spermatogenesis and learning how to detect the fingerprints of their disruption in the most robust manner possible. The approach involves an exciting interdisciplinary integration of basic biology and translational science, ferreting out the consequences of toxic exposures by applying newly discovered knowledge to protect human health.
U01 ES028184-01 (Boekelheide) 07/01/17-7/31/22
Human 3D Microtissues for Toxicity Testing via Integrated Imaging, Molecular and Functional Analysis
The Brown University Bioengineering Research Partnership improves upon traditional animal-based approaches for toxicity testing by developing in vitro 3D microtissue predictive biology platforms based on integrated imaging, molecular and functional analyses. These novel assays for the prostate, ovary, lung, brain, and heart are designed to address the unmet need for safety assessment of large numbers of environmental chemicals and emerging toxicants, thus reducing adverse human health impacts and improving public health.
5P42ES013660 (Boekelheide) 4/18/2005-03/31/2020
NIH/NIEHS Superfund Research Program
Toxicant Exposures in Rhode Island: Past, Present and Future
This program has 4 Research Projects and 5 Cores. Boekelheide is Associate Director and Leader of Project 1.
MA-2015-01887 (Boekelheide, PI) 11/26/2015-9/30/2018 (no cost extension)
Unilever
Developing fit-for-purpose predictive biology platforms for in vitro toxicity testing
This research agreement between Brown University and Unilever supports the further development and validation of unique 3-dimensional in vitro predictive biology platforms for toxicity testing.
005647-001 (Boekelheide) 08/01/17-07/31/18 (no cost extension)
Alternatives Research and Development Foundation
Screening Estrogenic Endocrine Disrupting Chemicals with Human MCF-7-3D Microtissues by in vitro Pathology
Endocrine disrupting chemicals (EDCs) can adversely affect estrogenic, androgenic, and thyroid hormone sensitive targets. In this project, we develop an innovative screening approach for estrogenic EDCs using human MCF-7 breast cancer cell 3-dimensional (3D) microtissue cultures.
| Year | Degree | Institution |
|---|---|---|
| 1980 | PhD | Duke University |
| 1980 | MD | Duke University |
| 1974 | BA | Harvard University |
Lifetime Achievement Award, Reproductive & Developmental Toxicology Specialty Section, Society of Toxicology, 2015
Doerenkamp-Zbinden Award, 2009 (given to authors of the National Academy of Sciences report entitled Toxicity Testing in the 21st Century: A Vision and a Strategy)
Center for Alternatives to Animal Testing (CAAT) Recognition Award, 2009 (given to authors of the National Academy of Sciences report entitled Toxicity Testing in the 21st Century: A Vision and a Strategy)
AstraZeneca Traveling Lectureship Award, Society of Toxicology, 2009
Annual Best Paper Award in Experimental Biology, 2002, Experimental Biology & Medicine
Burroughs Wellcome Toxicology Scholar Award, 1994-1999
Research Career Development Award, 1989 - 1994
International Life Sciences Institute Research Foundation Award in Comparative Toxicology, 1987- 1990
Pharmaceutical Manufacturers Association Foundation Faculty Development Award in Toxicologic Pathology, 1985-1987
Medical School Senior Citation, 1989
Sigma Xi, Duke University, 1981
Phi Beta Kappa, Duke University, 1980
Alpha Omega Alpha, Duke University, 1977
| Name | Title |
|---|---|
| Creton, Robbert | Professor of Medical Science (Research), Professor of Pathology and Laboratory Medicine (Research) |
| Freiman, Richard | Professor of Molecular Biology, Cell Biology and Biochemistry, Professor of Obstetrics and Gynecology |
| Gruppuso, Philip | Professor of Medical Science, Professor of Pediatrics, Professor of Molecular Biology, Cell Biology and Biochemistry (Research) |
| Hurt, Robert | Professor of Engineering |
| Huse, Susan | Assistant Professor of Pathology and Laboratory Medicine (Research) |
| Hwang, Kathleen | Associate Professor of Surgery, Associate Professor of Pathology and Laboratory Medicine |
| Kane, Agnes | Professor Emerita of Pathology and Laboratory Medicine |
| Morgan, Jeffrey | Professor of Pathology and Laboratory Medicine, Donna Weiss '89 and Jason Weiss Director of the Center for Alternatives to Animals in Testing, Professor of Engineering |
| Roye, G | Associate Professor of Surgery, Clinician Educator |
| Suuberg, Eric | C.V. Starr Professor of Technology Entrepreneurship, Professor of Engineering |
| BIOL 1820 - Environmental Health and Disease |
| BIOL 1865 - Toxicology |
| BIOL 2865 - Toxicology |
| BIOL 2920D - Environmental Technologies and Human Health |
