Shukla, Anita

Anita Shukla

Elaine I. Savage Professor of Engineering, Professor of Engineering

Overview

Anita Shukla is the Elaine I. Savage Professor of Engineering at Brown University. Her research involves the development of nano- to macroscale biomaterials for the treatment of bacterial and fungal infections. Professor Shukla’s honors include selection as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a National Academy of Medicine (NAM) Emerging Leaders in Health and Medicine Scholar. She is the recipient of a Presidential Early Career Award for Scientists and Engineers (PECASE), a National Science Foundation (NSF) CAREER award, an Office of Naval Research Director of Research Early Career Grant, and a Brown University Early Career Research Achievement Award and Dean’s Award for Excellence in Teaching. Prior to joining Brown in 2013, Professor Shukla was a National Institutes of Health Ruth Kirschstein postdoctoral fellow in the Department of Bioengineering at Rice University. She received her Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 2011 as an NSF Graduate Research Fellow. Professor Shukla also received an M.S. in Chemical Engineering Practice from MIT. She received her B.S. at Carnegie Mellon University in 2006 with majors in chemical engineering and biomedical engineering.

Brown Affiliations

Engineering

Research Areas

On the Web

Shukla Lab Webpage

Publications Visualize it

Wang, Yingying, Shukla, Anita. "Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication." Biomaterials Science, vol. 10, no. 11, 2022, pp. 2831-2843.

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Simpson, Aryssa, Shukla, Anita, Brown, Ashley C. "Biomaterials for Hemostasis." Annual Review of Biomedical Engineering, vol. 24, no. 1, 2022, pp. 111-135.

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Abbasi, Akram, Imaichi, Sachiko, Ling, Vincent, Shukla, Anita. "Mesenchymal Stem Cell Behavior on Soft Hydrogels with Aligned Surface Topographies." ACS Applied Bio Materials, vol. 5, no. 5, 2022, pp. 1890-1900.

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Battigelli, Alessia, Almeida, Bethany, Shukla, Anita. "Recent Advances in Bioorthogonal Click Chemistry for Biomedical Applications." Bioconjugate Chemistry, 2022.

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Alkekhia, Dahlia, LaRose, Cassi, Shukla, Anita. "β-Lactamase-Responsive Hydrogel Drug Delivery Platform for Bacteria-Triggered Cargo Release." ACS Applied Materials & Interfaces, 2022.

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Welch, E. Celeste, Powell, Jessica M., Clevinger, Tobias B., Fairman, Alexis E., Shukla, Anita. "Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials." Advanced Functional Materials, 2021, pp. 2104126.

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Bailey-Hytholt, Christina M., LaMastro, Veronica, Shukla, Anita. "Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions." Journal of Visualized Experiments, no. 174, 2021.

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Bailey-Hytholt, Christina M., Sayeed, Sumaiya, Shukla, Anita, Tripathi, Anubhav. "Enrichment of Placental Trophoblast Cells from Clinical Cervical Samples Using Differences in Surface Adhesion on an Inclined Plane." Annals of Biomedical Engineering, 2021.

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Deusenbery, Carly, Wang, Yingying, Shukla, Anita. "Recent Innovations in Bacterial Infection Detection and Treatment." ACS Infectious Diseases, 2021.

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Vera-González, Noel, Shukla, Anita. "Advances in Biomaterials for the Prevention and Disruption of Candida Biofilms." Frontiers in Microbiology, vol. 11, 2020.

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Vera‐González, Noel, Bailey‐Hytholt, Christina M., Langlois, Luc, Camargo Ribeiro, Felipe, Souza Santos, Evelyn Luzia, Junqueira, Juliana Campos, Shukla, Anita. "Anidulafungin liposome nanoparticles exhibit antifungal activity against planktonic and biofilm Candida albicans." Journal of Biomedical Materials Research Part A, 2020.

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Wang, Soobin, Battigelli, Alessia, Alkekhia, Dahlia, Fairman, Alexis, Antoci, Valentin, Yang, Wentian, Moore, Douglas, Shukla, Anita. "Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy." RSC Advances, vol. 10, no. 34, 2020, pp. 20073-20082.

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Shukla, Shashank, Favata, Joseph, Srivastava, Vikas, Shahbazmohamadi, Sina, Tripathi, Anubhav, Shukla, Anita. "Effect of polymer and ion concentration on mechanical and drug release behavior of gellan hydrogels using factorial design." Journal of Polymer Science, vol. 58, no. 10, 2020, pp. 1365-1379.

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Battigelli A, Almeida B, Shukla S, Rocha AD, Shukla A. "Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry." Chem. Commun., vol. 56, no. 55, 2020, pp. 7661-7664.

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Bailey-Hytholt, Christina M., Puranik, Tanaya, Tripathi, Anubhav, Shukla, Anita. "Investigating interactions of phthalate environmental toxicants with lipid structures." Colloids and Surfaces B: Biointerfaces, vol. 190, 2020, pp. 110923.

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Alkekhia D, Hammond PT, Shukla A. "Layer-by-Layer Biomaterials for Drug Delivery." Annual Review of Biomedical Engineering, 2020.

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Bailey-Hytholt, Christina M., Shen, Tun-Li, Nie, Bonnee, Tripathi, Anubhav, Shukla, Anita. "Placental Trophoblast-Inspired Lipid Bilayers for Cell-Free Investigation of Molecular Interactions." ACS Applied Materials & Interfaces, vol. 12, no. 28, 2020, pp. 31099-31111.

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de Alvarenga, Janaína Araújo, de Barros, Patrícia Pimentel, de Camargo Ribeiro, Felipe, Rossoni, Rodnei Dennis, Garcia, Maíra Terra, dos Santos Velloso, Marisol, Shukla, Shashank, Fuchs, Beth Burgwyn, Shukla, Anita, Mylonakis, Eleftherios, Junqueira, Juliana Campos. "Probiotic Effects of Lactobacillus paracasei 28.4 to Inhibit Streptococcus mutans in a Gellan-Based Formulation." Probiotics and Antimicrobial Proteins, 2020.

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Alkekhia, Dahlia, Safford, Hannah, Shukla, Shashank, Hopson, Russel, Shukla, Anita. "β-Lactamase triggered visual detection of bacteria using cephalosporin functionalized biomaterials." Chemical Communications, vol. 56, no. 75, 2020, pp. 11098-11101.

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Bailey-Hytholt, Christina M., Sayeed, Sumaiya, Kraus, Morey, Joseph, Richard, Shukla, Anita, Tripathi, Anubhav. "A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples." Scientific Reports, vol. 9, no. 1, 2019.

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Liu, Hanyang, Shukla, Shashank, Vera-González, Noel, Tharmalingam, Nagendran, Mylonakis, Eleftherios, Fuchs, Beth Burgwyn, Shukla, Anita. "Auranofin Releasing Antibacterial and Antibiofilm Polyurethane Intravascular Catheter Coatings." Frontiers in Cellular and Infection Microbiology, vol. 9, 2019, pp. 37.

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Almeida, Bethany, Wang, Yingying, Shukla, Anita. "Effects of Nanoparticle Properties on Kartogenin Delivery and Interactions with Mesenchymal Stem Cells." Annals of Biomedical Engineering, 2019.

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Alkekhia D, Shukla A. "Influence of poly-l-lysine molecular weight on antibacterial efficacy in polymer multilayer films." Journal of Biomedical Materials Research Part A, vol. 107, no. 6, 2019, pp. 1324-1339.

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Yu, Chao, Alkekhia, Dahlia, Shukla, Anita. "β-Lactamase Responsive Supramolecular Hydrogels with Host–Guest Self-Healing Capability." ACS Applied Polymer Materials, vol. 2, no. 1, 2019, pp. 55-65.

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Shukla, Shashank, Shukla, Anita. "Tunable antibiotic delivery from gellan hydrogels." Journal of Materials Chemistry B, vol. 6, no. 40, 2018, pp. 6444-6458.

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Bailey, Christina M., Tripathi, Anubhav, Shukla, Anita. "Effects of Flow and Bulk Vesicle Concentration on Supported Lipid Bilayer Formation." Langmuir, vol. 33, no. 43, 2017, pp. 11986-11997.

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Sheybani, Roya, Shukla, Anita. "Highly sensitive label-free dual sensor array for rapid detection of wound bacteria." Biosensors and Bioelectronics, vol. 92, 2017, pp. 425-433.

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Gwisai, Tinotenda, Hollingsworth, Nisha Rosita, Cowles, Sarah, Tharmalingam, Nagendran, Mylonakis, Eleftherios, Fuchs, Beth Burgwyn, Shukla, Anita. "Repurposing niclosamide as a versatile antimicrobial surface coating against device-associated, hospital-acquired bacterial infections." Biomedical Materials, vol. 12, no. 4, 2017, pp. 045010.

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Shukla A, Slater JH, Culver JC, Dickinson ME, West JL. "Biomimetic Surface Patterning Promotes Mesenchymal Stem Cell Differentiation." ACS Appl. Mater. Interfaces, vol. 8, no. 34, 2016, pp. 21883-92.

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Sheybani R, Shukla A. "Complementary sensors for rapid and sensitive detection of wound bacteria." 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 2016, 2016, pp. 1902-1905.

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Almeida, Bethany, Shukla, Anita. "Degradation of alkanethiol self-assembled monolayers in mesenchymal stem cell culture." Journal of Biomedical Materials Research Part A, vol. 105, no. 2, 2016, pp. 464-474.

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Gates, Samantha J., Shukla, Anita. "Layer-by-layer assembly of readily detachable chitosan and poly(acrylic acid) polyelectrolyte multilayer films." Journal of Polymer Science Part B: Polymer Physics, vol. 55, no. 2, 2016, pp. 127-131.

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Shukla, Anita, Almeida, Bethany. "Advances in cellular and tissue engineering using layer-by-layer assembly." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 6, no. 5, 2014, pp. 411-421.

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Monteiro, Isa P., Shukla, Anita, Marques, Alexandra P., Reis, Rui L., Hammond, Paula T. "Spray-assisted layer-by-layer assembly on hyaluronic acid scaffolds for skin tissue engineering." Journal of Biomedical Materials Research Part A, vol. 103, no. 1, 2014, pp. 330-340.

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Shukla A, Fang JC, Puranam S, Jensen FR, Hammond PT. "Hemostatic multilayer coatings." Adv. Mater., vol. 24, no. 4, 2012, pp. 492-6.

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Shukla A, Fang JC, Puranam S, Hammond PT. "Release of vancomycin from multilayer coated absorbent gelatin sponges." Journal of Controlled Release, vol. 157, no. 1, 2012, pp. 64-71.

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Shukla, Anita, Puranam, Sravanthi, Hammond, Paula T. "Vancomycin Storage Stability in Multilayer Thin Film Coatings for On-Demand Care." Journal of Biomaterials Science, Polymer Edition, vol. ahead-of-print, no. ahead-of-print, 2012, pp. 1-8.

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Shukla A, Puranam S, Hammond PT. "Vancomycin storage stability in multilayer thin film coatings for on-demand care." Journal of biomaterials science. Polymer edition, vol. 23, no. 15, 2012, pp. 1895-902.

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Shukla A, Fuller RC, Hammond PT. "Design of multi-drug release coatings targeting infection and inflammation." Journal of Controlled Release, vol. 155, no. 2, 2011, pp. 159-66.

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Engler AC, Shukla A, Puranam S, Buss HG, Jreige N, Hammond PT. "Effects of side group functionality and molecular weight on the activity of synthetic antimicrobial polypeptides." Biomacromolecules, vol. 12, no. 5, 2011, pp. 1666-74.

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Samuel RE, Shukla A, Paik DH, Wang MX, Fang JC, Schmidt DJ, Hammond PT. "Osteoconductive protamine-based polyelectrolyte multilayer functionalized surfaces." Biomaterials, vol. 32, no. 30, 2011, pp. 7491-502.

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Shukla A, Fleming KE, Chuang HF, Chau TM, Loose CR, Stephanopoulos GN, Hammond PT. "Controlling the release of peptide antimicrobial agents from surfaces." Biomaterials, vol. 31, no. 8, 2010, pp. 2348-57.

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Shukla A, Avadhany SN, Fang JC, Hammond PT. "Tunable vancomycin releasing surfaces for biomedical applications." Small, vol. 6, no. 21, 2010, pp. 2392-404.

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Background

Education and Training

Year	Degree	Institution
2011	PhD	Massachusetts Institute of Technology
2008	MS	Massachusetts Institute of Technology
2006	BS	Carnegie Mellon University

Postdoctoral/Other Training

NIH Ruth Kirschstein Postdoctoral Fellow

Rice University, Bioengineering

2011-2013

Houston, TX, USA

Honors and Awards

2024, Fellow, American Institute for Medical and Biological Engineering
2023, National Academy of Medicine Emerging Leaders in Health and Medicine Scholar
2023, Hazeltine Innovation Award, Brown University 2023
2022, Tau Beta Pi Excellence in Research Award, Rhode Island Alpha Chapter (student selected)
2021, National Academy of Engineering Frontiers of Engineering Grainger Grant
2020, National Academy of Engineering US Frontiers of Engineering Symposium, Invited Participant
2020, National Science Foundation CAREER Award
2020, Early Career Research Achievement Award, Brown University
2019, Presidential Early Career Award for Scientists and Engineers (PECASE)
2019, Tau Beta Pi Excellence in Research Award, Rhode Island Alpha Chapter (student selected)
2018, Henry Merritt Wriston Fellowship, Brown University
2017, Dean’s Award for Excellence in Teaching, Brown University
2017, Director of Research Early Career Grant, Office of Naval Research
2012, Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (NIH/NIGMS)
2010, Graduate Woman of Excellence, Massachusetts Institute of Technology
2008, Chemical Engineering Special Service Award, Massachusetts Institute of Technology
2006, National Science Foundation Graduate Research Fellowship
2006, Judith A. Resnik Award for Excellence in Science & Engineering, Carnegie Mellon University
2006, Andrew Carnegie Society Scholar, Carnegie Mellon University
2006, Ken Westerberg Award for Excellence in Chemical Engineering Research, Carnegie Mellon University
2006, McCabe Society Award, Carnegie Mellon University
2005, Barry M. Goldwater Excellence in Education National Scholarship

Affiliations Visualize it

Collaborators

Name	Title
Antoci, Valentin	Associate Professor of Orthopaedics
Bennett, Richard	Charles A. and Helen B. Stuart Professor of Molecular Microbiology and Immunology, Chair of Molecular Microbiology and Immunology
Fuchs, Helen	Assistant Professor of Medicine (Research)
Hoffman-Kim, Diane	Associate Professor of Neuroscience, Chair, Brown University Institutional Animal Care and Use Committee, Associate Professor of Engineering
Jamieson, Amanda	Esther Elizabeth Brintzenhoff Associate Professor of Molecular Microbiology and Immunology, Pathobiology Graduate Program Co-Director
Moore, Douglas	Clinical Assistant Professor of Orthopaedics
Mylonakis, Eleftherios	Charles C.J. Carpenter, MD Professor of Infectious Diseases, Professor of Medicine, Professor of Molecular Microbiology and Immunology
Tripathi, Anubhav	Professor of Engineering, Director of Biomedical Engineering
Yang, Wentian	Professor of Medicine, Professor of Orthopaedics

Affiliations

American Chemical Society
American Institute of Chemical Engineers
Biomedical Engineering Society
Society for Biomaterials

Researchers@Brown

Researchers@Brown

Anita Shukla

Elaine I. Savage Professor of Engineering, Professor of Engineering

Overview

Brown Affiliations

Research Areas

On the Web

Publications Visualize it

Research

Research Overview

Background

Education and Training

Postdoctoral/Other Training

Honors and Awards

Affiliations Visualize it

Collaborators

Affiliations

Teaching

Teaching