Reagan, John

selected

Mantripragada KC, Rizk SF, Reagan JL, LeGolvan M. Acquired Syphilis With Anemia and Leukoerythroblastic Reaction: A Case Report. Annals of Internal Medicine. 2016; 165 (3) : 226-7 . full text PubMed
Castillo, Jorge J., Reagan, John L., Sikov, William M., Winer, Eric S. Bortezomib in combination with infusional dose-adjusted EPOCH for the treatment of plasmablastic lymphoma British Journal of Haematology. 2015; 169 (3) : 352-355 . full text PubMed
Reagan JL, Sullivan MR, Winer ES, Lansigan F, Cardin MS, Castillo JJ. Potential for improved survival with intensification of daunorubicin based induction chemotherapy in acute myeloid leukemia patients who do not receive transplant: A multicenter retrospective study Leukemia Research. 2015; 39 (8) : 812-7 . full text PubMed
Mantripragada K, Reagan JL, Quesenberry PJ, Fast LD. Advances in cellular therapy for the treatment of leukemia. Discovery medicine. 2014; 17 (91) : 15-24 . PubMed
Reagan JL, Ingham RR 2nd, Dalia S, Butera JN, Sweeney JD. Differences in the clinical course of heparin induced thrombocytopenia before and after the availability of HIT IgG class testing. Thrombosis research. 2014; 134 (1) : 90-2 . full text PubMed
Reagan JL, Castillo JJ. Ofatumumab as front-line therapy in untreated chronic lymphocytic leukemia. Future oncology (London, England). 2014; 10 (7) : 1147-55 . full text PubMed
Gavini A, Reagan JL, Winer ES, Castillo JJ. Primary refractory Hodgkin lymphoma: limited options and poor survival--but not always. American journal of hematology. 2014; 89 (8) : 853-7 . full text PubMed
Castillo JJ, Reagan JL, Bishop KD, Apor E. Viral lymphomagenesis: from pathophysiology to the rationale for novel therapies. British Journal of Haematology. 2014; 165 (3) : 300-15 . full text PubMed

research overview

My current project focuses on awakening a patient's own immune system cells to recognize and target their blood cancer. This project is termed "Cellular Immunotherapy for Refractory Hematological Malignancies". The central aspect of this project is a clinical trial in which white blood cells taken from a relative are transfused into patient's with leukemia or lymphoma that has not responded to traditional therapies.

research statement

The use of the immune system to treat patients with blood cancers has been studied extensively. One of the primary modalities of immunotherapy for leukemia and lymphoma is allogeneic stem cell transplant. Unfortunately, many patients are unable to tolerate a stem cell transplant because of the toxicity of the therapy in the form of pre-conditioning chemotherapy regimens and risk of graft versus host disease. Previous studies have shown durable responses to T cell infusions in patients with relapsed and refractory hematological malignancies. In these patients the donor cells were rejected by the patient's own immune system thereby reducing the risk of graft versus host disease. Furthermore, it also obviates the need for pre-conditioning chemotherapy as donor cell engraftment is not needed. During this rejection phenomenon, the patients developed a complex cytokine storm that, we believe, was essential for the therapeutic response. In our clinical trial, the primary goal is to treat the blood cancer with donor T cell infusions while a secondary aim is to determine what is the underlying mechanism of action of response. I work closely with an immunologist, Dr. Loren Fast, to determine which cells within the patient's body are being activated by the donor T cell infusion and are therefore responsible for the clinical effect.

funded research

Leukemia and Lymphoma Society Special Fellow in Clinical Research Career Development Award, $195,0000, 7/1/2013

Center of Biomedical Research Excellence at Rhode Island Hospital, $50,000, 7/1/2013

education and training

MD. State University of New York Upstate 2010
BA. Hamilton College 2000

awards and honors

Leukemia and Lymphoma Society Special Fellow in Clinical Research 3 year career development award (2013-2016)

collaborator

Butera, James Clinical Associate Professor of Medicine
Fast, Loren Associate Professor of Medicine (Research)
Quesenberry, Matthew Assistant Professor of Medicine
Quesenberry, Peter Paul Calabresi, M.D. Professor of Oncology, Professor of Medicine
Safran, Howard Professor of Medicine
Winer, Eric Associate Professor of Medicine (Clinical)
Young, Carolyn Clinical Assistant Professor of Pathology and Laboratory Medicine

affiliations

American Society of Hematology (ASH)
American Society of Clinical Oncology (ASCO)
American College of Physicians (ACP)

Researchers @ Brown

John L. Reagan Assistant Professor of Medicine

Brown Affiliations

Research Areas

Publications