Dr. Jun Feng is currently an Associate Professor of Surgery at Warren Alpert Medical School of Brown University and at Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital. Dr. Feng is also the director and senior research scientist of Cardiothoracic Surgery Research Laboratory at Rhode Island Hospital. Dr. Feng is a graduate of Xinyang Medical School and Henan Medical University (Zhengzhou University) with special training in cardiovascular surgery. Dr. Feng then received his PhD in Physiology from School of Medicine, University of Montreal, Montreal, Quebec, Canada.
Dr. Feng serves as Principal Investigator on grants funded by Nationalal Institute of Health, American Heart Association, Rhode Island Research Foundation,and other national/ funding resources. Dr. Feng also serves as co-investigator on a number of grants funded by the National Institute of Health and other research-funding organizations. His research is focused on vascular/endothelial biology and cardiovascular diseases associated with metabolic syndrome, diabetes, hypertension and related cellular and electrical signaling. The overall goal of his research is to advance understanding of coronary heart diseases, particularly macrovascular and microvascular diseases caused by metabolic syndrome, diabetes, and hypertension; and to develop novel therapeutic strategies to effectively treat patients with metabolic syndrome, diabetes, hypertension and coronary artery diseases.
Dr. Feng has published more than 140 peer-review/editorial articles/book chapters and 160 abstracts as correspondent authors, first authors and co-authors. He has served as an editorial member, editorial commentator and peer reviewer for a number of scientific journals in cardiovascular research and medicine. He has served as mentors and advisor for a number of postdoctoral fellows, medical students and undergraduate students.
| Feng J. "From Plasma Free Hemoglobin To Exosome Hemoglobin." The Annals of Thoracic Surgery, 2022. |
| Sabe, Sharif A., Feng, Jun, Sellke, Frank W., Abid, M. Ruhul. "Mechanisms and Clinical Implications of Endothelium-dependent Vasomotor Dysfunction in Coronary Microvasculature." American Journal of Physiology-Heart and Circulatory Physiology, 2022. |
| Kant, Shawn, Sellke, Frank, Feng, Jun. "Metabolic regulation and dysregulation of endothelial small conductance calcium activated potassium channels." European Journal of Cell Biology, vol. 101, no. 2, 2022, pp. 151208. |
| Sabe, Sharif A., Kononov, Martin A., Bellam, Krishna G., Sodha, Neel, Ehsan, Afshin, Jackson, William F., Feng, Jun, Sellke, Frank W. "Poorly controlled hypertension is associated with increased coronary myogenic tone in patients undergoing cardiac surgery with cardiopulmonary bypass." The Journal of Thoracic and Cardiovascular Surgery, 2022. |
| Fayad FH, Sellke FW, Feng J. "Pulmonary hypertension associated with cardiopulmonary bypass and cardiac surgery." Journal of cardiac surgery, 2022. |
| Zhong K, Kant S, Sellke FW, Feng J. "SK Channels and Heart Disease." on Channels - From Basic Properties to Medical Treatment, edited by Zuzana Sevcikova Tomaskova, London, England, intechopen, 2022. |
| Xing H, Zhang Z, Shi G, He Y, Song Y, Liu Y, Harrington EO, Sellke FW, Feng J. "Chronic Inhibition of mROS Protects Against Coronary Endothelial Dysfunction in Mice With Diabetes." Frontiers in Cell and Developmental Biology, vol. 9, 2021, pp. 643810. |
| Scrimgeour LA, Ikeda I, Sellke NC, Shi G, Feng J, Cizginer S, Ehsan A, Sodha NR, Sellke FW. "Glycemic control is not associated with neurocognitive decline after cardiac surgery." Journal of cardiac surgery, 2021. |
| Song Y, Xing H, He Y, Zhang Z, Shi G, Wu S, Liu Y, Harrington EO, Sellke FW, Feng J. "Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia/reoxygenation." The Journal of Thoracic and Cardiovascular Surgery, 2021. |
| Shawn Kant, Frank Sellke, Jun Feng. "Potassium and Cardiac Surgery." Potassium in Human Health, edited by Jie Tang, London, England, IntechOpen, 2021. |
| Ziegler O, Sriram N, Gelev V, Radeva D, Todorov K, Feng J, Sellke FW, Robson SC, Hiromura M, Alexandrov BS, Usheva A. "The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients." Scientific reports, vol. 11, no. 1, 2021, pp. 19752. |
| Zhang Z, Shi G, Liu Y, Xing H, Kabakov AY, Zhao AS, Agbortoko V, Kim J, Singh AK, Koren G, Harrington EO, Sellke FW, Feng J. "Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes." The Journal of Thoracic and Cardiovascular Surgery, 2020. |
| Mirman B, Ikeda I, Zhang Z, Liu Y, Yu L, Ehsan A, Feng J, Sellke F. "Effects of neuropeptide Y on the microvasculature of human skeletal muscle." Surgery, 2020. |
| Liu Y, Kabakov AY, Xie A, Shi G, Singh AK, Sodha NR, Ehsan A, Usheva A, Agbortoko V, Koren G, Dudley SC Jr, Sellke FW, Feng J. "Metabolic regulation of endothelial SK channels and human coronary microvascular function." International Journal of Cardiology, vol. 312, 2020, pp. 1-9. |
| Anderson, Kelsey, Ziegler, Olivia, Shi, Guangbin, Sodha, Neel, Ikeda, Ian, Feng, Jun, Sellke, Frank. "Younger age is associated with greater early neurocognitive decline postcardiopulmonary bypass." JTCVS Open, vol. 1, 2020, pp. 1-9. |
| Feng J, Sellke FW. "Commentary: Ionic heterogeneity in vessel grafts." The Journal of Thoracic and Cardiovascular Surgery, 2019. |
| Lawandy, Isabella, Liu, Yuhong, Shi, Guangbin, Zhang, Zhiqi, Scrimgeour, Laura A., Pavlov, Vasile, Jaworski, Reed, Sellke, Frank W., Feng, Jun. "Increased coronary arteriolar contraction to serotonin in juvenile pigs with metabolic syndrome." Molecular and Cellular Biochemistry, 2019. |
| Karimi M, Pavlov VI, Ziegler O, Sriram N, Yoon SY, Agbortoko V, Alexandrova S, Asara J, Sellke FW, Sturek M, Feng J, Alexandrov BS, Usheva A. "Robust effect of metabolic syndrome on major metabolic pathways in the myocardium." PLoS ONE, vol. 14, no. 12, 2019, pp. e0225857. |
| Ziegler O, Anderson K, Liu Y, Ehsan A, Fingleton J, Sodha N, Feng J, Sellke FW. "Skeletal muscle microvasculature response to β-adrenergic stimuli is diminished with cardiac surgery." Surgery, 2019. |
| Sabe SA, Feng J, Liu Y, Scrimgeour LA, Ehsan A, Sellke FW. "Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes." Surgery, vol. 164, no. 2, 2018, pp. 288-293. |
| Liu, Yuhong, Cole, Victoria, Lawandy, Isabella, Ehsan, Afshin, Sellke, Frank W., Feng, Jun. "Decreased coronary arteriolar response to K<sub>Ca</sub> channel opener after cardioplegic arrest in diabetic patients." Molecular and Cellular Biochemistry, vol. 445, no. 1-2, 2018, pp. 187-194. |
| Sellke, Nicholas, Kuczmarski, Alex, Lawandy, Isabella, Cole, Victoria L., Ehsan, Afshin, Singh, Arun K., Liu, Yuhong, Sellke, Frank W., Feng, Jun. "Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery." The Journal of Thoracic and Cardiovascular Surgery, 2018. |
| Sellke, Nicholas, Gordon, Caroline, Lawandy, Isabella, Gorvitovskaia, Anastassia Y., Scrimgeour, Laura A., Fingleton, James G., Sellke, Frank W., Feng, Jun. "Impaired coronary contraction to phenylephrine after cardioplegic arrest in diabetic patients." Journal of Surgical Research, vol. 230, 2018, pp. 80-86. |
| Dobrilovic, Nikola, Fingleton, James G., Machan, Jason, Vognar, Lidia A., Feng, William, Coady, Michael A., Feng, Jun, Casey, Paula, Singh, Arun K. "Surgical outcomes for type-A aortic dissection in septuagenarians and octogenarians." Chirurgia, vol. 31, no. 3, 2018. |
| Feng J, Anderson K, Liu Y, Singh AK, Ehsan A, Sellke FW. "Cyclooxygenase 2 contributes to bradykinin-induced microvascular responses in peripheral arterioles after cardiopulmonary bypass." Journal of Surgical Research, vol. 218, 2017, pp. 246-252. |
| Potz BA, Scrimgeour LA, Feng J, Sellke FW. "Diabetes and Cardioplegia." Journal of Nature and Science, vol. 3, no. 6, 2017. |
| Feng J, Anderson K, Singh AK, Ehsan A, Mitchell H, Liu Y, Sellke FW. "Diabetes Upregulation of Cyclooxygenase 2 Contributes to Altered Coronary Reactivity After Cardiac Surgery." The Annals of Thoracic Surgery, vol. 104, no. 2, 2017, pp. 568-576. |
| Feng, Jun, Liu, Yuhong, Singh, Arun K., Ehsan, Afshin, Sellke, Nicholas, Liang, Justin, Sellke, Frank W. "Effects of diabetes and cardiopulmonary bypass on expression of adherens junction proteins in human peripheral tissue." Surgery, vol. 161, no. 3, 2017, pp. 823-829. |
| Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K, Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO, Sellke FW, Abid MR. "Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium." Cardiovascular Research, vol. 113, no. 2, 2017, pp. 234-246. |
| Feng, Jun. "Topical amiodarone: To be or not to be effective?." The Journal of Thoracic and Cardiovascular Surgery, 2017. |
| Sabe AA, Potz BA, Elmadhun NY, Liu Y, Feng J, Abid MR, Abbott JD, Senger DR, Sellke FW. "Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia." The Journal of Thoracic and Cardiovascular Surgery, vol. 151, no. 1, 2016, pp. 245-52. |
| Feng J, Sellke F. "Microvascular dysfunction in patients with diabetes after cardioplegic arrest and cardiopulmonary bypass." Current opinion in cardiology, vol. 31, no. 6, 2016, pp. 618-624. |
| Feng J. "Timely screening for Carney complex and PRKAR1A gene mutations." The Journal of Thoracic and Cardiovascular Surgery, vol. 152, no. 5, 2016, pp. 1440-1441. |
| Potz BA, Sabe AA, Elmadhun NY, Feng J, Liu Y, Mitchell H, Quesenberry P, Abid MR, Sellke FW. "Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia." Surgery, vol. 158, no. 2, 2015, pp. 445-52. |
| Feng J, Liu Y, Sabe AA, Sadek AA, Singh AK, Sodha NR, Sellke FW. "Differential impairment of adherens-junction expression/phosphorylation after cardioplegia in diabetic versus non-diabetic patients." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015. |
| Liu, Yuhong, Xie, An, Singh, Arun K., Ehsan, Afshin, Choudhary, Gaurav, Dudley, Samuel, Sellke, Frank W., Feng, Jun. "Inactivation of Endothelial Small/Intermediate Conductance of Calcium‐Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients." Journal of the American Heart Association, vol. 4, no. 8, 2015, pp. e002062. |
| Feng, Jun. "Invited Commentary." The Annals of Thoracic Surgery, vol. 99, no. 2, 2015, pp. 603-604. |
| Feng J. "Invited Commentary." The Annals of Thoracic Surgery, vol. 100, no. 2, 2015, pp. 589-90. |
| Feng, Jun. "Mediterranean-style diet to prevent postoperative atrial fibrillation: Role of antioxidants?." The Journal of Thoracic and Cardiovascular Surgery, vol. 149, no. 4, 2015, pp. 1182-1184. |
| Feng J, Cohn WE, Parnis SM, Sodha NR, Clements RT, Sellke N, Frazier OH, Sellke FW. "New continuous-flow total artificial heart and vascular permeability." Journal of Surgical Research, 2015. |
| Feng J. "Invited commentary." The Annals of Thoracic Surgery, vol. 97, no. 5, 2014, pp. 1650-1. |
| Lassaletta AD, Elmadhun NY, Zanetti AV, Feng J, Anduaga J, Gohh RY, Sellke FW, Bianchi C. "Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis." The Annals of Thoracic Surgery, vol. 97, no. 3, 2014, pp. 901-7. |
| Feng J, Liu Y, Dobrilovic N, Chu LM, Bianchi C, Singh AK, Sellke FW. "Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus." Circulation, vol. 128, no. 11 Suppl 1, 2013, pp. S144-51. |
| Feng J, Liu Y, Dobrilovic N, Singh AK, Sabe AA, Guan Y, Bianchi C, Sellke FW. "Altered expression and activation of mitogen-activated protein kinases in diabetic heart during cardioplegic arrest and cardiopulmonary bypass." Surgery, vol. 154, no. 3, 2013, pp. 436-43. |
| Lassaletta AD, Elmadhun NY, Liu Y, Feng J, Burgess TA, Karlson NW, Laham RJ, Sellke FW. "Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium." Circulation, vol. 128, no. 11 Suppl 1, 2013, pp. S136-43. |
| Shafique E, Choy WC, Liu Y, Feng J, Cordeiro B, Lyra A, Arafah M, Yassin-Kassab A, Zanetti AV, Clements RT, Bianchi C, Benjamin LE, Sellke FW, Abid MR. "Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK." Aging, vol. 5, no. 7, 2013, pp. 515-30. |
| Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW. "Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome." The Journal of Thoracic and Cardiovascular Surgery, vol. 144, no. 6, 2012, pp. 1486-93. |
| Lassaletta AD, Chu LM, Elmadhun NY, Burgess TA, Feng J, Robich MP, Sellke FW. "Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction." Journal of Surgical Research, vol. 178, no. 2, 2012, pp. 586-92. |
| Feng J, Liu Y, Chu LM, Singh AK, Dobrilovic N, Fingleton JG, Clements RT, Bianchi C, Sellke FW. "Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes." Circulation, vol. 126, no. 11 Suppl 1, 2012, pp. S73-80. |
| Feng J, Chu LM, Dobrilovic N, Liu Y, Singh AK, Sellke FW. "Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus." Surgery, vol. 152, no. 2, 2012, pp. 262-9. |
| Chu LM, Robich MP, Bianchi C, Feng J, Liu Y, Xu SH, Burgess T, Sellke FW. "Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia." AJP: Heart and Circulatory Physiology, vol. 302, no. 2, 2012, pp. H479-88. |
| Lassaletta AD, Chu LM, Robich MP, Elmadhun NY, Feng J, Burgess TA, Laham RJ, Sturek M, Sellke FW. "Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia." Basic research in cardiology, vol. 107, no. 2, 2012, pp. 243. |
| Robich MP, Chu LM, Burgess TA, Feng J, Han Y, Nezafat R, Leber MP, Laham RJ, Manning WJ, Sellke FW. "Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome." Journal of the American College of Surgeons, vol. 215, no. 5, 2012, pp. 681-9. |
| Feng J, Liu Y, Khabbaz KR, Hagberg R, Robich MP, Clements RT, Bianchi C, Sellke FW. "Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients." Surgery, vol. 149, no. 2, 2011, pp. 247-52. |
| Robich MP, Chu LM, Burgess TA, Feng J, Bianchi C, Sellke FW. "Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on myocardial function and perfusion." Journal of cardiovascular pharmacology, vol. 57, no. 1, 2011, pp. 122-30. |
| Chu LM, Robich MP, Lassaletta AD, Feng J, Xu SH, Heinl R, Liu Y, Sellke E, Sellke FW. "High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine." Surgery, vol. 150, no. 3, 2011, pp. 490-6. |
| Feng J, Liu Y, Singh AK, Dobrilovic N, Feng WC, Chu LM, Robich MP, Khabbaz KR, Sellke FW. "Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass." Surgery, vol. 150, no. 2, 2011, pp. 263-71. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 92, no. 5, 2011, pp. 1726. |
| Feng J. "Invited commentary." The Annals of Thoracic Surgery, vol. 92, no. 4, 2011, pp. 1307. |
| Clements RT, Feng J, Cordeiro B, Bianchi C, Sellke FW. "p38 MAPK-dependent small HSP27 and αB-crystallin phosphorylation in regulation of myocardial function following cardioplegic arrest." AJP: Heart and Circulatory Physiology, vol. 300, no. 5, 2011, pp. H1669-77. |
| Robich MP, Osipov RM, Chu LM, Han Y, Feng J, Nezafat R, Clements RT, Manning WJ, Sellke FW. "Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia." European journal of pharmacology, vol. 664, no. 1-3, 2011, pp. 45-53. |
| Chu LM, Robich MP, Lassaletta AD, Feng J, Laham RJ, Burgess T, Clements RT, Sellke FW. "Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia." Surgery, vol. 150, no. 3, 2011, pp. 390-9. |
| Clements RT, Cordeiro B, Feng J, Bianchi C, Sellke FW. "Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts." Circulation, vol. 124, no. 11 Suppl, 2011, pp. S55-61. |
| Feng J, Liu Y, Chu LM, Clements RT, Khabbaz KR, Robich MP, Bianchi C, Sellke FW. "Thromboxane-induced contractile response of human coronary arterioles is diminished after cardioplegic arrest." The Annals of Thoracic Surgery, vol. 92, no. 3, 2011, pp. 829-36. |
| Robich MP, Araujo EG, Feng J, Osipov RM, Clements RT, Bianchi C, Sellke FW. "Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass." The Journal of Thoracic and Cardiovascular Surgery, vol. 139, no. 4, 2010, pp. 1033-40. |
| Oyamada S, Osipov R, Bianchi C, Robich MP, Feng J, Liu Y, Burgess TA, Bell TM, Sheller MR, Sellke FW. "Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine." The Journal of pharmacology and experimental therapeutics, vol. 334, no. 2, 2010, pp. 449-59. |
| Osipov RM, Robich MP, Feng J, Chan V, Clements RT, Deyo RJ, Szabo C, Sellke FW. "Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass." Interactive cardiovascular and thoracic surgery, vol. 10, no. 4, 2010, pp. 506-12. |
| Chu LM, Osipov RM, Robich MP, Feng J, Sheller MR, Sellke FW. "Effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes mellitus." Circulation, vol. 122, no. 11 Suppl, 2010, pp. S162-9. |
| Feng J, Chu LM, Robich MP, Clements RT, Khabbaz KR, Hagberg R, Liu Y, Osipov RM, Sellke FW. "Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation." Circulation, vol. 122, no. 11 Suppl, 2010, pp. S150-5. |
| Robich MP, Matyal R, Chu LM, Feng J, Xu SH, Laham RJ, Hess PE, Bianchi C, Sellke FW. "Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia." Journal of Molecular and Cellular Cardiology, vol. 49, no. 6, 2010, pp. 1022-30. |
| Robich MP, Chu LM, Feng J, Burgess TA, Laham RJ, Bianchi C, Sellke FW. "Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium." The Journal of Thoracic and Cardiovascular Surgery, vol. 140, no. 5, 2010, pp. 1143-52. |
| Feng J, Liu Y, Khabbaz KR, Hagberg R, Sodha NR, Osipov RM, Sellke FW. "Endothelin-1-induced contractile responses of human coronary arterioles via endothelin-A receptors and PKC-alpha signaling pathways." Surgery, vol. 147, no. 6, 2010, pp. 798-804. |
| Feng J, Damrauer SM, Lee M, Sellke FW, Ferran C, Abid MR. "Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species." Arteriosclerosis, thrombosis, and vascular biology, vol. 30, no. 9, 2010, pp. 1703-10. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 90, no. 1, 2010, pp. 30. |
| Chu LM, Osipov RM, Robich MP, Feng J, Oyamada S, Bianchi C, Sellke FW. "Is hyperglycemia bad for the heart during acute ischemia?." The Journal of Thoracic and Cardiovascular Surgery, vol. 140, no. 6, 2010, pp. 1345-52. |
| Robich MP, Osipov RM, Nezafat R, Feng J, Clements RT, Bianchi C, Boodhwani M, Coady MA, Laham RJ, Sellke FW. "Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia." Circulation, vol. 122, no. 11 Suppl, 2010, pp. S142-9. |
| Robich MP, Osipov RM, Chu LM, Feng J, Burgess TA, Oyamada S, Clements RT, Laham RJ, Sellke FW. "Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia." Journal of the American College of Surgeons, vol. 211, no. 4, 2010, pp. 470-80. |
| Qiu L, Chuttani R, Zhang S, Feng J, Itani S, Fang H, Pleskow D, Sawhney MS, Salahuddin S, Modell MD, Vitkin E, Hanlon EB, Itzkan I, Perelman LT. "Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument." 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, vol. 2009, 2009, pp. 1997-2000. |
| Osipov RM, Robich MP, Feng J, Liu Y, Clements RT, Glazer HP, Sodha NR, Szabo C, Bianchi C, Sellke FW. "Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection." Journal of cardiovascular pharmacology, vol. 54, no. 4, 2009, pp. 287-97. |
| Osipov RM, Bianchi C, Feng J, Clements RT, Liu Y, Robich MP, Glazer HP, Sodha NR, Sellke FW. "Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion." Circulation, vol. 120, no. 11 Suppl, 2009, pp. S22-30. |
| Osipov RM, Robich MP, Feng J, Clements RT, Liu Y, Glazer HP, Wagstaff J, Bianchi C, Sellke FW. "Effect of thrombin fragment (TP508) on myocardial ischemia-reperfusion injury in hypercholesterolemic pigs." Journal of Applied Physiology, vol. 106, no. 6, 2009, pp. 1993-2001. |
| Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Stahl GL, Sellke FW. "Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury." The Journal of Thoracic and Cardiovascular Surgery, vol. 138, no. 4, 2009, pp. 977-84. |
| Clements RT, Sodha NR, Feng J, Boodhwani M, Liu Y, Mieno S, Khabbaz KR, Bianchi C, Sellke FW. "Impaired coronary microvascular dilation correlates with enhanced vascular smooth muscle MLC phosphorylation in diabetes." Microcirculation (New York, N.Y. : 1994), vol. 16, no. 2, 2009, pp. 193-206. |
| Feng J, Liu Y, Khabbaz KR, Sodha NR, Osipov RM, Hagberg R, Alper SL, Sellke FW. "Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass." Journal of Surgical Research, vol. 157, no. 1, 2009, pp. 123-8. |
| Osipov RM, Bianchi C, Clements RT, Feng J, Liu Y, Xu SH, Robich MP, Wagstaff J, Sellke FW. "Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury." The Annals of Thoracic Surgery, vol. 87, no. 3, 2009, pp. 786-93. |
| Boodhwani M, Mieno S, Feng J, Sodha NR, Clements RT, Xu SH, Sellke FW. "Atorvastatin impairs the myocardial angiogenic response to chronic ischemia in normocholesterolemic swine." The Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 1, 2008, pp. 117-22. |
| Sodha NR, Boodhwani M, Ramlawi B, Clements RT, Mieno S, Feng J, Xu SH, Bianchi C, Sellke FW. "Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia." Journal of cardiac surgery, vol. 23, no. 4, 2008, pp. 312-20. |
| Feng J, Liu Y, Clements RT, Sodha NR, Khabbaz KR, Senthilnathan V, Nishimura KK, Alper SL, Sellke FW. "Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest." Circulation, vol. 118, no. 14 Suppl, 2008, pp. S46-51. |
| Liu Y, Sellke EW, Feng J, Clements RT, Sodha NR, Khabbaz KR, Senthilnathan V, Alper SL, Sellke FW. "Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass." Surgery, vol. 144, no. 2, 2008, pp. 239-44. |
| Boodhwani M, Voisine P, Ruel M, Sodha NR, Feng J, Xu SH, Bianchi C, Sellke FW. "Comparison of vascular endothelial growth factor and fibroblast growth factor-2 in a swine model of endothelial dysfunction." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 33, no. 4, 2008, pp. 645-50; discussion 251-2. |
| Sodha NR, Boodhwani M, Clements RT, Feng J, Xu SH, Sellke FW. "Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity." Microvascular Research, vol. 75, no. 2, 2008, pp. 238-46. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 85, no. 1, 2008, pp. 87-8. |
| Khabbaz KR, Feng J, Boodhwani M, Clements RT, Bianchi C, Sellke FW. "Nonischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia." The Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 1, 2008, pp. 139-46. |
| Clements RT, Smejkal G, Sodha NR, Ivanov AR, Asara JM, Feng J, Lazarev A, Gautam S, Senthilnathan V, Khabbaz KR, Bianchi C, Sellke FW. "Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass." Circulation, vol. 118, no. 14 Suppl, 2008, pp. S24-31. |
| Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Sellke FW. "The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 33, no. 5, 2008, pp. 906-13. |
| Khan TA, Bianchi C, Ruel M, Feng J, Sellke FW. "Differential effects on the mesenteric microcirculatory response to vasopressin and phenylephrine after cardiopulmonary bypass." The Journal of Thoracic and Cardiovascular Surgery, vol. 133, no. 3, 2007, pp. 682-8. |
| Boodhwani M, Sodha NR, Mieno S, Xu SH, Feng J, Ramlawi B, Clements RT, Sellke FW. "Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes." Circulation, vol. 116, no. 11 Suppl, 2007, pp. I31-7. |
| Ramlawi, Basel, Scott, Jeffrey R., Feng, Jun, Mieno, Shigetoshi, Raman, Kathleen G., Gallo, David, Csizmadia, Eva, Yoke Chin, Beek, Bach, Fritz H., Otterbein, Leo E., Sellke, Frank W. "Inhaled carbon monoxide prevents graft-induced intimal hyperplasia in swine." Journal of Surgical Research, vol. 138, no. 1, 2007, pp. 121-127. |
| Boodhwani M, Sodha NR, Mieno S, Ramlawi B, Xu SH, Feng J, Clements RT, Ruel M, Sellke FW. "Insulin treatment enhances the myocardial angiogenic response in diabetes." The Journal of Thoracic and Cardiovascular Surgery, vol. 134, no. 6, 2007, pp. 1453-60; discussion 1460. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 83, no. 3, 2007, pp. 1119-20. |
| Clements RT, Sodha NR, Feng J, Mieno S, Boodhwani M, Ramlawi B, Bianchi C, Sellke FW. "Phosphorylation and translocation of heat shock protein 27 and alphaB-crystallin in human myocardium after cardioplegia and cardiopulmonary bypass." The Journal of Thoracic and Cardiovascular Surgery, vol. 134, no. 6, 2007, pp. 1461-70. |
| Sodha NR, Feng J, Clements RT, Bianchi C, Boodhwani M, Ramlawi B, Mieno S, Khabbaz KR, Sellke FW. "Protein kinase C alpha modulates microvascular reactivity in the human coronary and skeletal microcirculation." Surgery, vol. 142, no. 2, 2007, pp. 243-52. |
| Feng J, Yano K, Monahan-Earley R, Morgan ES, Dvorak AM, Sellke FW, Aird WC. "Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa." American journal of physiology. Regulatory, integrative and comparative physiology, vol. 293, no. 2, 2007, pp. R894-900. |
| Feng J, Sellke ME, Ramlawi B, Boodhwani M, Clements R, Li J, Bianchi C, Sellke FW. "Bradykinin induces microvascular preconditioning through the opening of calcium-activated potassium channels." Surgery, vol. 140, no. 2, 2006, pp. 192-7. |
| Ramlawi B, Rudolph JL, Mieno S, Feng J, Boodhwani M, Khabbaz K, Levkoff SE, Marcantonio ER, Bianchi C, Sellke FW. "C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery." Surgery, vol. 140, no. 2, 2006, pp. 221-6. |
| Boodhwani M, Feng J, Mieno S, Ramlawi B, Sodha N, Clements R, Sellke FW. "Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 29, no. 5, 2006, pp. 736-41. |
| Boodhwani M, Nakai Y, Voisine P, Feng J, Li J, Mieno S, Ramlawi B, Bianchi C, Laham R, Sellke FW. "High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response." Circulation, vol. 114, no. 1 Suppl, 2006, pp. I402-8. |
| Boodhwani M, Mieno S, Voisine P, Feng J, Sodha N, Li J, Sellke FW. "High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine." The Journal of Thoracic and Cardiovascular Surgery, vol. 132, no. 6, 2006, pp. 1299-306. |
| Mieno S, Boodhwani M, Ramlawi B, Li J, Feng J, Bianchi C, Laham RJ, Li J, Sellke FW. "Human coronary microvascular effects of cardioplegia-induced stromal-derived factor-1alpha." The Annals of Thoracic Surgery, vol. 82, no. 2, 2006, pp. 657-63. |
| Boodhwani M, Nakai Y, Mieno S, Voisine P, Bianchi C, Araujo EG, Feng J, Michael K, Li J, Sellke FW. "Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: role of endostatin and oxidative stress." The Annals of Thoracic Surgery, vol. 81, no. 2, 2006, pp. 634-41. |
| Ramlawi B, Feng J, Mieno S, Szabo C, Zsengeller Z, Clements R, Sodha N, Boodhwani M, Bianchi C, Sellke FW. "Indices of apoptosis activation after blood cardioplegia and cardiopulmonary bypass." Circulation, vol. 114, no. 1 Suppl, 2006, pp. I257-63. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 81, no. 6, 2006, pp. 2225-6. |
| Khan TA, Bianchi C, Voisine P, Sandmeyer J, Feng J, Sellke FW. "Aprotinin inhibits protease-dependent platelet aggregation and thrombosis." The Annals of Thoracic Surgery, vol. 79, no. 5, 2005, pp. 1545-50. |
| Khan TA, Bianchi C, Araujo E, Voisine P, Xu SH, Feng J, Li J, Sellke FW. "Aprotinin preserves cellular junctions and reduces myocardial edema after regional ischemia and cardioplegic arrest." Circulation, vol. 112, no. 9 Suppl, 2005, pp. I196-201. |
| Feng J, Bianchi C, Sandmeyer JL, Sellke FW. "Bradykinin preconditioning improves the profile of cell survival proteins and limits apoptosis after cardioplegic arrest." Circulation, vol. 112, no. 9 Suppl, 2005, pp. I190-5. |
| Feng J, Bianchi C, Li J, Sellke FW. "Bradykinin preconditioning preserves coronary microvascular reactivity during cardioplegia-reperfusion." The Annals of Thoracic Surgery, vol. 79, no. 3, 2005, pp. 911-6. |
| Voisine P, Li J, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Rosinberg A, Malik T, Nakai Y, Sellke FW. "Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction." Circulation, vol. 112, no. 9 Suppl, 2005, pp. I202-7. |
| Nakai Y, Voisine P, Bianchi C, Xu SH, Feng J, Malik T, Rosinberg A, Sellke FW. "Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia." Surgery, vol. 138, no. 2, 2005, pp. 291-8. |
| Feng J, Sellke FW. "Invited commentary." The Annals of Thoracic Surgery, vol. 80, no. 6, 2005, pp. 2234. |
| Feng J, Bianchi C, Sandmeyer JL, Li J, Sellke FW. "Molecular indices of apoptosis after intermittent blood and crystalloid cardioplegia." Circulation, vol. 112, no. 9 Suppl, 2005, pp. I184-9. |
| Voisine P, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Li J, Malik T, Rosinberg A, Sellke FW. "Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction." The Journal of Thoracic and Cardiovascular Surgery, vol. 129, no. 6, 2005, pp. 1414-20. |
| Boodhwani M, Cohn WE, Feng J, Ramlawi B, Mieno S, Schwarz A, Sellke FW. "Safety and efficacy of a novel gel for vascular occlusion in off-pump surgery." The Annals of Thoracic Surgery, vol. 80, no. 6, 2005, pp. 2333-7. |
| Feng J, Bianchi C, Li J, Sellke FW. "Improved profile of bad phosphorylation and caspase 3 activation after blood versus crystalloid cardioplegia." The Annals of Thoracic Surgery, vol. 77, no. 4, 2004, pp. 1384-9; discussion 1389-90. |
| Voisine P, Bianchi C, Ruel M, Malik T, Rosinberg A, Feng J, Khan TA, Xu SH, Sandmeyer J, Laham RJ, Sellke FW. "Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor." Surgery, vol. 136, no. 2, 2004, pp. 407-15. |
| Khan TA, Bianchi C, Voisine P, Feng J, Baker J, Hart M, Takahashi M, Stahl G, Sellke FW. "Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest." The Journal of Thoracic and Cardiovascular Surgery, vol. 128, no. 4, 2004, pp. 602-8. |
| Feng J, Li H, Rosenkranz ER. "K(ATP) channel opener protects neonatal rabbit heart better than St. Thomas' solution." Journal of Surgical Research, vol. 109, no. 2, 2003, pp. 69-73. |
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Rosenkranz ER, Feng J, Li HL:.
"Myocardial Preconditioning in the Experimental Model: A New Strategy to Improve Myocardial Protection." Myocardial Protection, edited by Tomas A. Salerno, Marco Ricci, Wiley-Blackwell, 2003, pp. 230-263.
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| Feng J, Li H, Rosenkranz ER. "Diazoxide protects the rabbit heart following cardioplegic ischemia." Molecular and Cellular Biochemistry, vol. 233, no. 1-2, 2002, pp. 133-8. |
| Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty JM Jr. "Preload induces troponin I degradation independently of myocardial ischemia." Circulation, vol. 103, no. 16, 2001, pp. 2035-7. |
| Feng J, Li H, Rosenkranz ER. "Bradykinin protects the rabbit heart after cardioplegic ischemia via NO-dependent pathways." The Annals of Thoracic Surgery, vol. 70, no. 6, 2000, pp. 2119-24. |
| Feng J, Chahine R, Nadeau R. "Influence of extracellular potassium on the antiarrhythmic effect of global preconditioning in isolated perfused rat hearts." Molecular and Cellular Biochemistry, vol. 214, no. 1-2, 2000, pp. 75-80. |
| Feng J, Li H, Rosenkranz ER. "Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts." Journal of Surgical Research, vol. 90, no. 2, 2000, pp. 131-7. |
| Thomas SA, Fallavollita JA, Lee TC, Feng J, Canty JM Jr. "Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine." Circulation research, vol. 85, no. 5, 1999, pp. 446-56. |
| Feng J, Rosenkranz ER. "Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways." The Annals of Thoracic Surgery, vol. 68, no. 5, 1999, pp. 1567-72. |
| Feng J, Wu G, Tang S. "The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart." Planta medica, vol. 65, no. 3, 1999, pp. 268-70. |
| Chahine R, Feng J. "Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart." Arzneimittel-Forschung, vol. 48, no. 4, 1998, pp. 360-4. |
| Feng J, Liu R, Wu G, Tang S. "Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart." Molecular and Cellular Biochemistry, vol. 167, no. 1-2, 1997, pp. 153-8. |
| Feng J, Yamaguchi N, Foucart S, Chahine R, Lamontagne D, Nadeau R. "Transient ischemia inhibits nonexocytotic release of norepinephrine following sustained ischemia in rat heart: is bradykinin involved?." Canadian journal of physiology and pharmacology, vol. 75, no. 6, 1997, pp. 665-70. |
| Feng J, Wu G, Tang S, Chahine R, Lamontagne D. "Beneficial effects of iloprost cardioplegia in ischemic arrest in isolated working rat heart." Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol. 54, no. 4, 1996, pp. 279-83. |
| Feng J, Chahine R, Yamaguchi N, Lamontagne D, Nadeau R. "Brief repetitive ischemia: effect on norepinephrine release, arrhythmias, and functional recovery in isolated perfused rat heart." Canadian journal of physiology and pharmacology, vol. 74, no. 12, 1996, pp. 1351-8. |
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Feng J, Yamaguchi N, Chahine R, Lamontagne D, Nadeau R.
"Perfusate potassium: effect on ischemia-induced arrhythmias in preconditioning in the isolated rat heart." Medical Science Research , vol. 24, 1996, pp. 327-329.
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| Feng J, Liu R, Wu G, Tang S. "Pretreatment with tetramethylpyrazine increases the release of PGI2 and decreases TXA2 release in isolated rat heart." Planta medica, vol. 62, no. 4, 1996, pp. 379-81. |
| Feng J, Wu G, Liu R, Tang S. "Prostaglandin E1 (PGE1) reduces cardiac-derived TXA2 release in ischaemic arrest in isolated working rat heart." International Journal of Cardiology, vol. 55, no. 3, 1996, pp. 265-70. |
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Feng J, Liu RY, Wu GZ, Tang SB.
"Tetramethylpyrazine reduces cardiac-derived TXA2 release in isolated working rat heart." Medical Science Research , vol. 24, 1996, pp. 121-122.
|
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Feng J, Atanasiu R, Yamaguchi N, Lamontagne D, Chahine R Nadeau R.
"Effects of ischemic preconditioning and hypothermia on ischemic contracture in the isolated rat heart." Medical Science Research , vol. 23, 1995, pp. 787-788.
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My research mainly focuses on metabolic regulation of calcium-activated potassium channels, endothelial function and microcirculation under a variety of pathological conditions such as diabetes, hypertension, obesity, heart failure, ischemia/reperfusion, cardioplegic arrest and cardiopulmonary bypass. Our goal is to develop new therapeutic strategies that ultimately should benefit patients with cardiovascular disease.
Ongoing Research Support
3R01HL13647-04S1 Feng (PI) 7/15/2020-3-31.2022
"Metaolic modulation of SK/IK channels for cerebrovascular endothelial protection related to Alzeimer's Disease"
The goal of this funded proposal is to investigate metabolic modulation of endothelial SK/IK channels in the cerebral microcirculation related to Alzeimer's disease.
Direct cost: $250,000.00 Total cost: $399,345.00
Role: Principal-Investigator
Hazel C. Pilon Cardiac Research Fund
Role: Principal-Investigator
Direct Cost: $50000.00; Total Cost: $57191.00 2018-2021
1R01 HL136347-01 Feng (PI) 4/1/2017-3/31/2022
“SKCa/IKCa Channel Activation and Endothelial Protection During Cardiac Surgery”
Direct Cost: $100,000; Total Cost: $1541,174.00
Role: Principal-Investigator
1RO1HL127072 Feng (PI) 9/1/2016-5/31/2022
Title: “Metabolic Regulation of SKCa/IKCa Channels and Endothelial Function”
Direct Cost: $100,0000; Total cost: $1,537,569
The goal of the proposed research is to determine diabetic regulation of endothelial SKCa/IKCa channels in human coronary microcirculation and endothelial protection.
R01 HL046716 Sellke (PI) 08/01/92-02/28/24
“Cardioplegia and Coronary Microvascular Reactivity”
The major goals of this project are to continue defining the effects of cardioplegia and extracorporeal circulation on endothelial and vascular smooth muscle pathways of vasomotor regulation.
Total cost: $2,467,832
Role: Co-investigator
Complete Research Support
15GRNT23230014 (AHA-Grant-in-Aid) Feng (PI) 7/1/2015-8/31/2019
Title: “Metabolic Regulation of Endothelial KCa Channels and Coronary Endothelial Function”
The goal of the proposed research is to determine the metabolic regulation of endothelial SKCa/IKCa channels and pig endothelial function.
Direct Cost: $180,000; Total Cost: $198,000
Role: Principle-Investigator
Brown University Sellke (PI) 6/1/2016-5/31/2017
Title: “A New Optical Technique for Biomolecule Analysis”
Major Goals: To investigate a new optical technique for analyzing protein expression
Total cost: $50,000.00
Role: Co-Investigator
R01HL090921 Frazier (PI) 09/01/09-12/31/16
“Effects of a Pulse Induced by a Constant-flow Total Cardiac Replacement Device”
Major Goals: The goal of the proposed BRP project is to show that a next-generation CRD comprising two integrated CF (HeartMate III) rotary pumps can provide adequate pulmonary and systemic circulation to meet physiologic demands.
Role: Co-Investigator
1P20GM103652 Feng (PI) 6/1/2014-5/30/2016
NIH-COBRE-Pilot Project: SK/IK Channel Dys-regulation and Endothelium Dysfunction in Diabetic Patients
Major Goals: To determine the role of endothelial SKCa/IKCa channels in endothelial dysfunction in diabetic patients
Role: Principle-Investigator
5P20 GM104937-07 Feng (PI) 9/1/2013- 8/30/2014
“Over-Expression of miR-365 in Mice Improves Skeletal Muscle Growth and Muscle Function”
Major Goals: To determine if over-expression of miR-365 in mice affects skeletal muscle growth and muscle function
Role: Principle-Investigator
RIF-20123834 Feng (PI) 3/15/2013- 8/30/2014
Calcium-Activated Potassium Channels and Protection of Diabetic Coronary Arterioles”
Major Goals: To examine the protective effects of exogenous administration of Calcium-Activated Potassium Channel activators in human coronary microcirculation.
Role: Principle-Investigator
07/1/07-7/31/12 NIH/NHLBI R01HL069024-06A1“Surgical Intramycardial Angiogenesis in a Swine Model” PI: Frank Sellke
Major Goals: The goal of the proposed research is to determine the cause(s) that lead diabetic patients to a poor response to endogenous angiogenesis after a chronic ischemic insult to the heart.
Role: Co-Investigator
08/01/08-05/31/10 NIH/NHLBI R01 HL85647
Angiogenesis in a model of diabetes and endothelial dysfunction
The goal of the proposed research is to study the effect of diabetes in a swine model of coronary endothelial dysfunction;
PI: Frank W. Sellke Role: Co-Investigator
08/01/2008- 5/31/2010, NIH/NHLBI, R01 HL085647-02, “Angiogenesis in a model of diabetes and endothelial dysfunction”. P.I. Frank W. Sellke; Role: Co-Investigator
| Year | Degree | Institution |
|---|---|---|
| 1998 | PhD | University of Montreal |
| 1990 | MSc | Henan University |
| 1983 | MD | Xinjiang Medical University (新疆医科大学) |
| Postdoctoral Fellow | SUNY Buffalo, Surgery | 1998-2000 | Buffalo, NY |
| Resident; Research Fellow | Henan Medical University, First Teaching Hospital, thoracic and cardiovascular surgery | 1990-1991 | Zhengzhou, Henan, China |
| Resident | Gushi Hospital, internal medicine | 1985-1987 | Gushi, Henan, China |
| Resident | Gushi Hospital, general surgery | 1984-1985 | Gushi, Henan, China |
Travel Award from 8th International Conference on Prostaglandins, Leuketrienes and Relative Compounds, 1992, Montreal, Canada
Scholarship Award for Graduate Student from China and Canada Exchange program, 1994-1995
AHA Scientific Session Travel Awards 2013
Honorary Master Degree of Art, Brown University
| Name | Title |
|---|---|
| Choudhary, Gaurav | Ruth and Paul Levinger Professor of Cardiology |
| Dudley, Samuel | Adjunct Professor of Medicine |
| Ehsan, Afshin | Professor of Surgery |
| Harrington, Elizabeth | Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology and Medicine, Professor of Medicine |
| Machan, Jason | Associate Professor of Surgery (Research), Associate Professor of Orthopaedics (Research) |
| O-Uchi, Jin | Assistant Professor of Medicine |
| Rounds, Sharon | Associate Dean for Translational Science, Professor of Medicine, Professor of Pathology and Laboratory Medicine |
| Singh, Arun | Clinical Professor Emeritus of Surgery |
| Sodha, Neel | Associate Professor of Surgery |
| Tremont, Geoffrey | Associate Professor of Psychiatry and Human Behavior |
| Xie, An | Assistant Professor of Medicine (Research) |
| Zhou, Anyu | Assistant Professor of Medicine (Research) |
POSTGRADUATE TRAINING
1984-1985 Resident, Department of General Surgery, Gushi Hospital, Gushi, Henan, P.R. China
1985-1987 Resident, Department of Internal Medicine, Gushi Hospital, Gushi, Henan, P.R.China
1990-1991 Research Fellow, Department of Thoracic and Cardiovascular Surgery, First Teaching Hospital, Henan Medical University, Zhengzhou, Henan, P.R. China
1998-2000 Postdoctoral Fellow, Department of Surgery, SUNY Buffalo, Buffalo, NY
ACADEMIC APPOINTMENTS
2016-Current Associate Professor of Surgery, Alpert Medical School of Brown University, Providence, RI
2009-2016 Assistant Professor of Surgery, Alpert Medical School of Brown University, Providence, RI
2002-2009 Instructor in Surgery, Department of Surgery, Harvard Medical School, Boston, MA.
Supervisor: Dr. Frank W. Sellke
1998-2000 Research Associate, Department of Surgery, SUNY Buffalo, Buffalo, NY,
Supervisor: Dr. Eliot Rosenkranz; Co-Supervisor: Dr. John Canty Jr.
1991-1992 Attending Physician, Faculty of Clinical Medicine, Henan Medical University, Zhengzhou, Henan, P.R. China
HOSPITAL APPOINTMENTS
2015-present Research Scientist, Department of Surgery, Rhode Island Hospital, Providence, RI
2014-Current Director of Cardiothoracic Surgery Research Laboratory, Department of Surgery, Rhode Island Hospital, CVRC, Providence, RI
2009-Current Research Associate, Department of Surgery, Rhode Island Hospital, Providence. RI
2002-2009 Research Staff, Cardiothoracic Surgery Laboratory, Beth Israel Deaconess Medical Center, Boston, MA
2000-2001 Director, Pediatric Cardiovasc Surgery Laboratory, Jackson Memorial Hospital, (City, State)
1998-2000 Staff, Children’s Hospital of Buffalo, Buffalo, NY
1990-1991 Resident and Research Fellow, Department of Thoracic and Cardiovascular Surgery, First Teaching Hospital, Henan Medical University, Zhengzhou, Henan, P.R. China
1987-1990 Research Assistant, Department of Thoracic and Cardiovascular Surgery, First Teaching Hospital, Henan Medical University, Zhengzhou Henan, P.R. China
1985-1987 Resident, Department of Internal Medicine, Gushi Hospital, Gushi, Henan, P.R. China
1984-1985 Resident, Department of General Surgery, Gushi Hospital, Gushi, Henan, P.R. China
Deputy Chairman for Young Workers Society
| Research Associate. Rhode Island Hospital, 2009-Present |
| Post-Doctoral Research Staff. Beth Israel Deaconess Medical Center, 2002-2009 |
| Director. Jackson Memorial Hospital, 2000-2001 |
| Staff. Children's Hospital of Buffalo, 1998-2000 |
| Research Associate. SUNY Buffalo, 1998-2000 |
| Research Assistant. First Teaching Hospital, Henan Medical University, 1987-1990 |
University Teaching:
Biology Independent Study, BIO-1950/60-Read Jaworski 2018-2019
Biology Independent Study, BIO-1950/60-Justin Kim 2019-2021
Biology Independent Study, BIO-1950/60-Yusuf Kaim 2021
Biology Independent Study, BIO-1950/60-Martin Kononov 2021-2022
Biology Independent Study, BIO-1950/60-Ju-Woo Nho 2022
Hospital and Medical School Teaching:
Faculty-Trainee Collaborative Research Grants:
Undergraduate student: Amy Zhao
Agency: Agency: Summer 2021 Brown-Conneted SPRINT UTRA Awards
Title: “Alterations of alpha-adrenergic receptor signaling in patients with hypertension following cardiac surgery”
Period: 6/15/2022-7/30/2022
Direct cost: $3570.00
Role: Co-mentor for Brown University Undergraduate student, Amy Zhao
Agency: Brown University SR-EIP
ID: NHLBI R25
Undergraduate student: Qian Wang
Period: 2021 summer 6/1/2016-8/20/2016
Title: “NADPH oxidase and coronary endothelial function”
Direct cost: $3570.00
Role: Mentor for National undergraduate student, Qian (Lina) Wang
Undergraduate student: Martin Kononov
Agency: Summer 2021 Brown-Conneted SPRINT UTRA Awards
Title: “Vasomotor Response to Vasopressin in Patients with Hypertension Following Cardiac Surgery”
Period: 6/1/2021-7/30/2021
Direct cost: $2000.00
Role: Co-Mentor for Brown University undergraduate student, Martin Kononov
Medical Student: Shawn Kant
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID: BTR
Title: “The Role of Gender Differences on Neurocognitive Decline following Cardiopulmonary Bypass”
Period: 6/1/2021-8/15/2021
Direct cost: $4,383.00
Role: Co-mentor for Brown Medical Student Shawn Kant
Medical Student:Ronald Phillips
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID: NIH T35HL094308
Title: “Effect of Cardioplegic arrest and CPB on Coronary myogenic tone After Cardiac Surgery”
Period: 6/1/2020-8/15/2020
Direct cost: $4,383.00
Role: Co-mentor for Brown Medical Student Ronald Phillips
Agency: AHA Scientific Session 2019, CVSA Vivien Thomas Young Investigator Award
Award Finalist: Zhiqi Zhang
Title: SK channels and Cardioprotection
Role: Mentor
Title: ““Effect of age on neurocognitive decline post-cardiopulmonary bypass in the setting of cardiac surgery”
Role: mentor for Brown Medical Student Ian Ikeda
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:BTR
Title: “: “Effect of Diabetes on Beta Adrenergic Receptor Signaling in Coronary Microvascular Reactivity After Cardiac Surgery””
Award: The Outstanding Presentation in Basic Science Research at the 12th Annual Warren Alpert Medical School Academic Symposium
Period: 10/1/2018-8/15/2019
Direct cost: $4,383.00
Role: Co-Mentor for Brown Medical Student Ben Mirman
Agency: Summer Karen T. Romer Undergraduate Teaching and Research Awards (UTRAs)
Title: “The therapeutic implications of PKC inhibition in endothelial dysfunction induced by cardioplegic-ischemia/reperfusion injury”
Period: 6/15/2019-7/30/2019
Direct cost: $3570
Role: Mentor for Brown University PLME undergraduate student, Rood Jorwski
Agency: Summer Karen T. Romer Undergraduate Teaching and Research Awards (UTRAs)
Title: “The therapeutic implications of PKC inhibition in endothelial dysfunction induced by cardioplegic-ischemia/reperfusion injury”
Period: 6/15/2018-7/30/2018
Direct cost: $3570
Role: Mentor for Brown University PLME student, Justin Kim
Agency: Summer Research Assistantship (SRA) Award
Title: “The therapeutic implications of PKC inhibition in endothelial dysfunction induced by cardioplegic-ischemia/reperfusion injury”
Period: 6/15/2018-7/30/2018
Direct cost: $3570
Role: Mentor for Brown University PLME student, Justin Kim
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:BTR
Title: “Effect of age on neurocognitive decline post-cardiopulmonary bypass in the setting of cardiac surgery”
Period: 6/1/2018-8/15/2018
Direct cost: $3750
Role: Mentor for Brown Medical Student Kelsey Anderson
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID: NIH T35HL094308
Title: “Effect of Diabetes on Beta Adrenergic Receptor Signaling in Coronary Microvascular Reactivity After Cardiac Surgery”
Period: 6/1/2018-8/15/2018
Direct cost: $4,383.00
Role: Co-mentor for Brown Medical Student Olivia Ziegler
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID: NIH T35HL094308
Title: “Effects of Diabetes on Neurocognitive Decline after Cardiac Surgery”
Period: 6/1/2017-8/15/2017
Direct cost: $4,383.00
Role: Co-mentor for Brown Medical Student Anastassia Gorvitvoskaia
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:BTR
Title: “The effects of glucose control on Norepinephrine-induced microvascular signaling during cardiac surgery”
Period: 6/12/2017-8/12/2017
Direct cost: $3750.00
Role: Co-Mentor for Brown Medical Student Caroline Gordon
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:NIH T35HL094308
Title: “The effects of glucose control on vasopressin-induced microvascular signaling during cardiac surgery”
Period: 6/1/2016-8/15/2016
Direct cost: 4,383.00
Role: Mentor for Brown Medical Student Nicholas Sellke
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:NIH T35HL094308
Title: “Effects of Diabetes on Neurocognitive Decline after Cardiac Surgery”
Period: 6/1/2016-8/15/2016
Direct cost: 4,383.00
Role: Co-mentor for Brown Medical Student Alexander Kuczmarski
Agency: Summer Assistantship through our Basic and Translational Research (BTR) Program.
ID:BTR
Title: “Role of Protein O-GlcNAcylation in Calpain Inhibitor-Induced Vascular Protection”
Period: 6/1/2016-8/15/2016
Direct cost: $3750.00
Role: Co-mentor for Brown Medical Student Se-Young Yoon
Agency: Leadership Alliance Summer Research at Brown University (Mentor)
ID: Brown University SR-EIP
Period: 2016 summer 6/1/2016-8/20/2016
Title: “KCa and Endothelial Function”
Direct cost: $3570.00
Role: Mentor for National undergraduate student, Victoria Cole
Agency: Brown University's Program in Liberal Medical Education (PLME) (Mentor)
ID: Summer Research Assistantship (SRA) Award
Title: “Diabetes Regulates COX1 and COX2 Expression in the Setting of Cardiac Surgery”
Period: 6/1/2015-8/8/2015
Direct cost: $3570
Role: Co-Mentor for Brown University PLME student, Kelsey Anderson
Agency: Summer Research Assistantship (SRA) Award (Co-Mentor)
ID: Summer Research Assistantship (SRA) Award
Title: “Diabetes Regulates COX1 and COX2 Expression in the Setting of Cardiac Surgery”
Period: 6/1/2015-8/8/2015
Direct cost: $3570
Role: Mentor for Brown University PLME student, Kelsey Anderson
Agency: Brown University's Program in Liberal Medical Education (PLME)
ID: Summer Research Assistantship (SRA) Award
Title: “Necroptosis in the Pig Ischemic Heart”
Period: 6/1/2015-8/8/2016
Direct cost: $3500
Role: Co-Mentor for Brown University PLME student, Justin Liang
Agency: Leadership Alliance Summer Research at Brown University (Advisor)
ID: Brown University SR-EIP
Title: “Expression and Localization of COX1 and COX2 in Human Diabetic Myocardium and Vasculature”
Period: 6/1/2014-8/8/2014
Direct cost: $3500.00
Role: Co-Mentor for National undergraduate student, Hunter Mitchell
04/01/04-03/30/09 T32 HL076130 Sellke (PI)
Cardiovascular Surgery Research Training Grant
The goal of this proposal is to give 2-3rd year surgical Residents, willing to pursue a career in academic medicine, a formal 2-year research training in basic and clinical research.
Role: Mentor
