Arturo Andrade, Ph.D. research focuses on elucidating cell-specific mechanisms of neuronal activity and drug action including opioids and cannabinoids.
His research interest expands into three main areas: a) Function and expression of presynaptic calcium channels in anxiety and pain, b) Development of calcium-dependent bioluminescence sensors for optimal control and imaging of neuronal activity, c) Development of biochemical sensors for neurotransmitters including glutamate, GABA, and serotonin. Our studies will have implications for multiple conditions including epilepsy, Parkinson's disease, neuropathic pain, Alzheimer's disease, schizophrenia, and bipolar disorder.
Our lab is currently funded by NIH/NSF. We utilize a variety of systems and techniques to answer our research questions. These include mammalian expression systems, mouse genetic models, electrophysiology, biochemistry, molecular biology, bioluminescence, and calcium imaging. We work with undergraduate/graduate students, and postdoctoral trainees.
In addition to my research role, I direct the Rodent Behavioral Phenotyping Core under the Carney Insitute for Brain Science at Brown. I coordinate research operations related to this core among a vibrant group of researchers interested in performing behavioral studies in rodents.
| Ahmadian-Alam, Leila, Andrade, Arturo, Song, Edward. "Electrochemical Detection of Glutamate and Histamine Using Redox-Labeled Stimuli-Responsive Polymer as a Synthetic Target Receptor." ACS Applied Polymer Materials, vol. 6, no. 10, 2024, pp. 5630-5641. |
| Ahmad HMN, Andrade A, Song E. "Continuous Real-Time Detection of Serotonin Using an Aptamer-Based Electrochemical Biosensor." Biosensors, vol. 13, no. 11, 2023. |
| Bunda, Alexandra, Andrade, Arturo. "BaseScope™ Approach to Visualize Alternative Splice Variants in Tissue." Methods in Molecular Biology, 2022, pp. 185-196. |
| Berry, Camryn, Sun, Herie, Tkachev, Vladimir, Rajadhyaksha, Anjali M., Andrade, Arturo. "Novel Insights into the Role of Voltage-Gated Calcium Channel Genes in Psychiatric Disorders." Voltage-Gated Calcium Channels, 2022, pp. 553-574. |
| Blazon M, LaCarubba B, Bunda A, Czepiel N, Mallat S, Londrigan L, Andrade A. "N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety." OBM neurobiology, vol. 5, no. 1, 2021. |
| Hwang H, Szucs MJ, Ding LJ, Allen A, Ren X, Haensgen H, Gao F, Rhim H, Andrade A, Pan JQ, Carr SA, Ahmad R, Xu W. "Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome." Biological Psychiatry, vol. 89, no. 3, 2021, pp. 256-269. |
| Bunda A, LaCarubba B, Bertolino M, Akiki M, Bath K, Lopez-Soto J, Lipscombe D, Andrade A. "Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli." Molecular Brain, vol. 12, no. 1, 2019, pp. 81. |
| Andrade A, Brennecke A, Mallat S, Brown J, Gomez-Rivadeneira J, Czepiel N, Londrigan L. "Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders." International Journal of Molecular Sciences, vol. 20, no. 14, 2019. |
| Bunda A, LaCarubba B, Akiki M, Andrade A. "Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b." FEBS open bio, vol. 9, no. 9, 2019, pp. 1603-1616. |
| Allen, Summer E., Toro, Cecilia P., Andrade, Arturo, López-Soto, Eduardo J., Denome, Sylvia, Lipscombe, Diane. "Cell-Specific RNA Binding Protein Rbfox2 Regulates Ca(V)2.2 mRNA Exon Composition and Ca(V)2.2 Current Size." eneuro, vol. 4, no. 5, 2017, pp. ENEURO.0332-16.2017. |
| Sandoval A, Duran P, Gandini MA, Andrade A, Almanza A, Kaja S, Felix R. "Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway." Cell calcium, vol. 66, 2017, pp. 1-9. |
| Groen JL, Andrade A, Ritz K, Jalalzadeh H, Haagmans M, Bradley TE, Jongejan A, Verbeek DS, Nürnberg P, Denome S, Hennekam RC, Lipscombe D, Baas F, Tijssen MA. "CACNA1B mutation is linked to unique myoclonus-dystonia syndrome." Human molecular genetics, vol. 24, no. 4, 2015, pp. 987-93. |
| Lipscombe D, Andrade A. "Calcium Channel CaVα₁ Splice Isoforms - Tissue Specificity and Drug Action." Current molecular pharmacology, vol. 8, no. 1, 2015, pp. 22-31. |
| Lipscombe D, Andrade A, Allen SE. "Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences." Biochimica et biophysica acta, vol. 1828, no. 7, 2013, pp. 1522-9. |
| Felix R, Calderón-Rivera A, Andrade A. "Regulation of high-voltage-activated Ca2+ channel function, trafficking, and membrane stability by auxiliary subunits." Wiley interdisciplinary reviews. Membrane transport and signaling, vol. 2, no. 5, 2013, pp. 207-220. |
| Jiang YQ, Andrade A, Lipscombe D. "Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA." Molecular pain, vol. 9, 2013, pp. 67. |
| Marangoudakis S, Andrade A, Helton TD, Denome S, Castiglioni AJ, Lipscombe D. "Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms." Journal of Neuroscience, vol. 32, no. 30, 2012, pp. 10365-9. |
| Calderón-Rivera A, Andrade A, Hernández-Hernández O, González-Ramírez R, Sandoval A, Rivera M, Gomora JC, Felix R. "Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit." Cell calcium, vol. 51, no. 1, 2012, pp. 22-30. |
| Andrade A, Denome S, Jiang YQ, Marangoudakis S, Lipscombe D. "Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing." Nature Neuroscience, vol. 13, no. 10, 2010, pp. 1249-56. |
| Castro A, Andrade A, Vergara P, Segovia J, Aguilar J, Felix R, Delgado-Lezama R. "Involvement of R-type Ca2+ channels in neurotransmitter release from spinal dorsolateral funiculus terminals synapsing motoneurons." The Journal of Comparative Neurology, vol. 513, no. 2, 2009, pp. 188-96. |
| Andrade A, Sandoval A, González-Ramírez R, Lipscombe D, Campbell KP, Felix R. "The alpha(2)delta subunit augments functional expression and modifies the pharmacology of Ca(V)1.3 L-type channels." Cell calcium, vol. 46, no. 4, 2009, pp. 282-92. |
| Barajas M, Andrade A, Hernandez-Hernandez O, Felix R, Arias-Montaño JA. "Histamine-induced Ca2+ entry in human astrocytoma U373 MG cells: evidence for involvement of store-operated channels." Journal of neuroscience research, vol. 86, no. 15, 2008, pp. 3456-68. |
| Sandoval A, Andrade A, Beedle AM, Campbell KP, Felix R. "Inhibition of recombinant N-type Ca(V) channels by the gamma 2 subunit involves unfolded protein response (UPR)-dependent and UPR-independent mechanisms." Journal of Neuroscience, vol. 27, no. 12, 2007, pp. 3317-27. |
| Andrade A, de León MB, Hernández-Hernández O, Cisneros B, Felix R. "Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells." FEBS Letters, vol. 581, no. 23, 2007, pp. 4430-8. |
| Andrade A, Sandoval A, Oviedo N, De Waard M, Elias D, Felix R. "Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features." European Journal of Neuroscience, vol. 25, no. 6, 2007, pp. 1705-10. |
| Avila T, Andrade A, Felix R. "Transforming growth factor-beta1 and bone morphogenetic protein-2 downregulate CaV3.1 channel expression in mouse C2C12 myoblasts." Journal of cellular physiology, vol. 209, no. 2, 2006, pp. 448-56. |
| Sandoval A, Oviedo N, Andrade A, Felix R. "Glycosylation of asparagines 136 and 184 is necessary for the alpha2delta subunit-mediated regulation of voltage-gated Ca2+ channels." FEBS Letters, vol. 576, no. 1-2, 2004, pp. 21-6. |
| Year | Degree | Institution |
|---|---|---|
| 2008 | PhD | Instituto Politécnico Nacional (IPN) |
| 2004 | MSc | Instituto Politécnico Nacional (IPN) |
| 2001 | BSc | Universidad Michoacana de San Nicolás de Hidalgo (UMSNH) |
2021 Outstanding Advisor Award. University of New Hampshire.
2012-2018 K99/R00. Pathway to Independence Award.
2008- present National Network of Investigators, Category I. National Council of Research and Technology, Mexico
-Granted to the top 25% researchers in Mexico.
1996-2001 Miguel Hidalgo Award to Academic Merit. University of Michoacan, Morelia, Mexico.
-Granted to the top 1% students.
2002-2008 Graduate Fellowship. National Council of Research and Technology, Mexico
2000-2007 Telmex Foundation Award. Telmex Foundation.
-Granted to the top 10% students in Mexico.
2000 University of Michoacan Award in Academic Achievement, Mexico
| Name | Title |
|---|---|
| Abdelfattah, Ahmed | Robert J. and Nancy D. Carney University Assistant Professor of Brain Science |
| Creton, Robbert | Professor of Medical Science (Research), Professor of Pathology and Laboratory Medicine (Research) |
| Fallon, Justin | Professor of Medical Science, Professor of Psychiatry and Human Behavior |
| Fleischmann, Alexander | Provost's Professor of Brain Science |
| Hart, Anne | Professor of Neuroscience, Chair of Neuroscience |
| Huang, Yu-Wen Alvin | GLF Translational Assistant Professor of Molecular Biology, Cell Biology and Biochemistry |
| Jaworski, Alexander | June G. Zimmerman Associate Professor of Brain Science |
| Kaun, Karla | Associate Professor of Neuroscience |
| Kreiling, Jill | Associate Professor of Molecular Biology, Cell Biology and Biochemistry (Research) |
| Lapierre, Louis | Adjunct Associate Professor of Molecular Biology, Cell Biology and Biochemistry |
| Lipscombe, Diane | Thomas J. Watson, Sr. Professor of Science, Professor of Neuroscience, Reliance Dhirubhai Ambani Director of the Robert J. and Nancy D. Carney Institute for Brain Science |
| Mayoral, Sonia | Robert J. and Nancy D. Carney Assistant Professor of Neuroscience |
| Moore, Christopher | Associate Director of the Carney Institute of Brain Science, Professor of Neuroscience, Professor of Brain Science |
| Ritt, Jason | Scientific Director of Quantitative Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Associate Professor of Brain Science (Research) |
| Sedivy, John | Hermon C. Bumpus Professor of Biology, Associate Dean and Director, Center for the Biology of Aging |
| Webb, Ashley | Assistant Professor of Molecular Biology, Cell Biology, and Biochemistry |
| Wong, Shiquan | Postdoctoral Research Associate in Molecular Biology, Cell Biology and Biochemistry |
| Director, Rodent Behavioral Phenotyping Core. Brown University, 2021- |
